LT3151B - Novel selective aromatase inhibiting compounds - Google Patents
Novel selective aromatase inhibiting compounds Download PDFInfo
- Publication number
- LT3151B LT3151B LTIP1524A LTIP1524A LT3151B LT 3151 B LT3151 B LT 3151B LT IP1524 A LTIP1524 A LT IP1524A LT IP1524 A LTIP1524 A LT IP1524A LT 3151 B LT3151 B LT 3151B
- Authority
- LT
- Lithuania
- Prior art keywords
- cyanophenyl
- fluorophenyl
- compound
- pharmaceutically acceptable
- triazole
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
- C07D233/61—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms with hydrocarbon radicals, substituted by nitrogen atoms not forming part of a nitro radical, attached to ring nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/04—1,2,3-Triazoles; Hydrogenated 1,2,3-triazoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Heart & Thoracic Surgery (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Cardiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Plant Substances (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Pyridine Compounds (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB9226209A GB2273704B (en) | 1992-12-16 | 1992-12-16 | Triazolyl diaryl selective aromatase inhibiting compounds |
Publications (2)
Publication Number | Publication Date |
---|---|
LTIP1524A LTIP1524A (en) | 1994-07-15 |
LT3151B true LT3151B (en) | 1995-01-31 |
Family
ID=10726697
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
LTIP1524A LT3151B (en) | 1992-12-16 | 1993-12-03 | Novel selective aromatase inhibiting compounds |
Country Status (31)
Country | Link |
---|---|
US (2) | US5703109A (xx) |
EP (1) | EP0674626B1 (xx) |
JP (1) | JP3186771B2 (xx) |
KR (1) | KR100347639B1 (xx) |
CN (1) | CN1056835C (xx) |
AT (1) | ATE194833T1 (xx) |
AU (1) | AU682332B2 (xx) |
BG (1) | BG62930B1 (xx) |
CA (1) | CA2150904A1 (xx) |
CZ (1) | CZ283043B6 (xx) |
DE (1) | DE69329072T2 (xx) |
DK (1) | DK0674626T3 (xx) |
EE (1) | EE03155B1 (xx) |
ES (1) | ES2148312T3 (xx) |
FI (1) | FI952867A (xx) |
GB (1) | GB2273704B (xx) |
GR (1) | GR3034618T3 (xx) |
HR (1) | HRP931494B1 (xx) |
IL (1) | IL107714A (xx) |
LT (1) | LT3151B (xx) |
NO (1) | NO310237B1 (xx) |
NZ (1) | NZ258588A (xx) |
PL (1) | PL176413B1 (xx) |
PT (1) | PT674626E (xx) |
RO (1) | RO113986B1 (xx) |
RU (1) | RU2131418C1 (xx) |
SI (1) | SI9300663B (xx) |
SK (1) | SK281667B6 (xx) |
TW (1) | TW327169B (xx) |
WO (1) | WO1994013645A1 (xx) |
ZA (1) | ZA938717B (xx) |
Families Citing this family (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6063930A (en) * | 1996-04-03 | 2000-05-16 | Merck & Co., Inc. | Substituted imidazole compounds useful as farnesyl-protein transferase inhibitors |
US6080870A (en) * | 1996-04-03 | 2000-06-27 | Merck & Co., Inc. | Biaryl substituted imidazole compounds useful as farnesyl-protein transferase inhibitors |
EP0891334A1 (en) * | 1996-04-03 | 1999-01-20 | Merck & Co., Inc. | Inhibitors of farnesyl-protein transferase |
US5972921A (en) * | 1997-12-12 | 1999-10-26 | Hormos Medical Oy Ltd. | Use of an aromatase inhibitor in the treatment of decreased androgen to estrogen ratio and detrusor urethral sphincter dyssynergia in men |
WO2002009703A1 (en) * | 2000-07-10 | 2002-02-07 | Hormos Medical Corporation | Method for treating cryptorchidism |
FI20010905A0 (fi) * | 2001-05-02 | 2001-05-02 | Vetcare Oy | Uusi eläinlääke |
EP1456184A1 (en) * | 2001-12-11 | 2004-09-15 | Emory University | Bis(cyanophenyl)methyl-triazole for use in prevention of breast cancer |
US6737433B1 (en) * | 2002-12-16 | 2004-05-18 | Laboratoire Theramex | 1-N-phenylamino-1H-imidazole derivatives as aromatase inhibitors and pharmaceutical compositions containing them |
JP2004196795A (ja) * | 2002-12-16 | 2004-07-15 | Wyeth | 外部寄生虫駆除剤としてのn−フェニル−3−シクロプロピルピラゾール−4−カルボニトリル |
US7345073B2 (en) | 2003-02-07 | 2008-03-18 | Hormos Medical Ltd. | Method for treating cryptorchidism |
US20040248989A1 (en) | 2003-06-05 | 2004-12-09 | Risto Santti | Method for the treatment or prevention of lower urinary tract symptoms |
CN1890221B (zh) * | 2003-12-15 | 2014-07-16 | 沙拉麦斯实验公司 | 1-n-苯基-氨基-1h-咪唑衍生物和含有它们的医药组合物 |
RU2480207C2 (ru) * | 2006-05-22 | 2013-04-27 | Хормос Медикал Лтд. | Способ лечения хронического абактериального простатита селективными модуляторами рецепторов эстрогена или ингибиторами ароматазы |
GB0914767D0 (en) * | 2009-08-24 | 2009-09-30 | Sterix Ltd | Compound |
CN102884072A (zh) | 2010-04-08 | 2013-01-16 | 爱默蕾大学 | 被取代的雄甾-4-烯二酮 |
WO2011147814A1 (de) * | 2010-05-27 | 2011-12-01 | Bayer Cropscience Ag | Heterocyclische alkanolderivate als fungizide |
KR101583521B1 (ko) | 2015-07-31 | 2016-01-08 | (주) 엘림비엠에스 | 내오염, 내마모 성능과 시공 작업성 및 광도 성능이 개선된 피브이씨 타일 바닥의 코팅방법 |
US11026519B2 (en) | 2018-04-19 | 2021-06-08 | Wonderland Switzerland Ag | Child carrier |
Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4937250A (en) | 1988-03-07 | 1990-06-26 | Ciba-Geigy Corporation | Alpha-heterocycle substituted tolunitriles |
EP0390558A1 (en) | 1989-03-30 | 1990-10-03 | Orion-Yhtymà Oy | Aromatase inhibiting 4(5)-imidazoles |
US4978672A (en) | 1986-03-07 | 1990-12-18 | Ciba-Geigy Corporation | Alpha-heterocyclc substituted tolunitriles |
US5071861A (en) | 1986-03-07 | 1991-12-10 | Ciba-Geigy Corporation | Alpha-heterocycle substituted tolunitriles |
US5073574A (en) | 1989-07-14 | 1991-12-17 | Ciba-Geigy Corporation | Tetrazolyl substituted benzonitriles and anti-tumor use thereof |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB1580535A (en) * | 1976-08-27 | 1980-12-03 | Ici Ltd | Substituted ketones and their use as herbicides |
US5112845A (en) * | 1986-03-07 | 1992-05-12 | Ciba-Geigy Corporation | Alpha-heterocycle substituted tolunitriles |
US4749713A (en) * | 1986-03-07 | 1988-06-07 | Ciba-Geigy Corporation | Alpha-heterocycle substituted tolunitriles |
DE4039559A1 (de) * | 1990-12-07 | 1992-06-11 | Schering Ag | Funktionalisierte vinylazole, verfahren zu deren herstellung, pharmazeutische praeparate die diese vinylazole enthalten sowie deren verwendung zur herstellung von arzneimitteln |
GB9125924D0 (en) * | 1991-06-18 | 1992-02-05 | Orion Yhtymae Oy | Stereoisomers of an imidazole derivative |
-
1992
- 1992-12-16 GB GB9226209A patent/GB2273704B/en not_active Expired - Fee Related
-
1993
- 1993-11-22 ZA ZA938717A patent/ZA938717B/xx unknown
- 1993-11-23 IL IL10771493A patent/IL107714A/xx not_active IP Right Cessation
- 1993-12-03 LT LTIP1524A patent/LT3151B/lt not_active IP Right Cessation
- 1993-12-14 AT AT94901975T patent/ATE194833T1/de not_active IP Right Cessation
- 1993-12-14 RU RU95114360/04A patent/RU2131418C1/ru not_active IP Right Cessation
- 1993-12-14 US US08/436,389 patent/US5703109A/en not_active Expired - Fee Related
- 1993-12-14 KR KR1019950702444A patent/KR100347639B1/ko not_active IP Right Cessation
- 1993-12-14 ES ES94901975T patent/ES2148312T3/es not_active Expired - Lifetime
- 1993-12-14 PL PL93309350A patent/PL176413B1/pl unknown
- 1993-12-14 SK SK778-95A patent/SK281667B6/sk unknown
- 1993-12-14 JP JP51384094A patent/JP3186771B2/ja not_active Expired - Fee Related
- 1993-12-14 DE DE69329072T patent/DE69329072T2/de not_active Expired - Fee Related
- 1993-12-14 WO PCT/FI1993/000539 patent/WO1994013645A1/en active IP Right Grant
- 1993-12-14 DK DK94901975T patent/DK0674626T3/da active
- 1993-12-14 PT PT94901975T patent/PT674626E/pt unknown
- 1993-12-14 EP EP94901975A patent/EP0674626B1/en not_active Expired - Lifetime
- 1993-12-14 NZ NZ258588A patent/NZ258588A/en unknown
- 1993-12-14 CA CA002150904A patent/CA2150904A1/en not_active Abandoned
- 1993-12-14 TW TW082110583A patent/TW327169B/zh active
- 1993-12-14 RO RO95-01149A patent/RO113986B1/ro unknown
- 1993-12-14 CZ CZ951532A patent/CZ283043B6/cs not_active IP Right Cessation
- 1993-12-14 AU AU56523/94A patent/AU682332B2/en not_active Ceased
- 1993-12-15 CN CN93120844A patent/CN1056835C/zh not_active Expired - Fee Related
- 1993-12-15 HR HR931494A patent/HRP931494B1/xx not_active IP Right Cessation
- 1993-12-16 SI SI9300663A patent/SI9300663B/sl unknown
-
1994
- 1994-11-22 EE EE9400434A patent/EE03155B1/xx not_active IP Right Cessation
-
1995
- 1995-06-05 BG BG99699A patent/BG62930B1/bg unknown
- 1995-06-09 FI FI952867A patent/FI952867A/fi unknown
- 1995-06-15 NO NO19952365A patent/NO310237B1/no unknown
-
1997
- 1997-09-15 US US08/929,424 patent/US5962495A/en not_active Expired - Fee Related
-
2000
- 2000-10-13 GR GR20000402303T patent/GR3034618T3/el not_active IP Right Cessation
Patent Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4978672A (en) | 1986-03-07 | 1990-12-18 | Ciba-Geigy Corporation | Alpha-heterocyclc substituted tolunitriles |
US5071861A (en) | 1986-03-07 | 1991-12-10 | Ciba-Geigy Corporation | Alpha-heterocycle substituted tolunitriles |
US4937250A (en) | 1988-03-07 | 1990-06-26 | Ciba-Geigy Corporation | Alpha-heterocycle substituted tolunitriles |
EP0390558A1 (en) | 1989-03-30 | 1990-10-03 | Orion-Yhtymà Oy | Aromatase inhibiting 4(5)-imidazoles |
US5073574A (en) | 1989-07-14 | 1991-12-17 | Ciba-Geigy Corporation | Tetrazolyl substituted benzonitriles and anti-tumor use thereof |
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
LT3151B (en) | Novel selective aromatase inhibiting compounds | |
US5098923A (en) | Aromatase inhibiting 4(5)-imidazoles | |
AU679119B2 (en) | Azole derivative and pharmaceutical composition thereof | |
US4363912A (en) | Indole thromboxane synthetase inhibitors | |
Karjalainen et al. | Synthesis of new potent and selective aromatase inhibitors based on long-chained diarylalkylimidazole and diarylalkyltriazole molecule skeletons | |
HRP920170A2 (en) | New selective aromatase inhibiting 4(5) imidazoles | |
PL162513B1 (pl) | Sposób wytwarzania nowych pochodnych i midazolu PL PL PL PL PL | |
EP0476944B1 (en) | Aromatase inhibiting 4(5)-imidazoles | |
HUT72299A (en) | Novel selective aromatase inhibiting heterocyclic compounds, pharmaceutical compositions containing them and process for preparing them | |
AU604011B2 (en) | Alpha-heteroaryl substituted toluonitriles |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
PC9A | Transfer of patents |
Free format text: RISTO ARVO SAKARI LAMMINTAUSTA,MELTOISTENTIE, FIN-20900 TURKU,FI,980210 |
|
MM9A | Lapsed patents |
Effective date: 20031203 |