HRP931494B1 - Novel selective aromataze inhibiting compounds - Google Patents

Novel selective aromataze inhibiting compounds

Info

Publication number
HRP931494B1
HRP931494B1 HR931494A HRP931494A HRP931494B1 HR P931494 B1 HRP931494 B1 HR P931494B1 HR 931494 A HR931494 A HR 931494A HR P931494 A HRP931494 A HR P931494A HR P931494 B1 HRP931494 B1 HR P931494B1
Authority
HR
Croatia
Prior art keywords
pct
choh
date
compounds
sec
Prior art date
Application number
HR931494A
Other languages
English (en)
Inventor
Arto Johannes Karjalainen
Marja-Liisa Sodervall
Arja Marketta Kalapudes
Reino Olavi Pelkonen
Arie Marja Laine
Risto Avro Sakari Lammintausta
Jarmo Sakari Salonen
Original Assignee
Risto Arvo Sakari Lammintausta
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Risto Arvo Sakari Lammintausta filed Critical Risto Arvo Sakari Lammintausta
Publication of HRP931494A2 publication Critical patent/HRP931494A2/xx
Publication of HRP931494B1 publication Critical patent/HRP931494B1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C07D233/61—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms with hydrocarbon radicals, substituted by nitrogen atoms not forming part of a nitro radical, attached to ring nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/08—Drugs for disorders of the urinary system of the prostate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/04—1,2,3-Triazoles; Hydrogenated 1,2,3-triazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Urology & Nephrology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Diabetes (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pyridine Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
HR931494A 1992-12-16 1993-12-15 Novel selective aromataze inhibiting compounds HRP931494B1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB9226209A GB2273704B (en) 1992-12-16 1992-12-16 Triazolyl diaryl selective aromatase inhibiting compounds

Publications (2)

Publication Number Publication Date
HRP931494A2 HRP931494A2 (en) 1996-08-31
HRP931494B1 true HRP931494B1 (en) 2001-06-30

Family

ID=10726697

Family Applications (1)

Application Number Title Priority Date Filing Date
HR931494A HRP931494B1 (en) 1992-12-16 1993-12-15 Novel selective aromataze inhibiting compounds

Country Status (31)

Country Link
US (2) US5703109A (xx)
EP (1) EP0674626B1 (xx)
JP (1) JP3186771B2 (xx)
KR (1) KR100347639B1 (xx)
CN (1) CN1056835C (xx)
AT (1) ATE194833T1 (xx)
AU (1) AU682332B2 (xx)
BG (1) BG62930B1 (xx)
CA (1) CA2150904A1 (xx)
CZ (1) CZ283043B6 (xx)
DE (1) DE69329072T2 (xx)
DK (1) DK0674626T3 (xx)
EE (1) EE03155B1 (xx)
ES (1) ES2148312T3 (xx)
FI (1) FI952867A0 (xx)
GB (1) GB2273704B (xx)
GR (1) GR3034618T3 (xx)
HR (1) HRP931494B1 (xx)
IL (1) IL107714A (xx)
LT (1) LT3151B (xx)
NO (1) NO310237B1 (xx)
NZ (1) NZ258588A (xx)
PL (1) PL176413B1 (xx)
PT (1) PT674626E (xx)
RO (1) RO113986B1 (xx)
RU (1) RU2131418C1 (xx)
SI (1) SI9300663B (xx)
SK (1) SK281667B6 (xx)
TW (1) TW327169B (xx)
WO (1) WO1994013645A1 (xx)
ZA (1) ZA938717B (xx)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997036876A1 (en) * 1996-04-03 1997-10-09 Merck & Co., Inc. Inhibitors of farnesyl-protein transferase
US6063930A (en) * 1996-04-03 2000-05-16 Merck & Co., Inc. Substituted imidazole compounds useful as farnesyl-protein transferase inhibitors
US6080870A (en) * 1996-04-03 2000-06-27 Merck & Co., Inc. Biaryl substituted imidazole compounds useful as farnesyl-protein transferase inhibitors
US5972921A (en) * 1997-12-12 1999-10-26 Hormos Medical Oy Ltd. Use of an aromatase inhibitor in the treatment of decreased androgen to estrogen ratio and detrusor urethral sphincter dyssynergia in men
WO2002009703A1 (en) * 2000-07-10 2002-02-07 Hormos Medical Corporation Method for treating cryptorchidism
FI20010905A0 (fi) * 2001-05-02 2001-05-02 Vetcare Oy Uusi eläinlääke
CN1325482C (zh) * 2001-12-11 2007-07-11 埃默里大学 双(氰基苯基)甲基－三唑在预防乳腺癌中的用途
JP2004196795A (ja) * 2002-12-16 2004-07-15 Wyeth 外部寄生虫駆除剤としてのｎ−フェニル−３−シクロプロピルピラゾール−４−カルボニトリル
EP1431292A1 (en) * 2002-12-16 2004-06-23 Laboratoire Theramex 1-N-phenylamino-1H-imidazole derivatives as aromatase inhibitors
US7345073B2 (en) 2003-02-07 2008-03-18 Hormos Medical Ltd. Method for treating cryptorchidism
US20040248989A1 (en) 2003-06-05 2004-12-09 Risto Santti Method for the treatment or prevention of lower urinary tract symptoms
MXPA06006837A (es) * 2003-12-15 2006-09-04 Theramex Derivados de 1-n-fenil-amino-ih-imidazol y composiciones farmaceuticas que los contienen.
RU2480207C2 (ru) * 2006-05-22 2013-04-27 Хормос Медикал Лтд. Способ лечения хронического абактериального простатита селективными модуляторами рецепторов эстрогена или ингибиторами ароматазы
GB0914767D0 (en) * 2009-08-24 2009-09-30 Sterix Ltd Compound
CA2794565C (en) 2010-04-08 2018-08-21 Emory University Substituted androst-4-ene diones
JP5870093B2 (ja) * 2010-05-27 2016-02-24 バイエル・インテレクチュアル・プロパティ・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツングＢａｙｅｒ Ｉｎｔｅｌｌｅｃｔｕａｌ Ｐｒｏｐｅｒｔｙ ＧｍｂＨ 殺菌剤としてのヘテロ環式アルカノール誘導体
KR101583521B1 (ko) 2015-07-31 2016-01-08 (주) 엘림비엠에스 내오염, 내마모 성능과 시공 작업성 및 광도 성능이 개선된 피브이씨 타일 바닥의 코팅방법
CA3115420C (en) 2018-04-19 2023-11-07 Wonderland Switzerland Ag Child carrier

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1580535A (en) * 1976-08-27 1980-12-03 Ici Ltd Substituted ketones and their use as herbicides
US4937250A (en) 1988-03-07 1990-06-26 Ciba-Geigy Corporation Alpha-heterocycle substituted tolunitriles
US4978672A (en) 1986-03-07 1990-12-18 Ciba-Geigy Corporation Alpha-heterocyclc substituted tolunitriles
US4749713A (en) * 1986-03-07 1988-06-07 Ciba-Geigy Corporation Alpha-heterocycle substituted tolunitriles
US5112845A (en) * 1986-03-07 1992-05-12 Ciba-Geigy Corporation Alpha-heterocycle substituted tolunitriles
US5071861A (en) 1986-03-07 1991-12-10 Ciba-Geigy Corporation Alpha-heterocycle substituted tolunitriles
AU627559B2 (en) * 1989-03-30 1992-08-27 Farmos-Yhtyma Oy Novel aromatase inhibiting 4(5)-imidazoles
ES2084687T3 (es) 1989-07-14 1996-05-16 Ciba Geigy Ag Benzonitrilos substituidos.
DE4039559A1 (de) * 1990-12-07 1992-06-11 Schering Ag Funktionalisierte vinylazole, verfahren zu deren herstellung, pharmazeutische praeparate die diese vinylazole enthalten sowie deren verwendung zur herstellung von arzneimitteln
GB9125924D0 (en) * 1991-06-18 1992-02-05 Orion Yhtymae Oy Stereoisomers of an imidazole derivative

Also Published As

Publication number Publication date
DE69329072D1 (de) 2000-08-24
GB9226209D0 (en) 1993-02-10
PL309350A1 (en) 1995-10-02
NO952365L (no) 1995-06-15
EP0674626B1 (en) 2000-07-19
DE69329072T2 (de) 2000-12-21
AU5652394A (en) 1994-07-04
FI952867A (fi) 1995-06-09
IL107714A (en) 2003-07-31
NZ258588A (en) 1996-11-26
CZ153295A3 (en) 1995-11-15
JP3186771B2 (ja) 2001-07-11
CA2150904A1 (en) 1994-06-23
GB2273704B (en) 1997-01-22
RU2131418C1 (ru) 1999-06-10
TW327169B (en) 1998-02-21
SK281667B6 (sk) 2001-06-11
AU682332B2 (en) 1997-10-02
CZ283043B6 (cs) 1997-12-17
KR950704263A (ko) 1995-11-17
CN1056835C (zh) 2000-09-27
NO310237B1 (no) 2001-06-11
SI9300663B (sl) 2002-02-28
FI952867A0 (fi) 1995-06-09
LTIP1524A (en) 1994-07-15
SI9300663A (en) 1994-09-30
HRP931494A2 (en) 1996-08-31
GR3034618T3 (en) 2001-01-31
EE03155B1 (et) 1999-02-15
GB2273704A (en) 1994-06-29
LT3151B (en) 1995-01-31
SK77895A3 (en) 1995-12-06
EP0674626A1 (en) 1995-10-04
ATE194833T1 (de) 2000-08-15
PT674626E (pt) 2000-11-30
PL176413B1 (pl) 1999-05-31
RO113986B1 (ro) 1998-12-30
BG62930B1 (bg) 2000-11-30
ZA938717B (en) 1994-06-30
IL107714A0 (en) 1994-02-27
NO952365D0 (no) 1995-06-15
BG99699A (bg) 1996-04-30
DK0674626T3 (da) 2000-11-13
ES2148312T3 (es) 2000-10-16
RU95114360A (ru) 1997-06-10
US5703109A (en) 1997-12-30
JPH08504424A (ja) 1996-05-14
US5962495A (en) 1999-10-05
CN1093357A (zh) 1994-10-12
WO1994013645A1 (en) 1994-06-23
KR100347639B1 (ko) 2002-11-29

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Legal Events

Date Code Title Description
A1OB Publication of a patent application
AIPI Request for the grant of a patent on the basis of a substantive examination of a patent application
PPPP Transfer of rights

Owner name: RISTO ARVO SAKARI LAMMINTAUSTA, FI

B1PR Patent granted
ODRP Renewal fee for the maintenance of a patent

Payment date: 20021209

Year of fee payment: 10

PBON Lapse due to non-payment of renewal fee

Effective date: 20031216