LT3033102T - Dalelės, konjuguotos su peptidu - Google Patents

Dalelės, konjuguotos su peptidu

Info

Publication number
LT3033102T
LT3033102T LTEP14836306.2T LT14836306T LT3033102T LT 3033102 T LT3033102 T LT 3033102T LT 14836306 T LT14836306 T LT 14836306T LT 3033102 T LT3033102 T LT 3033102T
Authority
LT
Lithuania
Prior art keywords
peptide conjugated
conjugated particles
particles
peptide
conjugated
Prior art date
Application number
LTEP14836306.2T
Other languages
English (en)
Lithuanian (lt)
Inventor
Lonnie D SHEA
Stephen D. Miller
Jonathan Woon Teck YAP
Daniel R. Getts
Derrick Mccarthy
Original Assignee
Northwestern University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=52468804&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=LT3033102(T) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Northwestern University filed Critical Northwestern University
Publication of LT3033102T publication Critical patent/LT3033102T/lt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/0005—Vertebrate antigens
    • A61K39/0008—Antigens related to auto-immune diseases; Preparations to induce self-tolerance
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/385—Haptens or antigens, bound to carriers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/58—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. poly[meth]acrylate, polyacrylamide, polystyrene, polyvinylpyrrolidone, polyvinylalcohol or polystyrene sulfonic acid resin
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    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
    • A61K47/6905—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a colloid or an emulsion
    • A61K47/6911—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a colloid or an emulsion the form being a liposome
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    • A61K47/6929—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a particulate, a powder, an adsorbate, a bead or a sphere the form being a solid microparticle having no hollow or gas-filled cores the form being a nanoparticle, e.g. an immuno-nanoparticle
    • A61K47/6931—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a particulate, a powder, an adsorbate, a bead or a sphere the form being a solid microparticle having no hollow or gas-filled cores the form being a nanoparticle, e.g. an immuno-nanoparticle the material constituting the nanoparticle being a polymer
    • A61K47/6935—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a particulate, a powder, an adsorbate, a bead or a sphere the form being a solid microparticle having no hollow or gas-filled cores the form being a nanoparticle, e.g. an immuno-nanoparticle the material constituting the nanoparticle being a polymer the polymer being obtained otherwise than by reactions involving carbon to carbon unsaturated bonds, e.g. polyesters, polyamides or polyglycerol
    • A61K47/6937—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a particulate, a powder, an adsorbate, a bead or a sphere the form being a solid microparticle having no hollow or gas-filled cores the form being a nanoparticle, e.g. an immuno-nanoparticle the material constituting the nanoparticle being a polymer the polymer being obtained otherwise than by reactions involving carbon to carbon unsaturated bonds, e.g. polyesters, polyamides or polyglycerol the polymer being PLGA, PLA or polyglycolic acid
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    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
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    • A61K9/5153—Polyesters, e.g. poly(lactide-co-glycolide)

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nanotechnology (AREA)
  • Diabetes (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Rheumatology (AREA)
  • Hematology (AREA)
  • Pulmonology (AREA)
  • Dispersion Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Pain & Pain Management (AREA)
  • Endocrinology (AREA)
  • Dermatology (AREA)
  • Physics & Mathematics (AREA)
  • Emergency Medicine (AREA)
  • Obesity (AREA)
  • Optics & Photonics (AREA)
  • Urology & Nephrology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
LTEP14836306.2T 2013-08-13 2014-08-13 Dalelės, konjuguotos su peptidu LT3033102T (lt)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201361865389P 2013-08-13 2013-08-13
US201361869279P 2013-08-23 2013-08-23
US201361887112P 2013-10-04 2013-10-04
PCT/US2014/050962 WO2015023796A2 (fr) 2013-08-13 2014-08-13 Particules conjuguées à un peptide

Publications (1)

Publication Number Publication Date
LT3033102T true LT3033102T (lt) 2020-03-10

Family

ID=52468804

Family Applications (1)

Application Number Title Priority Date Filing Date
LTEP14836306.2T LT3033102T (lt) 2013-08-13 2014-08-13 Dalelės, konjuguotos su peptidu

Country Status (24)

Country Link
US (9) US9616113B2 (fr)
EP (2) EP3033102B2 (fr)
JP (4) JP6553033B2 (fr)
KR (5) KR102485789B1 (fr)
CN (2) CN105555301B (fr)
AU (4) AU2014306603B2 (fr)
BR (1) BR112016003084A2 (fr)
CA (1) CA2918823A1 (fr)
CY (1) CY1122558T1 (fr)
DK (1) DK3033102T4 (fr)
ES (1) ES2762187T5 (fr)
FI (1) FI3033102T4 (fr)
HR (1) HRP20192270T4 (fr)
HU (1) HUE047329T2 (fr)
IL (3) IL292567A (fr)
LT (1) LT3033102T (fr)
ME (1) ME03590B (fr)
MX (5) MX2016001931A (fr)
PL (1) PL3033102T5 (fr)
PT (1) PT3033102T (fr)
RS (1) RS59801B2 (fr)
RU (1) RU2685186C2 (fr)
SI (1) SI3033102T2 (fr)
WO (1) WO2015023796A2 (fr)

Families Citing this family (39)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101819688B1 (ko) 2010-11-12 2018-01-17 코어 파마슈티칼스 디벨롭먼트 컴퍼니 변형된 면역-조절 입자
EP2841098A4 (fr) 2012-04-23 2016-03-02 Allertein Therapeutics Llc Nanoparticules pour le traitement d'allergies
EP3607973A1 (fr) 2012-06-21 2020-02-12 Northwestern University Particules conjuguées à des peptides
US9913883B2 (en) 2013-03-13 2018-03-13 Cour Pharmaceuticals Development Company Immune-modifying nanoparticles for the treatment of inflammatory diseases
EP2981285B1 (fr) 2013-04-03 2020-06-03 N-Fold Llc Nouvelles compositions de nanoparticules
CA2918823A1 (fr) 2013-08-13 2015-02-19 Stephen D. Miller Particules conjuguees a un peptide
EP4299058A3 (fr) 2014-06-24 2024-03-27 The Trustees of Princeton University Procédé d'encapsulation de composés biologiques, thérapeutiques et agents d'imagerie solubles
GB201508025D0 (en) 2015-05-11 2015-06-24 Ucl Business Plc Fabry disease gene therapy
EP3095440B1 (fr) * 2015-05-19 2020-01-15 PLS-Design GmbH Immunothérapie spécifique d'un antigène à l'aide de liposomes de tolérance
CN108289924A (zh) 2015-10-02 2018-07-17 哥本哈根大学 阻断组蛋白识别结构域的小分子
WO2017112828A1 (fr) * 2015-12-22 2017-06-29 The Trustees Of Princeton University Procédé d'encapsulation de composés biologiques, thérapeutiques et d'agents d'imagerie solubles
EP3393514A4 (fr) 2015-12-23 2019-08-14 Cour Pharmaceuticals Development Company Inc. Particules conjuguées par covalence de type polymère-antigène
IL260296B2 (en) * 2016-01-04 2024-01-01 Cour Pharmaceuticals Dev Company Inc Particles thermalize fusion proteins containing associated epitopes
WO2017139498A1 (fr) * 2016-02-09 2017-08-17 Cour Pharmaceuticals Development Company Inc. Timps encapsulant des épitopes du pollen du cèdre japonais
AU2017221521B2 (en) * 2016-02-18 2022-07-07 Cour Pharmaceuticals Development Company, Inc. Process for the preparation of tolerizing immune-modulating particles
WO2019055539A1 (fr) 2017-09-12 2019-03-21 Prudhomme Robert K Nanoparticules de polymère cellulosique et leurs procédés de formation
JP2021512905A (ja) 2018-02-08 2021-05-20 クール ファーマシューティカルズ ディベロップメント カンパニー インコーポレイテッド 寛容化粒子によるセリアック病の治療
US11731099B2 (en) 2018-07-20 2023-08-22 The Trustees Of Princeton University Method for controlling encapsulation efficiency and burst release of water soluble molecules from nanoparticles and microparticles produced by inverse flash nanoprecipitation
US20210382050A1 (en) 2018-10-19 2021-12-09 The Regents Of The University Of Michigan Method for monitoring autoimmune disease
CA3135803A1 (fr) * 2019-04-05 2020-10-08 Asp Health Inc. Composants consommables dans des systemes et procedes de distribution d'echantillon fluidique
CN110317255B (zh) * 2019-07-19 2020-07-31 北京工商大学 αs1-酪蛋白的抗原表位制备得到的单抗及牛乳过敏原检测方法
KR20220054305A (ko) * 2019-07-31 2022-05-02 온코어 파마, 인크. 면역 회피성 종양의 치료
EP4021490A4 (fr) * 2019-08-30 2023-10-25 Universidad De Chile Peptides autoantigéniques (calvicifiv), présentés par les cellules dentritiques tolérogéniques, utiles pour le traitement personnalisé de l'arthrite rhumatoïde
GB201913408D0 (en) * 2019-09-17 2019-10-30 King S College London Proinsulin peptides for type 1 diabetes
WO2021113440A2 (fr) * 2019-12-03 2021-06-10 China Medical University Oligopeptide, kit de test associé, composition médicale associée et utilisation de la composition médicale
WO2021155281A1 (fr) * 2020-01-31 2021-08-05 Applied Molecular Transport Inc. Compositions et méthodes pour le traitement de la maladie cœliaque
MX2022011606A (es) * 2020-03-20 2022-12-08 Univ Monash Composiciones y metodos para tratar el lupus.
EP4237008A2 (fr) * 2020-10-27 2023-09-06 Elucida Oncology, Inc. Conjugués particule vecteur-médicament lieurs auto-immolateurs et leurs utilisations
MX2023012257A (es) 2021-04-16 2024-01-08 Cour Pharmaceuticals Dev Company Inc Método de rastreo del mantenimiento de la inmunotolerancia.
MX2023012256A (es) * 2021-04-16 2024-01-08 Cour Pharmaceuticals Dev Company Inc Tratamiento de la alergia al cacahuate con nanopartículas tolerantes.
MX2024004851A (es) 2021-10-21 2024-06-12 Cour Pharmaceuticals Dev Company Inc Tratamiento de cirrosis biliar primaria (pbc) con nanoparticulas tolerizantes.
CN113908256B (zh) * 2021-11-26 2023-05-26 中国农业科学院兰州兽医研究所 Lancl1蛋白在制备抗病毒药物中的应用
CN114773434B (zh) * 2022-03-17 2024-04-05 南京市妇幼保健院 一种用于激活原始卵泡从而治疗或辅助治疗卵巢早衰的多肽pfap1及其应用
AU2023263417A1 (en) 2022-04-29 2024-10-24 Cour Pharmaceuticals Development Company Inc. Tolerizing immune modifying nanoparticles for overcoming the immunogenicity of therapeutic vectors and proteins
GB202211696D0 (en) * 2022-08-10 2022-09-21 Univ London Queen Mary Peptides and method
WO2024072751A1 (fr) * 2022-09-26 2024-04-04 The Methodist Hospital Formulations de microparticules pour thérapie intraveineuse et leurs procédés de fabrication et leurs méthodes d'utilisation
WO2024086706A1 (fr) 2022-10-19 2024-04-25 Cour Pharmaceuticals Development Company Inc. Traitement d'allergie à l'arachide avec nanoparticules de tolérisation
WO2024094562A1 (fr) * 2022-11-01 2024-05-10 Universität Zürich Nouveaux peptides mbp et leur utilisation dans le traitement de la sclérose en plaques
WO2024206202A1 (fr) 2023-03-24 2024-10-03 Cour Pharmaceuticals Development Company Inc. Nanoparticules de modification immunitaire de tolérisation pour le traitement de myasthénie

Family Cites Families (103)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3512940A (en) 1968-12-30 1970-05-19 Justin J Shapiro Test tube filter device
GB8311730D0 (en) 1983-04-29 1983-06-02 Bagshawe K D Handling of reaction mixtures
US4751180A (en) 1985-03-28 1988-06-14 Chiron Corporation Expression using fused genes providing for protein product
US4935233A (en) 1985-12-02 1990-06-19 G. D. Searle And Company Covalently linked polypeptide cell modulators
US4990253A (en) 1988-01-25 1991-02-05 Abbott Laboratories Fluid sample filtration device
US5358690A (en) 1989-01-10 1994-10-25 Lamina, Ltd. Environmental sample collection and membrane testing device
DE9013914U1 (de) 1990-10-05 1991-02-14 Walter Sarstedt Geräte und Verbrauchsmaterial für Medizin und Wissenschaft, 5223 Nümbrecht Trennvorrichtung für Flüssigkeits-, insbesondere Blutfraktionen
DE69332518T2 (de) 1992-02-28 2003-09-04 Autoimmune Inc Unterdrückung von autoimmunkrankheiten durch antigene in wartestellung
FR2695563B1 (fr) 1992-09-11 1994-12-02 Pasteur Institut Microparticules portant des antigènes et leur utilisation pour l'induction de réponses humorales ou cellulaires.
US6004763A (en) 1992-09-11 1999-12-21 Institut Pasteur Antigen-carrying microparticles and their use in the induction of humoral or cellular responses
JPH06157592A (ja) 1992-11-24 1994-06-03 Hitachi Chem Co Ltd ペプチドもしくはその誘導体、それらとタンパク質との結合体、及びこれらを免疫源とする抗エンドセリン−１抗体の製造方法
AU674584B2 (en) 1993-06-02 1997-01-02 Tvw Telethon Institute For Child Health Research Cryptic peptides for use in inducing immunologic tolerance
US5833860A (en) 1995-08-28 1998-11-10 Millipore Investment Holdings Limited Centrifugal adsorptive sample preparation device and method
US5804201A (en) 1996-03-11 1998-09-08 The Rockefeller University Immunomodulatory peptides of vespid antigen 5
CA2285329A1 (fr) 1997-03-31 1998-10-08 The Regents Of The University Of Michigan Matrices biodegradables a porosite ouverte et processus de fabrication
US7427602B1 (en) 1998-05-13 2008-09-23 The Regents Of The University Of Michigan Sustained DNA delivery from structural matrices
WO2001012222A1 (fr) 1999-08-18 2001-02-22 Kim Ho Youn Agent d'induction d'une tolerance immunologique
AU4139801A (en) * 1999-12-06 2001-06-12 Board Of Trustees Of The University Of Arkansas, The Controlled delivery of antigens
CA2410510A1 (fr) 2000-06-02 2001-12-13 Memorial Sloan-Kettering Cancer Center Cellules presentatrices d'antigene artificiel et leurs methodes d'utilisation
US7332168B2 (en) 2000-08-22 2008-02-19 Micromet Ag Composition for the elimination of autoreactive B-cells
US6890556B1 (en) 2001-02-14 2005-05-10 Northwestern University Controlled surface-associated delivery of genes and oligonucleotides
US7029697B2 (en) 2001-02-14 2006-04-18 Northwestern University Controlled surface-associated delivery of genes and oligonucleotides
US20020187147A1 (en) * 2001-02-15 2002-12-12 City Of Hope Antigen specific recombinant MHC class II molecules and methods of use
WO2003043586A2 (fr) 2001-11-20 2003-05-30 Advanced Inhalation Research, Inc. Compositions destinees a la liberation de produits a action continue
PT1487485E (pt) 2002-03-19 2011-03-11 Powderject Res Ltd Adjuvantes de imidazoquinolina para vacinas de adn
WO2003092654A1 (fr) 2002-05-02 2003-11-13 President And Fellows Of Harvard College Formulations limitant l'extension d'infections pulmonaires
JP5068931B2 (ja) 2002-07-12 2012-11-07 ザ ジョンズ ホプキンス ユニバーシティー 独自のクローン形質のリンパ球受容体に結合する試薬および方法
US7465463B2 (en) 2002-09-04 2008-12-16 Polyheal, Ltd. Compositions comprising microspheres with anti-inflammatory properties for healing of ocular tissues
WO2004053056A2 (fr) * 2002-09-24 2004-06-24 University Of Kentucky Research Foundation Systeme d'administration de vaccin a base de nanoparticules contenant un adjuvant
WO2005000272A1 (fr) * 2003-06-04 2005-01-06 Isis Pharmaceuticals, Inc. Compositions du type liposome, a duree de circulation longue
US20060051407A1 (en) 2003-06-27 2006-03-09 Yoram Richter Method of treating ischemia-reperfusion injury
US8592197B2 (en) 2003-07-11 2013-11-26 Novavax, Inc. Functional influenza virus-like particles (VLPs)
WO2005015160A2 (fr) 2003-08-07 2005-02-17 The Children's Hospital Of Philadelphia Colloides polymeres fonctionnalises
WO2005019429A2 (fr) 2003-08-22 2005-03-03 Potentia Pharmaceuticals, Inc. Compositions et procedes permettant d'augmenter la phagocytose ou l'activite des phagocytes
WO2005020933A2 (fr) 2003-09-02 2005-03-10 University Of South Florida Nanoparticules pour apport de medicament
AU2004289210B2 (en) 2003-11-05 2010-07-15 The Government Of The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Carbohydrate antigen-nanoparticle conjugates and uses thereof as antimetastatic agents in treating cancer
CN101023622B (zh) 2004-04-02 2010-12-08 捷讯研究有限公司 配置和供应无线手持设备
US7846466B2 (en) 2004-06-10 2010-12-07 Northwestern University Biodegradable scaffolds and uses thereof
WO2006080951A2 (fr) 2004-07-01 2006-08-03 Yale University Materiaux polymeres charges de medicaments cibles a forte densite
EP1846446B1 (fr) 2005-02-02 2013-06-26 Novo Nordisk A/S Derives d'insuline
JP2006248978A (ja) 2005-03-10 2006-09-21 Mebiopharm Co Ltd 新規なリポソーム製剤
US20110182805A1 (en) 2005-06-17 2011-07-28 Desimone Joseph M Nanoparticle fabrication methods, systems, and materials
EP1902080B1 (fr) * 2005-07-01 2010-02-24 Roche Diagnostics GmbH Particules de latex carboxylé
US20070014752A1 (en) 2005-07-08 2007-01-18 Krishnendu Roy Surface functionalization of polymeric materials
GB0514262D0 (en) * 2005-07-12 2005-08-17 Renovo Ltd Promotion of epithelial regeneration
US20070041934A1 (en) 2005-08-12 2007-02-22 Regents Of The University Of Michigan Dendrimer based compositions and methods of using the same
CA2633380A1 (fr) * 2005-12-16 2007-07-05 University Of Kansas Nanoagregats pour l'administration de substances therapeutiques
WO2007087341A2 (fr) 2006-01-25 2007-08-02 The Board Of Trustees Of The University Of Illinois Système presentateur d’antigene tolerogenique artificiel biodegradable
WO2007094003A2 (fr) * 2006-02-15 2007-08-23 Ramot At Tel Aviv University Ltd. Véhicules d'affichage de virus pour traiter la sclérose en plaques
JP2009528297A (ja) 2006-03-02 2009-08-06 シーバイオ リミテッド 抗原提示細胞の機能の調節による免疫応答の制御
AU2007309727A1 (en) * 2006-04-11 2008-05-02 Albany College Of Pharmacy And Health Sciences Nanoparticle and polymer formulations for thyroid hormone analogs, antagonists, and formulations thereof
US20090325931A1 (en) * 2006-07-28 2009-12-31 University Court Of The University Of Edinburgh Use of cdk inhibitors for the treatment of granulocyte mediated disorders
EP3590503A1 (fr) * 2006-10-12 2020-01-08 The University of Queensland Compositions et procédés pour moduler les réponses immunologiques
US20090214474A1 (en) 2006-11-01 2009-08-27 Barbara Brooke Jennings Compounds, methods, and treatments for abnormal signaling pathways for prenatal and postnatal development
ES2400696T3 (es) 2006-12-18 2013-04-11 Colorobbia Italia S.P.A. Nanopartículas magnéticas para su aplicación en la hipertermía, preparación de las mismas y uso en construcciones que tienen una aplicación farmacológica
ES2525801T3 (es) 2007-03-07 2014-12-30 Uti Limited Partnership Composiciones y métodos para la prevención y el tratamiento de enfermedades autoinmunes
US20080311140A1 (en) 2007-05-29 2008-12-18 Baylor College Of Medicine Antigen specific immunosuppression by dendritic cell therapy
BRPI0817664A2 (pt) 2007-10-12 2015-03-24 Massachusetts Inst Technology Nanopartículas, método para preparar nanopartículas e método para tratar terapeuticamente ou profilaticamente um indivíduo
US20110014292A1 (en) 2007-10-15 2011-01-20 Cooperative Research Centre For Asthma method of prophylaxis and agents for use therein
WO2009052561A1 (fr) 2007-10-22 2009-04-30 The Walter And Eliza Hall Institute Of Medical Research Compositions et procédés permettant de manipuler une réponse immunitaire
EP2057998A1 (fr) 2007-10-31 2009-05-13 Universitätsklinikum Hamburg-Eppendorf Utilisation de cellules modifiées dans le traitement de la sclérose en plaques
US20090123509A1 (en) * 2007-11-08 2009-05-14 Cory Berkland Biodegradable Colloidal Gels as Moldable Tissue Engineering Scaffolds
US20090238879A1 (en) 2008-01-24 2009-09-24 Northwestern University Delivery scaffolds and related methods of use
JP2009203174A (ja) 2008-02-26 2009-09-10 Hokkaido Univ タンパク質−リポソーム複合体を含有するイオントフォレーシス用組成物
WO2009131712A2 (fr) 2008-04-25 2009-10-29 Duke University Medical Center Lymphocytes b régulateurs et leurs applications
US20110206773A1 (en) 2008-05-20 2011-08-25 Yale University Sustained delivery of drugs from biodegradable polymeric microparticles
EP2123261A1 (fr) 2008-05-20 2009-11-25 Stallergenes S.A. Formulation à particules mucoadhésives pour induire la tolérance immune spécifique à antigène
US8323696B2 (en) 2008-08-29 2012-12-04 Ecole Polytechnique Federale De Lausanne Nanoparticles for immunotherapy
US9149441B2 (en) * 2008-09-29 2015-10-06 The Corporation Of Mercer University Nanospheres encapsulating bioactive material and method for formulation of nanospheres
CA2771995C (fr) 2008-10-02 2016-11-22 University Of Pittsburgh - Of The Commonwealth System Of Higher Education Administration d'un polymere adsorbant pour le traitement d'une inflammation systemique
US8277812B2 (en) 2008-10-12 2012-10-02 Massachusetts Institute Of Technology Immunonanotherapeutics that provide IgG humoral response without T-cell antigen
MX346450B (es) 2008-11-30 2017-03-17 Immusant Inc * Composiciones y métodos para el tratamiento de la enfermedad celíaca.
CA2746124A1 (fr) 2008-12-11 2010-06-17 The Governors Of The University Of Alberta Methodes et systemes destines a induire une tolerance immunologique a des antigenes du non-soi
SG173041A1 (en) 2009-01-20 2011-08-29 Univ Northwestern Compositions and methods for induction of antigen-specific tolerance
EP2255831A1 (fr) * 2009-05-25 2010-12-01 Institut Pasteur Construction de diépitopes à base de liposomes
CA2762653A1 (fr) 2009-05-27 2010-12-02 Selecta Biosciences, Inc. Composes agents immunomodulateurs-polymeres
WO2011031441A1 (fr) 2009-08-28 2011-03-17 The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Thérapie avec une molécule chimérique et un agent pro-apoptotique
JP5486750B2 (ja) 2009-09-18 2014-05-07 国立大学法人九州大学 金微粒子被覆体とその製造方法、およびその用途
RU2448685C2 (ru) * 2009-11-30 2012-04-27 Российская Федерация в лице Министерства промышленности и торговли Российской Федерации Липосомы, содержащие олигопептиды - фрагменты основного белка миелина, фармацевтическая композиция и способ лечения рассеянного склероза
US20110135744A1 (en) 2009-12-03 2011-06-09 The Regents Of The University Of California Nanoparticle Based Therapy for Dispersing Mucin
US20130209564A1 (en) * 2010-02-22 2013-08-15 Shyam M. Rele Polysaccharide Particle Vaccines
US8207290B2 (en) 2010-03-26 2012-06-26 Cerulean Pharma Inc. Methods and systems for generating nanoparticles
WO2011133617A1 (fr) * 2010-04-23 2011-10-27 The Board Of Trustees Of The University Of Illinois Système d'administration de nano-hybrides pour l'utilisation séquentielle de ciblage passif et actif
EP2576645B1 (fr) 2010-06-04 2015-03-18 Tongji University Copolymère du pyrène et du pyrrole et procédé de production du copolymère
AU2011261203B2 (en) 2010-06-04 2014-11-20 Flow Pharma Inc. Peptide particle formulation
AU2011272941B2 (en) 2010-06-30 2014-05-29 Compugen Ltd. C10RF32 for the treatment of multiple sclerosis, rheumatoid arthritis and other autoimmune disorders
AU2011276251B2 (en) * 2010-07-07 2015-02-05 Artifical Cell Technologies, Inc. Respiratory syncytial virus antigenic compositions and methods
CA2807141C (fr) 2010-07-31 2019-02-26 The Scripps Research Institute Compositions et methodes pour induire la tolerance immunitaire
WO2012019041A2 (fr) 2010-08-04 2012-02-09 Duke University Lymphocytes b régulateurs et leurs utilisations
KR101819688B1 (ko) 2010-11-12 2018-01-17 코어 파마슈티칼스 디벨롭먼트 컴퍼니 변형된 면역-조절 입자
SG10201509138XA (en) 2010-11-24 2015-12-30 Univ Nanyang Tech Method for coating particles with calcium phosphate and particles, microparticles and nanoparticles formed thereof
US10064406B2 (en) 2011-01-06 2018-09-04 Cytosorbents Corporation Polymeric sorbent for removal of impurities from whole blood and blood products
AU2012210179C1 (en) 2011-01-24 2016-11-10 Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. Nanoparticles based for dermal and systemic delivery of drugs
CA2828255A1 (fr) * 2011-02-25 2012-08-30 South Dakota State University Nanovecteurs de proteines s'appliquant a une administration topique
AU2012249550B2 (en) 2011-04-29 2017-07-13 Selecta Biosciences, Inc. Tolerogenic synthetic nanocarriers to reduce cytotoxic T lymphocyte responses
WO2013019669A2 (fr) 2011-07-29 2013-02-07 Selecta Biosciences, Inc. Nanosupports synthétiques qui génèrent des réponses immunitaires humorales et de lymphocytes t cytotoxiques (ltc)
US20130058975A1 (en) 2011-09-06 2013-03-07 Selecta Biosciences, Inc. Antigen-specific induced tolerogenic dendritic cells to reduce antibody responses
WO2013115965A1 (fr) * 2012-01-31 2013-08-08 Cerulean Pharma Inc. Conjugués polymère-agent, particules, compositions et méthodes d'utilisation associées
WO2013113326A1 (fr) * 2012-01-31 2013-08-08 Curevac Gmbh Composition pharmaceutique comprenant un complexe support polymère - charge et au moins un antigène de protéine ou de peptide
EP3607973A1 (fr) * 2012-06-21 2020-02-12 Northwestern University Particules conjuguées à des peptides
US9913883B2 (en) * 2013-03-13 2018-03-13 Cour Pharmaceuticals Development Company Immune-modifying nanoparticles for the treatment of inflammatory diseases
CA2918823A1 (fr) * 2013-08-13 2015-02-19 Stephen D. Miller Particules conjuguees a un peptide
WO2015058069A1 (fr) * 2013-10-18 2015-04-23 Moderna Therapeutics, Inc. Compositions et procédés pour tolériser des systèmes cellulaires

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