LT2003100A - S-omeprazolio įtraukimo kompleksas su ciklodekstrinais - Google Patents

S-omeprazolio įtraukimo kompleksas su ciklodekstrinais

Info

Publication number
LT2003100A
LT2003100A LT2003100A LT2003100A LT2003100A LT 2003100 A LT2003100 A LT 2003100A LT 2003100 A LT2003100 A LT 2003100A LT 2003100 A LT2003100 A LT 2003100A LT 2003100 A LT2003100 A LT 2003100A
Authority
LT
Lithuania
Prior art keywords
omeprazole
cyclodextrins
inclusion complex
cyclodextrin
complex
Prior art date
Application number
LT2003100A
Other languages
English (en)
Other versions
LT5182B (lt
Inventor
Yusuf Khwaja Hamied
Dharmaraj Ramachandra Rao
Original Assignee
Cipla Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cipla Ltd. filed Critical Cipla Ltd.
Publication of LT2003100A publication Critical patent/LT2003100A/lt
Publication of LT5182B publication Critical patent/LT5182B/lt

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/716—Glucans
    • A61K31/724—Cyclodextrins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
    • A61K47/6949—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit inclusion complexes, e.g. clathrates, cavitates or fullerenes
    • A61K47/6951—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit inclusion complexes, e.g. clathrates, cavitates or fullerenes using cyclodextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Nanotechnology (AREA)
  • Medical Informatics (AREA)
  • Biophysics (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)

Abstract

Įtraukimo kompleksas apima iš esmės gryną benzimidazolo optinio izomero cheminį junginį ir ciklodekstriną. Geriau, kompleksas apima S-omeprazolį ir ß-ciklodekstriną ir paruošiamas pridedant ciklodekstriną į aktyvios medžiagos vandeninį tirpalą ir tada išskiriant kompleksą iš tirpalo. ą
LT2003100A 2001-06-06 2003-12-03 S-omeprazolio įtraukimo kompleksas su ciklodekstrinais LT5182B (lt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB0113792A GB2376231A (en) 2001-06-06 2001-06-06 Benzimidazole-cyclodextrin inclusion complex

Publications (2)

Publication Number Publication Date
LT2003100A true LT2003100A (lt) 2004-09-27
LT5182B LT5182B (lt) 2004-12-27

Family

ID=9916040

Family Applications (1)

Application Number Title Priority Date Filing Date
LT2003100A LT5182B (lt) 2001-06-06 2003-12-03 S-omeprazolio įtraukimo kompleksas su ciklodekstrinais

Country Status (17)

Country Link
US (1) US20040147481A1 (lt)
EP (1) EP1401442B1 (lt)
JP (1) JP2004536810A (lt)
AT (1) ATE282412T1 (lt)
AU (1) AU2002344386B2 (lt)
CA (1) CA2449769C (lt)
DE (1) DE60201995T2 (lt)
ES (1) ES2232780T3 (lt)
GB (1) GB2376231A (lt)
LT (1) LT5182B (lt)
LV (1) LV13154B (lt)
NZ (1) NZ529956A (lt)
PL (1) PL366940A1 (lt)
PT (1) PT1401442E (lt)
RU (1) RU2313343C2 (lt)
WO (1) WO2002098423A1 (lt)
ZA (1) ZA200309841B (lt)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1707217A1 (en) 2004-12-17 2006-10-04 Wacker Chemie AG Process for preparing an alpha lipoic acid/cyclodextrin complex and product prepared
US20060229277A1 (en) * 2005-04-08 2006-10-12 Orbus Pharma, Inc. Stabilized pharmaceutical compositions comprising an HMG-CoA reductase inhibitor
KR20070069567A (ko) * 2005-12-28 2007-07-03 에스케이케미칼주식회사 저장안정성이 우수한 ｓ-오메프라졸 함유 포접 복합체 및이의 제조방법
EP1973896B1 (en) 2005-12-28 2009-04-15 Union Quimico-Farmaceutica, S.A. A process for the preparation of the (s)-enantiomer of omeprazole
US7947840B2 (en) 2007-09-25 2011-05-24 Hetero Drugs Limited Process for preparation of enantiomerically pure esomeprazole
WO2010097583A1 (en) * 2009-02-24 2010-09-02 Cipla Limited Esomeprazole potassium polymorph and its preparation
CN104277030B (zh) * 2013-07-03 2016-04-20 湖南理工学院 一种反应萃取分离泮托拉唑对映体的方法
CN103768028A (zh) * 2014-01-15 2014-05-07 山东新时代药业有限公司 一种注射用埃索美拉唑钠无菌冻干粉末及其制备工艺

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3427787A1 (de) * 1984-07-27 1986-01-30 Byk Gulden Lomberg Chemische Fabrik Gmbh, 7750 Konstanz Wirkstoffkomplexe von 5-methoxy-2((4-methoxy-3,5-dimethyl-2-pyridyl) methylsulfinyl)-1h-benzimidazol mit cyclodextrinen, deren herstellung und arzneimittel
TW224049B (lt) * 1991-12-31 1994-05-21 Sunkyong Ind Ltd
SE9301830D0 (sv) 1993-05-28 1993-05-28 Ab Astra New compounds
US5877192A (en) * 1993-05-28 1999-03-02 Astra Aktiebolag Method for the treatment of gastric acid-related diseases and production of medication using (-) enantiomer of omeprazole
SE504459C2 (sv) * 1994-07-15 1997-02-17 Astra Ab Förfarande för framställning av substituerade sulfoxider
JPH0948730A (ja) * 1995-06-02 1997-02-18 Takeda Chem Ind Ltd 水溶性の改善されたベンズイミダゾール系抗潰瘍剤含有安定組成物
AU5780696A (en) * 1995-06-02 1996-12-18 Takeda Chemical Industries Ltd. Stabilized composition comprising an antiulcerative benzimid azole
SE510666C2 (sv) 1996-12-20 1999-06-14 Astra Ab Nya Kristallmodifikationer
CZ291842B6 (cs) * 1997-03-13 2003-06-18 Hexal Ag Farmaceutická formulace
PT1018340E (pt) * 1999-01-06 2003-12-31 Tecnimede Sociedade Tecnico Medicinal Sa Complexos de inclusao de sais de aminoacidos de derivados do benzimidazol com ciclodextrinas, sua preparacao e formulacoes farmaceuticas que os contem
US6262085B1 (en) * 1999-08-26 2001-07-17 Robert R. Whittle Alkoxy substituted Benzimidazole compounds, pharmaceutical preparations containing the same, and methods of using the same
CN1636564A (zh) * 1999-08-26 2005-07-13 艾伊法马公司 含烷氧基取代苯并咪唑化合物的组合物和药物制剂及其制法
SE9903831D0 (sv) * 1999-10-22 1999-10-22 Astra Ab Formulation of substituted benzimidazoles

Also Published As

Publication number Publication date
EP1401442A1 (en) 2004-03-31
LT5182B (lt) 2004-12-27
RU2003137221A (ru) 2005-06-10
JP2004536810A (ja) 2004-12-09
RU2313343C2 (ru) 2007-12-27
PT1401442E (pt) 2005-02-28
CA2449769A1 (en) 2002-12-12
AU2002344386B2 (en) 2006-11-30
LV13154B (en) 2004-07-20
HK1064602A1 (en) 2005-02-04
ES2232780T3 (es) 2005-06-01
DE60201995D1 (de) 2004-12-23
PL366940A1 (en) 2005-02-07
NZ529956A (en) 2005-07-29
CA2449769C (en) 2010-12-14
GB2376231A (en) 2002-12-11
GB0113792D0 (en) 2001-07-25
ZA200309841B (en) 2005-03-14
WO2002098423A1 (en) 2002-12-12
DE60201995T2 (de) 2005-11-24
EP1401442B1 (en) 2004-11-17
US20040147481A1 (en) 2004-07-29
ATE282412T1 (de) 2004-12-15

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Effective date: 20060606