KR980003584A - 정제 형태인 자기 입자를 함유하는 시약 제제 - Google Patents

정제 형태인 자기 입자를 함유하는 시약 제제 Download PDF

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Publication number
KR980003584A
KR980003584A KR1019970023487A KR19970023487A KR980003584A KR 980003584 A KR980003584 A KR 980003584A KR 1019970023487 A KR1019970023487 A KR 1019970023487A KR 19970023487 A KR19970023487 A KR 19970023487A KR 980003584 A KR980003584 A KR 980003584A
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South Korea
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magnetic particles
sample
tablet
reagent formulation
reagent
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KR1019970023487A
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KR100260326B1 (ko
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헤르베르트 하르티히
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콜프 베른트, 크나우어 마르틴
베링거 만하임 게엠베하
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Publication of KR980003584A publication Critical patent/KR980003584A/ko
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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/566—Immunoassay; Biospecific binding assay; Materials therefor using specific carrier or receptor proteins as ligand binding reagents where possible specific carrier or receptor proteins are classified with their target compounds
    • G01N33/567—Immunoassay; Biospecific binding assay; Materials therefor using specific carrier or receptor proteins as ligand binding reagents where possible specific carrier or receptor proteins are classified with their target compounds utilising isolate of tissue or organ as binding agent
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54313—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being characterised by its particulate form
    • G01N33/54326—Magnetic particles
    • G01N33/5434—Magnetic particles using magnetic particle immunoreagent carriers which constitute new materials per se
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6834—Enzymatic or biochemical coupling of nucleic acids to a solid phase

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Organic Chemistry (AREA)
  • Hematology (AREA)
  • Biochemistry (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Microbiology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Cell Biology (AREA)
  • Food Science & Technology (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • Medicinal Chemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicinal Preparation (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Sampling And Sample Adjustment (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

본 발명은 부형제의 도움으로 함께 유지되는 다수의 자기 입자를 함유하는 정제의 형태로 시료의 성분들을 결합시키기 위한 시약 제제, 및 분석 시험에 있어서, 시약 제제의 용도에 관한 것이다.

Description

정제 형태인 자기 입자를 함유하는 시약 제제
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (10)

  1. 하기 : -성분들이 본질적으로 완전하게 결합할 수 있는 표면을 갖는 다수의 자기입자, 및 -부형제로 이루어지는, 시료의 성분들을 정제에 결합시키기 위한 시약 제제.
  2. 제1항에 있어서, 성분의 결합을 용이하게 하는 부형제를 함유하는 것을 특징으로 하는 시약 제제.
  3. 제1항에 있어서, 자기 입자간 100㎛이하의 직경을 갖는 것을 특징으로 하는 시약 제제.
  4. 제1항 또는 제2항에 있어서, 자기 입자가 유리-유사 표면을 갖는 것을 특징으로 하는 시약 제제.
  5. 제1항에 있어서, 정제가 5㎎ 이상인 것을 특징으로 하는 시약 제제.
  6. 제4항에 있어서, 부형제가 카오트로픽 염인 것을 특징으로 하는 시약 제제.
  7. 핵산을 결합시키기 위한 제1항 내지 제6항 중 어느 한 항에 따른 시약 제제의 용도.
  8. 핵산을 정제하기 위한 제1항 내지 제6항 중 어느 한 항에 따른 시약 제제의 용도.
  9. 하기 : -자기 입자 및 가용성 부형제를 함유하는 정제를 시료에 첨가하고, 및 -시료중 정제를 이동시키는 것으로 이루어지는, 시료중 자기 입자의 현탁액 제조 방법.
  10. 하기의 단계 : -다수의 자기 입자-함유 정제를 함유하는 디스펜서를 제공하고, 및 -디스펜서를 활성화시켜 정제를 방출시키는 것으로 이루어지는, 자기 입자를 시료에 혼합시키는 방법.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019970023487A 1996-06-07 1997-06-07 자기입자를함유하는정제형태의시약제제 KR100260326B1 (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19622885.9 1996-06-07
DE19622885A DE19622885A1 (de) 1996-06-07 1996-06-07 Reagenzzubereitung enthaltend magnetische Partikel in Form einer Tablette

Publications (2)

Publication Number Publication Date
KR980003584A true KR980003584A (ko) 1998-03-30
KR100260326B1 KR100260326B1 (ko) 2003-03-15

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KR1019970023487A KR100260326B1 (ko) 1996-06-07 1997-06-07 자기입자를함유하는정제형태의시약제제

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Country Link
US (2) US6274386B1 (ko)
EP (1) EP0811694B1 (ko)
JP (1) JP3821541B2 (ko)
KR (1) KR100260326B1 (ko)
AT (1) ATE234366T1 (ko)
AU (1) AU715803B2 (ko)
CA (1) CA2206760C (ko)
DE (2) DE19622885A1 (ko)
DK (1) DK0811694T3 (ko)
ES (1) ES2195053T3 (ko)
IL (1) IL121008A (ko)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100463475B1 (ko) 1995-06-08 2005-06-22 로셰 디아그노스틱스 게엠베하 자기성피그먼트
DE19520398B4 (de) * 1995-06-08 2009-04-16 Roche Diagnostics Gmbh Magnetisches Pigment
DE19743518A1 (de) * 1997-10-01 1999-04-15 Roche Diagnostics Gmbh Automatisierbare universell anwendbare Probenvorbereitungsmethode
EP2316571A3 (en) 1998-05-01 2011-07-27 Gen-Probe Incorporated Automated diagnostic analyzer and method
US8337753B2 (en) 1998-05-01 2012-12-25 Gen-Probe Incorporated Temperature-controlled incubator having a receptacle mixing mechanism
DE19836559A1 (de) 1998-08-12 2000-03-23 Antigen Gmbh Gefäß zur Entnahme von Blut
PT1144620E (pt) 1998-11-30 2004-01-30 Roche Diagnostics Gmbh Perticulas magneticas para a purificacao de acidos nucleicos
CZ20021608A3 (cs) 1999-11-17 2003-06-18 Roche Diagnostics Gmbh Magnetické skleněné částice, metody jejich přípravy a použití
JP4776133B2 (ja) * 2000-02-04 2011-09-21 キアゲン ゲゼルシャフト ミット ベシュレンクテル ハフツング 阻害物質に富む糞便試料及び他の生物学的材料からの核酸の単離
DE10006662A1 (de) * 2000-02-15 2001-08-23 Antigen Produktions Gmbh Gefäß zur Nukleinsäureanalytik
WO2001068599A2 (en) * 2000-03-17 2001-09-20 H. Lundbeck A/S Dosing form for reagents, use of said dosing form in organic chemical synthesis and production of said dosing form
EP1268050A2 (en) * 2000-03-17 2003-01-02 H. Lundbeck A/S Dosing form for a polymer support, use of said dosing form in organic chemical synthesis and method for production of said dosing form
US6602718B1 (en) 2000-11-08 2003-08-05 Becton, Dickinson And Company Method and device for collecting and stabilizing a biological sample
AU2003219759B2 (en) * 2002-02-14 2011-01-20 Veridex, Llc Methods and algorithms for cell enumeration in a low-cost cytometer
US9267167B2 (en) 2004-06-28 2016-02-23 Becton, Dickinson And Company Dissolvable films and methods including the same
US20080070308A1 (en) * 2004-06-28 2008-03-20 Thomas Ruhland Portous Article For Delivering Chemical Substances
US8189899B2 (en) * 2004-07-30 2012-05-29 Veridex, Llc Methods and algorithms for cell enumeration in a low-cost cytometer
KR100850430B1 (ko) * 2006-12-11 2008-08-05 (주)바이오니아 입자상 물질을 사용하는 핵산 분리 방법 및 핵산 분리용조성물
EP2143496A1 (en) * 2008-07-09 2010-01-13 F. Hoffmann-Roche AG Lysis reagent formulation containing magnetic particles in tablet form
JP2013503352A (ja) * 2009-08-31 2013-01-31 エムバイオ ダイアグノスティクス，インコーポレイティド 統合されたサンプル調製及び検体検出
TWI407994B (zh) 2009-10-22 2013-09-11 Ind Tech Res Inst 分離核酸的方法、試劑及套組
CN111757934A (zh) 2017-12-21 2020-10-09 豪夫迈·罗氏有限公司 通过单向双重探针引物延伸的靶标富集
EP3749782B1 (en) 2018-02-05 2022-11-02 F. Hoffmann-La Roche AG Generation of single-stranded circular dna templates for single molecule sequencing
CN111936635A (zh) 2018-03-02 2020-11-13 豪夫迈·罗氏有限公司 用于单分子测序的单链环状dna模板的产生
WO2020058389A1 (en) 2018-09-21 2020-03-26 F. Hoffmann-La Roche Ag System and method for modular and combinatorial nucleic acid sample preparation for sequencing
WO2021053008A1 (en) 2019-09-20 2021-03-25 F. Hoffmann-La Roche Ag Immune repertoire profiling by primer extension target enrichment
EP4179113A1 (en) 2020-07-08 2023-05-17 F. Hoffmann-La Roche AG Targeted depletion of non-target library molecules using poison primers during target capture of next-generation sequencing libraries
US20220177950A1 (en) 2020-12-03 2022-06-09 Roche Sequencing Solutions, Inc. Whole transcriptome analysis in single cells
WO2024013241A1 (en) 2022-07-14 2024-01-18 F. Hoffmann-La Roche Ag Variant allele enrichment by unidirectional dual probe primer extension

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3981776A (en) * 1967-02-16 1976-09-21 Rolf Saxholm Magnetically responsive, biologically active substance and associated methods and apparatus
US4169804A (en) * 1976-08-19 1979-10-02 Minnesota Mining And Manufacturing Company Magnetically responsive composite microparticle
US4115534A (en) * 1976-08-19 1978-09-19 Minnesota Mining And Manufacturing Company In vitro diagnostic test
US4233169A (en) * 1979-04-13 1980-11-11 Corning Glass Works Porous magnetic glass structure
US4343901A (en) 1980-10-22 1982-08-10 Uop Inc. Magnetic support matrix for enzyme immobilization
US4483920A (en) * 1982-05-17 1984-11-20 Hahnemann University Immobilization of message RNA directly from cells onto filter material
US4735796A (en) * 1983-12-08 1988-04-05 Gordon Robert T Ferromagnetic, diamagnetic or paramagnetic particles useful in the diagnosis and treatment of disease
US5746999A (en) * 1984-11-23 1998-05-05 Schering Aktiengesellschaft Magnetic particles for diagnostic purposes
US5597531A (en) * 1985-10-04 1997-01-28 Immunivest Corporation Resuspendable coated magnetic particles and stable magnetic particle suspensions
US4820627A (en) * 1986-03-24 1989-04-11 Em Diagnostic Systems, Inc. Method of preparing particles suitable for tabletting into diagnostic reagents
US5009994A (en) * 1986-03-24 1991-04-23 Em Diagnostic Systems, Inc. Particles containing mannitol suitable for tabletting into diagnostic reagents
US4712310A (en) * 1986-09-15 1987-12-15 E. I. Du Pont De Nemours And Company Co-spray technique
DK269889A (da) * 1988-06-06 1989-12-07 Photest Diagnostics Inc Heterogen immunoassay
AU640626B2 (en) * 1988-11-21 1993-09-02 Dynal As Nucleic acid probes
US5512439A (en) * 1988-11-21 1996-04-30 Dynal As Oligonucleotide-linked magnetic particles and uses thereof
US5234809A (en) * 1989-03-23 1993-08-10 Akzo N.V. Process for isolating nucleic acid
JPH04323560A (ja) * 1991-04-22 1992-11-12 Nippon Telegr & Teleph Corp <Ntt> レーザ磁気免疫測定に用いられる磁性微粒子標識材料並びに検体調整方法
DE4406139A1 (de) * 1994-02-25 1995-08-31 Matthias Werner Magnetische Depotarzneimittel für die perorale Applikation mit verbesserter Resorption der Wirkstoffe
US5593824A (en) * 1994-09-02 1997-01-14 Pharmacia Biotech, Inc. Biological reagent spheres
DE19520398B4 (de) * 1995-06-08 2009-04-16 Roche Diagnostics Gmbh Magnetisches Pigment

Also Published As

Publication number Publication date
IL121008A0 (en) 1997-11-20
US6274386B1 (en) 2001-08-14
US20010046714A1 (en) 2001-11-29
CA2206760A1 (en) 1997-12-07
ES2195053T3 (es) 2003-12-01
ATE234366T1 (de) 2003-03-15
CA2206760C (en) 2003-08-19
JPH1062422A (ja) 1998-03-06
DK0811694T3 (da) 2003-07-14
EP0811694A3 (de) 1999-01-13
IL121008A (en) 2001-08-08
JP3821541B2 (ja) 2006-09-13
EP0811694A2 (de) 1997-12-10
US6746874B2 (en) 2004-06-08
KR100260326B1 (ko) 2003-03-15
DE59709467D1 (de) 2003-04-17
AU715803B2 (en) 2000-02-10
DE19622885A1 (de) 1997-12-11
EP0811694B1 (de) 2003-03-12
AU2370597A (en) 1997-12-11

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