KR970702846A - 히드록시기를 함유하는 신규 1,3-디알킬우레아 유도체(novel 1,3-dia-lkylurea derivative having hydroxyl group) - Google Patents
히드록시기를 함유하는 신규 1,3-디알킬우레아 유도체(novel 1,3-dia-lkylurea derivative having hydroxyl group)Info
- Publication number
- KR970702846A KR970702846A KR1019960703618A KR19960703618A KR970702846A KR 970702846 A KR970702846 A KR 970702846A KR 1019960703618 A KR1019960703618 A KR 1019960703618A KR 19960703618 A KR19960703618 A KR 19960703618A KR 970702846 A KR970702846 A KR 970702846A
- Authority
- KR
- South Korea
- Prior art keywords
- alkyl group
- lower alkyl
- substituted
- group
- phenyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
- C07C275/04—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to acyclic carbon atoms
- C07C275/06—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to acyclic carbon atoms of an acyclic and saturated carbon skeleton
- C07C275/10—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to acyclic carbon atoms of an acyclic and saturated carbon skeleton being further substituted by singly-bound oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
- C07C275/04—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to acyclic carbon atoms
- C07C275/20—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to acyclic carbon atoms of an unsaturated carbon skeleton
- C07C275/24—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/14—The ring being saturated
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Detergent Compositions (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP27095794 | 1994-11-04 | ||
| JP94-270957 | 1994-11-04 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| KR970702846A true KR970702846A (ko) | 1997-06-10 |
| KR100376150B1 KR100376150B1 (ko) | 2003-11-01 |
Family
ID=17493383
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1019960703618A KR100376150B1 (ko) | 1994-11-04 | 1995-11-01 | 히드록시기를함유하는1,3-디알킬우레아유도체 |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US5891912A (ko) |
| EP (1) | EP0738711B1 (ko) |
| KR (1) | KR100376150B1 (ko) |
| CN (1) | CN1055681C (ko) |
| AT (1) | ATE190304T1 (ko) |
| CA (1) | CA2180021A1 (ko) |
| DE (1) | DE69515465T2 (ko) |
| ES (1) | ES2145929T3 (ko) |
| FI (1) | FI962751A (ko) |
| NO (1) | NO306944B1 (ko) |
| WO (1) | WO1996014293A1 (ko) |
Families Citing this family (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7091311B2 (en) * | 1996-06-07 | 2006-08-15 | Smithkline Beecham Corporation | Peptides and compounds that bind to a receptor |
| US5985968A (en) * | 1997-11-17 | 1999-11-16 | Air Products And Chemicals, Inc. | Surface tension reduction with N,N-dialkyl ureas |
| US6156784A (en) * | 1997-12-18 | 2000-12-05 | Boehringer Ingelheim Pharmaceuticals, Inc. | Compounds useful as phosphotyrosine mimics |
| US6677360B2 (en) * | 1998-12-16 | 2004-01-13 | Bayer Aktiengesellschaft | Biphenyl and biphenyl-analogous compounds as integrin antagonists |
| US6420396B1 (en) | 1998-12-16 | 2002-07-16 | Beiersdorf Ag | Biphenyl and biphenyl-analogous compounds as integrin antagonists |
| FR2820136A1 (fr) * | 2001-01-26 | 2002-08-02 | Aventis Pharma Sa | Nouveaux derives de l'uree, leur procede de preparation, leur application a titre de medicaments, compositions pharmaceutiques et nouvelle utilisation |
| US6842358B2 (en) * | 2002-08-01 | 2005-01-11 | Netlogic Microsystems, Inc. | Content addressable memory with cascaded array |
| KR20050093759A (ko) | 2002-09-18 | 2005-09-23 | 오르토-맥네일 파마슈티칼, 인코퍼레이티드 | 혈소판 및 조혈 줄기세포의 생산을 증가시키는 방법 |
| DE10252650A1 (de) * | 2002-11-11 | 2004-05-27 | Grünenthal GmbH | Cyclohexyl-Harnstoff-Derivate |
| US7045653B2 (en) | 2002-12-23 | 2006-05-16 | Pfizer, Inc. | Pharmaceuticals |
| EP1615915A1 (en) * | 2003-04-21 | 2006-01-18 | Elan Pharmaceuticals, Inc. | Phenacyl 2-hydroxy-3-diaminoalkanes |
| SG131110A1 (en) * | 2003-08-28 | 2007-04-26 | Ortho Mcneil Pharm Inc | Peptides and compounds that bind to thrombopoietin receptors |
| WO2005063699A1 (en) * | 2003-12-31 | 2005-07-14 | Council Of Scientific & Industrial Research | N-aryloxypropanolyl-n’-phenethyl-urea |
| US6962945B2 (en) | 2004-03-26 | 2005-11-08 | Council Of Scientific And Industrial Research | N-aryloxypropanolyl-N′-phenethyl-urea |
| FR2885129B1 (fr) | 2005-04-29 | 2007-06-15 | Proskelia Sas | Nouveaux derives de l'ureee substituee parun thiazole ou benzothiazole, leur procede de preparation, leur application a titre de medicaments, les compositions pharmaceutiques les renfermant et utilisation. |
| CA2630860A1 (en) * | 2005-11-25 | 2007-05-31 | Galapagos Sas | Urea derivatives useful as calcium receptor modulators |
| GB0613674D0 (en) * | 2006-07-10 | 2006-08-16 | Proskelia Sas | Derivatives of urea and related diamines, methods for their manufacture, and uses therefor |
| JP2012526810A (ja) | 2009-05-13 | 2012-11-01 | イントラ−セルラー・セラピーズ・インコーポレイテッド | 有機化合物 |
| UY32662A (es) * | 2009-05-28 | 2010-12-31 | Novartis Ag | Derivados amino-propionicos sustituidos como inhibidores de neprilisina |
| WO2010136474A2 (en) | 2009-05-28 | 2010-12-02 | Novartis Ag | Substituted aminobutyric derivatives as neprilysin inhibitors |
| JO2967B1 (en) | 2009-11-20 | 2016-03-15 | نوفارتس ايه جي | Acetic acid derivatives of carbamoyl methyl amino are substituted as new NEP inhibitors |
| WO2011136231A1 (ja) * | 2010-04-30 | 2011-11-03 | 日産化学工業株式会社 | ビスアミノフェニルアルキルウレアの新規な製造方法 |
| EA026989B1 (ru) | 2013-02-14 | 2017-06-30 | Новартис Аг | Производные замещенной бисфенилбутановой кислоты в качестве ингибиторов nep с улучшенной in vivo эффективностью |
| US9163040B2 (en) | 2013-02-14 | 2015-10-20 | Novartis Ag | Substituted bisphenyl butanoic phosphonic acid derivatives as NEP inhibitors |
| WO2014127331A1 (en) | 2013-02-17 | 2014-08-21 | Intra-Cellular Therapies, Inc. | Novel uses |
| WO2016022893A1 (en) | 2014-08-07 | 2016-02-11 | Intra-Cellular Therapies, Inc. | Organic compounds |
| US10682354B2 (en) | 2016-03-28 | 2020-06-16 | Intra-Cellular Therapies, Inc. | Compositions and methods |
| US11839614B2 (en) | 2018-01-31 | 2023-12-12 | Intra-Cellular Therapies, Inc. | Methods for treating or mitigating cardiotoxicity characterized by inhibition of adenosine A2 signaling and/or adenosine A2 receptor expression |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IE53315B1 (en) * | 1980-12-18 | 1988-10-12 | Schering Corp | Substituted dipeptides,processes for their preparation and pharmaceutical compositions containing them and their use in the inhibition of enkephalinase |
| EP0054862B1 (en) * | 1980-12-18 | 1985-11-27 | Schering Corporation | Substituted dipeptides, processes for their preparation and pharmaceutical compositions containing them and their use in the inhibition of enkephalinase |
| DE3134933A1 (de) * | 1981-09-03 | 1983-03-31 | Hoechst Ag, 6230 Frankfurt | "harnstoffderivate, verfahren zu ihrer herstellung und diese enthaltende medikamente sowie deren verwendung" |
| JPS5823851A (ja) * | 1982-07-29 | 1983-02-12 | Mitsubishi Gas Chem Co Inc | 耐熱性樹脂組成物 |
| US4668769A (en) * | 1985-08-02 | 1987-05-26 | Hoover Dennis J | Oxa- and azahomocyclostatine polypeptides |
| US4599198A (en) * | 1985-08-02 | 1986-07-08 | Pfizer Inc. | Intermediates in polypeptide synthesis |
| US4757050A (en) * | 1985-12-23 | 1988-07-12 | E. R. Squibb Sons, Inc. | Ureido renin inhibitors |
| CA1297631C (en) * | 1985-12-23 | 1992-03-17 | Sesha I. Natarajan | Ureido renin inhibitors |
| DE3619508A1 (de) * | 1986-06-10 | 1987-12-17 | Merck Patent Gmbh | Aminosaeurederivate |
| JP2775690B2 (ja) * | 1989-08-22 | 1998-07-16 | 昭和シェル石油株式会社 | スリップ・レイヤー・シート |
| US5475027A (en) * | 1990-11-19 | 1995-12-12 | G.D. Searle & Co. | Retroviral protease inhibitors |
| ES2059289T3 (es) * | 1990-11-19 | 1997-10-16 | Monsanto Co | Inhibidores de la proteasa retroviral. |
| JPH0672985A (ja) * | 1992-08-28 | 1994-03-15 | Ono Pharmaceut Co Ltd | （チオ）ウレア誘導体 |
| JP3118738B2 (ja) * | 1992-12-22 | 2000-12-18 | 小野薬品工業株式会社 | （チオ）ウレア誘導体 |
-
1995
- 1995-11-01 EP EP95936083A patent/EP0738711B1/en not_active Expired - Lifetime
- 1995-11-01 CA CA002180021A patent/CA2180021A1/en not_active Abandoned
- 1995-11-01 KR KR1019960703618A patent/KR100376150B1/ko not_active IP Right Cessation
- 1995-11-01 US US08/663,239 patent/US5891912A/en not_active Expired - Fee Related
- 1995-11-01 ES ES95936083T patent/ES2145929T3/es not_active Expired - Lifetime
- 1995-11-01 WO PCT/JP1995/002236 patent/WO1996014293A1/ja active IP Right Grant
- 1995-11-01 DE DE69515465T patent/DE69515465T2/de not_active Expired - Fee Related
- 1995-11-01 CN CN95191137A patent/CN1055681C/zh not_active Expired - Fee Related
- 1995-11-01 AT AT95936083T patent/ATE190304T1/de not_active IP Right Cessation
-
1996
- 1996-07-03 NO NO962810A patent/NO306944B1/no not_active IP Right Cessation
- 1996-07-04 FI FI962751A patent/FI962751A/fi not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| CN1138321A (zh) | 1996-12-18 |
| WO1996014293A1 (fr) | 1996-05-17 |
| CN1055681C (zh) | 2000-08-23 |
| NO962810L (no) | 1996-07-03 |
| EP0738711A1 (en) | 1996-10-23 |
| US5891912A (en) | 1999-04-06 |
| ATE190304T1 (de) | 2000-03-15 |
| FI962751A0 (fi) | 1996-07-04 |
| NO306944B1 (no) | 2000-01-17 |
| NO962810D0 (no) | 1996-07-03 |
| EP0738711A4 (en) | 1998-09-30 |
| FI962751A (fi) | 1996-07-04 |
| DE69515465D1 (de) | 2000-04-13 |
| CA2180021A1 (en) | 1996-05-17 |
| DE69515465T2 (de) | 2000-08-03 |
| EP0738711B1 (en) | 2000-03-08 |
| KR100376150B1 (ko) | 2003-11-01 |
| ES2145929T3 (es) | 2000-07-16 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| A201 | Request for examination | ||
| E902 | Notification of reason for refusal | ||
| E701 | Decision to grant or registration of patent right | ||
| GRNT | Written decision to grant | ||
| LAPS | Lapse due to unpaid annual fee |