KR970061868A - 방향족 니트릴의 제조 방법 - Google Patents

방향족 니트릴의 제조 방법 Download PDF

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KR970061868A
KR970061868A KR1019970004361A KR19970004361A KR970061868A KR 970061868 A KR970061868 A KR 970061868A KR 1019970004361 A KR1019970004361 A KR 1019970004361A KR 19970004361 A KR19970004361 A KR 19970004361A KR 970061868 A KR970061868 A KR 970061868A
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nitrile
phenyl
ethyl
alkyl
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리차드 브라이츄
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에른스트 알테르, 한스 페터 위틀린
시바 스페셜티 케미칼스 홀딩 인크.
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    • C07C281/06—Compounds containing any of the groups, e.g. semicarbazides
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    • C07C281/16—Compounds containing any of the groups, e.g. aminoguanidine
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Abstract

본 발명은 화학식 (3), (4), (5)의 3급 아민 염기의 존재 하에 100 내지 160℃의 온도에서 0.02 내지 1.5 바의 압력에서 반응과 더불어 방출되는 물을 증류시키고, 이어서 암모늄염을 제거하면서 화학식 (2)의 알데히드와 히드록실아미노술페이트를 반응시키고, 이렇게 얻은 니트릴을 통상적인 방법으로 단리하는 것으로 이루어진 화학식 (1)의 니트릴의 제조 방법에 관한 것이다.
상기 식 중, X는 CH 또는 N이고, R1및 R2는 각각 서로 독립적으로 수소, 클로로, 브로모, C1-C6알킬, C1-C6알콕시, C1-C6알킬아미노, CN, 페닐, 페녹시, 디메틸아미노, 피페리딜, 모르폴리닐 또는 피롤리딜이거나, 또는 R1및 R2가 함께 융합되어 벤젠 고리를 형성하고, R3및 R4는 각각 서로 독립적으로 수소, 메틸 또는 에틸이고, R5는 분지된 C3-C5알킬 또는 페닐이고, R6및 R7은 메틸 또는 에틸이다.

Description

방향족 니트릴의 제조 방법
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (9)

  1. 하기 화학식 (2)의 알데히드와 히드록실아미노술페이트를 반응시키고, 이어서 탈수시키는 화학식 (1)의 니트릴의 제조 방법에 있어서, 화학식 (3), (4), (5)의 3급 아민 염기의 존재 하에 100 내지 160℃. 바람직하게는 120 내지 150℃의 온도에서 0.02 내지 1.5 바의 압력, 바람직하게는 0.1 내지 대기압에서 반응과 더불어 방출되는 물을 증류시키고, 이어서, 암모늄염을 제거하면서 반응을 수행하고, 이렇게 얻은 니트릴을 통상적인 방법으로 단리하는 것으로 이루어진 화학식 (1)의 니트릴의 제조 방법.
    상기 식 중, X는 CH 또는 N이고, R1및 R2는 각각 서로 독립적으로 수소, 클로로, 브로모, C1-C6알킬, C1-C6알콕시, C1-C6알킬아미노, CN, 페닐, 페녹시, 디메틸아미노, 피페리딜, 모르폴리닐 또는 피롤리딜이거나, 또는 R1및 R2가 함게 융합되어 벤젠 고리를 형성하고, R3및 R4는 각각 서로 독립적으로 수소, 메틸 또는 에틸이고, R5는 분지된 C3-C5알킬 또는 페닐이고, R6및 R7은 메틸 또는 에틸이다.
  2. 제1항에 있어서, 공비성 혼합물을 형성하는 수불혼화성 유기 용매의 존재하에 반응을 수행하는 방법.
  3. 제2항에 있어서, 용매가 클로로벤젠 또는 톨루엔인 방법.
  4. 제1항에 있어서, 물을 미리 첨가하거나 첨가하지 않으면서 상 분리에 의해 암모늄 염을 제거하는 방법.
  5. 제1항에 있어서, 피리딘, 2-피콜린, 2,6-루티딘, 5-에틸-2-메틸피리딘, 퀴날딘, N,N-디메틸아민, N,N-디에틸아닐린 및 디메틸이소프로필아민으로 이루어진 군으로부터 선택된 3급 아민 염기를 사용하는 방법.
  6. 제5항에 있어서, 피리딘 또는 디메틸아민을 사용하는 방법.
  7. 제1항에 있어서, X가 CH이고, R2가 수소이고, R1이 수소, C1-C4알킬 또는 페닐이면서 시아노기와 파라위치인 화학식 (1)의 니트릴을 제조하는 방법.
  8. 제1항에 있어서, 히드록실아미노술페이트를 1몰의 알데히드 당 0.5 내지 0.58몰의 양으로 사용하는 방법.
  9. 제8항에 있어서, 아민 염기를 1몰의 히드록실아미노술페이트 당 1.0 내지 1.5 몰의 양으로 사용하는 방법.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019970004361A 1996-02-15 1997-02-14 방향족니트릴의제조방법 KR100452077B1 (ko)

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WO1998005630A1 (en) * 1996-08-08 1998-02-12 Alliedsignal Inc. Process for the preparation of organic nitriles
DE19917979A1 (de) 1999-04-21 2000-10-26 Clariant Gmbh Verfahren zur Herstellung von substituierten Phenyl-boronsäuren
ITMI20012131A1 (it) * 2001-10-16 2003-04-16 Miteni Spa Procedimento per la preparazione di alo-benzonitrili

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DD117872A1 (ko) * 1974-11-06 1976-02-05
US4456562A (en) * 1981-12-02 1984-06-26 Sumitomo Chemical Company, Limited Process for producing nitriles
EP0550762B1 (en) * 1991-07-25 1995-11-22 Kao Corporation Process for producing nitrile
TW275617B (ko) * 1993-01-28 1996-05-11 Ciba Geigy Ag
EP0731086B1 (de) * 1995-03-09 1999-04-28 Ciba SC Holding AG Verfahren zur Herstellung aromatischer Nitrile

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