KR970009340B1 - Mutant acidic fibroblast growth factor - Google Patents
Mutant acidic fibroblast growth factor Download PDFInfo
- Publication number
- KR970009340B1 KR970009340B1 KR88013730A KR880013730A KR970009340B1 KR 970009340 B1 KR970009340 B1 KR 970009340B1 KR 88013730 A KR88013730 A KR 88013730A KR 880013730 A KR880013730 A KR 880013730A KR 970009340 B1 KR970009340 B1 KR 970009340B1
- Authority
- KR
- South Korea
- Prior art keywords
- mutant
- bovine
- afgf
- human
- growth factor
- Prior art date
Links
- 108090000386 Fibroblast Growth Factor 1 Proteins 0.000 title abstract 2
- 102000003971 Fibroblast Growth Factor 1 Human genes 0.000 title 1
- 108090000623 proteins and genes Proteins 0.000 abstract 4
- 241000283690 Bos taurus Species 0.000 abstract 3
- 101000846416 Homo sapiens Fibroblast growth factor 1 Proteins 0.000 abstract 2
- 101000846393 Bos taurus Fibroblast growth factor 1 Proteins 0.000 abstract 1
- 102100031706 Fibroblast growth factor 1 Human genes 0.000 abstract 1
- HTTJABKRGRZYRN-UHFFFAOYSA-N Heparin Chemical compound OC1C(NC(=O)C)C(O)OC(COS(O)(=O)=O)C1OC1C(OS(O)(=O)=O)C(O)C(OC2C(C(OS(O)(=O)=O)C(OC3C(C(O)C(O)C(O3)C(O)=O)OS(O)(=O)=O)C(CO)O2)NS(O)(=O)=O)C(C(O)=O)O1 HTTJABKRGRZYRN-UHFFFAOYSA-N 0.000 abstract 1
- 230000004071 biological effect Effects 0.000 abstract 1
- 239000013604 expression vector Substances 0.000 abstract 1
- 229960002897 heparin Drugs 0.000 abstract 1
- 229920000669 heparin Polymers 0.000 abstract 1
- 230000035772 mutation Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
- C07K14/50—Fibroblast growth factor [FGF]
- C07K14/501—Fibroblast growth factor [FGF] acidic FGF [aFGF]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Biomedical Technology (AREA)
- Zoology (AREA)
- Biotechnology (AREA)
- Wood Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- General Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Biochemistry (AREA)
- Plant Pathology (AREA)
- Microbiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Physics & Mathematics (AREA)
- General Chemical & Material Sciences (AREA)
- Diabetes (AREA)
- Toxicology (AREA)
- Hematology (AREA)
- Gastroenterology & Hepatology (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US11260087A | 1987-10-22 | 1987-10-22 | |
| US112,600 | 1987-10-22 | ||
| US244431 | 1988-09-15 | ||
| US24443188A | 1988-09-16 | 1988-09-16 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| KR890006815A KR890006815A (ko) | 1989-06-16 |
| KR970009340B1 true KR970009340B1 (en) | 1997-06-10 |
Family
ID=26810140
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR88013730A KR970009340B1 (en) | 1987-10-22 | 1988-10-21 | Mutant acidic fibroblast growth factor |
Country Status (13)
| Country | Link |
|---|---|
| EP (1) | EP0319052B1 (ko) |
| JP (1) | JPH082309B2 (ko) |
| KR (1) | KR970009340B1 (ko) |
| AT (1) | ATE117723T1 (ko) |
| AU (1) | AU623351B2 (ko) |
| CA (1) | CA1340363C (ko) |
| DE (1) | DE3852870T2 (ko) |
| DK (1) | DK174961B1 (ko) |
| ES (1) | ES2070125T3 (ko) |
| IE (1) | IE65360B1 (ko) |
| IL (1) | IL88034A (ko) |
| NZ (1) | NZ226543A (ko) |
| PT (1) | PT88824B (ko) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0392605A1 (en) * | 1989-04-13 | 1990-10-17 | Merck & Co. Inc. | Method of enhancing acidic fibroblast growth factor expression |
| EP0406738A3 (en) * | 1989-07-03 | 1991-08-14 | Takeda Chemical Industries, Ltd. | Production of acidic fgf protein |
| CA2020720A1 (en) * | 1989-07-13 | 1991-01-14 | Shigeko Yamazaki | Method for the purification of therapeutically active recombinant acidic fibroblast growth factor |
| US5126323A (en) * | 1989-11-16 | 1992-06-30 | Genetics Institute, Inc. | Homogeneous purified k-fgf and compositions containing the same |
| CA2098484A1 (en) * | 1990-12-18 | 1992-06-19 | Tsutomu Arakawa | Analogs of acidic fibroblast growth factor having enhanced stability and biological activity |
| US5348941A (en) * | 1992-04-01 | 1994-09-20 | Merck & Co., Inc. | Stabilizers for fibroblast growth factors |
| US6743422B1 (en) | 1996-10-15 | 2004-06-01 | Amgen, Inc. | Keratinocyte growth factor-2 products |
| JP4088111B2 (ja) * | 2002-06-28 | 2008-05-21 | 日立電線株式会社 | 多孔質基板とその製造方法、ＧａＮ系半導体積層基板とその製造方法 |
| CA2691374A1 (en) * | 2007-06-29 | 2009-01-08 | Asubio Pharma Co., Ltd. | Recombinant c-terminal .alpha.-amidating enzyme derivative |
| PL221356B1 (pl) * | 2012-04-21 | 2016-03-31 | Wrocławskie Ct Badań Eit & Spółka Z Ograniczoną Odpowiedzialności | Zmodyfikowany genetycznie, rekombinowany czynnik wzrostu fibroblastów (FGF1) skoniugowany z nanocząsteczkami metalu lub tlenku metalu, jego sekwencja DNA i aminokwasowa oraz zastosowanie |
| CH717226B1 (it) * | 2020-07-14 | 2021-09-30 | Contrad Swiss Sa | Idrogel per applicazione topica efficace nel limitare la degenerazione di tendini e muscoli. |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL90047A (en) * | 1982-10-19 | 1992-12-01 | Cetus Oncology Corp | Cysteine-depleted biologically active muteins other than interferon - ' |
| US4711848A (en) * | 1984-03-14 | 1987-12-08 | Zymogenetics, Inc. | Site specific mutagenesis in alpha-1-antitrypsin |
| ATE105868T1 (de) * | 1985-09-12 | 1994-06-15 | Scios Nova Inc | Rekombinanter fibroblast-wachstumsfaktor. |
| US4868113A (en) * | 1986-03-03 | 1989-09-19 | Rorer Biotechnology, Inc. | Recombinant DNA vector encoding human endothelial cell growth factor |
-
1988
- 1988-10-12 NZ NZ226543A patent/NZ226543A/en unknown
- 1988-10-13 IL IL8803488A patent/IL88034A/en active Protection Beyond IP Right Term
- 1988-10-14 AT AT88202306T patent/ATE117723T1/de not_active IP Right Cessation
- 1988-10-14 ES ES88202306T patent/ES2070125T3/es not_active Expired - Lifetime
- 1988-10-14 EP EP88202306A patent/EP0319052B1/en not_active Expired - Lifetime
- 1988-10-14 DE DE3852870T patent/DE3852870T2/de not_active Expired - Lifetime
- 1988-10-21 KR KR88013730A patent/KR970009340B1/ko not_active IP Right Cessation
- 1988-10-21 IE IE318888A patent/IE65360B1/en not_active IP Right Cessation
- 1988-10-21 AU AU24305/88A patent/AU623351B2/en not_active Expired
- 1988-10-21 JP JP63264261A patent/JPH082309B2/ja not_active Expired - Lifetime
- 1988-10-21 CA CA000580927A patent/CA1340363C/en not_active Expired - Fee Related
- 1988-10-21 DK DK198805874A patent/DK174961B1/da not_active IP Right Cessation
- 1988-10-21 PT PT88824A patent/PT88824B/pt not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| EP0319052A3 (en) | 1990-04-25 |
| DK587488A (da) | 1989-06-06 |
| EP0319052A2 (en) | 1989-06-07 |
| IE65360B1 (en) | 1995-10-18 |
| AU2430588A (en) | 1989-04-27 |
| JPH082309B2 (ja) | 1996-01-17 |
| ATE117723T1 (de) | 1995-02-15 |
| EP0319052B1 (en) | 1995-01-25 |
| DK587488D0 (da) | 1988-10-21 |
| NZ226543A (en) | 1992-02-25 |
| CA1340363C (en) | 1999-02-02 |
| DE3852870D1 (de) | 1995-03-09 |
| AU623351B2 (en) | 1992-05-14 |
| DE3852870T2 (de) | 1995-08-17 |
| PT88824B (pt) | 1993-04-30 |
| IL88034A (en) | 1994-06-24 |
| ES2070125T3 (es) | 1995-06-01 |
| JPH02484A (ja) | 1990-01-05 |
| KR890006815A (ko) | 1989-06-16 |
| IE883188L (en) | 1989-04-22 |
| IL88034A0 (en) | 1989-06-30 |
| DK174961B1 (da) | 2004-03-29 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| A201 | Request for examination | ||
| E902 | Notification of reason for refusal | ||
| G160 | Decision to publish patent application | ||
| E701 | Decision to grant or registration of patent right | ||
| GRNT | Written decision to grant | ||
| FPAY | Annual fee payment |
Payment date: 20111129 Year of fee payment: 15 |
|
| EXPY | Expiration of term |