KR970001531B1 - 화합물의 제조 방법 - Google Patents

화합물의 제조 방법 Download PDF

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Publication number
KR970001531B1
KR970001531B1 KR1019890005923A KR890005923A KR970001531B1 KR 970001531 B1 KR970001531 B1 KR 970001531B1 KR 1019890005923 A KR1019890005923 A KR 1019890005923A KR 890005923 A KR890005923 A KR 890005923A KR 970001531 B1 KR970001531 B1 KR 970001531B1
Authority
KR
South Korea
Prior art keywords
compound
formula
lower alkanoyl
isomer
solution
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
KR1019890005923A
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English (en)
Korean (ko)
Other versions
KR890017256A (ko
Inventor
조지 그레이 마이클
그렉슨 마이클
Original Assignee
글락소 그룹 리미티드
비.에이.뉴샘
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 글락소 그룹 리미티드, 비.에이.뉴샘 filed Critical 글락소 그룹 리미티드
Publication of KR890017256A publication Critical patent/KR890017256A/ko
Application granted granted Critical
Publication of KR970001531B1 publication Critical patent/KR970001531B1/ko
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/02—Preparation
    • C07D501/04—Preparation from compounds already containing the ring or condensed ring systems, e.g. by dehydrogenation of the ring, by introduction, elimination or modification of substituents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
    • C07D501/26—Methylene radicals, substituted by oxygen atoms; Lactones thereof with the 2-carboxyl group
    • C07D501/34—Methylene radicals, substituted by oxygen atoms; Lactones thereof with the 2-carboxyl group with the 7-amino radical acylated by carboxylic acids containing hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Cephalosporin Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
KR1019890005923A 1988-05-03 1989-05-02 화합물의 제조 방법 Expired - Fee Related KR970001531B1 (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB888810394A GB8810394D0 (en) 1988-05-03 1988-05-03 Chemical process
GB8810394.0 1988-05-03

Publications (2)

Publication Number Publication Date
KR890017256A KR890017256A (ko) 1989-12-15
KR970001531B1 true KR970001531B1 (ko) 1997-02-11

Family

ID=10636247

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019890005923A Expired - Fee Related KR970001531B1 (ko) 1988-05-03 1989-05-02 화합물의 제조 방법

Country Status (8)

Country Link
JP (1) JPH0256490A (enrdf_load_stackoverflow)
KR (1) KR970001531B1 (enrdf_load_stackoverflow)
CH (1) CH678856A5 (enrdf_load_stackoverflow)
DE (1) DE3914658A1 (enrdf_load_stackoverflow)
FR (1) FR2631031A1 (enrdf_load_stackoverflow)
GB (2) GB8810394D0 (enrdf_load_stackoverflow)
IT (1) IT1235502B (enrdf_load_stackoverflow)
NL (1) NL8901111A (enrdf_load_stackoverflow)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100187959B1 (ko) * 1997-03-31 1999-06-01 윤재승 저융점 무정형 세푸록심 악세틸의 제조방법
CN1111537C (zh) * 1997-05-15 2003-06-18 第一制糖株式会社 高纯晶形头孢呋辛1－乙酰氧乙酯的制备方法
IT1313569B1 (it) 1999-07-27 2002-09-09 Antibioticos Spa Processo per la sintesi di derivati beta-lattamici.

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1453049A (en) * 1973-08-21 1976-10-20 Glaxo Lab Ltd Cephalosporing antibiotics
US4011215A (en) * 1974-08-15 1977-03-08 Glaxo Laboratories Limited 3-Chloroalkylcarbamoyloxymethyl-7-[2-(fur-2-yl)-2-methoxyiminoacetamido]ceph-3-em-4-carboxylic acids and physiologically acceptable salts or oxides thereof
CA1094545A (en) * 1976-02-16 1981-01-27 Michael Gregson Cephalosporin antibiotics
GB2018764B (en) * 1978-04-07 1982-09-02 Glaxo Group Ltd Cephalosporin compounds
US4252974A (en) * 1978-04-07 1981-02-24 Glaxo Group Limited Cephalosporin compounds
GB2034312B (en) * 1978-09-21 1983-05-11 Glaxo Group Ltd Process for the preparation of cephalosporins
YU44680B (en) * 1982-07-30 1990-12-31 Glaxo Lab Ltd Process for obtaining very pure amorphous form of cephuroxim axetile
GB8320520D0 (en) * 1983-07-29 1983-09-01 Glaxo Group Ltd Chemical process
GB8400024D0 (en) * 1984-01-03 1984-02-08 Glaxo Group Ltd Cephalosporin antibiotics

Also Published As

Publication number Publication date
GB2218093A (en) 1989-11-08
GB8810394D0 (en) 1988-06-08
JPH0256490A (ja) 1990-02-26
IT8947902A0 (it) 1989-05-02
GB8909987D0 (en) 1989-06-21
DE3914658A1 (de) 1989-11-16
FR2631031A1 (fr) 1989-11-10
NL8901111A (nl) 1989-12-01
CH678856A5 (enrdf_load_stackoverflow) 1991-11-15
IT1235502B (it) 1992-09-05
KR890017256A (ko) 1989-12-15

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