IT1235502B - Procedimento per preparare composti antibiotici in particolare cefuroxima axetil - Google Patents

Procedimento per preparare composti antibiotici in particolare cefuroxima axetil

Info

Publication number
IT1235502B
IT1235502B IT8947902A IT4790289A IT1235502B IT 1235502 B IT1235502 B IT 1235502B IT 8947902 A IT8947902 A IT 8947902A IT 4790289 A IT4790289 A IT 4790289A IT 1235502 B IT1235502 B IT 1235502B
Authority
IT
Italy
Prior art keywords
cefuroxima
axetil
procedure
antibiotic compounds
preparing antibiotic
Prior art date
Application number
IT8947902A
Other languages
English (en)
Other versions
IT8947902A0 (it
Inventor
Michael George Grey
Michael Gregson
Original Assignee
Glaxo Group Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd
Publication of IT8947902A0 publication Critical patent/IT8947902A0/it
Application granted granted Critical
Publication of IT1235502B publication Critical patent/IT1235502B/it

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/02—Preparation
    • C07D501/04—Preparation from compounds already containing the ring or condensed ring systems, e.g. by dehydrogenation of the ring, by introduction, elimination or modification of substituents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
    • C07D501/26—Methylene radicals, substituted by oxygen atoms; Lactones thereof with the 2-carboxyl group
    • C07D501/34—Methylene radicals, substituted by oxygen atoms; Lactones thereof with the 2-carboxyl group with the 7-amino radical acylated by carboxylic acids containing hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Cephalosporin Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
IT8947902A 1988-05-03 1989-05-02 Procedimento per preparare composti antibiotici in particolare cefuroxima axetil IT1235502B (it)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB888810394A GB8810394D0 (en) 1988-05-03 1988-05-03 Chemical process

Publications (2)

Publication Number Publication Date
IT8947902A0 IT8947902A0 (it) 1989-05-02
IT1235502B true IT1235502B (it) 1992-09-05

Family

ID=10636247

Family Applications (1)

Application Number Title Priority Date Filing Date
IT8947902A IT1235502B (it) 1988-05-03 1989-05-02 Procedimento per preparare composti antibiotici in particolare cefuroxima axetil

Country Status (8)

Country Link
JP (1) JPH0256490A (it)
KR (1) KR970001531B1 (it)
CH (1) CH678856A5 (it)
DE (1) DE3914658A1 (it)
FR (1) FR2631031A1 (it)
GB (2) GB8810394D0 (it)
IT (1) IT1235502B (it)
NL (1) NL8901111A (it)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100187959B1 (ko) * 1997-03-31 1999-06-01 윤재승 저융점 무정형 세푸록심 악세틸의 제조방법
CN1111537C (zh) * 1997-05-15 2003-06-18 第一制糖株式会社 高纯晶形头孢呋辛1－乙酰氧乙酯的制备方法
IT1313569B1 (it) * 1999-07-27 2002-09-09 Antibioticos Spa Processo per la sintesi di derivati beta-lattamici.

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1453049A (en) * 1973-08-21 1976-10-20 Glaxo Lab Ltd Cephalosporing antibiotics
US4011215A (en) * 1974-08-15 1977-03-08 Glaxo Laboratories Limited 3-Chloroalkylcarbamoyloxymethyl-7-[2-(fur-2-yl)-2-methoxyiminoacetamido]ceph-3-em-4-carboxylic acids and physiologically acceptable salts or oxides thereof
CA1094545A (en) * 1976-02-16 1981-01-27 Michael Gregson Cephalosporin antibiotics
CA1128930A (en) * 1978-04-07 1982-08-03 Stuart B. Laing Cephalosporin compounds
GB2018764B (en) * 1978-04-07 1982-09-02 Glaxo Group Ltd Cephalosporin compounds
GB2034312B (en) * 1978-09-21 1983-05-11 Glaxo Group Ltd Process for the preparation of cephalosporins
YU44680B (en) * 1982-07-30 1990-12-31 Glaxo Lab Ltd Process for obtaining very pure amorphous form of cephuroxim axetile
GB8320520D0 (en) * 1983-07-29 1983-09-01 Glaxo Group Ltd Chemical process
GB8400024D0 (en) * 1984-01-03 1984-02-08 Glaxo Group Ltd Cephalosporin antibiotics

Also Published As

Publication number Publication date
JPH0256490A (ja) 1990-02-26
CH678856A5 (it) 1991-11-15
GB8909987D0 (en) 1989-06-21
FR2631031A1 (fr) 1989-11-10
DE3914658A1 (de) 1989-11-16
NL8901111A (nl) 1989-12-01
GB2218093A (en) 1989-11-08
GB8810394D0 (en) 1988-06-08
KR970001531B1 (ko) 1997-02-11
IT8947902A0 (it) 1989-05-02
KR890017256A (ko) 1989-12-15

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Legal Events

Date Code Title Description
TA Fee payment date (situation as of event date), data collected since 19931001

Effective date: 19970429