KR960705934A - 엔도텔린 전환 효소(Endothelin Converting Enzyme) - Google Patents

엔도텔린 전환 효소(Endothelin Converting Enzyme)

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Publication number
KR960705934A
KR960705934A KR1019960702556A KR19960702556A KR960705934A KR 960705934 A KR960705934 A KR 960705934A KR 1019960702556 A KR1019960702556 A KR 1019960702556A KR 19960702556 A KR19960702556 A KR 19960702556A KR 960705934 A KR960705934 A KR 960705934A
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South Korea
Prior art keywords
endothelin converting
converting enzyme
seq
dna sequence
endothelin
Prior art date
Application number
KR1019960702556A
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English (en)
Inventor
부르크하르트 크뢰거
하랄트 소일베르거
토마스 메이어
마르틴 쉬미트
엘라르트 야콥
라이너 오터
토마스 숩코브스키
하인즈 힐렌
Original Assignee
요헨 카르크. 귄터 스타인호프
바스프 악티엔게젤샤프트
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Priority claimed from DE19934339100 external-priority patent/DE4339100A1/de
Priority claimed from DE19944403665 external-priority patent/DE4403665A1/de
Priority claimed from DE19944412372 external-priority patent/DE4412372A1/de
Application filed by 요헨 카르크. 귄터 스타인호프, 바스프 악티엔게젤샤프트 filed Critical 요헨 카르크. 귄터 스타인호프
Publication of KR960705934A publication Critical patent/KR960705934A/ko

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    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
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    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6489—Metalloendopeptidases (3.4.24)
    • C12N9/6497—Endothelin-converting enzyme (3.4.24.71)
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
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Abstract

본원 발명은 서열 확인 번호 : 30 또는 서열 확인 번호 : 36에 나타낸 폴리펩티드 서열 또는 그의 기능성 단편을 함유하는 엔도텔린 전환 효소 및 이것을 암호화하는 유전자 및 이들의 제조 방법 및 이들의 용도에 관한것이다.

Description

엔도텔린 전환 효소(Endothelin Converthing Enzyme)
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (16)

  1. 서열 확인 번호 : 30 또는 서열 확인 번호 : 36에 나타낸 폴리펩티드 서열 또는 그의 기능성 단편을 함유하는 엔도텔린 전환 효소.
  2. 제 1항에서 청구한 바의 엔도텔린 전환 효소를 암호화하고, a) 서열 확인 번호 : 29 또는 서열 확인 번호 : 35에 나타낸 구조를 갖는 DNA 서열, b) 서열 확인 30 또는 서열 확인 번호 : 36에 나타낸 구조를 갖는 단백질을 암호화하는 DNA 서열, c) DNA 서열 a) 또는 b)와 표준 조건하에서 혼성화하는 DNA 서열, d) 서열 확인 번호 : 30 또는 서열 확인 번호 : 36 또는 그의 단편에 대하여 생성된 항체에 의해 인식되는 단백질 산물을 암호화하는 DNA로 이루어진 군 중에서 선택된 것인 DNA 서열.
  3. 제 2항에서 청구한 바의 DNA 서열을 사용한 유전자 조작에 의해 엔도텔린 전환효소를 제조하는 방법.
  4. 포유류 세포들을 엔도텔린 전환 효소의 억제제로 자극하여 엔도텔린 전환 효소를 과잉 생산시키고, 엔도텔린 전환 효소를 통상의 단백질 화학 공정에 의해 이들 세포로부터 단리하는 것으로 이루어지는 제 1 항에서 청구한 바의 엔도텔린 전환 효소의 제조 방법.
  5. 제 4항에 있어서, 포스포라미돈을 억제제로 사용하는 방법.
  6. 서열 확인 번호 : 36의 부분 서열을 암호화하는 올리고뉴클레오티드 또는 혼성화 프로브로서 상보성 올리고뉴클레오티드 서열을 사용하여 유전자 푸올로부터 엔도텔린 전환 효소에 대한 유전자를 단리하고, 이 유전자를 통상의 유전 공학적 방법에 의해 숙주 생물체에서 발현시키는 것으로 이루어지는 제 1 항에서 청구한 바의 엔도텔린 전환 효소의 제조 방법.
  7. 엔도텔린 전환 효소의 억제제를 동정하기 위한 제 1 항에 청구된 바의 엔도텔린 전환 효소의 용도.
  8. 제 1항에 청구된 바의 엔도텔린 전환 효소를 사용하여 효소 분석으로 동정된 엔도텔린 전환 효소의 억제제.
  9. 약물로서 제 8항에 청구된 억제제의 용도.
  10. 공지의 화합물을 제 1 항에 청구된 바의 엔도텔린 전환 효소를 사용하는 효소분석에 이용하고, 억제 작용을 갖는 것들을 동정하고, 이 방식으로 동정된 화합물을 통상의 부형제 또는 보조 물질화 함께 약물로서 제형화하는 것으로 이루어니는 엔도텔린 전환 효소를 억제하는 약물의 생산 방법.
  11. 항체 생산을 위한 제 1 항에 청구된 바의 엔도텔린 전환 효소의 용도.
  12. 질병의 진단을 위한 제 1항 기재 항체의 용도.
  13. 하나 이상의 제 2 항에 청구된 DNA 서열의 여분의 복제수를 포함하거나 또는 정상적인 ECE 유전자가 스위치 오프된 유전자 전환 동물을 생산하기 위한 상기 DNA서열의 용도.
  14. 약물을 생산하기 위한 제 1항에 청구된 바의 엔도텔린 전환 효소의 용도.
  15. 앤티센스 올리고튜클레오티드를 제조하기 이ㅜ한 서열 확인 번호 : 35로부터의 부분 서열의 용도.
  16. 약물을 생산하기 위한 제 15항 기재 부분 서열의 용도.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019960702556A 1993-11-16 1994-11-10 엔도텔린 전환 효소(Endothelin Converting Enzyme) KR960705934A (ko)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
DEP4339100.1 1993-11-16
DE19934339100 DE4339100A1 (de) 1993-11-16 1993-11-16 Endothelinkonversionsenzym-1 (ECE-1)
DE19944403665 DE4403665A1 (de) 1994-02-07 1994-02-07 Endothelinkonversionsenzym (ECE)
DEP4403665.5 1994-02-07
DEP4412372.8 1994-04-12
DE19944412372 DE4412372A1 (de) 1994-04-12 1994-04-12 Endothelinkonversionsenzym (ECE)
PCT/EP1994/003706 WO1995014095A1 (de) 1993-11-16 1994-11-10 Endothelinkonversionsenzym (ece)

Publications (1)

Publication Number Publication Date
KR960705934A true KR960705934A (ko) 1996-11-08

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KR1019960702556A KR960705934A (ko) 1993-11-16 1994-11-10 엔도텔린 전환 효소(Endothelin Converting Enzyme)

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Country Link
US (1) US6066502A (ko)
EP (1) EP0728209B1 (ko)
JP (1) JPH09505733A (ko)
KR (1) KR960705934A (ko)
CN (1) CN1141651A (ko)
AT (1) ATE315656T1 (ko)
AU (1) AU8107094A (ko)
BR (1) BR9408077A (ko)
CA (1) CA2176507A1 (ko)
CZ (1) CZ139496A3 (ko)
DE (1) DE59410427D1 (ko)
FI (1) FI962047A (ko)
HU (1) HUT75554A (ko)
NO (1) NO962023L (ko)
NZ (1) NZ275817A (ko)
PL (1) PL314480A1 (ko)
SK (1) SK59896A3 (ko)
WO (1) WO1995014095A1 (ko)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6255468B1 (en) * 1998-05-07 2001-07-03 Smithkline Beecham Plc MPROT12 polynucleotides and methods thereof
EP1409690A2 (en) 1999-09-24 2004-04-21 Lexicon Genetics Incorporated Human endothelin converting enzyme-like proteins and polynucleotides encoding the same
DE502004000540D1 (de) * 2004-02-13 2006-06-14 Brahms Ag Verfahren zur Bestimmung der Bildung von Endothelinen zu Zwecken der medizinischen Diagnostik, sowie Antikörper und Kits für die Durchführung eines solchen Verfahrens
WO2009018209A1 (en) 2007-07-27 2009-02-05 The Regents Of The University Of Colorado, A Body Corporate ENDOTHELIN SINGLE NUCLEOTIDE POLYMORPHISMS AND METHODS OF PREDICTING β-ADRENERGIC RECEPTOR TARGETING AGENT EFFICACY

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2966939B2 (ja) * 1990-12-07 1999-10-25 日清製粉株式会社 ヒト細胞由来のエンドセリン変換酵素
EP0575405A1 (en) * 1991-02-04 1993-12-29 Berlex Laboratories, Inc. Endothelin converting enzyme

Also Published As

Publication number Publication date
WO1995014095A1 (de) 1995-05-26
CA2176507A1 (en) 1995-05-26
DE59410427D1 (en) 2006-04-06
CZ139496A3 (en) 1997-10-15
EP0728209B1 (de) 2006-01-11
ATE315656T1 (de) 2006-02-15
BR9408077A (pt) 1997-08-12
AU8107094A (en) 1995-06-06
JPH09505733A (ja) 1997-06-10
NO962023L (no) 1996-07-16
NO962023D0 (no) 1996-05-15
CN1141651A (zh) 1997-01-29
SK59896A3 (en) 1997-07-09
US6066502A (en) 2000-05-23
NZ275817A (en) 1997-02-24
HUT75554A (en) 1997-05-28
PL314480A1 (en) 1996-09-16
HU9601298D0 (en) 1996-07-29
FI962047A (fi) 1996-07-12
FI962047A0 (fi) 1996-05-14
EP0728209A1 (de) 1996-08-28

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