BR9408077A - Enzimas de conversão de endotelina seqências de dna, processos para a obtenção por técnicas genéticas, de enzimas de conversão de endotelina substâncias inhibidoras para enzimas de conversão de endotelina e para a prepação de medicamentos que inibem uma enzima de conversão de endotelina e aplicações da enzima de conversão de endotelina das substâncias inibidoras de anticorpos de uma sequência de dna e de sequências parciais - Google Patents

Enzimas de conversão de endotelina seqências de dna, processos para a obtenção por técnicas genéticas, de enzimas de conversão de endotelina substâncias inhibidoras para enzimas de conversão de endotelina e para a prepação de medicamentos que inibem uma enzima de conversão de endotelina e aplicações da enzima de conversão de endotelina das substâncias inibidoras de anticorpos de uma sequência de dna e de sequências parciais

Info

Publication number
BR9408077A
BR9408077A BR9408077A BR9408077A BR9408077A BR 9408077 A BR9408077 A BR 9408077A BR 9408077 A BR9408077 A BR 9408077A BR 9408077 A BR9408077 A BR 9408077A BR 9408077 A BR9408077 A BR 9408077A
Authority
BR
Brazil
Prior art keywords
endothelin
enzymes
enzyme
conversion
inhibiting substances
Prior art date
Application number
BR9408077A
Other languages
English (en)
Inventor
Burkhard Kroeger
Harald Seulberger
Thomas Meyer
Martin Schmidt
Elard Jacob
Rainer Otter
Thomas Subkowski
Heinz Hillen
Original Assignee
Basf Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE19934339100 external-priority patent/DE4339100A1/de
Priority claimed from DE19944403665 external-priority patent/DE4403665A1/de
Priority claimed from DE19944412372 external-priority patent/DE4412372A1/de
Application filed by Basf Corp filed Critical Basf Corp
Publication of BR9408077A publication Critical patent/BR9408077A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6489—Metalloendopeptidases (3.4.24)
    • C12N9/6497—Endothelin-converting enzyme (3.4.24.71)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/52—Genes encoding for enzymes or proenzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/40—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against enzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/24—Metalloendopeptidases (3.4.24)
    • C12Y304/24071—Endothelin-converting enzyme 1 (3.4.24.71)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biomedical Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Microbiology (AREA)
  • Cardiology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biophysics (AREA)
  • Pain & Pain Management (AREA)
  • Urology & Nephrology (AREA)
  • Plant Pathology (AREA)
  • Pulmonology (AREA)
  • Immunology (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Vascular Medicine (AREA)
  • Reproductive Health (AREA)
  • Oncology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
BR9408077A 1993-11-16 1994-11-10 Enzimas de conversão de endotelina seqências de dna, processos para a obtenção por técnicas genéticas, de enzimas de conversão de endotelina substâncias inhibidoras para enzimas de conversão de endotelina e para a prepação de medicamentos que inibem uma enzima de conversão de endotelina e aplicações da enzima de conversão de endotelina das substâncias inibidoras de anticorpos de uma sequência de dna e de sequências parciais BR9408077A (pt)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
DE19934339100 DE4339100A1 (de) 1993-11-16 1993-11-16 Endothelinkonversionsenzym-1 (ECE-1)
DE19944403665 DE4403665A1 (de) 1994-02-07 1994-02-07 Endothelinkonversionsenzym (ECE)
DE19944412372 DE4412372A1 (de) 1994-04-12 1994-04-12 Endothelinkonversionsenzym (ECE)
PCT/EP1994/003706 WO1995014095A1 (de) 1993-11-16 1994-11-10 Endothelinkonversionsenzym (ece)

Publications (1)

Publication Number Publication Date
BR9408077A true BR9408077A (pt) 1997-08-12

Family

ID=27205762

Family Applications (1)

Application Number Title Priority Date Filing Date
BR9408077A BR9408077A (pt) 1993-11-16 1994-11-10 Enzimas de conversão de endotelina seqências de dna, processos para a obtenção por técnicas genéticas, de enzimas de conversão de endotelina substâncias inhibidoras para enzimas de conversão de endotelina e para a prepação de medicamentos que inibem uma enzima de conversão de endotelina e aplicações da enzima de conversão de endotelina das substâncias inibidoras de anticorpos de uma sequência de dna e de sequências parciais

Country Status (18)

Country Link
US (1) US6066502A (pt)
EP (1) EP0728209B1 (pt)
JP (1) JPH09505733A (pt)
KR (1) KR960705934A (pt)
CN (1) CN1141651A (pt)
AT (1) ATE315656T1 (pt)
AU (1) AU8107094A (pt)
BR (1) BR9408077A (pt)
CA (1) CA2176507A1 (pt)
CZ (1) CZ139496A3 (pt)
DE (1) DE59410427D1 (pt)
FI (1) FI962047A (pt)
HU (1) HUT75554A (pt)
NO (1) NO962023L (pt)
NZ (1) NZ275817A (pt)
PL (1) PL314480A1 (pt)
SK (1) SK59896A3 (pt)
WO (1) WO1995014095A1 (pt)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6255468B1 (en) * 1998-05-07 2001-07-03 Smithkline Beecham Plc MPROT12 polynucleotides and methods thereof
CA2385813A1 (en) 1999-09-24 2001-03-29 Lexicon Genetics Incorporated Human endothelin converting enzyme-like proteins and polynucleotides encoding the same
ATE312351T1 (de) * 2004-02-13 2005-12-15 Brahms Ag Verfahren zur bestimmung der bildung von endothelinen zu zwecken der medizinischen diagnostik, sowie antikörper und kits für die durchführung eines solchen verfahrens
WO2009018209A1 (en) 2007-07-27 2009-02-05 The Regents Of The University Of Colorado, A Body Corporate ENDOTHELIN SINGLE NUCLEOTIDE POLYMORPHISMS AND METHODS OF PREDICTING β-ADRENERGIC RECEPTOR TARGETING AGENT EFFICACY

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2966939B2 (ja) * 1990-12-07 1999-10-25 日清製粉株式会社 ヒト細胞由来のエンドセリン変換酵素
EP0575405A1 (en) * 1991-02-04 1993-12-29 Berlex Laboratories, Inc. Endothelin converting enzyme

Also Published As

Publication number Publication date
EP0728209B1 (de) 2006-01-11
PL314480A1 (en) 1996-09-16
DE59410427D1 (en) 2006-04-06
JPH09505733A (ja) 1997-06-10
CN1141651A (zh) 1997-01-29
US6066502A (en) 2000-05-23
CZ139496A3 (en) 1997-10-15
SK59896A3 (en) 1997-07-09
HU9601298D0 (en) 1996-07-29
ATE315656T1 (de) 2006-02-15
NO962023D0 (no) 1996-05-15
HUT75554A (en) 1997-05-28
KR960705934A (ko) 1996-11-08
FI962047A0 (fi) 1996-05-14
FI962047A (fi) 1996-07-12
CA2176507A1 (en) 1995-05-26
NZ275817A (en) 1997-02-24
WO1995014095A1 (de) 1995-05-26
AU8107094A (en) 1995-06-06
NO962023L (no) 1996-07-16
EP0728209A1 (de) 1996-08-28

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