KR960703629A - 혈관내 의료 기구(lntravascular medical device) - Google Patents

혈관내 의료 기구(lntravascular medical device) Download PDF

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KR960703629A
KR960703629A KR1019960700959A KR19960700959A KR960703629A KR 960703629 A KR960703629 A KR 960703629A KR 1019960700959 A KR1019960700959 A KR 1019960700959A KR 19960700959 A KR19960700959 A KR 19960700959A KR 960703629 A KR960703629 A KR 960703629A
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medical device
agent
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cellulose
thrombolytic
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이. 페어노트 닐
오. 라게브 안토니
디. 부리스 3세 윌리암
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이. 페어노트 닐
메드 인스티튜트, 인코포레이티드
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L33/00—Antithrombogenic treatment of surgical articles, e.g. sutures, catheters, prostheses, or of articles for the manipulation or conditioning of blood; Materials for such treatment
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L31/16—Biologically active materials, e.g. therapeutic substances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L29/00—Materials for catheters, medical tubing, cannulae, or endoscopes or for coating catheters
    • A61L29/14—Materials characterised by their function or physical properties, e.g. lubricating compositions
    • A61L29/16—Biologically active materials, e.g. therapeutic substances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L33/00—Antithrombogenic treatment of surgical articles, e.g. sutures, catheters, prostheses, or of articles for the manipulation or conditioning of blood; Materials for such treatment
    • A61L33/0005—Use of materials characterised by their function or physical properties
    • A61L33/0011—Anticoagulant, e.g. heparin, platelet aggregation inhibitor, fibrinolytic agent, other than enzymes, attached to the substrate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L33/00—Antithrombogenic treatment of surgical articles, e.g. sutures, catheters, prostheses, or of articles for the manipulation or conditioning of blood; Materials for such treatment
    • A61L33/0005—Use of materials characterised by their function or physical properties
    • A61L33/0047—Enzymes, e.g. urokinase, streptokinase
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
    • A61L2300/252—Polypeptides, proteins, e.g. glycoproteins, lipoproteins, cytokines
    • A61L2300/254—Enzymes, proenzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/42—Anti-thrombotic agents, anticoagulants, anti-platelet agents

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Abstract

본 발명은 생물학적으로 불활성이고, 혈전분괴제(13) 또는 항혈전형성제(14)를 갖는, 환자의 혈관계에 도입시키기 위한 형태 및 크기의 구조물(11)을 갖는 혈관내 의료 기구(10)에 관한 것이다. 혈전붕괴제는 유리하게는 구주물을 환자의 혈관계 내에 위치시켰을 때 구조물 표면에서의 혈전의 형성을 용패시키거나 또는 붕괴시킨다. 항혈전형성제는 의료 기구 표면 상에서의 혈전의 형성을 억제한다. 구조물은 또한 의료 기구의 기재 물질의 적어도 일부분 또는 기재 물질 상의 코팅 물질(22)을 형성하는 생물학적으로 불활성인 물질(15)을 포함한다. 혈전붕괴제 및/또는 항혈전형성제는 기재 및/또는 코팅 물질과 균질하게 혼합된다.

Description

혈관내 의료 기구(lntravascular medical device)
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
제8도는 혈전붕괴제, 항혈전형성제 및 생물학적으로 불활성인 물질의 균질한 코팅을 갖는 제1도의 의료 기구(10)를 도시한 것이다.

Claims (54)

  1. 생물학적으로 불활성이고, 혈전붕괴제 및/또는 항혈전형성제를 포함하며, 환자의 혈관계에 도입시키기 위한 형태 및 크기의 구조물을 포함하는 혈관내 의료 기구.
  2. 제1항에 있어서, 구조물이 생물학적으로 불활성인 물질을 포함하는 의료 기구.
  3. 제1항에 있어서, 상기 구조물이 기재 물질 및 생물학적으로 불활성인 물질의 코팅을 포함하는 의료 기구.
  4. 제1항에 있어서, 상기 구조물이 생물학적으로 불활성인 물질을 포함하는 기재 물질을 포함하는 의료 기구.
  5. 제1항 내지 제4항 중 어느 한 항에 있어서, 상기 생물학적으로 불활성인 물질이 셀룰로오스, 셀롤로오스화합물, 셀룰로오스 기재 중합체, 셀룰로오스 에스테르, 셀룰로오스 에세테이트, 셀룰로오스 니트레이트, 폴리우레탄, 실리콘, 에틸렌 비닐 아세테이트 공중합체, 폴리메틸메타크릴레이트, 폴리히드록시에틸 메타크릴레이트, 폴리에틸렌 테레프탈레이트, 폴리테트라폴루오로에틸렌, 폴리에테르 우레탄, 폴리 에틸렌 옥시드, 나일론, 폴리에스테르, 폴리아미드, 폴리이미드, 폴리비닐 클로라이드, 폴리비닐 아세테이트, 폴리올레핀, 폴리스티렌, 폴리프로필렌, 폴리카프롤락톤, 에폭시드, 파릴렌, 히드록겔, 폴리비닐피롤리돈, 폴리비닐 알콜, 폴리에틸렌 글리콜, 폴리아크릴아미드, 폴리글리콜산, 폴리락트산, 단백질, 콜라겐, 알부민, 지질, 인지질 및 포스파티딜콜린 중 하나 이상을 포함하는 의료 기구.
  6. 제1항 내지 제5항 중 어느 한 항에 있어서, 상기 기재 물질이 금속, 스텐레스 강, 탄탈, 니티놀, 금, 백금, 인코넬, 티타늄, 이리듐, 카본, 플라스틱, 중합체 및 생물학적으로 불활성인 물질 중 하나 이상을 포함하는 의료 기구.
  7. 제1항에 있어서, 상기 혈전붕괴제가 플라스미노겐 활성화제를 포함하는 의료 기구.
  8. 제7항에 있어서, 상기 플라스미노겐 활성화제가 스트렙토키나제, 유로키나제 및 조직 플라스미노겐 활성화제(t-PA) 중 하나 이상을 포함하는 의료 기구.
  9. 제1항 내지 제6항 중 어느 한 항에 있어서, 상기 항혈전형성제가 항응혈제 및/또는 항혈소판제를 포함하는 의료 기구.
  10. 제9항에 있어서, 상기 항응혈제가 헤파린, 히루딘, 히룰로그, 아가트로반, 참진드기 항응혈제 펩티드 및 안티스타신을 포함하는 의료 기구.
  11. 제9항에 있어서, 상기 항혈소판제가 아스피린, 디피리다몰, 티클로피딘, 술핀피라존, 프로스타글란딘, 콘빌레브란트 인자 길항제, 당단백질 Ⅱb/Ⅲa 길항제를 포함하는 의료 기구.
  12. 제1항 내지 제6항 중 어느 한 항에 있어서, 상기 구조물이 소염제를 포함하는 의료 기구.
  13. 제12항에 있어서, 상기 소염제가 비스테로이드계 약제를 포함하는 의료 기구.
  14. 제13항에 있어서, 상기 비스트로이드계 약제가 하나 이상의 살리실레이트 및/또는 프로피온산 유도체를 포함하는 의료 기구.
  15. 제12항에 있어서, 상기 소염제가 스테로이드계 약제를 포함하는 의료 기구.
  16. 제15항에 있어서, 상기 스테로이드계 약제가 코르티손, 덱사메타손, 베타메타손 및 프레드니손 중 하나 이상을 포함하는 의료 기구.
  17. 기재 물질, 소염제, 혈전붕괴제 및/또는 항혈전형성제를 포함하며, 환자의 혈관계에 도입시키기 위한 형태 및 크기의 구조물을 포함하는 혈관내 의료 기구.
  18. 제17항에 있어서, 상기 기재 물질이 금속, 스텐레스 강, 탄탈, 니티놀, 금, 백금, 인코넬, 티타늄, 이리듐, 카본, 플라스틱, 중합체 및 생물학적으로 불활성인 물질 중 하나 이상을 포함하는 의료 기구.
  19. 제18항에 있어서, 상기 생물학적으로 불활성인 물질이 셀룰로오스, 셀롤로오스화합물, 셀룰로오스 기재 중합체, 셀룰로오스 에스테르, 셀룰로오스에테르 셀룰로오스 에세테이트, 셀룰로오스 니트레이트, 폴리우레탄, 실리콘, 에틸렌 비닐 아세테이트 공중합체, 폴리메틸메타크릴레이트, 폴리히드록시에틸 메타크릴레이트, 폴리에틸렌 테레프탈레이트, 폴리테트라폴루오로에틸렌, 폴리에테르 우레탄, 폴리 에틸렌 옥시드, 나일론, 폴리에스테르, 폴리아미드, 폴리이미드, 폴리비닐 클로라이드, 폴리비닐 아세테이트, 폴리올레핀, 폴리스티렌, 폴리프로필렌, 폴리카프롤락톤, 에폭시드, 파릴렌, 히드록겔, 폴리비닐피롤리돈, 폴리비닐 알콜, 폴리에틸렌 글리콜, 폴리아크릴아미드, 폴리글리콜산, 폴리락트산, 단백질, 콜라겐, 알부민, 지질, 인지질 및 포스파티,딜콜린 중 하나 이상을 포함하는 의료 기구.
  20. 제17항 내지 제19항 중 어느 한 항에 있어서, 상기 소염제가 비스테로이드계 약제를 포함하는 의료 기구.
  21. 제20항에 있어서, 상기 비스테로이드계 약제가 하나 이상의 살리실레이트 및/또는 프로피온산 유도체를 포함하는 의료 기구.
  22. 제20항에 있어서, 상기 소염제가 스테로이드계 약제를 포함하는 의료 기구.
  23. 제22항에 있어서, 상기 스테로이드계 약제가 코르티손, 덱사메타손, 베타메타손 및 프레드니손 중 하나 이상을 포함하는 의료 기구.
  24. 제17항 내지 제19항 중 어느 한 항에 있어서, 상기 항혈전형성제가 항응혈제 또는 항혈소판제를 포함하는 의료 기구.
  25. 제24항에 있어서, 상기 항응혈제가 헤파린, 히루딘, 히룰로그, 아가트로반, 참진드기 항응혈제 펩티드 및 안티스타신을 포함하는 의료 기구.
  26. 제24항에 있어서, 상기 항혈소판제가 아스피린, 디피리다몰, 티클로피딘, 술핀피라존, 프로스타글란딘, 폰빌레브란트 인자 길항제, 당단백질 Ⅱb/Ⅲa 길항제를 포함하는 의료 기구.
  27. 제17항 내지 제19항 중 어느 한 항에 있어서, 상기 혈전붕괴제가 플라스미노겐 활성화제를 포함하는 의료 기구.
  28. 제27항에 있어서, 상기 플라스미노겐 활성화제가 스트렙토키나제, 유로키나제 및 플라스미노겐 활성화제(t-PA) 중 하나 이상을 포함하는 의료 기구.
  29. 제17항에 있어서, 생물학적으로 불활성인 물질의 코팅을 추가로 포함하는 의료 기구.
  30. 제29항에 있어서, 상기 혈전붕괴제 및/또는 항혈전형성제가 상기 생물학적으로 불활성인 물질의 코팅내에 균일하게 포함되는 의료 기구.
  31. 기재 물질 및 이러한 기재 물질 상의 혈전붕괴제 코팅을 포함하며, 환자의 혈관계에 도입시키기 위한 형태 및 크기의 구조물을 포함하는 혈관내 의료 기구.
  32. 제31항에 있어서, 상기 기재 물질이 금속, 중합제 및 생물학적으로 유래된 물질로 이루어진 그룹 중 하나 이상을 포함하는 의료 기구.
  33. 제32항에 있어서, 상기 혈전붕괴제가 유로키나제, 스트렙토키나제 및 조직 플라스미노겐 활성화제로 이루어진 그룹 중 하나 이상을 포함하는 의료 기구.
  34. 제31항에 있어서, 상기 구조물이 기재 물질 상에 제2의 항혈전형성제 코팅을 추가로 포함하는 의료 기구.
  35. 제34항에 있어서, 상기 항혈전형성제가 헤파린, 히루딘 및 항혈소판제로 이루어진 그룹 중 하나 이상을 포함하는 의료 기구.
  36. 제35항에 있어서, 상기 구조물이 혈전붕괴제의 코팅 및 항혈전형성제의 제2 코팅 중 하나 이상을 부착시키기 위하여 제3의 하도제 코팅을 추가로 포함하는 의료 기구.
  37. 기재 물질, 혈전붕괴제 및 항혈전형성제를 포함하며, 환자의 혈관계에 도입시키기 위한 형태 및 크기의 구조물을 포함하는 혈관내 의료 기구.
  38. 제37항에 있어서, 상기 혈전붕괴제 및 항혈전형성제 중 하나 이상을 기재 물질에 부착시키기 위하여 하도제를 추가로 포함하는 의료 기구.
  39. 제38항에 있어서, 상기 혈전붕괴제가 유로키나제, 스트렙토키나제 및 조직 플라스미노겐 활성화제로 이루어진 그룹 중 하나 이상을 포함하는 의료 기구.
  40. 제39항에 있어서, 상기 항혈전형성제가 헤파린, 히루딘 및 항혈소판제로 이루어진 그룹 중 하나 이상을 포함하는 의료 기구.
  41. 제38항에 있어서, 상기 하도제가 셀룰로오스 에스테르 및 셀룰로오스 니트레이트로 이루어진 그룹 중 하나 이상을 포함하는 의료 기구.
  42. 혈전붕괴제 및 이러한 혈전붕괴제로 처리한 기재 물질을 포함하며, 환자의 혈관계에 도입시키기 위한 형태 및 크기의 구조물을 포함하는 혈관내 의료 기구.
  43. 제42항에 있어서, 상기 기재 물질이 금속, 카본, 중합체 및 생물학적으로 유래된 물질로 이루어진 그룹 중 하나 이상을 포함하는 의료 기구.
  44. 제42항에 있어서, 상기 구조물이 항혈전형성제를 포함하는 의료 기구.
  45. 제43항에 있어서, 상기 금속이 스텐레스 강, 탄탈, 니티놀, 금, 백금, 인코넬 및 이리듐으로 이루어진 그룹 중 하나 이상을 포함하는 의료 기구.
  46. 제43항에 있어서, 상기 중합체가 셀룰로오스 아세테이트, 셀룰로오스 니트레이트, 실리콘, 폴리에틸렌 테레프탈레인, 폴리우레탄, 폴리아미드, 폴리에스테르, 폴리오르토에스테르 및 폴리언히드리드로 이루어진 그룹 중 하나 이상을 포함하는 의료 기구.
  47. 제43항에 있어서, 상기 혈전붕괴제가 유로키나제, 스트렙토키나제 및 조직 플라스미노겐 활성화제로 이루어진 그룹 중 하나 이상을 포함하는 의료 기구.
  48. 제43항에 있어서, 상기 항혈전형성제가 헤파린, 히루딘 및 항혈소판제로 이루어진 그룹 중 하나 이상을 포함하는 의료 기구.
  49. 제43항에 있어서, 상기 구조물이 형전붕괴제 및 항혈전형성제 중 하나 이상을 기재 물질에 부착시키기 위한 하도제를 포함하는 의료 기구.
  50. 제49항에 있어서, 상기 하도제가 셀룰로오스 에스테르 및 셀룰로오스 니트레이트로 이루어진 그룹 중 하나 이상을 포함하는 의료 기구.
  51. 의료 기구용 기재 물질을 제공하는 단계; 혈전붕괴제를 제공하는 단계 및 상기 기재 물질을 상기 혈전붕괴제로 처리하는 단계를 포함하는, 의료 기구를 혈전붕괴제로 처리하는 방법.
  52. 제51항에 있어서, 기재 물질을 처리하는 단계가 기재 물질을 혈전붕괴제의 용액 중에 침지시키는 단계를 포함하는 방법.
  53. 제52항에 있어서, 기재 물질을 처리하는 단계가 기재 물질 상에서 혈전붕괴제를 건조시키고, 침지 및 건조 단계를 반복하는 단계를 추가로 포함하는 방법.
  54. 제51항에 있어서, 중합체 및 생물학적으로 유래된 물질로 이루어진 그룹 중 하나 이상을 제공하는 단계를 추가로 포함하고, 기재 물질을 처리하는 단계가 혈전붕괴제를 상기한 그룹 중 하나 이상과 혼합시키고, 혈전붕괴제 및 상기한 그룹 중 하나 이상을 기재 물질에 적용하는 단계를 포함하는 방법.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019960700959A 1993-08-30 1994-08-29 혈관내의료기구및이의제조방법 KR100427514B1 (ko)

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WO1995006487A3 (en) 1995-04-06
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DE69433226T2 (de) 2004-08-19
AU8123694A (en) 1995-03-22
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WO1995006487A2 (en) 1995-03-09
US5380299A (en) 1995-01-10
EP0716616A1 (en) 1996-06-19
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JP3987571B2 (ja) 2007-10-10
KR100427514B1 (ko) 2004-07-19
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