KR960017681A - 트레할로오스 유도체 제조방법 - Google Patents

트레할로오스 유도체 제조방법 Download PDF

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Publication number
KR960017681A
KR960017681A KR1019950045534A KR19950045534A KR960017681A KR 960017681 A KR960017681 A KR 960017681A KR 1019950045534 A KR1019950045534 A KR 1019950045534A KR 19950045534 A KR19950045534 A KR 19950045534A KR 960017681 A KR960017681 A KR 960017681A
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South Korea
Prior art keywords
trehalose
anhydrous
derivatives
enzyme
maltose
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KR1019950045534A
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KR100387305B1 (ko
Inventor
다카히코 만다이
다카시 시부야
도시유키 스기모토
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하야시바라 겐
가부시키가이샤 하야시바라 세부쓰 가가쿠 겐쿠쇼
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Publication of KR960017681A publication Critical patent/KR960017681A/ko
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Publication of KR100387305B1 publication Critical patent/KR100387305B1/ko

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H7/00—Compounds containing non-saccharide radicals linked to saccharide radicals by a carbon-to-carbon bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H13/00—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids
    • C07H13/02—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids
    • C07H13/04—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids having the esterifying carboxyl radicals attached to acyclic carbon atoms
    • C07H13/06—Fatty acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/12—Disaccharides

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Cosmetics (AREA)
  • Saccharide Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)

Abstract

무수 조건하에서 무수 트레할로오스와 반응성 시약을 반응시킴으로써 고품위의 트레할로오스 유도체를 상당히 고수율로 쉽사리 제조한다. 이들 트레할로오스 유도체를 식품, 화장품, 의약품, 세척제 및 화공약품 등의 제조, 화학합성, 효소적인 합성 등 여러가지 분야에서 계면 활성제, 보습제, 피부 미화제, 항종양제, 화학 및 효소합성의 중간체로 사용할 수 있다.

Description

트레할로오스 유도체 제조방법
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (8)

  1. 무수 조건하에 반응성 시약을 무수 트레할로오스와 반응시키는 단계를 포함하는 트레할로오스 유도체 제조방법.
  2. 제1항에 있어서, 상기 무수 트레할로오스는 무수 결정질 또는 무수 비결정질 트레할로오스인 제조방법.
  3. 제1항에 있어서, 상기 무수 트레할로오스는 건조 고형분 기준으로 트레할로오스를 적어도 70w/w％ 함유하는 제조방법.
  4. 제1항에 있어서, 상기 무수 트레할로오스는 카알 피서법으로 측정했을 경우 수분 3w/w％ 이하 함유하는 제조방법.
  5. 제1항에 있어서, 상기 무수 트레할로오스는 비환원성 당질생성 효소를 전분부분 가수분해물에 작용시켜 말단단위로서 트레할로오스 구조를 가진 비환원성 당질을 생성시키고, 트레할로오스 유리효소를 상기 비환원성 당질에 작용시켜 트레할로오스를 유리시킨 다음, 유리된 트레할로오스를 건조 또는 결정화하여 제조되는 방법.
  6. 제1항에 있어서, 상기 무수 트레할로오스 말토오스/트레할로오스 변환효소를 말토오스에 작용시켜 트레할로오스를 생성시키고, 생성된 트레할로오스를 건조 또는 결정화하여 제조되는 제조방법.
  7. 제1항에 있어서, 상기 반응성 시약은 산류, 염류, 알코올류, 케톤류, 할로겐, 아민류 및 이들의 반응성 유도체로 된 군으로 부터 선택되는 1종인 제조방법.
  8. 제1항에 있어서, 상기 트레할로오스 유도체는 에스테르 형태 또는 에테르 형태인 제조방법.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019950045534A 1994-11-30 1995-11-30 트레할로오스유도체제조방법 KR100387305B1 (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP6341189A JPH08157491A (ja) 1994-11-30 1994-11-30 トレハロース誘導体の製造方法
JP94-341189 1994-11-30

Publications (2)

Publication Number Publication Date
KR960017681A true KR960017681A (ko) 1996-06-17
KR100387305B1 KR100387305B1 (ko) 2003-12-18

Family

ID=18344057

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019950045534A KR100387305B1 (ko) 1994-11-30 1995-11-30 트레할로오스유도체제조방법

Country Status (6)

Country Link
US (1) US5906924A (ko)
EP (1) EP0714905B1 (ko)
JP (1) JPH08157491A (ko)
KR (1) KR100387305B1 (ko)
DE (1) DE69526182T2 (ko)
TW (1) TW450973B (ko)

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US6586006B2 (en) 1994-08-04 2003-07-01 Elan Drug Delivery Limited Solid delivery systems for controlled release of molecules incorporated therein and methods of making same
US6290991B1 (en) 1994-12-02 2001-09-18 Quandrant Holdings Cambridge Limited Solid dose delivery vehicle and methods of making same
JPH10508744A (ja) 1994-09-22 1998-09-02 クオドラント ホールディングス ケンブリッジ リミテッド 運動競技の間の水分補給および栄養摂取の用途のための組成物ならびにその製造法
US6964771B1 (en) 1995-06-07 2005-11-15 Elan Drug Delivery Limited Method for stably incorporating substances within dry, foamed glass matrices
US5762961A (en) * 1996-02-09 1998-06-09 Quadrant Holdings Cambridge Ltd. Rapidly soluble oral solid dosage forms, methods of making same, and compositions thereof
US5958455A (en) * 1996-02-09 1999-09-28 Quadrant Holdings Cambridge Ltd Oral solid dosage forms, methods of making same and compositions thereof
US6632648B1 (en) 1996-05-14 2003-10-14 Elan Drug Delivery Limited Methods of terminal sterilization of fibrinogen
US6468782B1 (en) 1996-12-05 2002-10-22 Quadrant Healthcare (Uk) Limited Methods of preserving prokaryotic cells and compositions obtained thereby
US6565885B1 (en) 1997-09-29 2003-05-20 Inhale Therapeutic Systems, Inc. Methods of spray drying pharmaceutical compositions
US20060165606A1 (en) 1997-09-29 2006-07-27 Nektar Therapeutics Pulmonary delivery particles comprising water insoluble or crystalline active agents
US6352722B1 (en) 1997-12-23 2002-03-05 Quadrant Holdings Cambridge Limited Derivatized carbohydrates, compositions comprised thereof and methods of use thereof
US7871598B1 (en) 2000-05-10 2011-01-18 Novartis Ag Stable metal ion-lipid powdered pharmaceutical compositions for drug delivery and methods of use
WO2001085136A2 (en) 2000-05-10 2001-11-15 Alliance Pharmaceutical Corporation Phospholipid-based powders for drug delivery
US8404217B2 (en) 2000-05-10 2013-03-26 Novartis Ag Formulation for pulmonary administration of antifungal agents, and associated methods of manufacture and use
JP5007417B2 (ja) * 2000-09-19 2012-08-22 株式会社林原 会合物形成剤
JP4625595B2 (ja) * 2001-06-06 2011-02-02 塩水港精糖株式会社 皮膚洗浄料
JP4790154B2 (ja) * 2001-06-06 2011-10-12 塩水港精糖株式会社 非身体用洗浄剤
EP1458360B1 (en) 2001-12-19 2011-05-11 Novartis AG Pulmonary delivery of aminoglycosides
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GB0909136D0 (en) 2009-05-28 2009-07-01 Profibrix Bv Dry powder composition
WO2014206866A1 (en) * 2013-06-24 2014-12-31 F. Hoffmann-La Roche Ag Stable intravenous formulation
JP6147411B2 (ja) * 2016-12-22 2017-06-14 第一工業製薬株式会社 ショ糖カルボン酸エステルの製造方法
JP6147410B2 (ja) * 2016-12-22 2017-06-14 第一工業製薬株式会社 ショ糖カルボン酸エステルの製造方法
CN116410901B (zh) * 2023-04-17 2024-02-06 赣州京善科技合伙企业(有限合伙) 一种长双歧杆菌冻干粉剂的制备方法及应用

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JPH0723389B2 (ja) * 1985-11-30 1995-03-15 株式会社林原生物化学研究所 マルト−ス誘導体の製造方法
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JP3559585B2 (ja) * 1993-06-03 2004-09-02 株式会社林原生物化学研究所 トレハロース遊離酵素とその製造方法並びに用途
JP3633648B2 (ja) * 1993-07-20 2005-03-30 株式会社林原生物化学研究所 マルトース・トレハロース変換酵素とその製造方法並びに用途

Also Published As

Publication number Publication date
EP0714905B1 (en) 2002-04-03
DE69526182T2 (de) 2002-09-26
TW450973B (en) 2001-08-21
US5906924A (en) 1999-05-25
DE69526182D1 (de) 2002-05-08
KR100387305B1 (ko) 2003-12-18
JPH08157491A (ja) 1996-06-18
EP0714905A3 (en) 1996-10-02
EP0714905A2 (en) 1996-06-05

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