KR960004532B1 - 폴리사이클릭 구아닌 유도체 - Google Patents

폴리사이클릭 구아닌 유도체 Download PDF

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Publication number
KR960004532B1
KR960004532B1 KR1019920703316A KR920703316A KR960004532B1 KR 960004532 B1 KR960004532 B1 KR 960004532B1 KR 1019920703316 A KR1019920703316 A KR 1019920703316A KR 920703316 A KR920703316 A KR 920703316A KR 960004532 B1 KR960004532 B1 KR 960004532B1
Authority
KR
South Korea
Prior art keywords
purin
phenylmethyl
methyl
title compound
imidazo
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
KR1019920703316A
Other languages
English (en)
Korean (ko)
Inventor
알. 뉴스테트 버나드
에이. 린도 네일
에이. 맥킷트릭 브라이언
Original Assignee
쉐링 코포레이션
에릭 에스. 딕커
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 쉐링 코포레이션, 에릭 에스. 딕커 filed Critical 쉐링 코포레이션
Application granted granted Critical
Publication of KR960004532B1 publication Critical patent/KR960004532B1/ko
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
    • C07D487/14—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Filtering Materials (AREA)
  • Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
KR1019920703316A 1990-06-21 1991-06-20 폴리사이클릭 구아닌 유도체 Expired - Fee Related KR960004532B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US54156890A 1990-06-21 1990-06-21
US07/541,568 1990-06-21
PCT/US1991/004154 WO1991019717A1 (en) 1990-06-21 1991-06-20 Polycyclic guanine derivatives

Publications (1)

Publication Number Publication Date
KR960004532B1 true KR960004532B1 (ko) 1996-04-06

Family

ID=24160139

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019920703316A Expired - Fee Related KR960004532B1 (ko) 1990-06-21 1991-06-20 폴리사이클릭 구아닌 유도체

Country Status (21)

Country Link
US (1) US5393755A (https=)
EP (1) EP0538332B1 (https=)
JP (1) JPH0747589B2 (https=)
KR (1) KR960004532B1 (https=)
AT (1) ATE155786T1 (https=)
AU (1) AU651607B2 (https=)
CA (1) CA2085733C (https=)
CZ (1) CZ281920B6 (https=)
DE (1) DE69126980T2 (https=)
FI (1) FI925731A7 (https=)
HU (1) HUT65623A (https=)
IE (1) IE912126A1 (https=)
IL (1) IL98559A0 (https=)
NO (1) NO924940L (https=)
NZ (1) NZ238609A (https=)
OA (1) OA09723A (https=)
PL (1) PL169481B1 (https=)
RU (1) RU2080322C1 (https=)
TW (1) TW197441B (https=)
WO (1) WO1991019717A1 (https=)
ZA (1) ZA914727B (https=)

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US5858694A (en) * 1997-05-30 1999-01-12 Cell Pathways, Inc. Method for identifying compounds for inhibition of cancerous lesions
US6410584B1 (en) * 1998-01-14 2002-06-25 Cell Pathways, Inc. Method for inhibiting neoplastic cells with indole derivatives
US6130053A (en) * 1999-08-03 2000-10-10 Cell Pathways, Inc. Method for selecting compounds for inhibition of neoplastic lesions
US6200771B1 (en) 1998-10-15 2001-03-13 Cell Pathways, Inc. Method of using a novel phosphodiesterase in pharmaceutical screeing to identify compounds for treatment of neoplasia
US6133271A (en) * 1998-11-19 2000-10-17 Cell Pathways, Inc. Method for inhibiting neoplastic cells and related conditions by exposure thienopyrimidine derivatives
US6187779B1 (en) 1998-11-20 2001-02-13 Cell Pathways, Inc. Method for inhibiting neoplastic cells and related conditions by exposure to 2,8-disubstituted quinazoline derivatives
US6369092B1 (en) 1998-11-23 2002-04-09 Cell Pathways, Inc. Method for treating neoplasia by exposure to substituted benzimidazole derivatives
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US6486155B1 (en) 1998-11-24 2002-11-26 Cell Pathways Inc Method of inhibiting neoplastic cells with isoquinoline derivatives
US6034099A (en) * 1998-11-24 2000-03-07 Cell Pathways, Inc. Method for inhibiting neoplastic lesions by administering 4-(arylmethylene)- 2, 3- dihydro-pyrazol-3-ones
US6025394A (en) 1999-01-29 2000-02-15 Cell Pathways, Inc. Method for treating patients with acne by administering substituted sulfonyl indenyl acetic acids, amides and alcohols
US6020379A (en) * 1999-02-19 2000-02-01 Cell Pathways, Inc. Position 7 substituted indenyl-3-acetic acid derivatives and amides thereof for the treatment of neoplasia
ES2166270B1 (es) * 1999-07-27 2003-04-01 Almirall Prodesfarma Sa Derivados de 8-fenil-6,9-dihidro-(1,2,4,)triazolo(3,4-i)purin-5-ona.
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US6569638B1 (en) 2000-03-03 2003-05-27 Cell Pathways, Inc Method for screening compounds for the treatment of neoplasia
US6821978B2 (en) 2000-09-19 2004-11-23 Schering Corporation Xanthine phosphodiesterase V inhibitors
ATE395349T1 (de) * 2001-08-28 2008-05-15 Schering Corp Polycyclische guanin phosphodiesterase inhibitoren
EP1790652A1 (en) * 2001-08-28 2007-05-30 Schering Corporation Polycyclic guanine phosphodiesterase V inhibitors
IL160307A0 (en) 2001-08-31 2004-07-25 Univ Rockefeller Phosphodiesterase activity and regulation of phosphodiesterase 1-b-mediated signaling in brain
EP1312363A1 (en) * 2001-09-28 2003-05-21 Pfizer Products Inc. Methods of treatment and kits comprising a growth hormone secretagogue
CA2465893A1 (en) * 2001-11-09 2003-05-22 Schering Corporation Polycyclic guanine derivative phosphodiesterase v inhibitors
US7342884B2 (en) * 2002-03-13 2008-03-11 Harmonic, Inc. Method and apparatus for one directional communications in bidirectional communications channel
SI1509525T1 (sl) 2002-05-31 2006-12-31 Schering Corp Postopek priprave inhibitorjev ksantinske fosfodiesteraze V in njihovih prekurzorjev
DE60307628T2 (de) * 2002-05-31 2007-08-09 Schering Corporation Verfahren zur herstellung von xanthin phosphodiesterase v inhibitoren und deren vorstufen
WO2005012303A1 (en) * 2003-07-31 2005-02-10 Schering Corporation Metabolite of xanthine phosphodiesterase 5 inhibitor and derivatives thereof useful for treatment of erectile dysfunction
WO2005012293A1 (ja) * 2003-08-01 2005-02-10 Nippon Soda Co., Ltd. フェニルアゾール化合物、製造法および抗酸化薬
KR20060101762A (ko) * 2003-11-21 2006-09-26 쉐링 코포레이션 포스포디에스테라제 ｖ 억제제 제형
US20070004745A1 (en) * 2005-03-25 2007-01-04 Schering-Plough Corporation Methods of treating benign prostatic hyperplasia or lower urinary tract symptoms by using PDE 5 inhibitors
AU2006255028B2 (en) * 2005-06-06 2012-04-19 Intra-Cellular Therapies, Inc. Organic compounds
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US7884202B2 (en) 2005-11-09 2011-02-08 Tosoh Corporation Nucleobase having perfluoroalkyl group and process for producing the same
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KR20090042227A (ko) 2006-06-06 2009-04-29 인트라-셀룰라 써래피스, 인코퍼레이티드. 유기 화합물
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JP5778582B2 (ja) 2008-12-06 2015-09-16 イントラ−セルラー・セラピーズ・インコーポレイテッドＩｎｔｒａ−Ｃｅｌｌｕｌａｒ Ｔｈｅｒａｐｉｅｓ， Ｉｎｃ． 有機化合物
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BRPI0922809A2 (pt) 2008-12-06 2018-05-29 Intracellular Therapies Inc compostos orgânicos
WO2010098839A1 (en) 2009-02-25 2010-09-02 Intra-Cellular Therapies, Inc. Pde 1 inhibitors for ophthalmic disorders
AU2010222289B2 (en) 2009-03-13 2013-07-11 Advinus Therapeutics Private Limited Substituted fused pyrimidine compounds
JP2012526810A (ja) 2009-05-13 2012-11-01 イントラ−セルラー・セラピーズ・インコーポレイテッド 有機化合物
JP6166534B2 (ja) 2009-08-05 2017-07-19 イントラ−セルラー・セラピーズ・インコーポレイテッドＩｎｔｒａ−Ｃｅｌｌｕｌａｒ Ｔｈｅｒａｐｉｅｓ， Ｉｎｃ． 新規調節タンパク質および阻害剤
WO2011081915A2 (en) * 2009-12-15 2011-07-07 Cebix Inc. Methods for treating erectile dysfunction in patients with insulin-dependent diabetes
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Also Published As

Publication number Publication date
US5393755A (en) 1995-02-28
HU9204032D0 (en) 1993-03-29
FI925731A0 (fi) 1992-12-17
ATE155786T1 (de) 1997-08-15
HUT65623A (en) 1994-07-28
FI925731A7 (fi) 1992-12-17
IE912126A1 (en) 1992-01-01
EP0538332B1 (en) 1997-07-23
CA2085733C (en) 1996-03-05
CA2085733A1 (en) 1991-12-22
AU651607B2 (en) 1994-07-28
TW197441B (https=) 1993-01-01
NO924940D0 (no) 1992-12-18
WO1991019717A1 (en) 1991-12-26
CZ281920B6 (cs) 1997-04-16
NO924940L (no) 1992-12-18
EP0538332A1 (en) 1993-04-28
RU2080322C1 (ru) 1997-05-27
NZ238609A (en) 1993-12-23
JPH0747589B2 (ja) 1995-05-24
JPH05508647A (ja) 1993-12-02
PL169481B1 (pl) 1996-07-31
DE69126980D1 (de) 1997-09-04
DE69126980T2 (de) 1998-01-08
AU8199291A (en) 1992-01-07
IL98559A0 (en) 1992-07-15
ZA914727B (en) 1992-03-25
CZ374992A3 (en) 1993-10-13
OA09723A (en) 1993-08-30
PL297299A1 (https=) 1992-07-13

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