KR950703062A - 4h-티에노(2, 3-6)티오 피란 유도체를 제조하기위한 효소적 비대칭 환원방법(enzymatic asymmetric reduction process to produce 4h-thieno(2, 3-6) thio pyrane derivatives) - Google Patents

4h-티에노(2, 3-6)티오 피란 유도체를 제조하기위한 효소적 비대칭 환원방법(enzymatic asymmetric reduction process to produce 4h-thieno(2, 3-6) thio pyrane derivatives) Download PDF

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KR950703062A
KR950703062A KR1019950700750A KR19950700750A KR950703062A KR 950703062 A KR950703062 A KR 950703062A KR 1019950700750 A KR1019950700750 A KR 1019950700750A KR 19950700750 A KR19950700750 A KR 19950700750A KR 950703062 A KR950703062 A KR 950703062A
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enzyme
thieno
thio
produce
reduction system
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KR1019950700750A
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KR100319837B1 (ko
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로버트 안토니 홀트
스튜어트 리차드 릭바이
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머린 패트리샤 헬렌 스테드
제네카 리미티드(Zeneca Limited)
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Priority claimed from GB929218502A external-priority patent/GB9218502D0/en
Priority claimed from GB939303824A external-priority patent/GB9303824D0/en
Application filed by 머린 패트리샤 헬렌 스테드, 제네카 리미티드(Zeneca Limited) filed Critical 머린 패트리샤 헬렌 스테드
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P41/00—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/18—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing at least two hetero rings condensed among themselves or condensed with a common carbocyclic ring system, e.g. rifamycin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/18—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing at least two hetero rings condensed among themselves or condensed with a common carbocyclic ring system, e.g. rifamycin
    • C12P17/185—Heterocyclic compounds containing sulfur atoms as ring hetero atoms in the condensed system
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P41/00—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture
    • C12P41/002—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by oxidation/reduction reactions

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  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines Containing Plant Substances (AREA)

Abstract

본 발명은 하기 식(I)의 화합물을 효소 환원시스템과 접촉시켜 상응하는 알콜의 트랜스(4S,6S) 형태로 환원시키는 방법에 관한 것이다.
식중, X는 H 또는 -SO2NH2임.

Description

4H-티에노(2, 3-6)티오 피란 유도체를 제조하기위한 효소적 비대칭 환원방법(ENZYMATIC ASYMMETRIC REDUCTION PROCESS TO PRODUCE 4H-THIENO(2, 3-6) THIO PYRANE DERIVATIVES)
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (10)

  1. 하기 구조식
    의 화합물을 효소환원 시스템과 접촉시켜 하기 구조식
    의 화합물로 전환시키는 방법.
  2. 제1항에 있어서, 효소 환원시스템이 적합한 미생물의 전 세포 또는 부분세포로서 제공되는 방법.
  3. 제1항 또는 제2항에 있어서, 생성물의 최소한 90%가 4S, 6S 이성질 체인 방법.
  4. 선행항중 어느 한 항에 있어서, pH 2 내지 5인 방법.
  5. 선행항중 어느 한 항에 있어서, 환원 효소가 Lactobacillus plantarum, Pichia haplophila, Candida utilis, Lactobacillus buchneri, Aspergillus flavus oryzae 로부터 유래하거나 특히 Neurospora crassa로부터 유래하는 방법.
  6. 선행항중 어느 한 항에 있어서, 효소시스템은 적합한 미생물의 전세포로서 공급되고 기재는 효소 환원시스템에서 효소 보조인자의 환원을 가능케하는 용도로 제공되는 방법.
  7. 제6항에 있어서, 기재가 글루코스, 프락토스, 슈크로스, 글리세롤 또는 락트산인 방법.
  8. 선행항중 어느 한 항에 있어서, 온도가 20 내지 40℃인 방법.
  9. 선행항중 어느 한 항에 있어서, 반응물의 농도가 5 내지 50g/l인 방법.
  10. 선행항중 어느 한 항에 있어서, 1리터당 5 내지 10g의 글루코스가 존재하는 방법.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019950700750A 1992-08-28 1993-08-20 4h-티에노(2,3-6)티오피란유도체를제조하기위한효소적비대칭환원방법 KR100319837B1 (ko)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
GB9218502.4 1992-08-28
GB929218502A GB9218502D0 (en) 1992-08-28 1992-08-28 Asymmetric reduction process
GB939303824A GB9303824D0 (en) 1993-02-25 1993-02-25 Asymmetric reduction process
GB9303824.8 1993-02-25
PCT/GB1993/001776 WO1994005802A1 (en) 1992-08-28 1993-08-20 Enzymatic asymmetric reduction process to produce 4 h-thieno(2,3-6)thio pyrane derivatives

Publications (2)

Publication Number Publication Date
KR950703062A true KR950703062A (ko) 1995-08-23
KR100319837B1 KR100319837B1 (ko) 2002-04-22

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Application Number Title Priority Date Filing Date
KR1019950700750A KR100319837B1 (ko) 1992-08-28 1993-08-20 4h-티에노(2,3-6)티오피란유도체를제조하기위한효소적비대칭환원방법

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US (1) US5580764A (ko)
EP (1) EP0658211B2 (ko)
JP (1) JP3333206B2 (ko)
KR (1) KR100319837B1 (ko)
AT (1) ATE144795T1 (ko)
AU (1) AU4729193A (ko)
CA (1) CA2142444C (ko)
DE (1) DE69305748T3 (ko)
DK (1) DK0658211T4 (ko)
ES (1) ES2093980T3 (ko)
FI (1) FI106565B (ko)
WO (1) WO1994005802A1 (ko)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3279671B2 (ja) * 1992-09-28 2002-04-30 鐘淵化学工業株式会社 チエノチオピラン誘導体の製造方法
US5474919A (en) * 1994-09-13 1995-12-12 Merck & Co., Inc. Bioconversion process for the synthesis of transhydroxy sulfone by Rhodotorula rubra or Rhodotorula piliminae
IL132500A0 (en) 1998-10-29 2001-03-19 Pfizer Prod Inc Stereoselective microbial reduction of a racemic tetralone
US6451587B1 (en) 1999-09-29 2002-09-17 Pfizer Inc. Microbial asymmetric reduction of 2-chloro-1-[-6-(2,5-dimethyl-pyrrol-1-yl)-pyridin-3-yl]-ethanone
ES2177415B1 (es) 2000-09-04 2004-10-16 Ragactives, S.L. Procedimiento para la obtencion de 4-alquilamino-5, 6-dihidro-4h-tieno-(2,3b)-tiopiran-2-sulfonamida-7-dioxidos, e intermedios.
US9097692B2 (en) * 2010-10-01 2015-08-04 Aug. Hedinger Gmbh & Co. Kg Method for quantitatively determining impurities in glycerin
ITMI20111028A1 (it) * 2011-06-08 2012-12-09 Zach System Spa Processo di riduzione asimmetrica
WO2012120086A1 (en) * 2011-03-10 2012-09-13 Zach System S.P.A. Asymmetric reduction process
ITMI20110365A1 (it) * 2011-03-10 2012-09-11 Zach System Spa Processo di riduzione asimmetrica
KR102019953B1 (ko) 2017-03-02 2019-11-04 (주)삼성컨트롤밸브 자동밸브를 이용한 분무 장치

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4863922A (en) * 1984-12-12 1989-09-05 Merck & Co., Inc. Substituted aromatic sulfonamides as antiglaucoma agents, compositions and use
US4968815A (en) * 1990-04-16 1990-11-06 Merck & Co., Inc. Synthesis of (S)-3-(thien-2-ylthio)butyric acid analogs
US5039802A (en) * 1990-04-18 1991-08-13 Merck & Co., Inc. Arylation process for preparation of chiral catalysts for ketone reduction
US5474919A (en) * 1994-09-13 1995-12-12 Merck & Co., Inc. Bioconversion process for the synthesis of transhydroxy sulfone by Rhodotorula rubra or Rhodotorula piliminae

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Publication number Publication date
ATE144795T1 (de) 1996-11-15
KR100319837B1 (ko) 2002-04-22
EP0658211B2 (en) 2003-12-10
FI106565B (fi) 2001-02-28
FI950892A0 (fi) 1995-02-27
ES2093980T3 (es) 1997-01-01
US5580764A (en) 1996-12-03
JPH08501216A (ja) 1996-02-13
DE69305748D1 (de) 1996-12-05
JP3333206B2 (ja) 2002-10-15
DE69305748T3 (de) 2004-07-29
DK0658211T3 (da) 1997-04-28
CA2142444C (en) 2008-08-05
EP0658211A1 (en) 1995-06-21
EP0658211B1 (en) 1996-10-30
FI950892A (fi) 1995-02-27
WO1994005802A1 (en) 1994-03-17
DK0658211T4 (da) 2004-04-13
CA2142444A1 (en) 1994-03-17
DE69305748T2 (de) 1997-03-13
AU4729193A (en) 1994-03-29

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