DE69305748D1 - Enzymatisches asymetrisches reduktionsverfahren zur herstellung von 4h thieno (2,3-6) thiopyren derivaten. - Google Patents

Enzymatisches asymetrisches reduktionsverfahren zur herstellung von 4h thieno (2,3-6) thiopyren derivaten.

Info

Publication number
DE69305748D1
DE69305748D1 DE69305748T DE69305748T DE69305748D1 DE 69305748 D1 DE69305748 D1 DE 69305748D1 DE 69305748 T DE69305748 T DE 69305748T DE 69305748 T DE69305748 T DE 69305748T DE 69305748 D1 DE69305748 D1 DE 69305748D1
Authority
DE
Germany
Prior art keywords
thiopyrene
thieno
enzymatic
derivatives
producing
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69305748T
Other languages
English (en)
Other versions
DE69305748T2 (de
DE69305748T3 (de
Inventor
Robert Antony Holt
Stuart Richard Rigby
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
NPIL Pharmaceuticals UK Ltd
Original Assignee
Zeneca Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26301521&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DE69305748(D1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from GB929218502A external-priority patent/GB9218502D0/en
Priority claimed from GB939303824A external-priority patent/GB9303824D0/en
Application filed by Zeneca Ltd filed Critical Zeneca Ltd
Publication of DE69305748D1 publication Critical patent/DE69305748D1/de
Publication of DE69305748T2 publication Critical patent/DE69305748T2/de
Application granted granted Critical
Publication of DE69305748T3 publication Critical patent/DE69305748T3/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P41/00—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/18—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing at least two hetero rings condensed among themselves or condensed with a common carbocyclic ring system, e.g. rifamycin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/18—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing at least two hetero rings condensed among themselves or condensed with a common carbocyclic ring system, e.g. rifamycin
    • C12P17/185—Heterocyclic compounds containing sulfur atoms as ring hetero atoms in the condensed system
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P41/00—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture
    • C12P41/002—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by oxidation/reduction reactions

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Genetics & Genomics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines Containing Plant Substances (AREA)
DE69305748T 1992-08-28 1993-08-20 Enzymatisches asymetrisches reduktionsverfahren zur herstellung von 4h thieno (2,3-6) thiopyren derivaten. Expired - Lifetime DE69305748T3 (de)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
GB9218502 1992-08-28
GB929218502A GB9218502D0 (en) 1992-08-28 1992-08-28 Asymmetric reduction process
GB9303824 1993-02-25
GB939303824A GB9303824D0 (en) 1993-02-25 1993-02-25 Asymmetric reduction process
PCT/GB1993/001776 WO1994005802A1 (en) 1992-08-28 1993-08-20 Enzymatic asymmetric reduction process to produce 4 h-thieno(2,3-6)thio pyrane derivatives

Publications (3)

Publication Number Publication Date
DE69305748D1 true DE69305748D1 (de) 1996-12-05
DE69305748T2 DE69305748T2 (de) 1997-03-13
DE69305748T3 DE69305748T3 (de) 2004-07-29

Family

ID=26301521

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69305748T Expired - Lifetime DE69305748T3 (de) 1992-08-28 1993-08-20 Enzymatisches asymetrisches reduktionsverfahren zur herstellung von 4h thieno (2,3-6) thiopyren derivaten.

Country Status (12)

Country Link
US (1) US5580764A (de)
EP (1) EP0658211B2 (de)
JP (1) JP3333206B2 (de)
KR (1) KR100319837B1 (de)
AT (1) ATE144795T1 (de)
AU (1) AU4729193A (de)
CA (1) CA2142444C (de)
DE (1) DE69305748T3 (de)
DK (1) DK0658211T4 (de)
ES (1) ES2093980T3 (de)
FI (1) FI106565B (de)
WO (1) WO1994005802A1 (de)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3279671B2 (ja) * 1992-09-28 2002-04-30 鐘淵化学工業株式会社 チエノチオピラン誘導体の製造方法
US5474919A (en) * 1994-09-13 1995-12-12 Merck & Co., Inc. Bioconversion process for the synthesis of transhydroxy sulfone by Rhodotorula rubra or Rhodotorula piliminae
IL132500A0 (en) 1998-10-29 2001-03-19 Pfizer Prod Inc Stereoselective microbial reduction of a racemic tetralone
US6451587B1 (en) 1999-09-29 2002-09-17 Pfizer Inc. Microbial asymmetric reduction of 2-chloro-1-[-6-(2,5-dimethyl-pyrrol-1-yl)-pyridin-3-yl]-ethanone
ES2177415B1 (es) 2000-09-04 2004-10-16 Ragactives, S.L. Procedimiento para la obtencion de 4-alquilamino-5, 6-dihidro-4h-tieno-(2,3b)-tiopiran-2-sulfonamida-7-dioxidos, e intermedios.
US9097692B2 (en) * 2010-10-01 2015-08-04 Aug. Hedinger Gmbh & Co. Kg Method for quantitatively determining impurities in glycerin
CN103415524B (zh) * 2011-03-10 2015-11-25 Zach系统股份公司 不对称还原方法
ITMI20110365A1 (it) * 2011-03-10 2012-09-11 Zach System Spa Processo di riduzione asimmetrica
ITMI20111028A1 (it) * 2011-06-08 2012-12-09 Zach System Spa Processo di riduzione asimmetrica
KR102019953B1 (ko) 2017-03-02 2019-11-04 (주)삼성컨트롤밸브 자동밸브를 이용한 분무 장치

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4863922A (en) * 1984-12-12 1989-09-05 Merck & Co., Inc. Substituted aromatic sulfonamides as antiglaucoma agents, compositions and use
US4968815A (en) * 1990-04-16 1990-11-06 Merck & Co., Inc. Synthesis of (S)-3-(thien-2-ylthio)butyric acid analogs
US5039802A (en) * 1990-04-18 1991-08-13 Merck & Co., Inc. Arylation process for preparation of chiral catalysts for ketone reduction
US5474919A (en) * 1994-09-13 1995-12-12 Merck & Co., Inc. Bioconversion process for the synthesis of transhydroxy sulfone by Rhodotorula rubra or Rhodotorula piliminae

Also Published As

Publication number Publication date
DK0658211T4 (da) 2004-04-13
FI950892A0 (fi) 1995-02-27
JPH08501216A (ja) 1996-02-13
DE69305748T2 (de) 1997-03-13
EP0658211B2 (de) 2003-12-10
US5580764A (en) 1996-12-03
DE69305748T3 (de) 2004-07-29
KR100319837B1 (ko) 2002-04-22
WO1994005802A1 (en) 1994-03-17
DK0658211T3 (da) 1997-04-28
EP0658211A1 (de) 1995-06-21
ATE144795T1 (de) 1996-11-15
FI950892A (fi) 1995-02-27
KR950703062A (ko) 1995-08-23
FI106565B (fi) 2001-02-28
CA2142444A1 (en) 1994-03-17
ES2093980T3 (es) 1997-01-01
EP0658211B1 (de) 1996-10-30
CA2142444C (en) 2008-08-05
AU4729193A (en) 1994-03-29
JP3333206B2 (ja) 2002-10-15

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Legal Events

Date Code Title Description
8363 Opposition against the patent
8327 Change in the person/name/address of the patent owner

Owner name: AVECIA LTD., BLACKLEY, MANCHESTER, GB

8366 Restricted maintained after opposition proceedings
8327 Change in the person/name/address of the patent owner

Owner name: NPIL PHARMACEUTICALS (UK) LTD., HUDDERSFLIED, WEST