KR950701637A - 에난티오 선택적인 옥사자보롤리딘 촉매(enantioselective oxazaborolidine catalysts) - Google Patents

에난티오 선택적인 옥사자보롤리딘 촉매(enantioselective oxazaborolidine catalysts)

Info

Publication number
KR950701637A
KR950701637A KR1019940704055A KR19940704055A KR950701637A KR 950701637 A KR950701637 A KR 950701637A KR 1019940704055 A KR1019940704055 A KR 1019940704055A KR 19940704055 A KR19940704055 A KR 19940704055A KR 950701637 A KR950701637 A KR 950701637A
Authority
KR
South Korea
Prior art keywords
phenyl
chiral
configuration
carbon atom
alkyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
KR1019940704055A
Other languages
English (en)
Korean (ko)
Inventor
제이. 퀼리치 죠지
Original Assignee
알렌 제이. 스피겔
화이자 인코포레이티드
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 알렌 제이. 스피겔, 화이자 인코포레이티드 filed Critical 알렌 제이. 스피겔
Publication of KR950701637A publication Critical patent/KR950701637A/ko
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/28—Radicals substituted by singly-bound oxygen or sulphur atoms
    • C07D213/30—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
    • C07F5/02—Boron compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C29/00—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring
    • C07C29/132—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by reduction of an oxygen containing functional group
    • C07C29/136—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by reduction of an oxygen containing functional group of >C=O containing groups, e.g. —COOH
    • C07C29/143—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by reduction of an oxygen containing functional group of >C=O containing groups, e.g. —COOH of ketones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/22—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D277/24—Radicals substituted by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/22—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
    • C07F5/02—Boron compounds
    • C07F5/025—Boronic and borinic acid compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
    • C07C2601/08—Systems containing only non-condensed rings with a five-membered ring the ring being saturated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
    • C07C2601/10—Systems containing only non-condensed rings with a five-membered ring the ring being unsaturated

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Physical Or Chemical Processes And Apparatus (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Catalysts (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Polyurethanes Or Polyureas (AREA)
KR1019940704055A 1992-05-14 1993-02-01 에난티오 선택적인 옥사자보롤리딘 촉매(enantioselective oxazaborolidine catalysts) Granted KR950701637A (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US88331792A 1992-05-14 1992-05-14
US883,317 1992-05-14
PCT/US1993/000687 WO1993023408A1 (en) 1992-05-14 1993-02-01 Enantioselective oxazaborolidine catalysts

Publications (1)

Publication Number Publication Date
KR950701637A true KR950701637A (ko) 1995-04-28

Family

ID=25382382

Family Applications (2)

Application Number Title Priority Date Filing Date
KR1019940704055A Granted KR950701637A (ko) 1992-05-14 1993-02-01 에난티오 선택적인 옥사자보롤리딘 촉매(enantioselective oxazaborolidine catalysts)
KR1019940704055A Expired - Fee Related KR0149208B1 (ko) 1992-05-14 1993-02-01 에난티오 선택적인 옥사자보롤리딘 촉매

Family Applications After (1)

Application Number Title Priority Date Filing Date
KR1019940704055A Expired - Fee Related KR0149208B1 (ko) 1992-05-14 1993-02-01 에난티오 선택적인 옥사자보롤리딘 촉매

Country Status (21)

Country Link
US (1) US5552548A (enExample)
EP (1) EP0640089B1 (enExample)
JP (1) JP2525127B2 (enExample)
KR (2) KR950701637A (enExample)
AT (1) ATE146790T1 (enExample)
AU (1) AU659929B2 (enExample)
CA (1) CA2134096C (enExample)
DE (1) DE69306945T2 (enExample)
DK (1) DK0640089T3 (enExample)
ES (1) ES2096275T3 (enExample)
FI (1) FI107259B (enExample)
GR (1) GR3022171T3 (enExample)
HU (1) HU215089B (enExample)
IL (1) IL105623A (enExample)
MX (1) MX9302785A (enExample)
MY (1) MY111251A (enExample)
NO (1) NO300500B1 (enExample)
NZ (1) NZ249302A (enExample)
TW (1) TW232696B (enExample)
WO (1) WO1993023408A1 (enExample)
ZA (1) ZA933340B (enExample)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH06329679A (ja) * 1993-01-20 1994-11-29 Nissan Chem Ind Ltd 光学活性β−アミノアルコキシボラン錯体
TW416958B (en) * 1993-05-14 2001-01-01 Pfizer Enantioselective oxazaborolidine catalysts
JPH08507310A (ja) * 1993-07-16 1996-08-06 ファイザー・インク． チアゾール誘導体のエナンチオ選択的調製
WO1995015299A1 (en) * 1993-11-30 1995-06-08 Pfizer Inc. Process for preparing a chiral tetralone
US5495054A (en) * 1994-05-31 1996-02-27 Sepracor, Inc. Tetrahydroindeno[1,2-D][1,3,2]oxazaboroles and their use as enantioselective catalysts
WO1998012155A1 (en) * 1996-09-18 1998-03-26 Shionogi & Co., Ltd. Process for preparing optically acitve alcohol by reduction with asymmetric borane
ES2130083B1 (es) * 1997-08-04 2000-01-16 Esteve Labor Dr Procedimiento para la obtencion de los enantiomeros de cizolirtina.
US6509472B2 (en) 2000-09-11 2003-01-21 Schering Corporation 4-Cyclohexyl-1,3,2-oxazaborolidine chiral accessories
ATE478080T1 (de) * 2006-06-26 2010-09-15 Basf Se Boranetherkomplexe
EP2139845A1 (en) * 2007-02-26 2010-01-06 Teva Pharmaceutical Industries Ltd. Intermediates and processes for the synthesis of ramelteon
WO2008124072A1 (en) * 2007-04-05 2008-10-16 The Board Of Regents Of The University Of Texas System Palmerolides: methods of preparation and derivatives thereof
EP2152074A4 (en) * 2007-04-30 2011-07-27 Adolor Corp (-) - E-10-OH-NT COMPOSITIONS, METHODS OF SYNTHESIS AND USE
WO2008151170A2 (en) * 2007-05-31 2008-12-11 Teva Pharmaceutical Industries Ltd. Process for the synthesis of ramelteon and its intermediates
US20090082568A1 (en) * 2007-09-21 2009-03-26 Basf Aktiengesellschaft Accelerated reduction of organic substances with boranes
WO2009056993A2 (en) * 2007-11-01 2009-05-07 Teva Pharmaceutical Industries Ltd. A process for the synthesis of ramelteon and its intermediates
WO2010045565A1 (en) * 2008-10-16 2010-04-22 Teva Pharmaceutical Industries Ltd. Process for the synthesis of ramelteon and its intermediates

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4943635A (en) * 1987-08-27 1990-07-24 President & Fellows Of Harvard College Enantioselective reduction of ketones
US5039802A (en) * 1990-04-18 1991-08-13 Merck & Co., Inc. Arylation process for preparation of chiral catalysts for ketone reduction
US5157129A (en) * 1990-04-18 1992-10-20 Merck & Co., Inc. Enantiospecific synthesis of s-(+)-5,6-dihydro-4-(r-amino)-4h-thieno(2,3-b)thiopyran-2-sulfonamide-7,7-dioxide
JPH06329679A (ja) * 1993-01-20 1994-11-29 Nissan Chem Ind Ltd 光学活性β−アミノアルコキシボラン錯体
TW416958B (en) * 1993-05-14 2001-01-01 Pfizer Enantioselective oxazaborolidine catalysts

Also Published As

Publication number Publication date
GR3022171T3 (en) 1997-03-31
ATE146790T1 (de) 1997-01-15
NO300500B1 (no) 1997-06-09
ES2096275T3 (es) 1997-03-01
EP0640089B1 (en) 1996-12-27
DK0640089T3 (da) 1997-06-16
NO944297D0 (no) 1994-11-11
WO1993023408A1 (en) 1993-11-25
AU3593193A (en) 1993-12-13
IL105623A (en) 1998-02-22
US5552548A (en) 1996-09-03
NO944297L (no) 1994-11-11
IL105623A0 (en) 1993-09-22
FI107259B (fi) 2001-06-29
EP0640089A1 (en) 1995-03-01
HU215089B (hu) 1998-09-28
FI932174L (fi) 1993-11-15
KR0149208B1 (ko) 1998-10-15
DE69306945D1 (de) 1997-02-06
HU9301395D0 (en) 1993-09-28
AU659929B2 (en) 1995-06-01
TW232696B (enExample) 1994-10-21
CA2134096A1 (en) 1993-11-25
MX9302785A (es) 1994-02-28
JPH07503734A (ja) 1995-04-20
HUT65136A (en) 1994-04-28
CA2134096C (en) 1997-11-25
ZA933340B (en) 1994-11-14
FI932174A0 (fi) 1993-05-13
DE69306945T2 (de) 1997-05-07
NZ249302A (en) 1996-11-26
JP2525127B2 (ja) 1996-08-14
MY111251A (en) 1999-10-30

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