KR950700047A - 국소 투여용 방향족 서방성 조성물(topical aromatic releasing compositions) - Google Patents

국소 투여용 방향족 서방성 조성물(topical aromatic releasing compositions)

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KR950700047A
KR950700047A KR1019940703141A KR19940703141A KR950700047A KR 950700047 A KR950700047 A KR 950700047A KR 1019940703141 A KR1019940703141 A KR 1019940703141A KR 19940703141 A KR19940703141 A KR 19940703141A KR 950700047 A KR950700047 A KR 950700047A
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hydrochloride
mixtures
group
acid
aromatic
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존 휴즈 티모씨
엔델 덱크너 조지
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린다 데이 로하르
리챠드슨 빅스 인코포레이티드
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Publication of KR950700047A publication Critical patent/KR950700047A/ko

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    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/12—Carboxylic acids; Salts or anhydrides thereof
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    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
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    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
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Abstract

본 발명은 실질적으로 와셀린을 갖지않고, 멘톨, 캄포르 및 유칼리유 및 그의 혼합물로 구성된 그룹으로 부터 선택된 하나이상의 방향족 화합물을 함유하는 국소 투여용 방향족 서방성 조성물에 관한 것이다. 본 발명의 양태에서, 이러한 조성물은 하나이상의 국소적 활성성분을 함유하고, 또한 호흡계 질환에 기인하는 증상을 치료하는데 유용하다.

Description

국소 투여용 방향족 서방성 조성물(TOPICAL AROMATIC RELEASING COMPOSITIONS)
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (7)

  1. (a) 아크릴산, 메타크릴산 및 에타크릴산으로 구성된 그룹으로부터 선택된 단량체 혼합물, 하기 일반식의 아크릴레이트 에스테르 약 1 내지 약 3.5중량%, 및 분자당 하나이상의 알케닐 에테르 그룹을 함유하는 다가 알콜의 중합가능한 가교결합 폴리알케닐 폴리에테르(여기서, 모 다가 알콜은 3개이상의 탄소원자 및 3개 이상의 하이드록실 그룹을 함유한다) 0.1 내지 0.6중량%의 중합체를 포함하는 카복실 공중합체 약 0.025 내지 약 3%; (b) 멘톨, 캄포르 및 유칼리유 및 그의 혼합물로 구성된 그룹으로부터 선택된 하나이상의 휘발성 방향족 화합물 약 0.1 내지 약 30%를 포함하는, 실질적으로 와셀린을 갖지 않는 방향족 코막힘제거제 조성물을 방출시키기에 유용한 국소 투여용 수중유적형 유화조성물;
    상기식에서, R은 수소 또는 10 내지 30개의 탄소원자를 함유하는 알킬 라디칼이고, R1은 수소, 메틸 또는 에틸이다.
  2. 제1항에 있어서, 상기 중합체 성분이 약 96 내지 약 97.9중량%의 아크릴산 및 약 2.5내지 약 3.5중량%의 아크릴산 에스테르(여기서, 알킬 그룹은 12 내지 22개의 탄소원자를 함유하고, R1은 메틸이다)를 함유하는 국소 투여용 방향족 서방성 조성물.
  3. 제2항에 있어서, 상기 카복실산 공중합체의 아크릴레이트 에스테르가 스테아릴 메타크릴레이트이고, 상기 공중합체가 알릴 펜타에리트리톨, 트리메틸올프로판 디알릴에테르 또는 알릴 수크로스로 구성된 그룹으로부터 선택된 가교결합 단량체 약 0.2 내지 0.4중량%를 포함하는 국소 투여용 방향족 서방성 조성물.
  4. 제3항에 있어서, 약 0.1 내지 약20%의 습윤제 및 약 0.1 내지 약20%의 약학적 활성성분을 또한 포함하는 국소 투여용 방향족 서방성 조성물.
  5. 제4항에 있어서, 상기 약학적 활성성분이 살균제, 상처 치료제, 비타민, 항비루스제, 진통제, 소염제, 지양제, 해열제, 마취제, 항진균제 및 그의 혼합물로 구성된 그룹으로부터 선택된 조성물.
  6. 제5항에 있어서, 상기 살균제가 β-락탐 약제, 퀴놀론 약제, 시프로플록사신, 노플록사신, 테트라사이클린, 에리트로마이신, 아미카신, 트리클로산, 독시사이클린, 카프레오마이신, 클로르헥시딘, 클로르테트 라사이클린, 옥시테트라사이클린, 클린다마이산, 에탐부톨, 메트로니다졸, 펜타미딘, 젠타마이신, 카나마이신,리네오마이신, 메타 사이클린, 메텐아밀, 미노사이클린, 네오마이신, 네틸마이신, 파로모마이신, 스트렙토마이신, 토브라마이신, 미코나졸 및 아만파딘, 그의 약학적으로 허용가능한 염 및 그의 혼합물로 구성된 그룹으로부터 선택되고; 상기 마취제 또는 지양제가 리도카인, 리도카인 하이드로클로라이드, 부피바카인 하이드로클로라이드, 클로르프로카인 하이드로클로라이드, 디부카인 하이드로클로라이드, 에티도카인 하이드로클로라이드, 메피바카인 하이드로클로라이드, 테트라카인, 테트라카인 하이드로클로라이드, 디클로닌 하이드로클로라이드 및 헥실카인 하이드로클로라이드, 벤조카인, 벤질 알콜, 부탐벤 피크레이트, 캄포르, 캄포르화 메타크레솔, 디부카인, 디부카인 하이드로클로라이드, 디메트이소컨 하이드로클로라이드, 디펜하이드라민 하이드로클로라이드, 쥬니퍼 타르, 멘톨, 페놀, 페놀레이트 나트륨, 프라목신 하이드로클로라이드, 레조르시놀 및 그의 혼합물로 구성된 그룹으로부터 선택되고; 상기 비스테로이드성 소염제가 프로피온산 유도체, 아세트산 유도체, 페남산 유도체, 비페닐카복실산 유도체 및 옥시캄, 및 그의 혼합물로 구성된 그룹으로부터 선택되고; 상기 비스테로이드성 소염제가 아스피린, 아세트아미노펜, 이부프로펜, 나프록센, 베녹사프로펜, 플루르피프로펜, 페노프로펜, 펜부펜, 케토프로펜, 인도프로펜, 피르프로펜, 카프로펜, 옥사프로진, 프라노프로펜, 미로프로펜, 티옥사프로펜, 수프로펜, 알미노프로펜, 티아프로펜산, 플루프로펜 및 부클록산 및 그의 혼합물로 구성된 그룹으로부터 선택된 프로피온산 유도체이고; 상기 비타민이 비타민 A 및 그의 유도체, 아스코르빈산, 비타민 B. 비오틴, 판토텐산, 비타민 D, 비타민 E 및 그의 혼합물로 구성된 그룹으로부터 선택된 조성물.
  7. 제6항에 있어서, 벤즈알데하이드, 시트랄, 네랄, 데카날, 알데하이드 C8, 알데하이드 C9, 알데하이드 C12, 톨릴 알데하이드, 2,6-디메틸-옥타날 및 2-도데세날 및 그의 혼합물로 구성된 그룹으로부터 선택된 추가의 방향족 성분을 또한 포함하는 조성물.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019940703141A 1992-03-10 1993-02-22 국소 투여용 방향족 서방성 조성물(topical aromatic releasing compositions) KR950700047A (ko)

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US07/850,328 1992-03-10
US07/850,328 US5322689A (en) 1992-03-10 1992-03-10 Topical aromatic releasing compositions
PCT/US1993/001520 WO1993017655A1 (en) 1992-03-10 1993-02-22 Topical aromatic releasing compositions

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ES2166761T3 (es) 2002-05-01
HUT68561A (en) 1995-06-28
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HU9402591D0 (en) 1994-11-28
CA2130464C (en) 1999-02-02
AU668142B2 (en) 1996-04-26
PL172276B1 (pl) 1997-08-29
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RU94040855A (ru) 1996-11-10
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US5322689A (en) 1994-06-21
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