KR950002748A - 서방성 제제의 제조방법 - Google Patents

서방성 제제의 제조방법 Download PDF

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Publication number
KR950002748A
KR950002748A KR1019940016023A KR19940016023A KR950002748A KR 950002748 A KR950002748 A KR 950002748A KR 1019940016023 A KR1019940016023 A KR 1019940016023A KR 19940016023 A KR19940016023 A KR 19940016023A KR 950002748 A KR950002748 A KR 950002748A
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South Korea
Prior art keywords
water soluble
soluble polypeptide
biodegradable matrix
sustained release
biodegradable
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KR1019940016023A
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English (en)
Inventor
야스따까 이가리
가즈미찌 야마모또
가요꼬 오까모또
유따까 야마가따
Original Assignee
다께다 구니오
다께다 야꾸힝 고오교 가부시끼가이샤
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Application filed by 다께다 구니오, 다께다 야꾸힝 고오교 가부시끼가이샤 filed Critical 다께다 구니오
Publication of KR950002748A publication Critical patent/KR950002748A/ko

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A61K9/1694—Processes resulting in granules or microspheres of the matrix type containing more than 5% of excipient
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/21—Interferons [IFN]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
    • A61K9/1647—Polyesters, e.g. poly(lactide-co-glycolide)

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  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

수용액중에서 수용액 폴리팹티드를 생분해성 매트릭스내로 침투시키는 것으로 구성되는 서방성 제제의 제조방법.
본 발명의 제조방법으로 수용성 폴리펩티드를 유기 용매와 접촉시킴이 없이 수용성 폴리펩티드를 생분해성 매트릭스내로 침투시킬 수 있다. 그러므로 수용성 폴리펩티드의 생활성에 영향을 미침이 없이 수용성 폴리펩티드가 제조되므로 의약품으로 사용하기에 효율적이다.

Description

서방성 제제의 제조방법
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
제1도는 인터페론 용액 pH 및 여러 아연 염과 미소캡슐내의 인터페론 함량 사이의 관계를 나타내며, 여기에서 ●는 아연 염(실시예 7), ○는 염화 아연(비교예 2) 및 △는 탄산 아연(비교예 3)을 나타낸다, 제2도는 인터페론 용액 pH 및 아세트산 칼슘(실시예 5)과 미소캡슐내의 인터페론 함량을 보여준다.

Claims (16)

  1. 수용액중에서 수용성 폴리펩티드를 생분해성 매트릭스내로 침투시키는 것으로 구성되는 서방성 제제의 제제방법.
  2. 제1항에 있어서, 생분해성 매트릭스가 생분해성 중합체 및 지방족 카르복실산의 수용액 금속염을 혼합함으로써 제조되는 방법.
  3. 제2항에 있어서, 지방족 카르복실산이 지방족 모노카르복실산인 방법.
  4. 제2항에 있어서, 수용성 금속염이 다가 금속염인 방법.
  5. 제1항에 있어서, 수용성 폴리펩티드가 생분해성 매트릭스내로 수성으로 침투된 후에 생분해성 매트릭스를 건조하는 단계를 포함하는 방법.
  6. 제5항에 있어서, 건조단계가 동결건조인 방법.
  7. 제1항에 있어서, 수용성 폴리펩티드가 사이토카인인 방법.
  8. 제7항에 있어서, 사이토카인이 인터페론인 방법.
  9. 제1항에 있어서, 생분해성 매트릭스가 미세입자 형태인 방법.
  10. 제1항에 있어서, 생분해성 매트릭스가 생분해성 중합체로부터 제조되는 방법.
  11. 제10항에 있어서, 생분해성 중합체가 지방족 폴리에스테르인 방법.
  12. 제11항에 있어서, 지방족 폴리에스테르가 α-히드록시카르복실산으로부터 유도된 공중합체인 방법.
  13. 제12항에 있어서, 공중합체가 락트산-글리콜산 공중합체인 방법.
  14. 수용성 폴리펩티드를 생분해성 매트릭스내로 침투시켜서 제조한 서방성 체제.
  15. 생분해성 중합체 및 지방족 카르복실산의 수용성 금속염을 혼합한 다음 수용성 폴리펩티드를 생성 생분해성 매트릭스내로 침투시켜서 제조한 서방성 제제.
  16. 제14항에 있어서, 주사용 제제인 서방성 제제
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019940016023A 1993-07-05 1994-07-05 서방성 제제의 제조방법 KR950002748A (ko)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
JP16579393 1993-07-05
JP93-165793 1993-07-05
JP8176594 1994-04-20
JP94-81765 1994-04-20

Publications (1)

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KR950002748A true KR950002748A (ko) 1995-02-16

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US (1) US5534269A (ko)
EP (1) EP0633020B1 (ko)
KR (1) KR950002748A (ko)
CN (1) CN1106653A (ko)
AT (1) ATE184480T1 (ko)
AU (1) AU674077B2 (ko)
CA (1) CA2127317C (ko)
DE (1) DE69420632T2 (ko)
FI (1) FI943205A (ko)
NO (1) NO942515L (ko)
NZ (1) NZ260909A (ko)

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Also Published As

Publication number Publication date
NZ260909A (en) 1995-04-27
NO942515L (no) 1995-01-06
DE69420632T2 (de) 2000-03-02
US5534269A (en) 1996-07-09
NO942515D0 (no) 1994-07-04
CN1106653A (zh) 1995-08-16
CA2127317C (en) 2008-10-07
FI943205A0 (fi) 1994-07-05
FI943205A (fi) 1995-01-06
EP0633020A1 (en) 1995-01-11
ATE184480T1 (de) 1999-10-15
EP0633020B1 (en) 1999-09-15
DE69420632D1 (de) 1999-10-21
AU674077B2 (en) 1996-12-05
CA2127317A1 (en) 1995-01-06
AU6614594A (en) 1995-01-12

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