KR940009183A - 단백질분해 효소 억제제로 유용한 신규 2-사카리닐메틸 아릴 카복실레이트, 이를 함유하는 조성물 및 용도 - Google Patents
단백질분해 효소 억제제로 유용한 신규 2-사카리닐메틸 아릴 카복실레이트, 이를 함유하는 조성물 및 용도 Download PDFInfo
- Publication number
- KR940009183A KR940009183A KR1019930016236A KR930016236A KR940009183A KR 940009183 A KR940009183 A KR 940009183A KR 1019930016236 A KR1019930016236 A KR 1019930016236A KR 930016236 A KR930016236 A KR 930016236A KR 940009183 A KR940009183 A KR 940009183A
- Authority
- KR
- South Korea
- Prior art keywords
- lower alkyl
- alkyl
- alkylene
- piperazinyl
- phenyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D275/00—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings
- C07D275/04—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings condensed with carbocyclic rings or ring systems
- C07D275/06—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings condensed with carbocyclic rings or ring systems with hetero atoms directly attached to the ring sulfur atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6536—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having nitrogen and sulfur atoms with or without oxygen atoms, as the only ring hetero atoms
- C07F9/6539—Five-membered rings
- C07F9/6541—Five-membered rings condensed with carbocyclic rings or carbocyclic ring systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Rheumatology (AREA)
- Pulmonology (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Indole Compounds (AREA)
- Thiazole And Isothizaole Compounds (AREA)
- Detergent Compositions (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Peptides Or Proteins (AREA)
- Adhesives Or Adhesive Processes (AREA)
- Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
- Pyrrole Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US965,593 | 1992-10-23 | ||
| US07/965,593 US5306818A (en) | 1990-11-01 | 1992-10-23 | Tetrahydro 2-saccharinylmerthyl aryl carboxylates |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| KR940009183A true KR940009183A (ko) | 1994-05-20 |
Family
ID=25510194
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1019930016236A Ceased KR940009183A (ko) | 1992-10-23 | 1993-08-20 | 단백질분해 효소 억제제로 유용한 신규 2-사카리닐메틸 아릴 카복실레이트, 이를 함유하는 조성물 및 용도 |
Country Status (22)
| Country | Link |
|---|---|
| US (1) | US5306818A (https=) |
| EP (1) | EP0594257B1 (https=) |
| JP (1) | JPH06211849A (https=) |
| KR (1) | KR940009183A (https=) |
| AT (1) | ATE140227T1 (https=) |
| AU (1) | AU679446B2 (https=) |
| CA (1) | CA2105731A1 (https=) |
| CZ (1) | CZ221093A3 (https=) |
| DE (1) | DE69303573T2 (https=) |
| DK (1) | DK0594257T3 (https=) |
| ES (1) | ES2092751T3 (https=) |
| FI (1) | FI934675A7 (https=) |
| GR (1) | GR3021300T3 (https=) |
| HU (1) | HUT68879A (https=) |
| IL (2) | IL107315A0 (https=) |
| MX (1) | MX9305196A (https=) |
| MY (1) | MY131384A (https=) |
| NO (1) | NO304375B1 (https=) |
| NZ (1) | NZ248360A (https=) |
| SG (1) | SG50627A1 (https=) |
| SK (1) | SK116693A3 (https=) |
| TW (1) | TW272973B (https=) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5550139A (en) * | 1994-01-03 | 1996-08-27 | The Wichita State University | Serine protease inhibitors |
| DE4427997A1 (de) * | 1994-08-08 | 1996-02-15 | Basf Ag | 5-Hydroxypyrazol-4-yl-carbonyl-substituierte Saccharinderivate |
| DE4427998A1 (de) * | 1994-08-08 | 1996-02-15 | Basf Ag | Saccharinderivate |
| DE4427995A1 (de) * | 1994-08-08 | 1996-02-15 | Basf Ag | Saccharinderivate |
| US5556909A (en) * | 1994-12-02 | 1996-09-17 | Sanofi Winthrop Inc. | Substituted 2-arylcarbonyloxymethyl-1,2,5-thiadiazolidin-3-one 1,1-dioxide derivatives and compositions and method of use thereof |
| NZ337536A (en) * | 1997-03-10 | 2001-02-23 | Basf Ag | Saccharin-5-carbonyl-cyclohexane-1,3,5-trione derivatives, their preparation and their use as herbicides |
| US6420401B1 (en) | 1997-08-22 | 2002-07-16 | Wichita State University | 1,2,5, thiadiazolidin-3-one 1,1-dioxide derivatives |
| JP2003508480A (ja) * | 1999-09-10 | 2003-03-04 | ザ、プロクター、エンド、ギャンブル、カンパニー | 酵素インヒビター |
| MY147790A (en) * | 2005-04-28 | 2013-01-31 | Takeda Pharmaceutical | Stable emulsion composition |
| US10058542B1 (en) | 2014-09-12 | 2018-08-28 | Thioredoxin Systems Ab | Composition comprising selenazol or thiazolone derivatives and silver and method of treatment therewith |
| EP3606921B1 (en) | 2017-04-06 | 2022-06-01 | Inventiva | New compounds inhibitors of the yap/taz-tead interaction and their use in the treatment of malignant mesothelioma. |
| EP3632908A1 (en) | 2018-10-02 | 2020-04-08 | Inventiva | Inhibitors of the yap/taz-tead interaction and their use in the treatment of cancer |
| CN119751424B (zh) * | 2025-01-04 | 2025-12-05 | 重庆圣华曦药业股份有限公司 | 一种合成甲磺酸贝舒地尔的方法 |
Family Cites Families (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3002884A (en) * | 1959-04-15 | 1961-10-03 | Rohm & Haas | Horticultural process with n-halomethyl-1,2-benzisothiazolin - 3 - one-1,1-dioxides for controlling fungus diseases |
| US3314960A (en) * | 1964-08-25 | 1967-04-18 | American Home Prod | Benzisothiazol glutarimides |
| FR1451417A (fr) * | 1965-07-15 | 1966-01-07 | Roussel Uclaf | Nouveaux esters d'acides cycliques et leur procédé de préparation |
| JPS4835457A (https=) * | 1971-09-02 | 1973-05-24 | ||
| US4195023A (en) * | 1975-08-20 | 1980-03-25 | Merck & Co., Inc. | 2-(2-Furoyl)1,2-benzisothiazole-3-one, 2-(2-furoyl) saccharin, and 2-(2-thenoyl) saccharin |
| US4276298A (en) * | 1978-03-24 | 1981-06-30 | Merck & Co., Inc. | 2-Aryl-1,2-benzisothiazolinone-1,1-dioxides and their use as selective protease inhibitors |
| US4263393A (en) * | 1979-09-06 | 1981-04-21 | Eastman Kodak Company | Novel electron donor precursors and photographic element containing them |
| DE2966957D1 (en) * | 1979-10-08 | 1984-06-07 | Merck & Co Inc | 2-aryl-1,2-benzisothiazolinone-1,1-dioxides and pharmaceutical compositions containing them |
| US4350752A (en) * | 1980-12-29 | 1982-09-21 | Eastman Kodak Company | Photographic elements and film units containing imidomethyl blocked photographic reagents |
| US4363865A (en) * | 1981-03-04 | 1982-12-14 | Eastman Kodak Company | Imido methyl blocked photographic dyes and dye releasing compounds |
| US4410618A (en) * | 1982-06-11 | 1983-10-18 | Eastman Kodak Company | Blocked photographic reagents |
| US4547371A (en) * | 1983-04-18 | 1985-10-15 | Merck & Co., Inc. | Substituted cephalosporin sulfones as anti-inflammatory and anti-degenerative agents |
| US4623645A (en) * | 1983-04-18 | 1986-11-18 | Merck & Co., Inc. | Substituted cephalosporin sulfoxides as anti-inflammatory and antidegenerative agents |
| US4659855A (en) * | 1983-05-09 | 1987-04-21 | Georgia Tech Research Corporation | Aryl sulfonyl fluoride compounds |
| DE3617976A1 (de) * | 1986-05-28 | 1988-01-14 | Alter Sa | 1,4-dihydropyridin, verfahren zu dessen herstellung und dessen verwendung in antithrombotischen medikamenten |
| KR0183397B1 (ko) * | 1989-05-04 | 1999-05-01 | 존 엠. 스피나토 | 단백질 분해 효소 저해제로서 유용한 사카린 유도체들 및 그의 제조방법 |
| US5236917A (en) * | 1989-05-04 | 1993-08-17 | Sterling Winthrop Inc. | Saccharin derivatives useful as proteolytic enzyme inhibitors and compositions and method of use thereof |
| FR2659327A1 (fr) * | 1990-03-08 | 1991-09-13 | Centre Nat Rech Scient | Derives du benzisothiazolinone-1-dioxyde, utilisables comme inhibiteurs des elastases. |
| AU642537B2 (en) * | 1990-11-01 | 1993-10-21 | Sanofi | 2-saccharinylmethyl aryl carboxylates useful as proteolytic enzyme inhibitors and compositions and method of use thereof |
| TW282463B (https=) * | 1991-11-15 | 1996-08-01 | Sterling Winthrop Inc | |
| TW226016B (https=) * | 1991-12-30 | 1994-07-01 | Sterling Winthrop Inc | |
| AU653279B2 (en) * | 1991-12-30 | 1994-09-22 | Sanofi | Novel 2-saccharinylmethyl heterocyclic carboxylates useful as proteolytic enzyme inhibitors and compositions and method of use thereof |
-
1992
- 1992-10-23 US US07/965,593 patent/US5306818A/en not_active Expired - Fee Related
-
1993
- 1993-08-09 NZ NZ248360A patent/NZ248360A/en unknown
- 1993-08-10 AU AU44526/93A patent/AU679446B2/en not_active Ceased
- 1993-08-20 KR KR1019930016236A patent/KR940009183A/ko not_active Ceased
- 1993-09-08 CA CA002105731A patent/CA2105731A1/en not_active Abandoned
- 1993-09-17 JP JP5231485A patent/JPH06211849A/ja not_active Withdrawn
- 1993-09-22 TW TW082107789A patent/TW272973B/zh active
- 1993-09-26 MX MX9305196A patent/MX9305196A/es not_active IP Right Cessation
- 1993-10-18 IL IL107315A patent/IL107315A0/xx unknown
- 1993-10-18 IL IL10731593A patent/IL107315A/en not_active IP Right Cessation
- 1993-10-19 CZ CZ932210A patent/CZ221093A3/cs unknown
- 1993-10-20 SG SG1996007173A patent/SG50627A1/en unknown
- 1993-10-20 DE DE69303573T patent/DE69303573T2/de not_active Expired - Fee Related
- 1993-10-20 EP EP93202925A patent/EP0594257B1/en not_active Expired - Lifetime
- 1993-10-20 AT AT93202925T patent/ATE140227T1/de not_active IP Right Cessation
- 1993-10-20 DK DK93202925.9T patent/DK0594257T3/da active
- 1993-10-20 ES ES93202925T patent/ES2092751T3/es not_active Expired - Lifetime
- 1993-10-22 MY MYPI93002196A patent/MY131384A/en unknown
- 1993-10-22 NO NO933817A patent/NO304375B1/no unknown
- 1993-10-22 FI FI934675A patent/FI934675A7/fi unknown
- 1993-10-22 SK SK1166-93A patent/SK116693A3/sk unknown
- 1993-10-22 HU HU9303009A patent/HUT68879A/hu unknown
-
1996
- 1996-10-09 GR GR960402671T patent/GR3021300T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| FI934675A0 (fi) | 1993-10-22 |
| DE69303573T2 (de) | 1997-02-27 |
| AU679446B2 (en) | 1997-07-03 |
| ATE140227T1 (de) | 1996-07-15 |
| AU4452693A (en) | 1994-05-05 |
| SK116693A3 (en) | 1995-02-08 |
| TW272973B (https=) | 1996-03-21 |
| CA2105731A1 (en) | 1994-04-24 |
| GR3021300T3 (en) | 1997-01-31 |
| NO933817D0 (no) | 1993-10-22 |
| IL107315A0 (en) | 1994-01-25 |
| HUT68879A (en) | 1995-08-28 |
| NO304375B1 (no) | 1998-12-07 |
| DE69303573D1 (de) | 1996-08-14 |
| NO933817L (no) | 1994-04-25 |
| FI934675A7 (fi) | 1994-04-24 |
| CZ221093A3 (en) | 1994-05-18 |
| HU9303009D0 (en) | 1994-01-28 |
| US5306818A (en) | 1994-04-26 |
| DK0594257T3 (da) | 1996-11-11 |
| EP0594257B1 (en) | 1996-07-10 |
| MX9305196A (es) | 1994-05-31 |
| EP0594257A1 (en) | 1994-04-27 |
| IL107315A (en) | 1999-03-12 |
| NZ248360A (en) | 1995-08-28 |
| ES2092751T3 (es) | 1996-12-01 |
| SG50627A1 (en) | 1998-07-20 |
| MY131384A (en) | 2007-08-30 |
| JPH06211849A (ja) | 1994-08-02 |
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Patent event code: PA01091R01D Comment text: Patent Application Patent event date: 19930820 |
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| N231 | Notification of change of applicant | ||
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Patent event code: PA02012R01D Patent event date: 19980819 Comment text: Request for Examination of Application Patent event code: PA02011R01I Patent event date: 19930820 Comment text: Patent Application |
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Comment text: Notification of reason for refusal Patent event date: 20000629 Patent event code: PE09021S01D |
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Patent event date: 20000915 Comment text: Decision to Refuse Application Patent event code: PE06012S01D Patent event date: 20000629 Comment text: Notification of reason for refusal Patent event code: PE06011S01I |