KR940005620A - 에이즈의 치료에 유용한 에이치아이브이(hiv) 프로테아제 억제제 - Google Patents
에이즈의 치료에 유용한 에이치아이브이(hiv) 프로테아제 억제제 Download PDFInfo
- Publication number
- KR940005620A KR940005620A KR1019930011214A KR930011214A KR940005620A KR 940005620 A KR940005620 A KR 940005620A KR 1019930011214 A KR1019930011214 A KR 1019930011214A KR 930011214 A KR930011214 A KR 930011214A KR 940005620 A KR940005620 A KR 940005620A
- Authority
- KR
- South Korea
- Prior art keywords
- heterocycle
- alkyl
- aryl
- cycloalkyl
- unsaturated heterocycle
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 239000004030 hiv protease inhibitor Substances 0.000 title abstract 2
- 208000030507 AIDS Diseases 0.000 title 1
- 125000000623 heterocyclic group Chemical group 0.000 claims abstract 22
- 125000003118 aryl group Chemical group 0.000 claims abstract 14
- 125000000753 cycloalkyl group Chemical group 0.000 claims abstract 10
- 150000001875 compounds Chemical class 0.000 claims abstract 6
- 150000003839 salts Chemical class 0.000 claims abstract 5
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims abstract 3
- 125000000217 alkyl group Chemical group 0.000 claims abstract 3
- 229910052739 hydrogen Inorganic materials 0.000 claims abstract 3
- 239000001257 hydrogen Substances 0.000 claims abstract 3
- 125000003275 alpha amino acid group Chemical group 0.000 claims abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 claims abstract 2
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 6
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 claims 4
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 3
- -1 quinolin-2-ylmethyl Chemical group 0.000 claims 3
- 239000003377 acid catalyst Substances 0.000 claims 1
- 150000001413 amino acids Chemical class 0.000 claims 1
- 125000004093 cyano group Chemical group *C#N 0.000 claims 1
- 239000003085 diluting agent Substances 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 229940122440 HIV protease inhibitor Drugs 0.000 abstract 1
Classifications
-
- D—TEXTILES; PAPER
- D01—NATURAL OR MAN-MADE THREADS OR FIBRES; SPINNING
- D01G—PRELIMINARY TREATMENT OF FIBRES, e.g. FOR SPINNING
- D01G1/00—Severing continuous filaments or long fibres, e.g. stapling
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
- C07D303/02—Compounds containing oxirane rings
- C07D303/36—Compounds containing oxirane rings with hydrocarbon radicals, substituted by nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
- C07K5/021—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-(X)n-C(=0)-, n being 5 or 6; for n > 6, classification in C07K5/06 - C07K5/10, according to the moiety having normal peptide bonds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06139—Dipeptides with the first amino acid being heterocyclic
-
- D—TEXTILES; PAPER
- D02—YARNS; MECHANICAL FINISHING OF YARNS OR ROPES; WARPING OR BEAMING
- D02G—CRIMPING OR CURLING FIBRES, FILAMENTS, THREADS, OR YARNS; YARNS OR THREADS
- D02G3/00—Yarns or threads, e.g. fancy yarns; Processes or apparatus for the production thereof, not otherwise provided for
- D02G3/02—Yarns or threads characterised by the material or by the materials from which they are made
-
- D—TEXTILES; PAPER
- D02—YARNS; MECHANICAL FINISHING OF YARNS OR ROPES; WARPING OR BEAMING
- D02J—FINISHING OR DRESSING OF FILAMENTS, YARNS, THREADS, CORDS, ROPES OR THE LIKE
- D02J1/00—Modifying the structure or properties resulting from a particular structure; Modifying, retaining, or restoring the physical form or cross-sectional shape, e.g. by use of dies or squeeze rollers
- D02J1/22—Stretching or tensioning, shrinking or relaxing, e.g. by use of overfeed and underfeed apparatus, or preventing stretch
-
- D—TEXTILES; PAPER
- D06—TREATMENT OF TEXTILES OR THE LIKE; LAUNDERING; FLEXIBLE MATERIALS NOT OTHERWISE PROVIDED FOR
- D06M—TREATMENT, NOT PROVIDED FOR ELSEWHERE IN CLASS D06, OF FIBRES, THREADS, YARNS, FABRICS, FEATHERS OR FIBROUS GOODS MADE FROM SUCH MATERIALS
- D06M13/00—Treating fibres, threads, yarns, fabrics or fibrous goods made from such materials, with non-macromolecular organic compounds; Such treatment combined with mechanical treatment
- D06M13/322—Treating fibres, threads, yarns, fabrics or fibrous goods made from such materials, with non-macromolecular organic compounds; Such treatment combined with mechanical treatment with compounds containing nitrogen
- D06M13/402—Amides imides, sulfamic acids
-
- D—TEXTILES; PAPER
- D06—TREATMENT OF TEXTILES OR THE LIKE; LAUNDERING; FLEXIBLE MATERIALS NOT OTHERWISE PROVIDED FOR
- D06M—TREATMENT, NOT PROVIDED FOR ELSEWHERE IN CLASS D06, OF FIBRES, THREADS, YARNS, FABRICS, FEATHERS OR FIBROUS GOODS MADE FROM SUCH MATERIALS
- D06M7/00—Treating fibres, threads, yarns, fabrics, or fibrous goods made of other substances with subsequent freeing of the treated goods from the treating medium, e.g. swelling, e.g. polyolefins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- D—TEXTILES; PAPER
- D06—TREATMENT OF TEXTILES OR THE LIKE; LAUNDERING; FLEXIBLE MATERIALS NOT OTHERWISE PROVIDED FOR
- D06M—TREATMENT, NOT PROVIDED FOR ELSEWHERE IN CLASS D06, OF FIBRES, THREADS, YARNS, FABRICS, FEATHERS OR FIBROUS GOODS MADE FROM SUCH MATERIALS
- D06M2200/00—Functionality of the treatment composition and/or properties imparted to the textile material
- D06M2200/40—Reduced friction resistance, lubricant properties; Sizing compositions
-
- D—TEXTILES; PAPER
- D10—INDEXING SCHEME ASSOCIATED WITH SUBLASSES OF SECTION D, RELATING TO TEXTILES
- D10B—INDEXING SCHEME ASSOCIATED WITH SUBLASSES OF SECTION D, RELATING TO TEXTILES
- D10B2331/00—Fibres made from polymers obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polycondensation products
- D10B2331/02—Fibres made from polymers obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polycondensation products polyamides
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Textile Engineering (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Pharmacology & Pharmacy (AREA)
- Virology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Communicable Diseases (AREA)
- Crystallography & Structural Chemistry (AREA)
- Oncology (AREA)
- Tropical Medicine & Parasitology (AREA)
- AIDS & HIV (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Mechanical Engineering (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Plural Heterocyclic Compounds (AREA)
- Epoxy Compounds (AREA)
- Treatments For Attaching Organic Compounds To Fibrous Goods (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US901,447 | 1986-08-28 | ||
| US90144792A | 1992-06-19 | 1992-06-19 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| KR940005620A true KR940005620A (ko) | 1994-03-21 |
Family
ID=25414213
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1019930011214A Withdrawn KR940005620A (ko) | 1992-06-19 | 1993-06-18 | 에이즈의 치료에 유용한 에이치아이브이(hiv) 프로테아제 억제제 |
| KR1019930011216A Ceased KR940000634A (ko) | 1992-06-18 | 1993-06-18 | 폴리아미드 기재 연속 필라멘트의 토우 및 이의 제조방법 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1019930011216A Ceased KR940000634A (ko) | 1992-06-18 | 1993-06-18 | 폴리아미드 기재 연속 필라멘트의 토우 및 이의 제조방법 |
Country Status (21)
| Country | Link |
|---|---|
| US (1) | US5578608A (enExample) |
| EP (1) | EP0575097B1 (enExample) |
| JP (1) | JP3195462B2 (enExample) |
| KR (2) | KR940005620A (enExample) |
| CN (1) | CN1082035A (enExample) |
| AU (1) | AU663958B2 (enExample) |
| BR (1) | BR9302389A (enExample) |
| CA (1) | CA2098165A1 (enExample) |
| CO (1) | CO4130200A1 (enExample) |
| CZ (1) | CZ113393A3 (enExample) |
| DE (1) | DE69329606T2 (enExample) |
| ES (1) | ES2152241T3 (enExample) |
| FI (1) | FI932847A7 (enExample) |
| HU (1) | HUT67571A (enExample) |
| IL (1) | IL105973A0 (enExample) |
| MX (1) | MX9303572A (enExample) |
| NO (1) | NO932130L (enExample) |
| NZ (1) | NZ247837A (enExample) |
| PL (1) | PL299369A1 (enExample) |
| TW (1) | TW218873B (enExample) |
| YU (1) | YU42893A (enExample) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2130754C (en) | 1992-03-11 | 2005-02-08 | Damian W. Grobelny | Amine derivatives of oxo- and hydroxy-substituted hydrocarbons |
| ATE253050T1 (de) | 1992-03-11 | 2003-11-15 | Narhex Ltd | Aminderivate von oxo- und hydroxy- substituierten kohlenwasserstoffen |
| US6071895A (en) | 1992-03-11 | 2000-06-06 | Narhex Limited | Polar-substituted hydrocarbons |
| US5888992A (en) | 1992-03-11 | 1999-03-30 | Narhex Limited | Polar substituted hydrocarbons |
| NZ264143A (en) * | 1993-08-09 | 1996-11-26 | Lilly Co Eli | Use of an aspartyl protease inhibitor to inhibit beta-amyloid peptide production |
| EP0812839A1 (en) * | 1994-12-08 | 1997-12-17 | LG Chemical Limited | Irreversible HIV protease inhibitors, compositions containing same and process for the preparation thereof |
| US5696134A (en) * | 1993-11-30 | 1997-12-09 | Lg Chemical Limited | Irreversible HIV protease inhibitors, intermediates, compositions and processes for the preparation thereof |
| KR0159652B1 (ko) * | 1995-10-26 | 1998-12-01 | 성재갑 | 항 에이즈 효과를 갖는 비가역적 인간 면역 결핍 바이러스 프로테아제 저해제 및 그의 제조방법 |
| KR0125117B1 (ko) * | 1994-06-15 | 1997-12-05 | 성재갑 | 항 에이즈(aids)효과를 갖는 신규한 인간 면역 결핍 바이러스(hiv)프로테아제 억제 화합물 및 그의 제조방법 |
| US5693847A (en) * | 1995-04-19 | 1997-12-02 | Vertex Pharmaceuticals Incorporated | Heteroatom functionalized α-methyl ketones |
| US7431956B2 (en) | 2003-06-20 | 2008-10-07 | Sensient Imaging Technologies, Inc. | Food grade colored fluids for printing on edible substrates |
| US7431957B2 (en) | 2004-06-10 | 2008-10-07 | Sensient Imaging Technologies, Inc. | Food grade ink jet inks for printing on edible substrates |
| US9113647B2 (en) | 2008-08-29 | 2015-08-25 | Sensient Colors Llc | Flavored and edible colored waxes and methods for precision deposition on edible substrates |
| WO2014075676A1 (en) * | 2012-11-15 | 2014-05-22 | V-Biotek Holding Aps | Amines from trigonella foemum - graecum |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5142056A (en) * | 1989-05-23 | 1992-08-25 | Abbott Laboratories | Retroviral protease inhibiting compounds |
| JPS60193979A (ja) * | 1984-03-15 | 1985-10-02 | Mitsui Toatsu Chem Inc | Ν−（ω−グリシドキシアルキル）置換アミド化合物及びその製造方法 |
| US5155227A (en) * | 1984-07-19 | 1992-10-13 | University Of Florida | Compounds for site-enhanced delivery of radionuclides |
| FR2582514B1 (fr) * | 1985-05-30 | 1988-02-19 | Rhone Poulenc Sante | Medicaments a base d'amides, nouveaux amides et leur preparation |
| CA1340588C (en) * | 1988-06-13 | 1999-06-08 | Balraj Krishan Handa | Amino acid derivatives |
| EP0361341A3 (en) * | 1988-09-28 | 1991-07-03 | Miles Inc. | Therapeutics for aids based on inhibitors of hiv protease |
| JPH06501681A (ja) * | 1990-07-06 | 1994-02-24 | スミスクライン・ビーチャム・コーポレイション | レトロウイルス・プロテアーゼの阻害剤 |
| IE913840A1 (en) * | 1990-11-20 | 1992-05-20 | Abbott Lab | Retroviral protease inhibiting compounds |
| CN1071930A (zh) * | 1991-07-10 | 1993-05-12 | 伊莱利利公司 | 用作治疗艾滋病的人免疫缺陷病毒蛋白酶的抑制剂 |
-
1993
- 1993-06-10 CA CA002098165A patent/CA2098165A1/en not_active Abandoned
- 1993-06-10 EP EP93304504A patent/EP0575097B1/en not_active Expired - Lifetime
- 1993-06-10 IL IL105973A patent/IL105973A0/xx unknown
- 1993-06-10 NO NO932130A patent/NO932130L/no unknown
- 1993-06-10 ES ES93304504T patent/ES2152241T3/es not_active Expired - Lifetime
- 1993-06-10 DE DE69329606T patent/DE69329606T2/de not_active Expired - Fee Related
- 1993-06-10 CZ CZ931133A patent/CZ113393A3/cs unknown
- 1993-06-10 NZ NZ247837A patent/NZ247837A/en unknown
- 1993-06-10 TW TW082104596A patent/TW218873B/zh active
- 1993-06-15 MX MX9303572A patent/MX9303572A/es unknown
- 1993-06-17 BR BR9302389A patent/BR9302389A/pt not_active Application Discontinuation
- 1993-06-17 PL PL29936993A patent/PL299369A1/xx unknown
- 1993-06-17 JP JP14606193A patent/JP3195462B2/ja not_active Expired - Fee Related
- 1993-06-18 AU AU41354/93A patent/AU663958B2/en not_active Ceased
- 1993-06-18 KR KR1019930011214A patent/KR940005620A/ko not_active Withdrawn
- 1993-06-18 KR KR1019930011216A patent/KR940000634A/ko not_active Ceased
- 1993-06-18 FI FI932847A patent/FI932847A7/fi not_active Application Discontinuation
- 1993-06-18 CO CO93392259A patent/CO4130200A1/es unknown
- 1993-06-18 HU HU9301795A patent/HUT67571A/hu unknown
- 1993-06-19 CN CN93107424A patent/CN1082035A/zh active Pending
- 1993-06-21 YU YU42893A patent/YU42893A/sh unknown
-
1995
- 1995-01-17 US US08/372,722 patent/US5578608A/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| NZ247837A (en) | 1995-04-27 |
| NO932130D0 (no) | 1993-06-10 |
| CO4130200A1 (es) | 1995-02-13 |
| DE69329606T2 (de) | 2001-05-03 |
| AU4135493A (en) | 1993-12-23 |
| EP0575097A1 (en) | 1993-12-22 |
| CZ113393A3 (en) | 1994-03-16 |
| NO932130L (no) | 1993-12-20 |
| ES2152241T3 (es) | 2001-02-01 |
| FI932847A0 (fi) | 1993-06-18 |
| JP3195462B2 (ja) | 2001-08-06 |
| YU42893A (sh) | 1996-07-24 |
| HUT67571A (en) | 1995-04-28 |
| PL299369A1 (en) | 1993-12-27 |
| DE69329606D1 (de) | 2000-12-07 |
| HU9301795D0 (en) | 1993-09-28 |
| CN1082035A (zh) | 1994-02-16 |
| KR940000634A (ko) | 1994-01-03 |
| US5578608A (en) | 1996-11-26 |
| FI932847A7 (fi) | 1993-12-20 |
| TW218873B (enExample) | 1994-01-11 |
| CA2098165A1 (en) | 1993-12-20 |
| BR9302389A (pt) | 1994-01-11 |
| EP0575097B1 (en) | 2000-11-02 |
| IL105973A0 (en) | 1993-10-20 |
| AU663958B2 (en) | 1995-10-26 |
| JPH0656812A (ja) | 1994-03-01 |
| MX9303572A (es) | 1994-01-31 |
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