KR940003911A - 1,2,2,2-테트라플루오로에틸 디플루오로메틸 에테르의 제조방법 - Google Patents

1,2,2,2-테트라플루오로에틸 디플루오로메틸 에테르의 제조방법 Download PDF

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Publication number
KR940003911A
KR940003911A KR1019930002576A KR930002576A KR940003911A KR 940003911 A KR940003911 A KR 940003911A KR 1019930002576 A KR1019930002576 A KR 1019930002576A KR 930002576 A KR930002576 A KR 930002576A KR 940003911 A KR940003911 A KR 940003911A
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South Korea
Prior art keywords
ether
product
acid
cfhochcl
cfhoccl
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KR1019930002576A
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English (en)
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에이 로조브 레오니드
후앙 차아랑
지이 버어니스 제랄드
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래리 아아르 커세트
아나퀘스트 인코포레이팃드
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Publication of KR940003911A publication Critical patent/KR940003911A/ko

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C41/00—Preparation of ethers; Preparation of compounds having groups, groups or groups
    • C07C41/01—Preparation of ethers
    • C07C41/18—Preparation of ethers by reactions not forming ether-oxygen bonds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C41/00—Preparation of ethers; Preparation of compounds having groups, groups or groups
    • C07C41/01—Preparation of ethers
    • C07C41/18—Preparation of ethers by reactions not forming ether-oxygen bonds
    • C07C41/22—Preparation of ethers by reactions not forming ether-oxygen bonds by introduction of halogens; by substitution of halogen atoms by other halogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C41/00—Preparation of ethers; Preparation of compounds having groups, groups or groups
    • C07C41/01—Preparation of ethers
    • C07C41/18—Preparation of ethers by reactions not forming ether-oxygen bonds
    • C07C41/24—Preparation of ethers by reactions not forming ether-oxygen bonds by elimination of halogens, e.g. elimination of HCl
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C43/00—Ethers; Compounds having groups, groups or groups
    • C07C43/02—Ethers
    • C07C43/03—Ethers having all ether-oxygen atoms bound to acyclic carbon atoms
    • C07C43/04—Saturated ethers
    • C07C43/12—Saturated ethers containing halogen

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

출발 물질로서 헥사플루오로프로펜 에폭시드를 사용하는 테스플루란, 1,2,2,2-테트라플루오로에틸 디플루오로메틸 에테르의 개선된 제조에 관한 것이다. 헥사플루오로프로펜 에폭시드는 그것이 비교적 값싸고 환경적으로 허용가능하여 유리하다.

Description

1,2,2,2-테트라플루오로에틸 디플루오로메틸 에테르의 제조방법
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (10)

  1. 하기(a)-(e)로 구성되는 1,2,2,2-테트라플루오로에틸 디플루오로메틸 에테르의 제조방법 :
    (a) 헥사플루오로프로펜 에폭시드를 메탄올과 반응시켜 메틸2-메톡시테트라플루오로프로피오네이트를 산출하고 ; (b) 단계 (a)의 생성물을 가수분해하여 2-메톡시테트라플루오로프로피온 산을 형성하고; (c) 상기 산을 탈카르복실화시켜 1,2,2,2-테트라플루오로에틸 메틸 에테르를 형성하고; (d) 상기 에테르를 염소화시켜 CF3CFHOCHCl2를 형성하고; (e) 단계 (d)의 생성물을 불소화제와 반응시켜 1,2,2,2스테트라플루오로에틸 디플루오로메틸 에테르를 형성한다.
  2. 제1항에 있어서, 수성 염기에서 가열하므로써 단계(a)의 생성물을 가수분해하여 2-메톡시테트라플루오로프로피온산을 형성하는 방법.
  3. 제1항에 있어서, 단계(b)에서 형성된 산을 글리콜 및 수성 염기의 존재하에 가열하므로써 탈카르복실화하는 방법.
  4. 제1항에 있어서, 단계(b) 및 (c)는 중간 생성물을 분리 또는 정제없이 동일한 반응 용기에서 수행되는 방법.
  5. 제1항에 있어서, 단계(a) 내지 (c)는 중간 생성물의 분리 또는 정제없이 동일한 반응 용기에서 수행되는 방법.
  6. 제1항에 있어서, 단계(d)에서 상기 염소화는 자외선 또는 형광등의 존재하에 염소 기체와 단계(c)에서 형성된 에테르를 반응시켜 수행되는 방법.
  7. 제6항에 있어서, 상기 염소화는 CF3CFHOCH2Cl, CF3CHHOCHCl2및 CF3CFHOCCl3의 혼합물을 형성하고, 상기 염소화는 반응 혼합물내에 단계(c)에서 형성된 에테르도, CF3CFHOCH2Cl도 잔류하지 않을 때까지 수행하여, 이로써, CF3CFHOCHCl2및 CF3CFHOCCl3의 혼합물을 형성하는 방법.
  8. 제7항에 있어서, 부가적으로 CF3CFHOCCl3를 환원시켜 CF3CFHOCHCl2를 형성하는 단계를 포함하는 방법.
  9. 제8항에 있어서, 상기 환원은 저급 알칸올의 존재하에 자외선으로 반응을 조사함으로써 수행되는 방법.
  10. 제1항에 있어서, 상기 불소화제는 오염화안티모니의 존재하에 삼불화브롬 또는 불화수소인 방법.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019930002576A 1992-08-14 1993-02-24 1,2,2,2-테트라플루오로에틸 디플루오로메틸 에테르의 제조방법 KR940003911A (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US7/930,867 1992-08-14
US07/930,867 US5205914A (en) 1992-08-14 1992-08-14 Synthesis of desflurane

Publications (1)

Publication Number Publication Date
KR940003911A true KR940003911A (ko) 1994-03-14

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KR1019930002576A KR940003911A (ko) 1992-08-14 1993-02-24 1,2,2,2-테트라플루오로에틸 디플루오로메틸 에테르의 제조방법

Country Status (9)

Country Link
US (1) US5205914A (ko)
EP (1) EP0583540A1 (ko)
JP (1) JPH0687777A (ko)
KR (1) KR940003911A (ko)
CN (1) CN1083466A (ko)
AU (1) AU641600B1 (ko)
CA (1) CA2091048A1 (ko)
NO (1) NO930574L (ko)
ZA (1) ZA931259B (ko)

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US5741950A (en) * 1996-12-16 1998-04-21 Minnesota Mining And Manufacturing Company Method of preparing nonafluoroisobutyl methyl ether
US6800786B1 (en) 2002-09-25 2004-10-05 Baxter International, Inc. Preparation of desflurane
MXPA06012990A (es) * 2004-05-12 2007-02-12 Baxter Int Microesferas de acidos nucleicos, produccion y suministro de las mismas.
MX2007005900A (es) * 2004-11-17 2007-07-24 Minrad Inc Proceso para la produccion de 1,2,2,2-tetrafluoroetildifluorometil eter.
BRPI0607384A2 (pt) * 2005-02-15 2009-09-01 Halocarbon Prod Corp separação/purificação de desflurano do fluoreto de hidrogênio
US7605291B2 (en) * 2006-04-27 2009-10-20 Adalberto Maldonado Method for the preparation of volatile Anesthetics
CN106866416A (zh) * 2015-12-10 2017-06-20 浙江蓝天环保高科技股份有限公司 一种制备2-氟-2-烷氧基三氟丙酸酯的方法
JP6974718B2 (ja) * 2017-01-13 2021-12-01 セントラル硝子株式会社 １，２，２，２−テトラフルオロエチルジフルオロメチルエーテル（デスフルラン）の製造方法
US10683252B2 (en) 2016-12-29 2020-06-16 Central Glass Company, Limited Production method for 1,2,2,2-tetrafluoroethyl difluoromethyl ether (desflurane)
JP6886104B2 (ja) 2016-12-29 2021-06-16 セントラル硝子株式会社 ハロゲン化α−フルオロエーテル類の製造方法
WO2018165623A1 (en) * 2017-03-10 2018-09-13 The Chemours Company Fc, Llc Uses of fluorinated epoxides and novel mixtures thereof
JP2019064948A (ja) * 2017-09-29 2019-04-25 セントラル硝子株式会社 １，２，２，２−テトラフルオロエチルジフルオロメチルエーテル（デスフルラン）の製造方法
JP7032639B2 (ja) 2017-12-22 2022-03-09 セントラル硝子株式会社 ジフルオロメチル－１，２，２，２－テトラフルオロエチルエーテルの精製方法および製造方法

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US3242218A (en) * 1961-03-29 1966-03-22 Du Pont Process for preparing fluorocarbon polyethers
US3342875A (en) * 1962-03-26 1967-09-19 Du Pont Hydrogen capped fluorocarbon polyethers
DE2361058A1 (de) * 1973-12-07 1975-06-19 Hoechst Ag 1.2.2.2-tetrafluoraethyl-chlorfluormethylaether und verfahren zu dessen herstellung
US4972040A (en) * 1988-07-18 1990-11-20 Boc, Inc. Process for the preparation of CHF2 OCHFCF3
US5026924A (en) * 1989-03-14 1991-06-25 Anaquest, Inc. Process for production of 1,2,2,2-tetrafluoroethyl difluoromethyl ether
JP2544681B2 (ja) * 1990-08-17 1996-10-16 株式会社小糸製作所 自動車用前照灯装置

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AU641600B1 (en) 1993-09-23
CN1083466A (zh) 1994-03-09
NO930574D0 (no) 1993-02-18
CA2091048A1 (en) 1994-02-15
JPH0687777A (ja) 1994-03-29
NO930574L (no) 1994-02-15
US5205914A (en) 1993-04-27
ZA931259B (en) 1993-10-25
EP0583540A1 (en) 1994-02-23

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