KR930019609A - 부타디엔 유도체 및 그의 제법 - Google Patents
부타디엔 유도체 및 그의 제법 Download PDFInfo
- Publication number
- KR930019609A KR930019609A KR1019930004851A KR930004851A KR930019609A KR 930019609 A KR930019609 A KR 930019609A KR 1019930004851 A KR1019930004851 A KR 1019930004851A KR 930004851 A KR930004851 A KR 930004851A KR 930019609 A KR930019609 A KR 930019609A
- Authority
- KR
- South Korea
- Prior art keywords
- group
- substituted
- compound
- lower alkoxy
- unsubstituted
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
- KAKZBPTYRLMSJV-UHFFFAOYSA-N butadiene group Chemical class C=CC=C KAKZBPTYRLMSJV-UHFFFAOYSA-N 0.000 title claims abstract 7
- 238000002360 preparation method Methods 0.000 title claims abstract 5
- 125000003545 alkoxy group Chemical group 0.000 claims abstract 21
- 150000003839 salts Chemical class 0.000 claims abstract 18
- 125000000217 alkyl group Chemical group 0.000 claims abstract 14
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims abstract 11
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims abstract 10
- 125000005036 alkoxyphenyl group Chemical group 0.000 claims abstract 8
- 125000003277 amino group Chemical group 0.000 claims abstract 8
- 150000001875 compounds Chemical class 0.000 claims 19
- 125000005400 pyridylcarbonyl group Chemical group N1=C(C=CC=C1)C(=O)* 0.000 claims 8
- 125000004070 6 membered heterocyclic group Chemical group 0.000 claims 4
- -1 amino, hydroxy Chemical group 0.000 claims 4
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 claims 4
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 4
- 125000004453 alkoxycarbonyl group Chemical group 0.000 claims 2
- 238000003402 intramolecular cyclocondensation reaction Methods 0.000 claims 2
- 125000004573 morpholin-4-yl group Chemical group N1(CCOCC1)* 0.000 claims 2
- 125000004076 pyridyl group Chemical group 0.000 claims 2
- VXNZUUAINFGPBY-UHFFFAOYSA-N 1-Butene Chemical compound CCC=C VXNZUUAINFGPBY-UHFFFAOYSA-N 0.000 claims 1
- 239000002253 acid Substances 0.000 claims 1
- 125000003282 alkyl amino group Chemical group 0.000 claims 1
- 125000005098 aryl alkoxy carbonyl group Chemical group 0.000 claims 1
- IAQRGUVFOMOMEM-UHFFFAOYSA-N butene Natural products CC=CC IAQRGUVFOMOMEM-UHFFFAOYSA-N 0.000 claims 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 1
- 238000006482 condensation reaction Methods 0.000 claims 1
- 125000004989 dicarbonyl group Chemical group 0.000 claims 1
- 239000003085 diluting agent Substances 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 150000002148 esters Chemical class 0.000 claims 1
- OHVFKSYQKWXSDA-OTYYAQKOSA-N methyl (e,2e)-3-carbamoyl-4-phenyl-2-[(3,4,5-trimethoxyphenyl)methylidene]but-3-enoate Chemical compound C=1C=CC=CC=1\C=C(\C(N)=O)/C(/C(=O)OC)=C\C1=CC(OC)=C(OC)C(OC)=C1 OHVFKSYQKWXSDA-OTYYAQKOSA-N 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 150000003222 pyridines Chemical class 0.000 claims 1
- 238000007086 side reaction Methods 0.000 claims 1
- 229940127217 antithrombotic drug Drugs 0.000 abstract 2
- 230000002785 anti-thrombosis Effects 0.000 abstract 1
- 239000000543 intermediate Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
- C07C235/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton
- C07C235/32—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton containing six-membered aromatic rings
- C07C235/34—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton containing six-membered aromatic rings having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
- A61K31/225—Polycarboxylic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C243/00—Compounds containing chains of nitrogen atoms singly-bound to each other, e.g. hydrazines, triazanes
- C07C243/24—Hydrazines having nitrogen atoms of hydrazine groups acylated by carboxylic acids
- C07C243/26—Hydrazines having nitrogen atoms of hydrazine groups acylated by carboxylic acids with acylating carboxyl groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C243/30—Hydrazines having nitrogen atoms of hydrazine groups acylated by carboxylic acids with acylating carboxyl groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of an unsaturated carbon skeleton
- C07C243/32—Hydrazines having nitrogen atoms of hydrazine groups acylated by carboxylic acids with acylating carboxyl groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of an unsaturated carbon skeleton the carbon skeleton containing rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Emergency Medicine (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pyridine Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP4119480A JP2541420B2 (ja) | 1992-03-26 | 1992-03-26 | ３−ブテン酸誘導体及びその製法 |
| JP92-119480 | 1992-03-26 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| KR930019609A true KR930019609A (ko) | 1993-10-18 |
Family
ID=14762339
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1019930004851A Ceased KR930019609A (ko) | 1992-03-26 | 1993-03-26 | 부타디엔 유도체 및 그의 제법 |
Country Status (3)
| Country | Link |
|---|---|
| JP (1) | JP2541420B2 (enrdf_load_stackoverflow) |
| KR (1) | KR930019609A (enrdf_load_stackoverflow) |
| TW (1) | TW225515B (enrdf_load_stackoverflow) |
-
1992
- 1992-03-26 JP JP4119480A patent/JP2541420B2/ja not_active Expired - Lifetime
-
1993
- 1993-03-24 TW TW082102204A patent/TW225515B/zh active
- 1993-03-26 KR KR1019930004851A patent/KR930019609A/ko not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| TW225515B (enrdf_load_stackoverflow) | 1994-06-21 |
| JP2541420B2 (ja) | 1996-10-09 |
| JPH05279308A (ja) | 1993-10-26 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| AU6520998A (en) | 1,4-substituted cyclic amine derivatives | |
| KR880011153A (ko) | 벤즈옥사졸 유도체 및 이의 제조방법 | |
| AU2102992A (en) | New thiazolylbenzofuran derivatives, processes for the preparation thereof and pharmaceutical composition comprising the same | |
| AU8345491A (en) | Heterocyclic derivatives | |
| PT798295E (pt) | Novo derivado de amidinonaftilo ou sal deste | |
| KR890012970A (ko) | 테트라히드로 이소퀴놀린 유도체 | |
| KR920021518A (ko) | 피라진 유도체 | |
| KR930006018A (ko) | 이미다조피리딘 유도체 및 그의 제조방법 | |
| PL309874A1 (en) | Novel derivatives of pyrrolocarbasol, method of obtaining them and pharmaceutical composition containing such derivatives | |
| IE40511L (en) | Pyridyl piperidine derivatives | |
| IE860222L (en) | Imidazole derivatives. | |
| KR910009672A (ko) | 피리다진 유도체, 이의 제조방법 및 이것을 함유하는 약학 조성물 | |
| ATE154344T1 (de) | Butadienderivate, ihre herstellung und verwendung als antithrombotisches mittel | |
| KR930019609A (ko) | 부타디엔 유도체 및 그의 제법 | |
| KR930006024A (ko) | 이미다조 인돌리진 유도체 및 그의 제조방법 | |
| KR910007912A (ko) | 피리돈의 신규 유도체, 이들의 제조 방법, 신규 중간체, 약제로서 이들의 용도 및 이들을 함유한 조성물 | |
| DE68922053D1 (de) | Pyridoindolderivate und Verfahren zu ihrer Herstellung. | |
| KR930000513A (ko) | 헤테로사이클릭 유도체 | |
| IE891261L (en) | Heterotetracyclic lactam derivatives | |
| AU539986B2 (en) | Nitroso-urea compounds + alkylene amine derivatives of ureas | |
| ATE143658T1 (de) | Pyrrolidin-derivate | |
| IL83216A (en) | 1((5-(10->9)abeo-6-methylergolin-8beta-yl)methyl)-imidazolidine-(and hexahydropyrimidine)-2,4-dione derivatives,their preparation and pharmaceutical compositions containing them | |
| KR910000623A (ko) | 비페닐 유도체, 이의 제조방법 및 이를 위한 중간체 | |
| IE35532L (en) | Nitrofuran and nitrothiophene derivatives | |
| GB1459142A (en) | Pharmaceutical compositions containing aminobenzanilides |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PA0109 | Patent application |
Patent event code: PA01091R01D Comment text: Patent Application Patent event date: 19930326 |
|
| PG1501 | Laying open of application | ||
| A201 | Request for examination | ||
| PA0201 | Request for examination |
Patent event code: PA02012R01D Patent event date: 19961228 Comment text: Request for Examination of Application Patent event code: PA02011R01I Patent event date: 19930326 Comment text: Patent Application |
|
| E902 | Notification of reason for refusal | ||
| PE0902 | Notice of grounds for rejection |
Comment text: Notification of reason for refusal Patent event date: 19981126 Patent event code: PE09021S01D |
|
| E601 | Decision to refuse application | ||
| PE0601 | Decision on rejection of patent |
Patent event date: 19990225 Comment text: Decision to Refuse Application Patent event code: PE06012S01D Patent event date: 19981126 Comment text: Notification of reason for refusal Patent event code: PE06011S01I |