KR930012036A - 골 흡수 억제용 약제학적 조성물 - Google Patents

골 흡수 억제용 약제학적 조성물 Download PDF

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Publication number
KR930012036A
KR930012036A KR1019920024122A KR920024122A KR930012036A KR 930012036 A KR930012036 A KR 930012036A KR 1019920024122 A KR1019920024122 A KR 1019920024122A KR 920024122 A KR920024122 A KR 920024122A KR 930012036 A KR930012036 A KR 930012036A
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South Korea
Prior art keywords
group
bone resorption
pharmaceutical composition
hydroxyl group
hydrogen atom
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KR1019920024122A
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English (en)
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KR100257496B1 (ko
Inventor
미즈호 이나즈
료이치 사토
쓰토무 이노우에
히로시 기타가와
마사카즈 가토
엥글레르트 하인리히
까르니아또 드니
랑 한스-요헨
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원본미기재
훽스트 제팬 리미티드
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Publication of KR930012036A publication Critical patent/KR930012036A/ko
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Publication of KR100257496B1 publication Critical patent/KR100257496B1/ko

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Rheumatology (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

본 발명은 약제학적 담체 및 치료적 유효량의 일반식(I)의 벤조피란 유도체를 포함하는, 골 흡수 억제용 약제학적 조성물에 관한 것이다.
상기식에서, 점선 결합은 임의의 이중결합이고, R1은 수소 원자 또는 하이드록실 그룹이며, R2는 시아노 그룹, 페닐설포닐 그룹 또는 할로겐 치환된 메톡실 그룹이고, R3은 구조식
의 그룹이다.
당해 조성물은 골 흡수를 억제하므로, 골 물질 대사 관련 질병의 치료 및 예방에 유용하다.

Description

골 흡수 억제용 약제학적 조성물
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (3)

  1. 약제학적 담체 및 치료적 유효량의 일반식(I)의 벤조피란 유도체를 포함하는, 골 흡수 억제용 약제학적 조성물.
    상기식에서, 점선 결합은 임의의 이중결합이고, R1은 수소원자 또는 하이드록실 그룹이며, R2는 시아노 그룹, 페닐설포닐 그룹 또는 할로겐 치환된 메톡실 그룹이고, R3은 구조식
    의 그룹이다.
  2. 제1항에 있어서, R1이 하이드록실 그룹이고 R2가 시아노 그룹이며 R3이 R1에 대해 트란스위치로 존재하는 2-옥소-1-피롤리디닐 그룹이고 점선 결합이 단일결합인 약제학적 조성물.
  3. 제1항에 있어서, R1이 하이드록실 그룹이고 R2가 페닐설포닐 그룹이며 R3이 R1에 대해 트란스 위치로 존재하는 2-옥소-1-피롤리디닐 그룹이고 점선 결합이 단일결합인 약제학적 조성물.
    ※ 참고사항 : 최초출원 내용에 의하여 공개되는 것임.
KR1019920024122A 1991-12-16 1992-12-14 골 흡수 억제용 약제학적 조성물 KR100257496B1 (ko)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
JP33176791 1991-12-16
JP91-331,767 1991-12-16
JP23914492A JP3502403B2 (ja) 1991-12-16 1992-09-08 骨吸収抑制剤
JP92-239,144 1992-09-08

Publications (2)

Publication Number Publication Date
KR930012036A true KR930012036A (ko) 1993-07-20
KR100257496B1 KR100257496B1 (ko) 2000-08-01

Family

ID=26534099

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019920024122A KR100257496B1 (ko) 1991-12-16 1992-12-14 골 흡수 억제용 약제학적 조성물

Country Status (10)

Country Link
US (1) US5317029A (ko)
EP (1) EP0547545B1 (ko)
JP (1) JP3502403B2 (ko)
KR (1) KR100257496B1 (ko)
AT (1) ATE114465T1 (ko)
CA (1) CA2085421A1 (ko)
DE (1) DE69200757T2 (ko)
DK (1) DK0547545T3 (ko)
ES (1) ES2066546T3 (ko)
TW (1) TW223016B (ko)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5280040A (en) * 1993-03-11 1994-01-18 Zymogenetics, Inc. Methods for reducing bone loss using centchroman derivatives
US5837702A (en) * 1993-10-07 1998-11-17 Bristol-Myers Squibb Co. 4-arylamino-benzopyran and related compounds
US5389646A (en) * 1993-12-30 1995-02-14 Zymogenetics, Inc. Methods for treatment and prevention of bone loss using 2,3-benzopyrans
GB9408577D0 (en) * 1994-04-29 1994-06-22 Fujisawa Pharmaceutical Co New compound
US5629429A (en) * 1995-06-07 1997-05-13 Bristol-Myers Squibb Company Process for preparing 4-arylamino-benzopyran and related compounds
US5869478A (en) * 1995-06-07 1999-02-09 Bristol-Myers Squibb Company Sulfonamido substituted benzopyran derivatives
US5612370A (en) * 1995-06-07 1997-03-18 Bristol-Myers Squibb Company Phenylglycine and phenylalaninen amido benzopyran derivatives
US5612323A (en) * 1995-06-07 1997-03-18 Bristol-Myers Squibb Company Phosphinic ester substituted benzopyran derivatives
EP0783888A1 (en) * 1995-12-26 1997-07-16 Sankyo Company Limited Use of troglitazone and related thiazolidinediones in the manufacture of a medicament for the treatment and prophylaxis of osteoporosis
US20080108086A1 (en) * 1999-06-02 2008-05-08 Cantor Thomas L Parathyroid hormone antagonists and uses thereof
US7893021B2 (en) * 1999-06-02 2011-02-22 Scantibodies Laboratory, Inc. Parathyroid hormone antagonists and uses thereof
KR100389127B1 (ko) * 2000-10-09 2003-06-25 동부한농화학 주식회사 벤조피라닐 헤테로고리 유도체, 그의 제조방법 및 그를포함하는 약학적 조성물
TWI396543B (zh) 2005-05-12 2013-05-21 Sankyo Co 取代丙烯醯胺衍生物及含有它之醫藥組成物

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ZM7682A1 (en) * 1981-09-25 1983-05-23 Beecham Group Plc Active compounds
EP0091748B1 (en) * 1982-04-08 1986-06-18 Beecham Group Plc Antihypertensive benzopyranols
JPS58219183A (ja) * 1982-04-28 1983-12-20 ビ−チヤム・グル−プ・ピ−エルシ− 新規なクロマノ−ル，その製法及びそれらを含む製薬組成物
DE3368629D1 (en) * 1982-04-28 1987-02-05 Beecham Group Plc Novel chromenes and chromans
GB8513369D0 (en) * 1985-05-28 1985-07-03 Beecham Group Plc Treatment
DE3703227A1 (de) * 1987-02-04 1988-08-18 Hoechst Ag Substituierte 3,4-dihydro-2h-benzopyrane, verfahren zu ihrer herstellung, ihre verwendung sowie pharmazeutische praeparate auf basis dieser verbindungen
DE3823533A1 (de) * 1988-07-12 1990-02-08 Beiersdorf Ag Substituierte 4-heterocyclyl-2h-benzo(b)pyrane, verfahren und 4-hydroxy-3-brom-, 3,4-oxiranyl-3,4-dehydro-2h-benzo(b)pyrane als zwischenprodukte zu ihrer herstellung, sowie sie enthaltende pharmazeutsche praeparate

Also Published As

Publication number Publication date
ES2066546T3 (es) 1995-03-01
US5317029A (en) 1994-05-31
EP0547545A1 (en) 1993-06-23
EP0547545B1 (en) 1994-11-30
CA2085421A1 (en) 1993-06-17
TW223016B (ko) 1994-05-01
JP3502403B2 (ja) 2004-03-02
DK0547545T3 (da) 1995-05-15
JPH05221860A (ja) 1993-08-31
DE69200757D1 (de) 1995-01-12
KR100257496B1 (ko) 2000-08-01
ATE114465T1 (de) 1994-12-15
DE69200757T2 (de) 1995-05-11

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