KR930004459A - 미확인(Mystery)돼지 질병 관련 바이러스제 - Google Patents

미확인(Mystery)돼지 질병 관련 바이러스제 Download PDF

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KR930004459A
KR930004459A KR1019920015234A KR920015234A KR930004459A KR 930004459 A KR930004459 A KR 930004459A KR 1019920015234 A KR1019920015234 A KR 1019920015234A KR 920015234 A KR920015234 A KR 920015234A KR 930004459 A KR930004459 A KR 930004459A
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sirs
simian
atcc
cell line
virus
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KR1019920015234A
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KR0138092B1 (ko
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더블유. 클라덱 다니
이. 고르시카 데이비드
엘. 하리스 루이스
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원본미기재
베링거 인겔하임 애니멀 헬쓰, 인코포레이티드
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/08—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses
    • C07K16/10—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses from RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/525—Virus
    • A61K2039/5254—Virus avirulent or attenuated
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/55—Medicinal preparations containing antigens or antibodies characterised by the host/recipient, e.g. newborn with maternal antibodies
    • A61K2039/552—Veterinary vaccine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
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    • C12N2770/00011—Details
    • C12N2770/10011—Arteriviridae
    • C12N2770/10034—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
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    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
    • C12N2770/00011—Details
    • C12N2770/10011—Arteriviridae
    • C12N2770/10051—Methods of production or purification of viral material

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Abstract

내용 없음.

Description

미확인(Mystery)돼지 질병 관련 바이러스제
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (11)

  1. 돼지에서 SIRS 질병을 유발시킬 수 있는 SIRS 바이러스 ATCC-VR 2332의 생물학적 순수 배양물, 및 그의 모둔 동물 병인성 돌연변이체.
  2. 돼지 내에서 비-동물 변인성(non-zoopathogenic)을 나타내도록 변형시킨 변형된 SIRS 생(生)바이러스 ATCC-VR 2332 및 약제학적으로 허용되는 담체를 함유하는 백신 조성물.
  3. 사멸되거나 불활성화된 SIRS 바이러스 ATCC-VR 2332 및 약제학적으로 허용되는 담체를 함유하는 백신 조성물.
  4. 제2항의 백신 조성물을 돼지에게 투여함을 특징으로 하여, SIRS에 대하여 돼지를 면역화시키는 방법.
  5. 제3항의 백신 조성물을 돼지에게 투여함을 특징으로 하여, SIRS에 대하여 돼지를 면역화시키는 방법.
  6. 적당한 성장 배지내에서 혈청의 존재하에 시미안 세포 전체 또는 부분 쉬트상에 SIRS바이러스 ATCC-VR 2332를 접종하고, 접종된 세포 쉬트를 약 34내지 37℃에서 CPE(세포 변성 효과)가 관찰될 때까지 배양함을 특징으로 하여, SIRS 바이러스 ATCC-VR 2332를 성장 및 분리시키는 방법.
  7. 제6항에 있어서, 시미안 세포주가 MA-104인 방법.
  8. SIRS 바이러스 ATCC-VR 2332를 35내지 37℃에서 시미안 세포주를 통해 계대 배양한 후, 수득된 바이러스를 약 31℃에서 시미안 세포주를 통해 계대 배양함을 특징으로 하여 SIRS 바이러스 ATCC-VR 2332를 약독화시키는 방법.
  9. SIRS 바이러스 ATCC-VR 2332를 pH약 7.6에서 혈청 존재하의 보존 배지상에서 시미안 세포주를 통하여 약 35내지 37℃에서 CO2부재하에 약 25회 계대 배양한 후, 수득된 바이르스를 pH 약 7.6에서 혈청 존재하의 보존 배지상에서 시미안 세포주를 통해 약 31℃에서 약 12회 계대 배양함을 특징으로 하여 SIRS 바이러스인 ATCC-VR 2332를 약독회시키는 방법.
  10. 제9항에 있어서, 시미안 세포가 MA-104인 방법.
  11. 제10항에 있어서, 계대 배양을 CO2부재하에서 수행하는 방법.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019920015234A 1991-08-26 1992-08-24 미확인(Mystery) 돼지 질병 관련 바이러스제 KR0138092B1 (ko)

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KR1019970060582A KR0138068B1 (ko) 1991-08-26 1997-11-17 미확인(Mystery) 돼지 질병 관련 바이러스제

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US74983991A 1991-08-26 1991-08-26
US749,839 1991-08-26
US84169292A 1992-02-26 1992-02-26
US841,692 1992-02-26
US92189192A 1992-08-05 1992-08-05
US921,891 1992-08-05

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KR0138092B1 KR0138092B1 (ko) 1998-04-30

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EP (1) EP0529584B1 (ko)
JP (2) JP2750557B2 (ko)
KR (1) KR0138092B1 (ko)
AT (1) ATE140238T1 (ko)
CA (1) CA2076744C (ko)
DE (1) DE59206730D1 (ko)
DK (1) DK0529584T3 (ko)
ES (1) ES2089316T3 (ko)
GR (1) GR3020603T3 (ko)
HU (1) HU216311B (ko)
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PL (1) PL169952B1 (ko)
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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR200452417Y1 (ko) * 2011-01-21 2011-02-25 임진재 원통형 쿠션 벨트를 이용한 소파 쿠션장치

Families Citing this family (53)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK0587780T4 (da) 1991-06-06 2008-10-13 Boehringer Ingelheim Vetmed Smitstof, som forårsager Mystery Swine Disease,vaccinepræparater og diagnostiske sæt
US6042830A (en) * 1992-08-05 2000-03-28 Boehringer Ingelheim Vetmedica, Inc. Viral agent associated with mystery swine disease
US5846805A (en) 1991-08-26 1998-12-08 Boehringer Ingelheim Animal Health, Inc. Culture of swine infertility and respiratory syndrome virus in simian cells
US6982160B2 (en) * 1991-08-26 2006-01-03 Boehringer Ingelheim Vetmedica, Inc. Immunogenic compositions that include SIRS virus
US6080570A (en) * 1991-08-26 2000-06-27 Boehringer Ingelheim Vetmedica, Inc. Method of producing a vaccine for Swine Infertility and Respiratory Syndrome
JPH07501049A (ja) * 1991-10-14 1995-02-02 アクゾ・ノベル・エヌ・ベー ブタ生殖・呼吸系症候群ワクチン及び診断方法
FR2686097B1 (fr) * 1992-01-14 1994-12-30 Rhone Merieux Preparation d'antigenes et de vaccins de virus de la mystery disease, antigenes et vaccins obtenus pour la prevention de cette maladie.
US5695766A (en) 1992-10-30 1997-12-09 Iowa State University Research Foundation Highly virulent porcine reproductive and respiratory syndrome viruses which produce lesions in pigs and vaccines that protect pigs against said syndrome
US6773908B1 (en) 1992-10-30 2004-08-10 Iowa State University Research Foundation, Inc. Proteins encoded by polynucleic acids of porcine reproductive and respiratory syndrome virus (PRRSV)
US6380376B1 (en) 1992-10-30 2002-04-30 Iowa State University Research Foundation Proteins encoded by polynucleic acids of porcine reproductive and respiratory syndrome virus (PRRSV)
US6592873B1 (en) 1992-10-30 2003-07-15 Iowa State University Research Foundation, Inc. Polynucleic acids isolated from a porcine reproductive and respiratory syndrome virus (PRRSV) and proteins encoded by the polynucleic acids
US6251397B1 (en) 1992-10-30 2001-06-26 Iowa State University Research Foundation, Inc. Proteins encoded by polynucleic acids isolated from a porcine reproductive and respiratory syndrome virus and immunogenic compositions containing the same
SK98695A3 (en) * 1993-02-08 1996-11-06 Bayer Ag Process for growing porcine reproductive and respiratory syndrome virus and its use in vaccines
ATE206455T1 (de) * 1994-04-11 2001-10-15 Akzo Nobel Nv Europäische vakzinstämme des fortplanzungs- atmungs-syndromsvirus des schweins
GB2289279B (en) * 1994-05-13 1998-09-16 Iberica Cyanamid Diagnostic kits and vaccines containing recombinant PRRSV proteins
ES2102971B1 (es) * 1996-01-25 1998-03-01 Hipra Lab Sa Nueva cepa atenuada del virus causante del sindrome respiratorio y reproductivo porcino (prrs), las vacunas y medios de diagnostico obtenibles con la misma y los procedimientos para su obtencion.
US5866401A (en) * 1996-03-01 1999-02-02 Schering Corporation Porcine reproductive and respiratory syndrome vaccine
US5976537A (en) * 1996-07-02 1999-11-02 The United States Of America As Represented By The Secretary Of Agriculture Porcine reproductive and respiratory syndrome vaccine
US20040224327A1 (en) * 1996-10-30 2004-11-11 Meulenberg Johanna Jacoba Maria Infectious clones of RNA viruses and vaccines and diagnostic assays derived thereof
EP0839912A1 (en) * 1996-10-30 1998-05-06 Instituut Voor Dierhouderij En Diergezondheid (Id-Dlo) Infectious clones of RNA viruses and vaccines and diagnostic assays derived thereof
JP2000512313A (ja) 1997-05-06 2000-09-19 スティヒティング ディーンスト ラントバウキュンディフ オンデルズーク ワクチンまたは診断検定用ｐｒｒｓウイルスのペプチド配列同定ｐｒｒｓｖ抗原部位
CA2290220C (en) 1998-12-22 2013-11-19 Pfizer Products Inc. An infectious cdna clone of north american porcine reproductive and respiratory syndrome (prrs) virus and uses thereof
EP1157121B1 (en) * 1999-03-08 2013-04-24 Boehringer Ingelheim Vetmedica GmbH Prrsv replicon
AU4482200A (en) 1999-04-22 2000-11-10 United States Department Of Agriculture Porcine reproductive and respiratory syndrome vaccine, based on isolate ja-142
US6841364B2 (en) * 2002-01-22 2005-01-11 Protatek International, Inc. Infectious cDNA clones of porcine reproductive and respiratory syndrome virus and expression vectors thereof
US7906311B2 (en) * 2002-03-20 2011-03-15 Merial Limited Cotton rat lung cells for virus culture
TW200604526A (en) 2004-06-18 2006-02-01 Unviersity Of Minnesota Identifying virally infected and vaccinated organisms
US7632636B2 (en) 2004-09-21 2009-12-15 Boehringer Ingelheim Vetmedica, Inc. Porcine reproductive and respiratory syndrome isolates and methods of use
WO2006053061A2 (en) * 2004-11-10 2006-05-18 Kansas State University Research Foundation Porcine reproductive and respiratory syndrome virus receptor components and uses thereof
UA95602C2 (ru) 2004-12-30 2011-08-25 Берингер Ингельхейм Ветмедика, Инк. Иммуногенная композиция цвс2 и способы приготовления такой композиции
PT1904631E (pt) 2005-06-24 2012-07-16 Univ Minnesota Vírus srrp, clones infecciosos, os seus mutantes e processos de utilização
DK2371383T3 (en) 2005-12-29 2015-11-30 Boehringer Ingelheim Vetmed Use of a PCV2 immunogenic composition for reduction of clinical symptoms in pigs
HUE054868T2 (hu) 2005-12-29 2021-10-28 Boehringer Ingelheim Animal Health Usa Inc Multivalens PVC2 immunogén készítmények és eljárások ezek elõállítására
RU2520087C2 (ru) 2006-12-15 2014-06-20 Бёрингер Ингельхайм Ветмедика, Инк. Лечение свиней с помощью антигена pcv2
EP1941903A1 (en) 2007-01-03 2008-07-09 Boehringer Ingelheim Vetmedica Gmbh Prophylaxis and treatment of PRDC
ES2560432T3 (es) * 2007-01-12 2016-02-19 The Board Of Trustees Of The University Of Illinois Células no símicas para el desarrollo del virus del síndrome reproductivo y respiratorio porcino (PRRS)
EP1958644A1 (en) 2007-02-13 2008-08-20 Boehringer Ingelheim Vetmedica Gmbh Prevention and treatment of sub-clinical pcvd
WO2008109237A2 (en) * 2007-02-13 2008-09-12 Washington State University Research Foundation Macrophage cell-lines for propagation of porcine reproductive and respiratory syndrome virus
US7666585B2 (en) * 2007-06-15 2010-02-23 Protatek International, Inc. Construction of chimera PRRSV, compositions and vaccine preparations
CA2691755A1 (en) * 2007-06-25 2008-12-31 South Dakota State University Recombinant north american type 1 porcine reproductive and respiratory syndrome virus and methods of use
US20110117129A1 (en) * 2008-08-25 2011-05-19 Boehringer Ingelheim Vetmedica, Inc. Vaccine Against Highly Pathogenic Porcine Reproductive and Respiratory Syndrome (HP PRRS)
JP5306943B2 (ja) * 2009-08-24 2013-10-02 全国農業協同組合連合会 弱毒ウイルスの作出方法
TWI627281B (zh) 2009-09-02 2018-06-21 百靈佳殷格翰家畜藥品公司 降低ｐｃｖ－２組合物殺病毒活性之方法及具有改良免疫原性之ｐｃｖ－２組合物
DK2675475T3 (en) 2011-02-17 2015-09-14 Boehringer Ingelheim Vetmed NEW EUROPEAN PRRSV TRIAL
MX346636B (es) 2011-02-17 2017-03-27 Boehringer Ingelheim Vetmedica Gmbh Procedimiento para la produccion a escala comercial de prrsv.
WO2013017570A1 (en) 2011-07-29 2013-02-07 Boehringer Ingelheim Vetmedica Gmbh Novel prrs virus inducing type i interferon in susceptible cells
US9187731B2 (en) 2011-07-29 2015-11-17 Boehringer Ingelheim Vetmedica Gmbh PRRS virus inducing type I interferon in susceptible cells
JP6386999B2 (ja) * 2012-05-17 2018-09-05 ゾエティス・エルエルシー ブタ生殖および呼吸症候群（ｐｒｒｓ）ウイルスに対する離乳前の効果的なワクチン接種
CA2892948C (en) 2012-12-07 2022-09-20 The Board Of Trustees Of The University Of Illinois Porcine reproductive and respiratory syndrome virus compositions and uses thereof
CN105073130A (zh) 2013-03-15 2015-11-18 勃林格殷格翰动物保健公司 猪生殖与呼吸综合征病毒、组合物、疫苗及使用方法
EA035265B1 (ru) 2013-10-02 2020-05-21 Бёрингер Ингельхайм Энимал Хелс Ю-Эс-Эй Инк. Вариант белка opc2 pcv2 и содержащие его вирусоподобные частицы
WO2018099889A1 (en) 2016-11-29 2018-06-07 Intervet International B.V. Swine vaccine
WO2018112169A2 (en) 2016-12-14 2018-06-21 Zoetis Services Llc Effective vaccination against european strains of porcine reproductive and respiratory syndrome (prrs) virus prior to weaning

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS62198626A (ja) * 1986-02-26 1987-09-02 Biseibutsu Kagaku Kenkyusho:Kk 血球凝集性脳脊髄炎ウイルス感染症予防ワクチン
FR2602791B1 (fr) * 1986-08-18 1988-11-10 Ministere Agri Direction Quali Procede de culture du virus de la rhinotracheite infectieuse de la dinde, et vaccin prepare a partir du virus ainsi obtenu

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR200452417Y1 (ko) * 2011-01-21 2011-02-25 임진재 원통형 쿠션 벨트를 이용한 소파 쿠션장치

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DK0529584T3 (da) 1996-08-12
JPH08295636A (ja) 1996-11-12
SG45288A1 (en) 1998-01-16
US5476778A (en) 1995-12-19
CA2076744A1 (en) 1993-02-27
PL295727A1 (en) 1993-05-17
GR3020603T3 (en) 1996-10-31
KR0138092B1 (ko) 1998-04-30
JPH05276940A (ja) 1993-10-26
JP2750557B2 (ja) 1998-05-13
HUT62323A (en) 1993-04-28
PL169952B1 (pl) 1996-09-30
HU216311B (hu) 1999-06-28
ATE140238T1 (de) 1996-07-15
MX9204885A (es) 1994-05-31
EP0529584B1 (de) 1996-07-10
EP0529584A2 (de) 1993-03-03
EP0529584A3 (en) 1993-04-14
CA2076744C (en) 2000-06-27
ES2089316T3 (es) 1996-10-01
TW289050B (ko) 1996-10-21

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