KR930002353A - 6-옥소 아제피노 인돌 화합물과 이의 제조방법 및 이들의 제조를 위한 중간화합물과 이 화합물을 포함하는 약제 - Google Patents
6-옥소 아제피노 인돌 화합물과 이의 제조방법 및 이들의 제조를 위한 중간화합물과 이 화합물을 포함하는 약제 Download PDFInfo
- Publication number
- KR930002353A KR930002353A KR1019920013719A KR920013719A KR930002353A KR 930002353 A KR930002353 A KR 930002353A KR 1019920013719 A KR1019920013719 A KR 1019920013719A KR 920013719 A KR920013719 A KR 920013719A KR 930002353 A KR930002353 A KR 930002353A
- Authority
- KR
- South Korea
- Prior art keywords
- group
- lower alkyl
- hydrogen
- compound
- substituted
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 150000001875 compounds Chemical class 0.000 title claims 33
- -1 6-oxo azepine indole compound Chemical class 0.000 title claims 4
- 239000003814 drug Substances 0.000 title claims 2
- 238000002360 preparation method Methods 0.000 title 2
- 125000000217 alkyl group Chemical group 0.000 claims 52
- 229910052739 hydrogen Inorganic materials 0.000 claims 36
- 239000001257 hydrogen Substances 0.000 claims 36
- 150000002431 hydrogen Chemical class 0.000 claims 25
- 125000003545 alkoxy group Chemical group 0.000 claims 24
- 229910052736 halogen Inorganic materials 0.000 claims 20
- 150000002367 halogens Chemical class 0.000 claims 20
- 125000004432 carbon atom Chemical group C* 0.000 claims 18
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 18
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 17
- 125000000753 cycloalkyl group Chemical group 0.000 claims 12
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 11
- 125000001316 cycloalkyl alkyl group Chemical group 0.000 claims 8
- 229910052757 nitrogen Inorganic materials 0.000 claims 6
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims 5
- 125000004433 nitrogen atom Chemical group N* 0.000 claims 5
- 239000002253 acid Substances 0.000 claims 4
- 125000006239 protecting group Chemical group 0.000 claims 4
- 150000003839 salts Chemical class 0.000 claims 4
- 125000003277 amino group Chemical group 0.000 claims 3
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims 3
- 125000001570 methylene group Chemical group [H]C([H])([*:1])[*:2] 0.000 claims 3
- 229910052760 oxygen Inorganic materials 0.000 claims 3
- 239000001301 oxygen Substances 0.000 claims 3
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims 2
- 125000004453 alkoxycarbonyl group Chemical group 0.000 claims 2
- 150000001540 azides Chemical class 0.000 claims 2
- 229910052799 carbon Inorganic materials 0.000 claims 2
- 125000004093 cyano group Chemical group *C#N 0.000 claims 2
- 125000000623 heterocyclic group Chemical group 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 claims 2
- 239000000546 pharmaceutical excipient Substances 0.000 claims 2
- 125000005543 phthalimide group Chemical group 0.000 claims 2
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 2
- 125000001424 substituent group Chemical group 0.000 claims 2
- LMBFAGIMSUYTBN-MPZNNTNKSA-N teixobactin Chemical compound C([C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H]1C(N[C@@H](C)C(=O)N[C@@H](C[C@@H]2NC(=N)NC2)C(=O)N[C@H](C(=O)O[C@H]1C)[C@@H](C)CC)=O)NC)C1=CC=CC=C1 LMBFAGIMSUYTBN-MPZNNTNKSA-N 0.000 claims 2
- 125000005037 alkyl phenyl group Chemical group 0.000 claims 1
- 239000002168 alkylating agent Substances 0.000 claims 1
- 229940100198 alkylating agent Drugs 0.000 claims 1
- 125000006295 amino methylene group Chemical group [H]N(*)C([H])([H])* 0.000 claims 1
- 238000004517 catalytic hydrocracking Methods 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 125000005842 heteroatom Chemical group 0.000 claims 1
- 230000000269 nucleophilic effect Effects 0.000 claims 1
- 230000001012 protector Effects 0.000 claims 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/06—Peri-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pain & Pain Management (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Nutrition Science (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Plural Heterocyclic Compounds (AREA)
- Indole Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE4125292A DE4125292A1 (de) | 1991-07-31 | 1991-07-31 | 6-oxo-azepinoindol-verbindungen sowie verfahren und zwischenprodukte zu ihrer herstellung und diese verbindungen enthaltende arzneimittel |
| DEP4125292.6 | 1991-07-31 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| KR930002353A true KR930002353A (ko) | 1993-02-23 |
Family
ID=6437366
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1019920013719A Withdrawn KR930002353A (ko) | 1991-07-31 | 1992-07-30 | 6-옥소 아제피노 인돌 화합물과 이의 제조방법 및 이들의 제조를 위한 중간화합물과 이 화합물을 포함하는 약제 |
Country Status (21)
| Country | Link |
|---|---|
| US (1) | US5272143A (https=) |
| EP (1) | EP0525584B1 (https=) |
| JP (1) | JP3174158B2 (https=) |
| KR (1) | KR930002353A (https=) |
| CN (2) | CN1069733A (https=) |
| AT (1) | ATE161012T1 (https=) |
| AU (1) | AU649153B2 (https=) |
| CA (1) | CA2075102A1 (https=) |
| CZ (1) | CZ239392A3 (https=) |
| DE (2) | DE4125292A1 (https=) |
| ES (1) | ES2110454T3 (https=) |
| FI (1) | FI923440A7 (https=) |
| HU (2) | HU211105B (https=) |
| IE (1) | IE922310A1 (https=) |
| IL (1) | IL102503A (https=) |
| MX (1) | MX9204457A (https=) |
| NO (1) | NO300375B1 (https=) |
| NZ (1) | NZ243715A (https=) |
| RU (1) | RU2078765C1 (https=) |
| TW (1) | TW207541B (https=) |
| ZA (1) | ZA925093B (https=) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5414130A (en) * | 1993-12-23 | 1995-05-09 | The Dow Chemical Company | Process for the preparation of diaminoresorcinol |
| US6495541B1 (en) | 1999-01-11 | 2002-12-17 | Agouron Pharmaceuticals, Inc. | Tricyclic inhibitors of poly(ADP-ribose) polymerases |
| ECSP003637A (es) | 1999-08-31 | 2002-03-25 | Agouron Pharma | Inhibidores triciclicos de poli (adp-ribosa) polimerasas |
| MX2007003314A (es) * | 2004-09-22 | 2007-08-06 | Pfizer | Combinaciones terapeuticas que comprenden inhibidor de poli(adp-ribosa)polimerasas. |
| PT1794163E (pt) * | 2004-09-22 | 2010-03-01 | Pfizer | Método para a preparação de inibidores de poli(adpribose)- polimerases |
| KR101653707B1 (ko) * | 2008-05-29 | 2016-09-02 | 알바니 몰레큘라 리써치, 인크. | 5-ｈｔ3 수용체 조절제, 이의 제조 방법, 및 그의 용도 |
| EP4166558A1 (en) * | 2010-02-12 | 2023-04-19 | Pfizer Inc. | Salts and polymorphs of 8-fluoro-2-{4- [(methylamino)methyl]phenyl}-1 ,3,4,5-tetrahydro-6h-azepino[5,4,3- cd]indol-6-one |
| US10513515B2 (en) | 2017-08-25 | 2019-12-24 | Biotheryx, Inc. | Ether compounds and uses thereof |
| CA3106239A1 (en) | 2018-07-27 | 2020-01-30 | Biotheryx, Inc. | Bifunctional compounds as cdk modulators |
| WO2021222150A2 (en) | 2020-04-28 | 2021-11-04 | Anwita Biosciences, Inc. | Interleukin-2 polypeptides and fusion proteins thereof, and their pharmaceutical compositions and therapeutic applications |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4910193A (en) * | 1985-12-16 | 1990-03-20 | Sandoz Ltd. | Treatment of gastrointestinal disorders |
-
1991
- 1991-07-31 DE DE4125292A patent/DE4125292A1/de not_active Withdrawn
-
1992
- 1992-07-08 ZA ZA925093A patent/ZA925093B/xx unknown
- 1992-07-15 IE IE231092A patent/IE922310A1/en not_active Application Discontinuation
- 1992-07-15 IL IL10250392A patent/IL102503A/en not_active IP Right Cessation
- 1992-07-21 ES ES92112431T patent/ES2110454T3/es not_active Expired - Lifetime
- 1992-07-21 AT AT92112431T patent/ATE161012T1/de not_active IP Right Cessation
- 1992-07-21 EP EP92112431A patent/EP0525584B1/de not_active Expired - Lifetime
- 1992-07-21 DE DE59209055T patent/DE59209055D1/de not_active Expired - Fee Related
- 1992-07-24 HU HU9202430A patent/HU211105B/hu not_active IP Right Cessation
- 1992-07-24 NZ NZ243715A patent/NZ243715A/en unknown
- 1992-07-30 NO NO923004A patent/NO300375B1/no unknown
- 1992-07-30 FI FI923440A patent/FI923440A7/fi not_active Application Discontinuation
- 1992-07-30 MX MX9204457A patent/MX9204457A/es not_active IP Right Cessation
- 1992-07-30 AU AU20677/92A patent/AU649153B2/en not_active Ceased
- 1992-07-30 JP JP20377092A patent/JP3174158B2/ja not_active Expired - Fee Related
- 1992-07-30 KR KR1019920013719A patent/KR930002353A/ko not_active Withdrawn
- 1992-07-30 RU SU925052604A patent/RU2078765C1/ru active
- 1992-07-30 CN CN92108977A patent/CN1069733A/zh active Pending
- 1992-07-31 CZ CS922393A patent/CZ239392A3/cs unknown
- 1992-07-31 CA CA002075102A patent/CA2075102A1/en not_active Abandoned
- 1992-07-31 US US07/922,527 patent/US5272143A/en not_active Expired - Lifetime
- 1992-09-10 TW TW081107187A patent/TW207541B/zh active
-
1994
- 1994-09-30 HU HU94P/P00032P patent/HU210217A9/hu unknown
-
1996
- 1996-01-19 CN CN96100699A patent/CN1141773A/zh active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| MX9204457A (es) | 1993-05-01 |
| AU649153B2 (en) | 1994-05-12 |
| AU2067792A (en) | 1993-02-04 |
| NZ243715A (en) | 1995-03-28 |
| EP0525584A1 (de) | 1993-02-03 |
| JPH05202052A (ja) | 1993-08-10 |
| IL102503A0 (en) | 1993-01-14 |
| FI923440A7 (fi) | 1993-02-01 |
| HUT65453A (en) | 1994-06-28 |
| ES2110454T3 (es) | 1998-02-16 |
| DE4125292A1 (de) | 1993-02-04 |
| CN1141773A (zh) | 1997-02-05 |
| US5272143A (en) | 1993-12-21 |
| FI923440A0 (fi) | 1992-07-30 |
| JP3174158B2 (ja) | 2001-06-11 |
| CN1069733A (zh) | 1993-03-10 |
| CZ239392A3 (en) | 1993-04-14 |
| NO300375B1 (no) | 1997-05-20 |
| CA2075102A1 (en) | 1993-02-01 |
| ATE161012T1 (de) | 1997-12-15 |
| IE922310A1 (en) | 1993-02-10 |
| HU9202430D0 (en) | 1992-10-28 |
| ZA925093B (en) | 1993-04-28 |
| TW207541B (https=) | 1993-06-11 |
| EP0525584B1 (de) | 1997-12-10 |
| IL102503A (en) | 1995-12-31 |
| NO923004L (no) | 1993-02-01 |
| HU210217A9 (en) | 1995-02-28 |
| RU2078765C1 (ru) | 1997-05-10 |
| HU211105B (en) | 1995-10-30 |
| NO923004D0 (no) | 1992-07-30 |
| DE59209055D1 (de) | 1998-01-22 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PA0109 | Patent application |
Patent event code: PA01091R01D Comment text: Patent Application Patent event date: 19920730 |
|
| PG1501 | Laying open of application | ||
| PC1203 | Withdrawal of no request for examination | ||
| WITN | Application deemed withdrawn, e.g. because no request for examination was filed or no examination fee was paid |