KR920702675A - 신규 폴리스티렌술포네이트 - Google Patents

신규 폴리스티렌술포네이트

Info

Publication number
KR920702675A
KR920702675A KR1019910701913A KR910701913A KR920702675A KR 920702675 A KR920702675 A KR 920702675A KR 1019910701913 A KR1019910701913 A KR 1019910701913A KR 910701913 A KR910701913 A KR 910701913A KR 920702675 A KR920702675 A KR 920702675A
Authority
KR
South Korea
Prior art keywords
hydroxypropoxy
ethyl
amino
benzonitrile
compound
Prior art date
Application number
KR1019910701913A
Other languages
English (en)
Inventor
크젤 잘마르 안데르슨
레이프 로게르 시몬슨
Original Assignee
클래스 빌헬름슨
악티에볼라게트 헤슬레
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 클래스 빌헬름슨, 악티에볼라게트 헤슬레 filed Critical 클래스 빌헬름슨
Publication of KR920702675A publication Critical patent/KR920702675A/ko

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C317/00—Sulfones; Sulfoxides
    • C07C317/26—Sulfones; Sulfoxides having sulfone or sulfoxide groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
    • C07C317/28—Sulfones; Sulfoxides having sulfone or sulfoxide groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton with sulfone or sulfoxide groups bound to acyclic carbon atoms of the carbon skeleton
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/275—Nitriles; Isonitriles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/74—Synthetic polymeric materials
    • A61K31/795—Polymers containing sulfur
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/58—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. poly[meth]acrylate, polyacrylamide, polystyrene, polyvinylpyrrolidone, polyvinylalcohol or polystyrene sulfonic acid resin
    • A61K47/585—Ion exchange resins, e.g. polystyrene sulfonic acid resin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Graft Or Block Polymers (AREA)
  • Polymers With Sulfur, Phosphorus Or Metals In The Main Chain (AREA)
  • Polyesters Or Polycarbonates (AREA)
  • Polyoxymethylene Polymers And Polymers With Carbon-To-Carbon Bonds (AREA)
  • Manufacture Of Porous Articles, And Recovery And Treatment Of Waste Products (AREA)

Abstract

내용 없음

Description

신규 폴리스티렌술포네이트
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (10)

  1. 입체 이성질체 혼합물 형태 또는 순수 입체 이성질체 형태의 하기 구조식(Ⅰ)의 4-〔3-〔에틸〔3-(프로필술피닐)프로필〕아미노〕-2-히드록시프로폭시〕-벤조니트릴 화합물과 폴리스티렌술폰산의 염.
  2. 제1항에 있어서, 구조식(Ⅰ)의 화합물이 입체 이성질체 혼합물 형태임을 특징으로 하는 염.
  3. 제1항에 있어서, 구조식(Ⅰ)의 화합물이 하기 입체 이성질체: 4-〔3-〔에틸〔3-(프로필술피닐)프로필〕아미노〕-2(R)-히드록시프로폭시〕-벤조니트릴, 4-〔3-〔에틸〔3-((R＊)-프로필술피닐)아미노〕-2(R)-히드록시프로폭시〕-벤조니트릴, 4-〔3-〔에틸〔3-((S＊)-프로필술피닐)아미노〕-2(R)-히드록시프로폭시〕-벤조니트릴, 4-〔3-〔에틸〔3-((R＊)-프로필피닐〕아미노〕-2(S)-히드록시프로폭시〕-벤조니트릴, 4-〔3-〔에틸〔3-((S＊)-프로필피닐)아미노〕-2(S)-히드록시프로폭시〕-벤조니트릴, 4-〔3-〔에틸〔3-((S＊)-프로필피닐)아미노〕-2(R)-히드록시프로폭시〕-벤조니트릴중 어느 한 형태임을 특징으로 하는 염.
  4. 제1항에 기재된 구조식(Ⅰ)의 화합물을 폴리스티렌술폰산과 반응시킴을 특징으로 하는, 제1항 내지 제3항중 어느 하나의 항에 기재된 염의 제조 방법.
  5. 제4항에 있어서, 폴리스티렌술폰산이 소립자 형태임을 특징으로 하는 방법.
  6. 제5항에 있어서, 산 형태 또는 이온 교환 반응에 적합한 금속 이온과의 염 형태의 폴리스티렌술폰산 소립자를 적당한 반응 매질 중의 구조식(Ⅰ)의 화합물의 용액에 첨가함을 특징으로 하는 방법.
  7. 제5항에 있어서, 이온 교환 반응에 적합한 금속 이온과의 염 형태의 폴리스티렌술폰산 소립자를 이온교환 작업용 컬럼에 충전시키고, 이 컬럼에 적당한 염 형태의 구조식(Ⅰ)의 화합물의 용액을 감함을 특징으로 하는 방법.
  8. 제1항 내지 3항 중 어느 하나의 항에 기재된 염의 유효량을 치료를 요하는 숙주에 투여하는 것을 특징으로 하는, 인간을 포함한 포유동물의 심부정맥을 예방 또는 경감시키는 방법.
  9. 약제, 특히 항부정맥제로서 유용한 제1항 내지 3항 중 어느 하나의 항에 기재된 염.
  10. 심부정맥 억제 작용을 갖는 약제 제조를 위한 제1항 내지 제3항 중 어느 하나의 항에 기재된 염의 용도.
    ※ 참고사항: 최초출원 내용에 의하여 공개하는 것임.
KR1019910701913A 1989-06-20 1990-06-19 신규 폴리스티렌술포네이트 KR920702675A (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
SE8902236-2 1989-06-20
SE8902236A SE8902236D0 (sv) 1989-06-20 1989-06-20 Novel polystyrenesulfonate
PCT/SE1990/000437 WO1990015793A1 (en) 1989-06-20 1990-06-19 Novel polystyrenesulfonate

Publications (1)

Publication Number Publication Date
KR920702675A true KR920702675A (ko) 1992-10-06

Family

ID=20376341

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019910701913A KR920702675A (ko) 1989-06-20 1990-06-19 신규 폴리스티렌술포네이트

Country Status (29)

Country Link
US (1) US5068272A (ko)
EP (1) EP0404747B1 (ko)
JP (1) JPH04506213A (ko)
KR (1) KR920702675A (ko)
CN (1) CN1048220A (ko)
AT (1) ATE88463T1 (ko)
AU (1) AU641671B2 (ko)
BG (1) BG51351A3 (ko)
CA (1) CA2059282A1 (ko)
DD (1) DD295158A5 (ko)
DE (1) DE69001397T2 (ko)
DK (1) DK0404747T3 (ko)
ES (1) ES2054324T3 (ko)
FI (1) FI915936A0 (ko)
HR (1) HRP920600A2 (ko)
HU (1) HUT59086A (ko)
IE (1) IE902160A1 (ko)
IL (1) IL94676A0 (ko)
LT (1) LTIP1724A (ko)
MX (1) MX21203A (ko)
NO (1) NO914928L (ko)
NZ (1) NZ234022A (ko)
PL (1) PL163537B1 (ko)
PT (1) PT94416A (ko)
RU (1) RU2004539C1 (ko)
SE (1) SE8902236D0 (ko)
WO (1) WO1990015793A1 (ko)
YU (1) YU120590A (ko)
ZA (1) ZA904412B (ko)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE8705150D0 (sv) * 1987-12-23 1987-12-23 Haessle Ab Novel antiarrhythmic agents
SE9003902D0 (sv) * 1990-12-07 1990-12-07 Astra Ab Solid dosage forms of a drug
SE8902235D0 (sv) * 1989-06-20 1989-06-20 Haessle Ab Novel cyclodextrin inclusion complexes
US6290946B1 (en) 1999-05-13 2001-09-18 Geltex Pharmaceuticals, Inc. Anionic polymers as toxin binders and antibacterial agents

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1457876A (en) * 1972-12-15 1976-12-08 Ici Ltd Alkanolamine derivatives device for use in
GB1433920A (en) * 1973-10-01 1976-04-28 Ici Ltd Alkanolamine derivatives
SE8705150D0 (sv) * 1987-12-23 1987-12-23 Haessle Ab Novel antiarrhythmic agents
SE8902237D0 (sv) * 1989-06-20 1989-06-20 Haessle Ab Novel stereoisomers
SE8902235D0 (sv) * 1989-06-20 1989-06-20 Haessle Ab Novel cyclodextrin inclusion complexes

Also Published As

Publication number Publication date
NZ234022A (en) 1992-05-26
LTIP1724A (en) 1995-07-25
PL163537B1 (pl) 1994-04-29
PT94416A (pt) 1991-02-08
ES2054324T3 (es) 1994-08-01
CN1048220A (zh) 1991-01-02
YU120590A (sh) 1992-07-20
BG51351A3 (en) 1993-04-15
HU905546D0 (en) 1992-03-30
US5068272A (en) 1991-11-26
NO914928D0 (no) 1991-12-13
ZA904412B (en) 1991-02-27
HRP920600A2 (en) 1994-08-31
RU2004539C1 (ru) 1993-12-15
DD295158A5 (de) 1991-10-24
CA2059282A1 (en) 1990-12-21
HUT59086A (en) 1992-04-28
JPH04506213A (ja) 1992-10-29
EP0404747A1 (en) 1990-12-27
DK0404747T3 (da) 1993-08-23
WO1990015793A1 (en) 1990-12-27
DE69001397T2 (de) 1994-03-17
AU641671B2 (en) 1993-09-30
IL94676A0 (en) 1991-04-15
MX21203A (es) 1993-11-01
IE902160A1 (en) 1991-01-02
DE69001397D1 (de) 1993-05-27
NO914928L (no) 1991-12-13
PL285700A1 (en) 1991-02-11
IE902160L (en) 1990-12-20
EP0404747B1 (en) 1993-04-21
FI915936A0 (fi) 1991-12-17
AU5937790A (en) 1991-01-08
SE8902236D0 (sv) 1989-06-20
ATE88463T1 (de) 1993-05-15

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