KR920019739A - 약학적 화합물 - Google Patents

약학적 화합물 Download PDF

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Publication number
KR920019739A
KR920019739A KR1019920006702A KR920006702A KR920019739A KR 920019739 A KR920019739 A KR 920019739A KR 1019920006702 A KR1019920006702 A KR 1019920006702A KR 920006702 A KR920006702 A KR 920006702A KR 920019739 A KR920019739 A KR 920019739A
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KR
South Korea
Prior art keywords
hydroxy
pharmaceutically acceptable
phenyl
enyl
prop
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KR1019920006702A
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English (en)
Inventor
알란 하이트 게리
데이비드 마이엘리치 에드워드
웰스 스나이더 데이비드
슈와레쯔 툴리오
Original Assignee
리로이 휘테커
일라이 릴리 앤드 캄파니
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Application filed by 리로이 휘테커, 일라이 릴리 앤드 캄파니 filed Critical 리로이 휘테커
Publication of KR920019739A publication Critical patent/KR920019739A/ko

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/23—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
    • C07C323/39—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton at least one of the nitrogen atoms being part of any of the groups, X being a hetero atom, Y being any atom
    • C07C323/43—Y being a hetero atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C335/00—Thioureas, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C335/40—Thioureas, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of thiourea or isothiourea groups further bound to other hetero atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C275/64—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups singly-bound to oxygen atoms

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Pulmonology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Immunology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Dermatology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

내용 없음

Description

약학적 화합물
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (5)

  1. 하기 일반식(I)의 N-하이드록시-N-[3-(2-치환된 페닐)프로프-2-에닐]우레아 및 티오우레아, 및 그의 약학적으로 허용되는 염.
    상기식에서, X는 0 또는 S이고, Y는 0 또는 S이며, R1은 수소, C1-C4알킬 또는 C3-C8사이클로알킬이고, R2는 수소 또는 메틸이며, R4는 수소 또는 할로이고, n은 1 또는 2이며, R3는 C2-C12알케닐, C3-C12알카디에닐, C4-C12알카트리에닐, C2-C12알키닐, C4-C12알케니닐, C3-C8-사이클로알킬메틸, 비치환되거나 치환된 스티릴, 또는 비치환되거나 치환된 페닐에티닐(여기서, 스티릴 및 페닐에티닐의 페닐 고리는 1,2 또는 3개의 같거나 다른 할로, 하이드록시, C1-C4알킬, C1-C4알콕시, C1-C4알킬티오, 트리플루오로메틸 또는 트리플루오로 메톡시로 치환될 수도 있다)이다.
  2. 제1항에 있어서, N-하이드록시-N-[3-[2-(2-프로피닐티오)페닐]프로프-2-에닐]우레아 및 그의약학적으로 허용되는 염인 화합물.
  3. 제1항에 있어서, N-하이드록시-N[3-[2-(사이클로헥실메틸티오)페닐]프로프-2-에닐]우레아 및 그의 약학적으로 허용되는 염인 화합물.
  4. 제1항에 있어서, N-하이드록시-N[3-[2-(사이클로헥실메틸티오)페닐]프로프-2-에닐]우레아 및 그의 약학적으로 허용되는 염인 화합물.
  5. 활성 성분으로서의 제1항 내지 제4항중 어느 한 항에 따른 화합물을 하나 이상의 약학적으로 허용되는 담체, 희석제 또는 부형제와 함께 포함하는, 천식치료용, 관절염치료용, 항알러지성, 염증성 장 질환치료용, 건선치료용, 쇼크치료용, 성인 호흡 곤란 증후군치료용 또는 허혈치료용 조성물.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019920006702A 1991-04-23 1992-04-21 약학적 화합물 KR920019739A (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US690,131 1991-04-23
US07/690,131 US5130485A (en) 1991-04-23 1991-04-23 N-hydroxy-N-(3-(2-substituted phenyl)prop-2-enyl)ureas and thioureas useful as 5-lipoxygenase inhibiting agents

Publications (1)

Publication Number Publication Date
KR920019739A true KR920019739A (ko) 1992-11-19

Family

ID=24771221

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019920006702A KR920019739A (ko) 1991-04-23 1992-04-21 약학적 화합물

Country Status (19)

Country Link
US (1) US5130485A (ko)
EP (1) EP0510947A1 (ko)
JP (1) JPH05148218A (ko)
KR (1) KR920019739A (ko)
CN (1) CN1066060A (ko)
AU (1) AU647911B2 (ko)
BR (1) BR9201451A (ko)
CA (1) CA2066509A1 (ko)
CS (1) CS119592A3 (ko)
FI (1) FI921785A (ko)
HU (1) HU209794B (ko)
IE (1) IE921280A1 (ko)
IL (1) IL101624A0 (ko)
MX (1) MX9201809A (ko)
NO (1) NO921529L (ko)
NZ (1) NZ242427A (ko)
TW (1) TW215081B (ko)
YU (1) YU42592A (ko)
ZA (1) ZA922872B (ko)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5283361A (en) * 1991-04-23 1994-02-01 Eli Lilly And Company N-hydroxy-N-[3-[2-(halophenylthio)phenyl]prop-2-enyl]ureas as lipoxygenase inhibitors
US5288743A (en) * 1992-11-20 1994-02-22 Abbott Laboratories Indole carboxylate derivatives which inhibit leukotriene biosynthesis
US5891460A (en) * 1995-06-07 1999-04-06 University Of Southern California University Park Campus Method for reducing or preventing post-surgical adhesion formation using ketotifen and analogs thereof
NZ720946A (en) 2009-04-29 2017-09-29 Amarin Pharmaceuticals Ie Ltd Pharmaceutical compositions comprising epa and a cardiovascular agent and methods of using the same
US11724991B1 (en) * 2023-01-06 2023-08-15 King Faisal University Selective 5-LO inhibitors for the treatment of bronchial asthma

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IE59397B1 (en) * 1985-03-16 1994-02-23 Wellcome Found New aryl derivatives
AU602485B2 (en) * 1985-03-16 1990-10-18 Wellcome Foundation Limited, The Lipoxygenase and/or cyclooxygenase inhibitory compounds
GB8619593D0 (en) * 1986-08-12 1986-09-24 Roussel Lab Ltd Chemical compounds
US4897422A (en) * 1987-02-10 1990-01-30 Abbott Laboratories Lipoxygenase inhibiting compounds
DE3882732T2 (de) * 1987-02-10 1993-12-02 Abbott Lab Indol, Benzofuran, Benzothiophen enthaltende, Lipoxygenase hemmende Verbindungen.
EP0292699B1 (en) * 1987-04-24 1994-03-23 Abbott Laboratories Urea based lipoxygenase inhibiting compounds
PT93049A (pt) * 1989-02-03 1990-08-31 Wellcome Found Processo para a preparacao de compostos de aril-hidroxi-ureia possuindo actividade anti-inflamatoria e de composicoes farmaceuticas que os contem
EP0588785A1 (en) * 1989-03-30 1994-03-30 Abbott Laboratories Urea based lipoxygenase inhibiting compounds

Also Published As

Publication number Publication date
NZ242427A (en) 1993-11-25
NO921529D0 (no) 1992-04-21
US5130485A (en) 1992-07-14
CA2066509A1 (en) 1992-10-24
HUT61978A (en) 1993-03-29
IL101624A0 (en) 1992-12-30
HU9201342D0 (en) 1992-07-28
FI921785A0 (fi) 1992-04-22
HU209794B (en) 1994-11-28
JPH05148218A (ja) 1993-06-15
AU1501692A (en) 1992-10-29
IE921280A1 (en) 1992-11-04
TW215081B (ko) 1993-10-21
AU647911B2 (en) 1994-03-31
FI921785A (fi) 1992-10-24
BR9201451A (pt) 1992-12-01
CN1066060A (zh) 1992-11-11
ZA922872B (en) 1993-10-21
YU42592A (sh) 1995-01-31
MX9201809A (es) 1994-05-31
NO921529L (no) 1992-10-26
CS119592A3 (en) 1992-12-16
EP0510947A1 (en) 1992-10-28

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