KR920018218A - 인체 혈청 알부민의 제조방법 - Google Patents

인체 혈청 알부민의 제조방법 Download PDF

Info

Publication number
KR920018218A
KR920018218A KR1019920004650A KR920004650A KR920018218A KR 920018218 A KR920018218 A KR 920018218A KR 1019920004650 A KR1019920004650 A KR 1019920004650A KR 920004650 A KR920004650 A KR 920004650A KR 920018218 A KR920018218 A KR 920018218A
Authority
KR
South Korea
Prior art keywords
serum albumin
human serum
acid
producing
medium
Prior art date
Application number
KR1019920004650A
Other languages
English (en)
Other versions
KR100218853B1 (ko
Inventor
가오루 고바야시
시노부 구와에
도모시 오오야
히로또시 후꾸쯔가
아끼노리 스미
와따루 오따니
다까오 오무라
가즈마사 요꼬야마
Original Assignee
스야마 다다까즈
가부시끼가이샤 미도리쥬우지
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 스야마 다다까즈, 가부시끼가이샤 미도리쥬우지 filed Critical 스야마 다다까즈
Publication of KR920018218A publication Critical patent/KR920018218A/ko
Application granted granted Critical
Publication of KR100218853B1 publication Critical patent/KR100218853B1/ko

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/76—Albumins
    • C07K14/765—Serum albumin, e.g. HSA
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/14—Fungi; Culture media therefor
    • C12N1/16—Yeasts; Culture media therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Virology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Botany (AREA)
  • Toxicology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)

Abstract

내용 없음

Description

인체 혈청 알부민의 제조방법
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (8)

  1. 유전자 조작으로 제조한 인체 혈청 알부민 생산성 숙주를 탄소수 10∼26인 지방산 또는 그의 염을 함유하는 배지에서 배양함을 특징으로 하는 인체 혈청 알부민의 제조방법.
  2. 제1항에 있어서, 지방산을 0.006∼0.4%(w/v)의 농도로 배지에 첨가함을 특징으로 하는 인체 혈청 알부민의 제조방법.
  3. 제1항에 있어서, 지방산 또는 그의 염이 미리스트산, 팔미트산, 팔미톨레산, 올레산, t-벡센산, 리놀레산, 아라키돈산 및 그의 염으로 구성된 군에서 선택됨을 특징으로 하는 인체 혈청 알부민의 제조방법.
  4. 제1항에 있어서, 인체 혈청 알부민 생산성 숙주가 균류임을 특징으로 하는 인체 혈청 알부민의 제조방법.
  5. 제4항에 있어서, 균류가 효모임을 특징으로 하는 인체 혈청 알부민의 제조방법.
  6. 제5항에 있어서, 효모가 사카로마이세스(Saccharomyces)속 및 피키아(Pichia)속으로 구성된 군에서 선택됨을 특징으로 하는 인체 혈청 알부민의 제조방법.
  7. 제1항에 있어서, 배지가 액체 배지임을 특징으로 하는 인체 혈청 알부민의 제조방법.
  8. 숙주를 탄소수 10∼26인 지방산 또는 그의 염이 첨가된 배지에서 배양함을 특징으로 하는 유전자 조작으로 제조한 인체 혈청 알부민 생산성 숙주를 배양하는 방법.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019920004650A 1991-03-20 1992-03-20 인체 혈청 알부민의 제조방법 KR100218853B1 (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP91-81719 1991-03-20
JP3081719A JPH0671432B2 (ja) 1991-03-20 1991-03-20 ヒト血清アルブミンの製造方法

Publications (2)

Publication Number Publication Date
KR920018218A true KR920018218A (ko) 1992-10-21
KR100218853B1 KR100218853B1 (ko) 1999-10-01

Family

ID=13754223

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019920004650A KR100218853B1 (ko) 1991-03-20 1992-03-20 인체 혈청 알부민의 제조방법

Country Status (9)

Country Link
US (1) US5334512A (ko)
EP (1) EP0504823B1 (ko)
JP (1) JPH0671432B2 (ko)
KR (1) KR100218853B1 (ko)
CA (1) CA2063511C (ko)
DE (1) DE69220113T2 (ko)
DK (1) DK0504823T3 (ko)
ES (1) ES2102420T3 (ko)
TW (1) TW198683B (ko)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH07126182A (ja) * 1993-10-27 1995-05-16 Green Cross Corp:The 組換えヒト血清アルブミン製剤の滅菌方法
CA2136564C (en) * 1993-11-26 2008-04-08 Kaoru Kobayashi Process for producing human serum albumin
JPH07308199A (ja) 1994-05-18 1995-11-28 Green Cross Corp:The ヒト血清アルブミンの製造方法
CA2286395C (en) * 1997-04-03 2009-06-23 Yoshitomi Pharmaceutical Industries Ltd. Production method of heterologous protein
GB9902000D0 (en) 1999-01-30 1999-03-17 Delta Biotechnology Ltd Process
GB0217033D0 (en) 2002-07-23 2002-08-28 Delta Biotechnology Ltd Gene and polypeptide sequences
US8263401B2 (en) * 2004-05-26 2012-09-11 University Of Medicine And Dentistry Of New Jersey Adenylyl cyclase antibodies, compositions and uses thereof
CA2593922A1 (en) * 2004-12-22 2006-06-29 Novozymes A/S Recombinant production of serum albumin
CA2724052A1 (en) * 2008-05-15 2009-11-19 R-Tech Ueno, Ltd. Pharmaceutical composition for the treatment of dry eye and/or corneal and conjunctival lesion
KR20190102011A (ko) * 2016-12-21 2019-09-02 프로메틱 파마 에스엠티 리미티드 상피-중간엽 전이를 예방 또는 최소화하는 방법 및 조성물
US11739166B2 (en) 2020-07-02 2023-08-29 Davol Inc. Reactive polysaccharide-based hemostatic agent
KR20240032272A (ko) 2022-09-02 2024-03-12 조신아 아동원예지도사 교육방법

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL66614A (en) * 1981-08-28 1985-09-29 Genentech Inc Method of constructing a dna sequence encoding a polypeptide,microbial production of human serum albumin,and pharmaceutical compositions comprising it
EP0079739A3 (en) * 1981-11-12 1984-08-08 The Upjohn Company Albumin-based nucleotides, their replication and use, and plasmids for use therein
NZ207926A (en) * 1983-04-25 1988-04-29 Genentech Inc Use of yeast #a#-factor to assist in expression of proteins heterologus to yeast
AU5890286A (en) * 1985-06-17 1986-12-24 Genex Corp. Cloned human serum albumin gene
FI870103A (fi) * 1986-01-13 1987-07-14 Genex Corp Producering av humanserum albumin i en bacillus-stam.
GB8613388D0 (en) * 1986-06-03 1986-07-09 Delta Biotechnology Ltd Induction of galactose regulated gene expression in yeast
GB8615701D0 (en) * 1986-06-27 1986-08-06 Delta Biotechnology Ltd Stable gene integration vector
JPS6460370A (en) * 1987-05-27 1989-03-07 Sankyo Co High-temperature culture of yeast
US5024947A (en) * 1987-07-24 1991-06-18 Cetus Corporation Serum free media for the growth on insect cells and expression of products thereby
JP2791418B2 (ja) * 1987-12-02 1998-08-27 株式会社ミドリ十字 異種蛋白質の製造方法、組換えｄｎａ、形質転換体
JPH01240191A (ja) * 1988-02-16 1989-09-25 Green Cross Corp:The 酵母で機能する新規シグナルペプチドおよびこれを用いた異種蛋白質の分泌発現
IL89992A0 (en) * 1988-04-25 1989-12-15 Phillips Petroleum Co Expression of human serum albumin in methylotrophic yeasts
GB8820951D0 (en) * 1988-09-07 1988-10-05 Delta Biotechnology Ltd Fermentation method
CA2017176A1 (en) * 1989-05-22 1990-11-22 Yoshitomi Pharmaceutical Industries Ltd. Albumin gene-containing plasmid, transformant carrying same, production of such transformant and production of albumin
JP2855130B2 (ja) * 1989-07-19 1999-02-10 吉富製薬株式会社 異種蛋白発現用融合酵母菌、該菌の製造方法および異種蛋白の製造方法
JPH0671434B2 (ja) * 1989-09-18 1994-09-14 株式会社ミドリ十字 ヒト血清アルブミンの製造方法

Also Published As

Publication number Publication date
CA2063511A1 (en) 1992-09-21
KR100218853B1 (ko) 1999-10-01
US5334512A (en) 1994-08-02
DE69220113D1 (de) 1997-07-10
CA2063511C (en) 2001-11-27
TW198683B (ko) 1993-01-21
EP0504823B1 (en) 1997-06-04
EP0504823A3 (en) 1993-04-07
DE69220113T2 (de) 1997-09-25
JPH0671432B2 (ja) 1994-09-14
JPH04293495A (ja) 1992-10-19
ES2102420T3 (es) 1997-08-01
DK0504823T3 (da) 1997-06-23
EP0504823A2 (en) 1992-09-23

Similar Documents

Publication Publication Date Title
KR920018218A (ko) 인체 혈청 알부민의 제조방법
DE69223722T2 (de) Verfahren zur Herstellung von 8,11-Eicasodiensäure
EP0112174A3 (en) Serum-free cell culture medium and process for making same
CA2210992A1 (en) Mixture of fatty acids, derivatives and a compound of vegetal origin having attractive effect on cats
DE3585133D1 (de) Verfahren zur herstellung von peroxydase.
DK1549753T3 (da) Fremgangsmåde til fremstilling af mikrobielt fedt eller olie med nedsat uforsæbeligt stofindhold
DE69840022D1 (de) Verfahren zur herstellung von hochungesättigten fettsäuren und hochungesättigte fettsäuren enthaltendes lipid
HUP9801420A2 (hu) Eljárás L-aminosavak előállítására fermentálással
KR840007966A (ko) 라이신 함유 농축물의 제법
DK0535939T3 (da) Fremgangsmåde til fremstilling af omega 9-type polyumættet fedtsyre
DE3271820D1 (en) Fully synthetic cell culture medium
ATE129015T1 (de) Verfahren zur herstellung von mehrfach ungesättigten fettsäuren mit ungerader zahl von kohlenstoffatomen.
KR840000643A (ko) 구아노신의 제조법
ATE100148T1 (de) Verfahren zur herstellung von hochgradig ungesaettigten fettsaeuren.
ATE112308T1 (de) Verfahren zur herstellung von proteinen.
JPS55118391A (en) Novel acyl-coa oxidase and its preparation
ATE75259T1 (de) Verfahren zur herstellung von exozellulaeren biopolymeren mit verdickungswirkung fuer waessrige medien.
KR920012425A (ko) 동물세포 배양용 고농도 배지 및 배양공정
KR840000901A (ko) 옥센돌론 수성 현탁제의 제조방법
GR3006760T3 (ko)
EP0320609A3 (de) Anionisches Oberflächenleimungsmittel für Papier
KR910012254A (ko) 연속발효에 의한 l-라이신의 제조방법
JPS5763086A (en) Production of lipase
SU908794A1 (ru) Питательна среда дл культивировани L-форм микробактерий туберкулеза
Northey et al. In vitro conversion of Histoplasma capsulatum

Legal Events

Date Code Title Description
A201 Request for examination
E701 Decision to grant or registration of patent right
N231 Notification of change of applicant
GRNT Written decision to grant
FPAY Annual fee payment

Payment date: 20110527

Year of fee payment: 13

EXPY Expiration of term