KR920018066A - 트랜스-Pt(IV)복합체 - Google Patents
트랜스-Pt(IV)복합체 Download PDFInfo
- Publication number
- KR920018066A KR920018066A KR1019920003874A KR920003874A KR920018066A KR 920018066 A KR920018066 A KR 920018066A KR 1019920003874 A KR1019920003874 A KR 1019920003874A KR 920003874 A KR920003874 A KR 920003874A KR 920018066 A KR920018066 A KR 920018066A
- Authority
- KR
- South Korea
- Prior art keywords
- compound
- trans
- formula
- ptcl
- hydroxyl
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 claims 20
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 4
- 239000003446 ligand Substances 0.000 claims 4
- BASFCYQUMIYNBI-UHFFFAOYSA-N platinum Substances [Pt] BASFCYQUMIYNBI-UHFFFAOYSA-N 0.000 claims 3
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 claims 2
- 125000000217 alkyl group Chemical group 0.000 claims 2
- 150000007942 carboxylates Chemical group 0.000 claims 2
- 229910052801 chlorine Inorganic materials 0.000 claims 2
- 239000000460 chlorine Substances 0.000 claims 2
- 125000000753 cycloalkyl group Chemical group 0.000 claims 2
- 125000005843 halogen group Chemical group 0.000 claims 2
- 150000003141 primary amines Chemical class 0.000 claims 2
- 235000014653 Carica parviflora Nutrition 0.000 claims 1
- 241000243321 Cnidaria Species 0.000 claims 1
- 150000001412 amines Chemical class 0.000 claims 1
- 239000003085 diluting agent Substances 0.000 claims 1
- 239000002552 dosage form Substances 0.000 claims 1
- 229910052736 halogen Inorganic materials 0.000 claims 1
- 150000002367 halogens Chemical group 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 229910052697 platinum Inorganic materials 0.000 claims 1
- VXPLXMJHHKHSOA-UHFFFAOYSA-N propham Chemical group CC(C)OC(=O)NC1=CC=CC=C1 VXPLXMJHHKHSOA-UHFFFAOYSA-N 0.000 claims 1
- 230000017105 transposition Effects 0.000 claims 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F15/00—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F15/00—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table
- C07F15/0006—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table compounds of the platinum group
- C07F15/0086—Platinum compounds
- C07F15/0093—Platinum compounds without a metal-carbon linkage
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
내용 없음
Description
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
Claims (14)
- 일반식 Ⅰ ;PtX2Y2L1L2(여기서, L1및 L2가 모두 NH3가 아닌 것을 조건으로 L1및 L2각각은 아민 리간드이고, X 및 Y 각각은 할로겐, 히드록실, 또는 카르복실레이트, 또는 Y2또는 X2및 Y2는 디카르복실레이트이며, 여기서 리간드인 L1및 L2는 플라티늄 원자상에서 산호 트랜스 배치 위치이다)인 것을 특징으로 하는 트랜스-Pt(Ⅳ)화합물.
- 제1항에 있어서, 식 Ⅰ중 X가 염소인 것을 특징으로 하는 화합물.
- 제1항 또는 제2항에 있어서, 식 Ⅰ중 Y가 염소 또는 히드록실인 것을 특징으로 하는 화합물.
- 제3항에 있어서, 식 Ⅰ중 Y가 히드록실인 것을 특징으로 하는 화합물.
- 제1항 내지 제4항중 어느 한 항에 있어서, 식 Ⅰ중 리간드 L1및/또는 L2가 1차 아민 R-NH2(여기서, R은 직쇄사슬알킬, 분지된 사슬알킬 또는 시클로알킬임)인 것을 특징으로 하는 화합물.
- 제5항에 있어서, 리간드 L1및/또는 L2가 1차 아민 R-NH2(여기서, R은 시클로알킬)인 것을 특징으로 하는 화합물.
- 제1항에 있어서, 트랜스-〔PtCl2(OH2)(NH3)(c-C5H9NH|2〕인 것을 특징으로 하는 화합물.
- 제1항에 있어서, 트랜스-〔PtCl2(OH2)(NH3)(c-C6H11NH|2〕인 것을 특징으로 하는 화합물.
- 제1항에 있어서, 트랜스-〔PtCl2(OH2)((NH3)2(CHNH2)〕인 것을 특징으로 하는 화합물.
- 제1항에 있어서, 트랜스-〔PtCl2(OH2)(NH3)((NH3)2CHNH|2〕인 것을 특징으로 하는 화합물.
- 제1항에 있어서, 트랜스-〔PtCl2(OCOCH3)(NH3)(c-C6H11NH2)〕인 것을 특징으로 하는 화합물.
- 약제학적으로 수용가능한 희석제 또는 담체와 혼합한 특허청구번위 제1항 내지 제12항중의 어느 한 항에서 정의한 트랜스-Pt(Ⅳ)화합물로 이루어지는 것을 특징으로 하는 약제학적 조성물.
- 제12항에 있어서, 단위 투약 형태인 것을 특징으로 하는 조성물.
- 식 Ⅱ ;트랜스-〔PtX2L1L2〕(여기서, L1및 L2는 특허청구 범위 제1항에서 정의한 바와 같고, X는 할로겐 원자이다)의 트랜스-Pt(Ⅱ)화합물을 원하는 Y기원과 반응시키고, X2가 (OH)2이면 할로겐 원자를 히드록실로 교체하고, Y 또는 X 및 Y가 카르복실레이트이며, Y2및 Y2를 (OH)2로 가지는 대응화합물을 아실화시키는 것을 이루어진 것을 특징으로 하는 특허청구 점위 제1항에서 정의한 식 Ⅰ의 화합물을 제조하는 방법.※참고사항 : 최초출원 내용에 의하여 공개하는 것임.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB919105037A GB9105037D0 (en) | 1991-03-09 | 1991-03-09 | Improvements in chemical compounds |
GB91/05037.7 | 1991-03-09 |
Publications (1)
Publication Number | Publication Date |
---|---|
KR920018066A true KR920018066A (ko) | 1992-10-21 |
Family
ID=10691311
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
KR1019920003874A KR920018066A (ko) | 1991-03-09 | 1992-03-09 | 트랜스-Pt(IV)복합체 |
Country Status (14)
Country | Link |
---|---|
US (1) | US5194645A (ko) |
EP (1) | EP0503830A1 (ko) |
JP (1) | JPH04327596A (ko) |
KR (1) | KR920018066A (ko) |
AU (1) | AU641850B2 (ko) |
CA (1) | CA2061759A1 (ko) |
FI (1) | FI921021A (ko) |
GB (1) | GB9105037D0 (ko) |
HU (2) | HUT60747A (ko) |
IE (1) | IE920725A1 (ko) |
IL (1) | IL101068A0 (ko) |
NO (1) | NO920894L (ko) |
NZ (1) | NZ241768A (ko) |
ZA (1) | ZA921737B (ko) |
Families Citing this family (29)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4857432A (en) * | 1987-05-18 | 1989-08-15 | Canon Kabushiki Kaisha | Toner for developing electrostatic charge image |
US5624919A (en) * | 1993-09-14 | 1997-04-29 | The University Of Vermont And State Agricultural College | Trans platinum (IV) complexes |
IT1273391B (it) * | 1994-03-31 | 1997-07-08 | Boehringer Mannheim Italia | Platino complessi cationici trinucleari ad attivita' antitumorale e composizioni farmaceutiche che li contengono |
GB9502799D0 (en) * | 1995-02-14 | 1995-04-05 | Johnson Matthey Plc | Improvements in platinum complexes |
WO1996026949A1 (fr) * | 1995-02-28 | 1996-09-06 | Debiopharm Sa | Nouveaux complexes de platine (iv), leur procede de production et agents cancerostatiques les contenant |
CZ288912B6 (cs) * | 1998-05-27 | 2001-09-12 | Lachema, A. S. | Komplex platiny v oxidačním čísle IV, způsob přípravy tohoto komplexu, tento komplex jako léčivo a farmaceutická kompozice tento komplex obsahující |
CZ288406B6 (en) * | 1998-05-27 | 2001-06-13 | Lachema Np | Platinum complex of oxidation number II, process for preparing such complex, the complex functioning as medicament and pharmaceutical composition in which the complex is comprised |
ES2160466B1 (es) * | 1998-12-23 | 2002-06-16 | Univ Madrid Autonoma | Trans-(ptcl2(n,n-dimetilamina)(isopropilamina)). |
IL145671A0 (en) | 1999-04-13 | 2002-06-30 | Anormed Inc | Process for preparing amine platinum complexes |
US6413953B1 (en) * | 1999-04-13 | 2002-07-02 | Anormed Inc. | Pt(IV) antitumor agent |
AU775373B2 (en) | 1999-10-01 | 2004-07-29 | Immunogen, Inc. | Compositions and methods for treating cancer using immunoconjugates and chemotherapeutic agents |
AUPQ641100A0 (en) * | 2000-03-23 | 2000-04-15 | Australia Nuclear Science & Technology Organisation | Methods of synthesis and use of radiolabelled platinum chemotherapeutic ag ents |
GB0011903D0 (en) * | 2000-05-18 | 2000-07-05 | Astrazeneca Ab | Combination chemotherapy |
US6894049B1 (en) | 2000-10-04 | 2005-05-17 | Anormed, Inc. | Platinum complexes as antitumor agents |
ES2181602B1 (es) * | 2001-07-30 | 2004-06-16 | Universidad Autonoma De Madrid | "complejo de pt(iv) con actividad antineoplasica: trans-(ptcl2 (oh)2( dimetilamina) (isopropilamina)) aplicable como antitumoral. |
ES2214138B1 (es) * | 2003-02-21 | 2005-10-16 | Universidad Autonoma De Madrid | Compuestos trans de platino (iv) de formula trans, trans, trans - (ptcl2 (oh)2 (amina) (dimetilamina)) con actividad antitumoral. |
CN1296377C (zh) * | 2003-06-11 | 2007-01-24 | 南京大学 | 含醚键羧酸根为配体的铂(ⅱ)配合物的制备 |
CZ296459B6 (cs) * | 2004-09-14 | 2006-03-15 | Pliva-Lachema A. S. | Perorální farmaceutická kompozice pro cílený transport komplexu platiny do kolorektální oblasti, zpusob její prípravy a tato kompozice pro pouzití jako lécivo |
WO2007006019A1 (en) * | 2005-07-06 | 2007-01-11 | University Of South Florida | Materials and methods for screening, diagnosis and prognosis of conditions associated with stat protein expression |
US8178564B2 (en) * | 2006-11-06 | 2012-05-15 | Poniard Pharmaceuticals, Inc. | Use of picoplatin to treat colorectal cancer |
US8173686B2 (en) | 2006-11-06 | 2012-05-08 | Poniard Pharmaceuticals, Inc. | Use of picoplatin to treat colorectal cancer |
US8168662B1 (en) | 2006-11-06 | 2012-05-01 | Poniard Pharmaceuticals, Inc. | Use of picoplatin to treat colorectal cancer |
US8168661B2 (en) * | 2006-11-06 | 2012-05-01 | Poniard Pharmaceuticals, Inc. | Use of picoplatin to treat colorectal cancer |
US20110033528A1 (en) * | 2009-08-05 | 2011-02-10 | Poniard Pharmaceuticals, Inc. | Stabilized picoplatin oral dosage form |
US20100260832A1 (en) * | 2007-06-27 | 2010-10-14 | Poniard Pharmaceuticals, Inc. | Combination therapy for ovarian cancer |
TW200916094A (en) * | 2007-06-27 | 2009-04-16 | Poniard Pharmaceuticals Inc | Stabilized picoplatin dosage form |
WO2009011861A1 (en) * | 2007-07-16 | 2009-01-22 | Poniard Pharmaceuticals, Inc. | Oral formulations for picoplatin |
WO2009099634A2 (en) * | 2008-02-08 | 2009-08-13 | Poniard Pharmaceuticals, Inc. | Picoplatin and amrubicin to treat lung cancer |
EP2404925A1 (en) | 2010-07-09 | 2012-01-11 | Universidad Autónoma de Madrid | New all trans platinum (IV) complexes, their preparation and their use as antitumor agents |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4329299A (en) * | 1979-08-23 | 1982-05-11 | Johnson, Matthey & Co., Limited | Composition of matter containing platinum |
IL63658A0 (en) * | 1980-09-03 | 1981-11-30 | Johnson Matthey Plc | Co-ordination compound of platinum and its preparation |
FI861110A0 (fi) * | 1986-03-17 | 1986-03-17 | Kautar Oy | Foerfarande foer framstaellning av en haerdad stenmaterialprodukt, isynnerhet betong. |
DE68918878T2 (de) * | 1988-02-02 | 1995-02-23 | Johnson Matthey Inc | Pt(IV) Komplexe. |
GB8806044D0 (en) * | 1988-03-14 | 1988-04-13 | Johnson Matthey Plc | Platinum coordination compounds |
FI905018A0 (fi) * | 1989-10-17 | 1990-10-12 | Bristol Myers Squibb Co | I vatten och loesningsmedel loesliga axiala hydroxi-och mono- och dikarboxylsyraderivat med stor tumoeraktivitet. |
-
1991
- 1991-03-09 GB GB919105037A patent/GB9105037D0/en active Pending
-
1992
- 1992-02-24 CA CA002061759A patent/CA2061759A1/en not_active Abandoned
- 1992-02-25 IL IL101068A patent/IL101068A0/xx unknown
- 1992-02-27 NZ NZ241768A patent/NZ241768A/en unknown
- 1992-03-03 AU AU11419/92A patent/AU641850B2/en not_active Ceased
- 1992-03-04 EP EP92301845A patent/EP0503830A1/en not_active Withdrawn
- 1992-03-06 NO NO92920894A patent/NO920894L/no unknown
- 1992-03-06 IE IE072592A patent/IE920725A1/en unknown
- 1992-03-09 KR KR1019920003874A patent/KR920018066A/ko not_active Application Discontinuation
- 1992-03-09 US US07/848,681 patent/US5194645A/en not_active Expired - Fee Related
- 1992-03-09 HU HU9200793A patent/HUT60747A/hu unknown
- 1992-03-09 FI FI921021A patent/FI921021A/fi not_active Application Discontinuation
- 1992-03-09 JP JP4050519A patent/JPH04327596A/ja active Pending
- 1992-03-09 ZA ZA921737A patent/ZA921737B/xx unknown
-
1994
- 1994-07-20 HU HU94P/P00014P patent/HU210070A9/hu unknown
Also Published As
Publication number | Publication date |
---|---|
US5194645A (en) | 1993-03-16 |
ZA921737B (en) | 1992-11-25 |
GB9105037D0 (en) | 1991-04-24 |
CA2061759A1 (en) | 1992-09-10 |
IL101068A0 (en) | 1992-11-15 |
EP0503830A1 (en) | 1992-09-16 |
AU641850B2 (en) | 1993-09-30 |
HU9200793D0 (en) | 1992-05-28 |
HUT60747A (en) | 1992-10-28 |
NZ241768A (en) | 1993-10-26 |
NO920894D0 (no) | 1992-03-06 |
JPH04327596A (ja) | 1992-11-17 |
HU210070A9 (en) | 1995-02-28 |
NO920894L (no) | 1992-09-10 |
FI921021A (fi) | 1992-09-10 |
FI921021A0 (fi) | 1992-03-09 |
AU1141992A (en) | 1992-09-10 |
IE920725A1 (en) | 1992-09-09 |
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Legal Events
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WITN | Application deemed withdrawn, e.g. because no request for examination was filed or no examination fee was paid |