KR920009810A - 나프토에산 유도체 - Google Patents
나프토에산 유도체 Download PDFInfo
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- KR920009810A KR920009810A KR1019910021899A KR910021899A KR920009810A KR 920009810 A KR920009810 A KR 920009810A KR 1019910021899 A KR1019910021899 A KR 1019910021899A KR 910021899 A KR910021899 A KR 910021899A KR 920009810 A KR920009810 A KR 920009810A
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Abstract
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Claims (16)
- 하기 일반식(Ⅰ)로 나타내어지는 나프토에산 유도체 및 그의 염.[식중, R1, R2및 R3는 각각 독립적으로 수소 원자, 할로겐 원자, 히드록실기, 저급 알킬기, 저급 알콕시기, 저급 알카노일옥시기, 히드록시저급알킬기, 저급 알콕시-저급 알킬기, 저급 알카노일옥시-저급알킬기 또는 아랄킬옥시기를 나타내며, R4는 수소 원자 또는 저급 알킬기를 나타내며, R5는 치환 또는 무치환의 아릴기 또는 치환 또는 무치환의 헤테로아로마틱기를 나타내며, X는, 시클로알킬렌기, 2가의 질소를 함유하는 복소환식기 또는 기, -R8-NH- 또는 -NH-R8-을 나타내고, 여기서 R6및 R7은 각각 수소 원자 또는 저급 알킬기를 나타내고, R8은 시클로알킬렌기를 나타내든가 또는 R6및 R7은 R4와 함께 C1~3의 알킬렌기를 형성하여도 무방하며, Y는 -S(O)p- -(CH2)-n, -O- 또는 단일 결합을 나타내고, Z는 치환 또는 무치환의 알킬렌기 또는 단일 결합을 나타내고, ℓ은 0~4의 정수이며, m은 0~8의 정수이며, n은 0 또는 1이며 p는 0~2의 정수이며, q는 0 또는 1이다.]
- 제1항에 있어서, R1및/또는 R2가 상기 일반식의 5- 및/또는 7-위치에 존재하고, R3은 상기 일반식의 2-위치에 존재하는 화합물.
- 제2항에 있어서, R1및 R2중 하나가 수소원자이고, 다른 하나는 히드록실기, 저급알콕시기, 저급 알카노일옥시기 또는 피리딜-치환저급 알콕시기를 나타내고, R3는 히드록실기, 저급 알콕시기 또는 저급 알카노일옥시기를 나타내는 화합물.
- 제1항에 있어서, q가 0이고 R4는 수소원자인 화합물.
- 제1항에 있어서, X가 -CH2-,를 나타내는 화합물.
- 제1항에 있어서, Y가 -S-, -CH2-, -O- 또는 단일 결합을 나타내는 화합물.
- 제1항에 있어서, Z가 -CH2, -CH2CH2-,또는 단일결합을 나타내고, 여기서는 R9는 페닐기, 할로페닐기, 또는 피리딜기를 나타내는 화합물.
- 제1항에 있어서, R5가 페닐기, 나프틸기, 모노- 또는 디-할로페닐기, 저급 알킬페닐기, 저급 알콕시페닐기, 저급 알킬티오페닐기, 니트로페닐기, 시아노페닐기, 저급 알콕시카르보닐페닐기, 저급 알카노일페닐기, 비페닐릴기, 모노- 또는 디트리플루오로메틸페닐기, 메틸렌옥시페닐기, 티에닐기, 힐로티에닐기, 푸릴기 또는 피리딜기를 나타내는 화합물.
- 제1항에 있어서,(CH)-ℓx-부분이 피페라진-1,4-디일기, 피페리딘-1,4-디일기, 퍼히드로아제판-1,4-디일기, 호모피페라진-1,4-디일기 또는 이미다졸리딘-1,3-디일기를 나타내는 화합물.
- 제1항에 있어서, 하기 일반식(Ⅰ-1)로 나타내어지는 화합물.[식중, R11은 히드록실기, 저급 알카노일옥시기, 또는 피리딜-치환 저급 알콕시기를 나타내며, R31은 히드록실기 또는 저급 라카노일옥시기를 나타내며, R51은 페닐기, 할로겐페닐기 또는 티에닐기를 나타내며;X는 -CH2-,를 나타내며, 여기에서 R61은 수소원자이든지, 또는 R61은 R41과 함께 C1~2의 알킬렌기를 형성하여도 무방하며; Y1은 -S- -O- 또는 단일 결합을 나타내며, Z1은을 나타내며; ℓ은 0~4의 정수이며, m은 0~4의 정수이다.]
- 제10항에 있어서, R11은 피리딜메톡시기를 나타내며, R31이 히드록실기를 나타내며, R41이 수소 원자이며, R51이 페닐기를 나타내며; X1이을 나타내며, Y1이 -O- 또는 단일 결합이며 Z1이이며; ℓ은 2~4이며 m은 화합물.
- 하기 일반식(Ⅱ)로 나타내어지는 카르복실산 또는 그의 반응성 유도체를 하기 일반식(Ⅲ)으로 나타내어지는 화합물과 반응시킴을 특징으로 하는 제1항에 기재된 일반식(Ⅰ)로 나타내어지는 나프토에산 유도체의 제조방법.[식들 중에서, R1, R2m, R3, R4, R5, X, Y, Z, q, ℓ, 및 m은 제1항에서 정의한 바와 같다].
- 제1항에 기재된 일반식(Ⅰ)로 나타내어지는 나프토에산 유도체 또는 그의 제약학적으로 허용가능한 염을 함유하는 의약.
- 제1항에 기재된 일반식(Ⅰ)로 나타내어지는 나프토에산 유도체 또는 그의 제약학적으로 허용가능한 염을 함유하는 항알레르기제.
- 제1항에 기재된 일반식(Ⅰ)로 나타내어지는 나프토에산 유도체 또는 그의 제약학적으로 허용가능한 염의 유효량과 제약적으로 허용가능한 담체 또는 희석제로 구성된 제약학적 조성물.
- 제1항에 기재된 일반식(Ⅰ)로 나타내어지는 나프토에산 유도체 또는 그의 제약학적으로 허용가능한 염의 유효량을 환자에게 투여하는 것을 구성되는 알레르기 질환 환자의 처치방법.※참고사항 : 최초출원 내용에 의하여 공개되는 것임.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP90-330004 | 1990-11-30 | ||
JP2330004A JP2671059B2 (ja) | 1990-11-30 | 1990-11-30 | ナフトエ酸誘導体 |
Publications (2)
Publication Number | Publication Date |
---|---|
KR920009810A true KR920009810A (ko) | 1992-06-25 |
KR0141683B1 KR0141683B1 (en) | 1998-06-01 |
Family
ID=18227695
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
KR91021899A KR0141683B1 (en) | 1990-11-30 | 1991-11-30 | Naphthoic acid derivative |
Country Status (10)
Country | Link |
---|---|
US (1) | US5324728A (ko) |
EP (1) | EP0492178B1 (ko) |
JP (1) | JP2671059B2 (ko) |
KR (1) | KR0141683B1 (ko) |
AT (1) | ATE128710T1 (ko) |
CA (1) | CA2056662C (ko) |
DE (1) | DE69113593T2 (ko) |
DK (1) | DK0492178T3 (ko) |
ES (1) | ES2077777T3 (ko) |
GR (1) | GR3018167T3 (ko) |
Families Citing this family (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5395835A (en) * | 1994-03-24 | 1995-03-07 | Warner-Lambert Company | Naphthalamides as central nervous system agents |
US5714613A (en) * | 1995-06-05 | 1998-02-03 | Fujirebio Inc. | Method of producing 2-naphthamide derivative, and compounds for producing 2-naphthamide derivative |
AU6179998A (en) * | 1997-02-24 | 1998-09-09 | Zymogenetics Inc. | Calcitonin mimetics |
US6559140B2 (en) * | 2000-03-09 | 2003-05-06 | Abbott Laboratories | Cyclic and bicyclic diamino histamine-3 receptor antagonists |
JP4550353B2 (ja) * | 2002-07-24 | 2010-09-22 | 株式会社医薬分子設計研究所 | 造血器型プロスタグランジンd2合成酵素阻害剤 |
US7314875B2 (en) * | 2004-04-13 | 2008-01-01 | Cephalon, Inc. | Tricyclic aromatic and bis-phenyl sulfinyl derivatives |
US7511077B2 (en) * | 2005-02-09 | 2009-03-31 | Neuromed Pharmaceuticals Ltd. | Diamine calcium channel blockers |
EP2091944B1 (en) | 2006-11-17 | 2011-05-18 | Pfizer Inc. | Substituted bicyclocarboxyamide compounds |
US7923014B2 (en) * | 2007-02-12 | 2011-04-12 | The Board Of Regents Of The University Of Texas System | Expression and purification of HIP/PAP and uses therefor |
EP2964611B1 (en) | 2013-03-08 | 2022-10-19 | The United States of America, as represented by The Secretary, Department of Health and Human Services | Potent and selective inhibitors of monoamine transporters; method of making; and use thereof |
GEP20186887B (en) | 2014-04-04 | 2018-08-27 | Pfizer | Bicyclic-fused heteroaryl or aryl compounds and their use as irak4 inhibitors |
US11365195B2 (en) | 2017-11-13 | 2022-06-21 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Atypical inhibitors of monoamine transporters; method of making; and use thereof |
EP4159725A4 (en) * | 2020-05-29 | 2023-12-20 | Daegu-Gyeongbuk Medical Innovation Foundation | CARBOXAMIDE DERIVATIVE AND PHARMACEUTICAL COMPOSITION THEREOF AS AN ACTIVE SUBSTANCE FOR THE PREVENTION OR TREATMENT OF MENTAL DISEASES |
Family Cites Families (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3644518A (en) * | 1965-05-24 | 1972-02-22 | Makoto Yoshida | Process for the production of naphthamide derivatives |
GB1316667A (en) * | 1969-05-26 | 1973-05-09 | Xerox Corp | Benzobrazanquinone pigments |
JPS58210055A (ja) * | 1982-06-01 | 1983-12-07 | Ricoh Co Ltd | 新規な2−ヒドロキシ−3−ナフトエ酸アミド誘導体 |
FR2531704B1 (fr) * | 1982-08-13 | 1985-08-09 | Sanofi Sa | Amides d'acides (hetero)aromatiques n-substitues, leurs sels, procede pour leur preparation et compositions pharmaceutiques en contenant |
JPS5955878A (ja) * | 1982-09-24 | 1984-03-31 | Chugai Pharmaceut Co Ltd | 新規なフエニルピペラジン誘導体 |
JPS60139646A (ja) * | 1983-12-27 | 1985-07-24 | Otsuka Pharmaceut Factory Inc | ナフタレン誘導体 |
US4673684A (en) * | 1984-04-04 | 1987-06-16 | Terumo Corporation | Amide derivatives and 5-lipoxygenase inhibitors containing the same as an active ingredient |
US4939133A (en) * | 1985-10-01 | 1990-07-03 | Warner-Lambert Company | N-substituted-2-hydroxy-α-oxo-benzeneacetamides and pharmaceutical compositions having activity as modulators of the arachidonic acid cascade |
JPH0660160B2 (ja) * | 1985-12-13 | 1994-08-10 | テルモ株式会社 | アミド誘導体およびこれを含有する抗アレルギ−剤 |
DK623586A (da) * | 1985-12-27 | 1987-06-28 | Eisai Co Ltd | Piperidinderivater eller salte deraf og farmaceutiske kompositioner indeholdende forbindelserne |
FR2601366B1 (fr) * | 1986-07-10 | 1988-11-25 | Andre Buzas | Derives de la benzhydryloxyethyl-piperazine, procedes d'obtention et de compositions pharmaceutiques les contenant. |
JPS6477A (en) * | 1987-03-24 | 1989-01-05 | Takeda Chem Ind Ltd | 1,4-disubstituted piperazine compound |
GB8725260D0 (en) * | 1987-10-28 | 1987-12-02 | Lilly Industries Ltd | Organic compounds |
CA2015949A1 (en) * | 1989-05-22 | 1990-11-22 | Yasuo Ito | Piperidine derivative, method for preparation thereof, and a pharmaceutical composition comprising the same |
-
1990
- 1990-11-30 JP JP2330004A patent/JP2671059B2/ja not_active Expired - Fee Related
-
1991
- 1991-11-29 EP EP91120553A patent/EP0492178B1/en not_active Expired - Lifetime
- 1991-11-29 CA CA002056662A patent/CA2056662C/en not_active Expired - Fee Related
- 1991-11-29 ES ES91120553T patent/ES2077777T3/es not_active Expired - Lifetime
- 1991-11-29 AT AT91120553T patent/ATE128710T1/de not_active IP Right Cessation
- 1991-11-29 DE DE69113593T patent/DE69113593T2/de not_active Expired - Fee Related
- 1991-11-29 DK DK91120553.2T patent/DK0492178T3/da active
- 1991-11-30 KR KR91021899A patent/KR0141683B1/ko not_active IP Right Cessation
- 1991-12-02 US US07/801,501 patent/US5324728A/en not_active Expired - Lifetime
-
1995
- 1995-11-22 GR GR950403286T patent/GR3018167T3/el unknown
Also Published As
Publication number | Publication date |
---|---|
KR0141683B1 (en) | 1998-06-01 |
DK0492178T3 (da) | 1995-11-20 |
CA2056662A1 (en) | 1992-05-31 |
DE69113593D1 (de) | 1995-11-09 |
GR3018167T3 (en) | 1996-02-29 |
EP0492178A3 (en) | 1992-08-05 |
EP0492178A2 (en) | 1992-07-01 |
JPH04364156A (ja) | 1992-12-16 |
JP2671059B2 (ja) | 1997-10-29 |
DE69113593T2 (de) | 1996-03-28 |
ATE128710T1 (de) | 1995-10-15 |
EP0492178B1 (en) | 1995-10-04 |
ES2077777T3 (es) | 1995-12-01 |
CA2056662C (en) | 2000-03-28 |
US5324728A (en) | 1994-06-28 |
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