KR920009810A - 나프토에산 유도체 - Google Patents

나프토에산 유도체 Download PDF

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KR920009810A
KR920009810A KR1019910021899A KR910021899A KR920009810A KR 920009810 A KR920009810 A KR 920009810A KR 1019910021899 A KR1019910021899 A KR 1019910021899A KR 910021899 A KR910021899 A KR 910021899A KR 920009810 A KR920009810 A KR 920009810A
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lower alkyl
hydrogen atom
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야스오 세끼네
데쯔야끼 아마우라
마사또 니시무라
에리 고지마
야스꼬 에모또
야스시 히가시데
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후꾸야마 마사루
후지레비오 가부시끼가이샤
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Abstract

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Description

나프토에산 유도체
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (16)

  1. 하기 일반식(Ⅰ)로 나타내어지는 나프토에산 유도체 및 그의 염.
    [식중, R1, R2및 R3는 각각 독립적으로 수소 원자, 할로겐 원자, 히드록실기, 저급 알킬기, 저급 알콕시기, 저급 알카노일옥시기, 히드록시저급알킬기, 저급 알콕시-저급 알킬기, 저급 알카노일옥시-저급알킬기 또는 아랄킬옥시기를 나타내며, R4는 수소 원자 또는 저급 알킬기를 나타내며, R5는 치환 또는 무치환의 아릴기 또는 치환 또는 무치환의 헤테로아로마틱기를 나타내며, X는, 시클로알킬렌기, 2가의 질소를 함유하는 복소환식기 또는 기, -R8-NH- 또는 -NH-R8-을 나타내고, 여기서 R6및 R7은 각각 수소 원자 또는 저급 알킬기를 나타내고, R8은 시클로알킬렌기를 나타내든가 또는 R6및 R7은 R4와 함께 C1~3의 알킬렌기를 형성하여도 무방하며, Y는 -S(O)p- -(CH2)-n, -O- 또는 단일 결합을 나타내고, Z는 치환 또는 무치환의 알킬렌기 또는 단일 결합을 나타내고, ℓ은 0~4의 정수이며, m은 0~8의 정수이며, n은 0 또는 1이며 p는 0~2의 정수이며, q는 0 또는 1이다.]
  2. 제1항에 있어서, R1및/또는 R2가 상기 일반식의 5- 및/또는 7-위치에 존재하고, R3은 상기 일반식의 2-위치에 존재하는 화합물.
  3. 제2항에 있어서, R1및 R2중 하나가 수소원자이고, 다른 하나는 히드록실기, 저급알콕시기, 저급 알카노일옥시기 또는 피리딜-치환저급 알콕시기를 나타내고, R3는 히드록실기, 저급 알콕시기 또는 저급 알카노일옥시기를 나타내는 화합물.
  4. 제1항에 있어서, q가 0이고 R4는 수소원자인 화합물.
  5. 제1항에 있어서, X가 -CH2-,를 나타내는 화합물.
  6. 제1항에 있어서, Y가 -S-, -CH2-, -O- 또는 단일 결합을 나타내는 화합물.
  7. 제1항에 있어서, Z가 -CH2, -CH2CH2-,또는 단일결합을 나타내고, 여기서는 R9는 페닐기, 할로페닐기, 또는 피리딜기를 나타내는 화합물.
  8. 제1항에 있어서, R5가 페닐기, 나프틸기, 모노- 또는 디-할로페닐기, 저급 알킬페닐기, 저급 알콕시페닐기, 저급 알킬티오페닐기, 니트로페닐기, 시아노페닐기, 저급 알콕시카르보닐페닐기, 저급 알카노일페닐기, 비페닐릴기, 모노- 또는 디트리플루오로메틸페닐기, 메틸렌옥시페닐기, 티에닐기, 힐로티에닐기, 푸릴기 또는 피리딜기를 나타내는 화합물.
  9. 제1항에 있어서,(CH)-ℓx-부분이 피페라진-1,4-디일기, 피페리딘-1,4-디일기, 퍼히드로아제판-1,4-디일기, 호모피페라진-1,4-디일기 또는 이미다졸리딘-1,3-디일기를 나타내는 화합물.
  10. 제1항에 있어서, 하기 일반식(Ⅰ-1)로 나타내어지는 화합물.
    [식중, R11은 히드록실기, 저급 알카노일옥시기, 또는 피리딜-치환 저급 알콕시기를 나타내며, R31은 히드록실기 또는 저급 라카노일옥시기를 나타내며, R51은 페닐기, 할로겐페닐기 또는 티에닐기를 나타내며;
    X는 -CH2-,를 나타내며, 여기에서 R61은 수소원자이든지, 또는 R61은 R41과 함께 C1~2의 알킬렌기를 형성하여도 무방하며; Y1은 -S- -O- 또는 단일 결합을 나타내며, Z1은을 나타내며; ℓ은 0~4의 정수이며, m은 0~4의 정수이다.]
  11. 제10항에 있어서, R11은 피리딜메톡시기를 나타내며, R31이 히드록실기를 나타내며, R41이 수소 원자이며, R51이 페닐기를 나타내며; X1이을 나타내며, Y1이 -O- 또는 단일 결합이며 Z1이이며; ℓ은 2~4이며 m은 화합물.
  12. 하기 일반식(Ⅱ)로 나타내어지는 카르복실산 또는 그의 반응성 유도체를 하기 일반식(Ⅲ)으로 나타내어지는 화합물과 반응시킴을 특징으로 하는 제1항에 기재된 일반식(Ⅰ)로 나타내어지는 나프토에산 유도체의 제조방법.
    [식들 중에서, R1, R2m, R3, R4, R5, X, Y, Z, q, ℓ, 및 m은 제1항에서 정의한 바와 같다].
  13. 제1항에 기재된 일반식(Ⅰ)로 나타내어지는 나프토에산 유도체 또는 그의 제약학적으로 허용가능한 염을 함유하는 의약.
  14. 제1항에 기재된 일반식(Ⅰ)로 나타내어지는 나프토에산 유도체 또는 그의 제약학적으로 허용가능한 염을 함유하는 항알레르기제.
  15. 제1항에 기재된 일반식(Ⅰ)로 나타내어지는 나프토에산 유도체 또는 그의 제약학적으로 허용가능한 염의 유효량과 제약적으로 허용가능한 담체 또는 희석제로 구성된 제약학적 조성물.
  16. 제1항에 기재된 일반식(Ⅰ)로 나타내어지는 나프토에산 유도체 또는 그의 제약학적으로 허용가능한 염의 유효량을 환자에게 투여하는 것을 구성되는 알레르기 질환 환자의 처치방법.
    ※참고사항 : 최초출원 내용에 의하여 공개되는 것임.
KR91021899A 1990-11-30 1991-11-30 Naphthoic acid derivative KR0141683B1 (en)

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KR0141683B1 (en) 1998-06-01
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EP0492178B1 (en) 1995-10-04
JP2671059B2 (ja) 1997-10-29
EP0492178A2 (en) 1992-07-01
JPH04364156A (ja) 1992-12-16
CA2056662C (en) 2000-03-28
DK0492178T3 (da) 1995-11-20
ES2077777T3 (es) 1995-12-01
EP0492178A3 (en) 1992-08-05
ATE128710T1 (de) 1995-10-15
GR3018167T3 (en) 1996-02-29
DE69113593D1 (de) 1995-11-09
CA2056662A1 (en) 1992-05-31

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