JPS6477A - 1,4-disubstituted piperazine compound - Google Patents

1,4-disubstituted piperazine compound

Info

Publication number
JPS6477A
JPS6477A JP63064884A JP6488488A JPS6477A JP S6477 A JPS6477 A JP S6477A JP 63064884 A JP63064884 A JP 63064884A JP 6488488 A JP6488488 A JP 6488488A JP S6477 A JPS6477 A JP S6477A
Authority
JP
Japan
Prior art keywords
formula
compound expressed
paf
disease
caused
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP63064884A
Other languages
Japanese (ja)
Other versions
JPH0177A (en
Inventor
Hirosada Sugihara
Katsumi Ito
Kohei Nishikawa
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Takeda Pharmaceutical Co Ltd
Original Assignee
Takeda Chemical Industries Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Takeda Chemical Industries Ltd filed Critical Takeda Chemical Industries Ltd
Priority to JP63-64884A priority Critical patent/JPH0177A/en
Priority claimed from JP63-64884A external-priority patent/JPH0177A/en
Publication of JPS6477A publication Critical patent/JPS6477A/en
Publication of JPH0177A publication Critical patent/JPH0177A/en
Pending legal-status Critical Current

Links

Abstract

NEW MATERIAL:A compound expressed by formula I (A is condensed macrocyclic hydrocarbon group; R is phenyl which is substituted by lower alkoxy; X is methylene, carboxyl or thiocarbonyl; m is 2 or 3) or salt thereof.
EXAMPLE: 1-( 2,3-Dimethoxy-6,7-dihydro-5H-benzocycloheptene-8-ylcarbonyl )-4-(3,4, 5-trimethoxybenzoyl)piperazine.
USE: A platelet activating factor (PAF) antagonist. Useful in prevention and treatment for circulation hindrance disease (e.g. thrombosis or angina pectoris) caused by PAF, alimentary disease (e.g. gastric ulcer) caused by PAF, disease related to allergy and inflammation, etc.
PREPARATION: For example, a compound expressed by the formula A-COOH is subjected to dehydration and condensation reaction with a compound expressed by formula II to provide the aimed compound expressed by formula I.
COPYRIGHT: (C)1989,JPO&Japio
JP63-64884A 1987-03-24 1988-03-17 1,4-disubstituted piperazine compounds Pending JPH0177A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP63-64884A JPH0177A (en) 1987-03-24 1988-03-17 1,4-disubstituted piperazine compounds

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP62-69804 1987-03-24
JP6980487 1987-03-24
JP63-64884A JPH0177A (en) 1987-03-24 1988-03-17 1,4-disubstituted piperazine compounds

Publications (2)

Publication Number Publication Date
JPS6477A true JPS6477A (en) 1989-01-05
JPH0177A JPH0177A (en) 1989-01-05

Family

ID=

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH04364156A (en) * 1990-11-30 1992-12-16 Fujirebio Inc Naphthoic acid derivative
JP2005538968A (en) * 2002-06-29 2005-12-22 ツェンタリス ゲゼルシャフト ミット ベシュレンクテル ハフツング Aryl- and heteroarylcarbonylpiperazines and their use to treat benign and malignant tumor diseases

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH04364156A (en) * 1990-11-30 1992-12-16 Fujirebio Inc Naphthoic acid derivative
JP2005538968A (en) * 2002-06-29 2005-12-22 ツェンタリス ゲゼルシャフト ミット ベシュレンクテル ハフツング Aryl- and heteroarylcarbonylpiperazines and their use to treat benign and malignant tumor diseases

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