JPS6477A - 1,4-disubstituted piperazine compound - Google Patents
1,4-disubstituted piperazine compoundInfo
- Publication number
- JPS6477A JPS6477A JP63064884A JP6488488A JPS6477A JP S6477 A JPS6477 A JP S6477A JP 63064884 A JP63064884 A JP 63064884A JP 6488488 A JP6488488 A JP 6488488A JP S6477 A JPS6477 A JP S6477A
- Authority
- JP
- Japan
- Prior art keywords
- formula
- compound expressed
- paf
- disease
- caused
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Abstract
NEW MATERIAL:A compound expressed by formula I (A is condensed macrocyclic hydrocarbon group; R is phenyl which is substituted by lower alkoxy; X is methylene, carboxyl or thiocarbonyl; m is 2 or 3) or salt thereof.
EXAMPLE: 1-( 2,3-Dimethoxy-6,7-dihydro-5H-benzocycloheptene-8-ylcarbonyl )-4-(3,4, 5-trimethoxybenzoyl)piperazine.
USE: A platelet activating factor (PAF) antagonist. Useful in prevention and treatment for circulation hindrance disease (e.g. thrombosis or angina pectoris) caused by PAF, alimentary disease (e.g. gastric ulcer) caused by PAF, disease related to allergy and inflammation, etc.
PREPARATION: For example, a compound expressed by the formula A-COOH is subjected to dehydration and condensation reaction with a compound expressed by formula II to provide the aimed compound expressed by formula I.
COPYRIGHT: (C)1989,JPO&Japio
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP63-64884A JPH0177A (en) | 1987-03-24 | 1988-03-17 | 1,4-disubstituted piperazine compounds |
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP62-69804 | 1987-03-24 | ||
JP6980487 | 1987-03-24 | ||
JP63-64884A JPH0177A (en) | 1987-03-24 | 1988-03-17 | 1,4-disubstituted piperazine compounds |
Publications (2)
Publication Number | Publication Date |
---|---|
JPS6477A true JPS6477A (en) | 1989-01-05 |
JPH0177A JPH0177A (en) | 1989-01-05 |
Family
ID=
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH04364156A (en) * | 1990-11-30 | 1992-12-16 | Fujirebio Inc | Naphthoic acid derivative |
JP2005538968A (en) * | 2002-06-29 | 2005-12-22 | ツェンタリス ゲゼルシャフト ミット ベシュレンクテル ハフツング | Aryl- and heteroarylcarbonylpiperazines and their use to treat benign and malignant tumor diseases |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH04364156A (en) * | 1990-11-30 | 1992-12-16 | Fujirebio Inc | Naphthoic acid derivative |
JP2005538968A (en) * | 2002-06-29 | 2005-12-22 | ツェンタリス ゲゼルシャフト ミット ベシュレンクテル ハフツング | Aryl- and heteroarylcarbonylpiperazines and their use to treat benign and malignant tumor diseases |
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