KR920007681B1 - 화학적으로 변형된 림포킨의 제조방법 - Google Patents

화학적으로 변형된 림포킨의 제조방법 Download PDF

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Publication number
KR920007681B1
KR920007681B1 KR1019850001381A KR850001381A KR920007681B1 KR 920007681 B1 KR920007681 B1 KR 920007681B1 KR 1019850001381 A KR1019850001381 A KR 1019850001381A KR 850001381 A KR850001381 A KR 850001381A KR 920007681 B1 KR920007681 B1 KR 920007681B1
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KR
South Korea
Prior art keywords
lymphokine
molecular sieve
interferon
polyethylene glycol
ifn
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KR1019850001381A
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English (en)
Korean (ko)
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KR850006875A (ko
Inventor
오사무 니시무라
마사히꼬 후지노
Original Assignee
다께다야꾸힝고오교 가부시끼가이샤
구라바야시 이꾸시로
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Publication of KR850006875A publication Critical patent/KR850006875A/ko
Application granted granted Critical
Publication of KR920007681B1 publication Critical patent/KR920007681B1/ko

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
    • C07K1/1072—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups
    • C07K1/1077—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups by covalent attachment of residues other than amino acids or peptide residues, e.g. sugars, polyols, fatty acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/54—Interleukins [IL]
    • C07K14/55—IL-2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/555—Interferons [IFN]
    • C07K14/56—IFN-alpha
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/555—Interferons [IFN]
    • C07K14/57—IFN-gamma
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Medicinal Chemistry (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • Analytical Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Microbiology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
KR1019850001381A 1984-03-06 1985-03-05 화학적으로 변형된 림포킨의 제조방법 KR920007681B1 (ko)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
JPPCT/JP84/00085 1984-03-06
PCT/JP1984/000085 WO1985003934A1 (en) 1984-03-06 1984-03-06 Chemically modified protein and process for its preparation
PCT/JP1984/000575 WO1985003868A1 (en) 1984-03-06 1984-12-05 Chemically modified lymphokine and process for its preparation
JPPCT/JP84/00575 1984-12-05

Publications (2)

Publication Number Publication Date
KR850006875A KR850006875A (ko) 1985-10-21
KR920007681B1 true KR920007681B1 (ko) 1992-09-14

Family

ID=13818260

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019850001381A KR920007681B1 (ko) 1984-03-06 1985-03-05 화학적으로 변형된 림포킨의 제조방법

Country Status (5)

Country Link
US (1) USH1662H (ja)
JP (2) JPH0676439B2 (ja)
KR (1) KR920007681B1 (ja)
AU (1) AU2867784A (ja)
WO (2) WO1985003934A1 (ja)

Families Citing this family (43)

* Cited by examiner, † Cited by third party
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EP0229108B1 (en) * 1985-06-26 1990-12-27 Cetus Corporation Solubilization of proteins for pharmaceutical compositions using polymer conjugation
JP2958019B2 (ja) * 1988-05-06 1999-10-06 住友製薬株式会社 ポリエチレングリコール誘導体、修飾ペプチドおよびその製造方法
US5214131A (en) * 1988-05-06 1993-05-25 Sumitomo Pharmaceuticals Company, Limited Polyethylene glycol derivatives, modified peptides and production thereof
US5349052A (en) * 1988-10-20 1994-09-20 Royal Free Hospital School Of Medicine Process for fractionating polyethylene glycol (PEG)-protein adducts and an adduct for PEG and granulocyte-macrophage colony stimulating factor
GB8824591D0 (en) 1988-10-20 1988-11-23 Royal Free Hosp School Med Fractionation process
JP2997004B2 (ja) * 1989-05-26 2000-01-11 住友製薬株式会社 ポリエチレングリコール誘導体、修飾ペプチドおよびその製造方法
US5342940A (en) * 1989-05-27 1994-08-30 Sumitomo Pharmaceuticals Company, Limited Polyethylene glycol derivatives, process for preparing the same
FR2675807B1 (fr) * 1991-04-23 1994-07-01 Medgenix Group Sa Conjugue de calcitonine et de polyethylene glycol.
US5382657A (en) * 1992-08-26 1995-01-17 Hoffmann-La Roche Inc. Peg-interferon conjugates
US5359030A (en) * 1993-05-10 1994-10-25 Protein Delivery, Inc. Conjugation-stabilized polypeptide compositions, therapeutic delivery and diagnostic formulations comprising same, and method of making and using the same
US5824784A (en) 1994-10-12 1998-10-20 Amgen Inc. N-terminally chemically modified protein compositions and methods
WO1998032466A1 (en) * 1997-01-29 1998-07-30 Polymasc Pharmaceuticals Plc Pegylation process
ES2344679T3 (es) 2000-08-11 2010-09-03 Kyowa Hakko Kirin Co., Ltd. Polipeptidos que controlan el metabolismo del acido fosforico, el metabolismo del calcio, el metabolismo de la calcificacion y de la vitamina d y moleculas de adn que los codifican.
EP1466925B1 (en) 2001-12-28 2009-09-02 Kyowa Hakko Kirin Co., Ltd. Antibodies against fibroblast growth factor 23
CN1630530A (zh) * 2002-01-18 2005-06-22 比奥根艾迪克Ma公司 聚亚烷基聚合物及其用途
BR0317752A (pt) * 2002-12-26 2005-11-22 Mountain View Pharmaceuticals Conjugados poliméricos de citocinas, quimiocinas, fatores do crescimento, hormÈnios polipeptìdicos e seus antagonistas com atividade de ligação a receptores conservada
EP1667708B9 (en) 2002-12-26 2012-10-31 Mountain View Pharmaceuticals, Inc. POLYETHYLENE GLYCOL CONJUGATES OF INTERFERON-BETA-1b WITH ENHANCED IN VITRO BIOLOGICAL POTENCY
CN100519581C (zh) 2003-08-25 2009-07-29 东丽株式会社 干扰素-β复合物
EP1676862B1 (en) 2003-09-24 2010-12-22 Kyowa Hakko Kirin Co., Ltd. Recombinant antibody against human insulin-like growth factor
RU2395294C2 (ru) * 2004-06-18 2010-07-27 Дженентек, Инк. Способы применения агонистов аро-2l-рецепторов и активаторов nk-клеток
EP2389944A1 (en) * 2004-07-29 2011-11-30 ZymoGenetics, L.L.C. Use of IL-28 and IL-29 to treat cancer
JPWO2006080171A1 (ja) 2005-01-31 2008-06-19 株式会社 エフェクター細胞研究所 免疫増強剤
WO2007066698A1 (ja) 2005-12-06 2007-06-14 Kyowa Hakko Kogyo Co., Ltd. 抗ｐｅｒｐ遺伝子組換え抗体
JPWO2007102562A1 (ja) * 2006-03-01 2009-07-23 学校法人慶應義塾 新規抗血栓薬
US7883705B2 (en) 2007-02-14 2011-02-08 Kyowa Hakko Kirin Co., Ltd. Anti FGF23 antibody and a pharmaceutical composition comprising the same
EP2138576A4 (en) 2007-03-16 2011-02-23 Kyowa Hakko Kirin Co Ltd ANTI-CLAUDIN-4 ANTIBODY
KR20100097674A (ko) 2007-12-05 2010-09-03 교와 핫꼬 기린 가부시키가이샤 헤파린 결합 상피 세포 증식 인자 유사 증식 인자에 결합하는 단일 클론 항체
CA2729567C (en) 2008-06-30 2018-04-24 Kyowa Hakko Kirin Co., Ltd. Anti-cd27 antibody
CN103145835B (zh) 2008-07-17 2014-10-29 协和发酵麒麟株式会社 抗-系统asc氨基酸转运蛋白2 (asct2)抗体
ES2602459T3 (es) 2008-12-26 2017-02-21 Kyowa Hakko Kirin Co., Ltd. Anticuerpo anti-CD4
PT2423228E (pt) 2009-04-20 2016-02-26 Kyowa Hakko Kirin Co Ltd Anticorpo contendo igg2 em que foram introduzidas mutações de aminoácidos
ES2602971T3 (es) 2010-03-02 2017-02-23 Kyowa Hakko Kirin Co., Ltd. Composición de anticuerpo modificado
ES2682078T3 (es) 2010-06-11 2018-09-18 Kyowa Hakko Kirin Co., Ltd. Anticuerpo anti-TIM-3
AU2012274461A1 (en) 2011-06-20 2014-01-16 Kyowa Hakko Kirin Co., Ltd. Anti-erbB3 antibody
EP2868667B1 (en) 2012-07-02 2019-01-30 Kyowa Hakko Kirin Co., Ltd. Therapeutic agent for anemia including renal anemia and cancer-induced anemia which contains anti-bmp9 antibody as active ingredient
CA2893378A1 (en) 2012-12-07 2014-06-12 Kyowa Hakko Kirin Co., Ltd. Anti-folr1 antibody
CN110959014B (zh) 2017-07-18 2024-01-16 协和麒麟株式会社 抗人ccr1单克隆抗体
CN111344307A (zh) 2017-11-08 2020-06-26 协和麒麟株式会社 与CD40和EpCAM结合的双特异性抗体
AU2018384239A1 (en) 2017-12-12 2020-07-02 Kyowa Kirin Co., Ltd. Anti-BMP10 antibody, and therapeutic agent for hypertension and hypertensive diseases comprising said antibody as active ingredient
US20220017635A1 (en) 2018-12-28 2022-01-20 Kyowa Kirin Co., Ltd. BISPECIFIC ANTIBODY BINDING TO TfR
EP3971293A4 (en) 2019-05-15 2023-02-08 Kyowa Kirin Co., Ltd. BISPECIFIC ANTIBODIES CAPABLE OF BINDING TO CD40 AND GPC3
US20220259328A1 (en) 2019-05-15 2022-08-18 Kyowa Kirin Co., Ltd. Bispecific antibody binding to cd40 and fap
WO2023027177A1 (ja) 2021-08-26 2023-03-02 協和キリン株式会社 Ｃｄ１１６およびｃｄ１３１に結合するバイスペシフィック抗体

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US4179337A (en) * 1973-07-20 1979-12-18 Davis Frank F Non-immunogenic polypeptides
US4002531A (en) * 1976-01-22 1977-01-11 Pierce Chemical Company Modifying enzymes with polyethylene glycol and product produced thereby
DE2930542A1 (de) * 1979-07-27 1981-02-12 Hoechst Ag Neue insulinderivate und verfahren zu ihrer herstellung
JPS57118789A (en) * 1981-01-13 1982-07-23 Eisai Co Ltd Modified streptokinase and its preparation
JPS57192435A (en) * 1981-05-20 1982-11-26 Toyobo Co Ltd Modified polypeptide
JPS58154596A (ja) * 1982-03-09 1983-09-14 Toray Ind Inc インタ−フエロンの修飾方法

Also Published As

Publication number Publication date
JPH0676439B2 (ja) 1994-09-28
AU2867784A (en) 1984-12-04
JPS61178926A (ja) 1986-08-11
WO1985003868A1 (en) 1985-09-12
JPS60226821A (ja) 1985-11-12
WO1985003934A1 (en) 1985-09-12
KR850006875A (ko) 1985-10-21
USH1662H (en) 1997-07-01
JPH0696599B2 (ja) 1994-11-30

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