KR920005988A - 아라키돈산 대사를 억제하는 디페닐 화합물 및 약제학적 조성물에서의 이들의 용도 - Google Patents

아라키돈산 대사를 억제하는 디페닐 화합물 및 약제학적 조성물에서의 이들의 용도 Download PDF

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KR920005988A
KR920005988A KR1019910015407A KR910015407A KR920005988A KR 920005988 A KR920005988 A KR 920005988A KR 1019910015407 A KR1019910015407 A KR 1019910015407A KR 910015407 A KR910015407 A KR 910015407A KR 920005988 A KR920005988 A KR 920005988A
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pharmaceutical composition
compound
formula
allergic
chlorine
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쉐베 탄크레트
루터 헬무트
요르다노브 덴트쇼
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베르너 발데그
시바-가이기 에이지
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/075—Ethers or acetals
    • A61K31/085—Ethers or acetals having an ether linkage to aromatic ring nuclear carbon
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A61K31/065—Diphenyl-substituted acyclic alcohols
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A61K31/05—Phenols
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A61K31/05—Phenols
    • A61K31/055—Phenols the aromatic ring being substituted by halogen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A61K31/05—Phenols
    • A61K31/06—Phenols the aromatic ring being substituted by nitro groups
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/095—Sulfur, selenium, or tellurium compounds, e.g. thiols
    • A61K31/10—Sulfides; Sulfoxides; Sulfones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
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  • General Health & Medical Sciences (AREA)
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Abstract

내용 없음

Description

아라키돈산 대사를 억제하는 디페닐 화합물 및 약제학적 조성물에서의 이들의 용도
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
제1도는 일정하게 인공호흡시키는 동안의 시간에 대한 대조군 동물(n=6) 및 실험하기 2시간 전에 펜티클로르 100mg/kg을 경구투여하여 예비처리한 실험 동물(n=6)에 대한 출발값의 %로서의 1회 호흡되는 숨의 용적(tidal volume)을 도시한 것이다.
제2도는 일정하게 인공호흡시키는 동안의 시간에 대한 대조군 동물(n=6) 및 실험하기 2시간 전에 펜티클로르 100mg/kg을 경구투여하여 예비처리한 실험동물(n=6)에 대한 초기값.

Claims (10)

  1. 다음 일반식(Ⅰ)의 화합물을 포함하는 약제학적 조성물.
    상기식에서, X는 산소, 황 또는 -CH2-이고, Y는 염소 또는 브롬이며, Z는 SO2H, NO2또는 C1-C4알킬 라디칼이고, r은 0 내지 3의 수이며, o는 0 내지 3의 수이고, p는 0 또는 1의 수이며, m은 1 또는 2의 수이고, n은 0 또는 1의 수이다.
  2. 제1항에 있어서, 다음 일반식(Ⅰ)의 화합물을 포함하는 약제학적 조성물.
    상기식에서, X는 산소, 황 또는 -CH2-이고, Y는 염소 또는 브롬이며, Z는 SO2H, NO2또는 C1-C4알킬 라디칼이고, r은 0 내지 3의 수이며, o는 0 내지 3의 수이고, p는 0 또는 1의 수이며, m은 1 또는 2의 수이고, n은 0 또는 1의 수이다.
  3. 제2항에 있어서, X가 산소, 황 또는 -CH2-이고, Y가 염소 또는 브롬이며, m이 0이고, n이 0 또는 1이며, o는 1 또는 2이고, r이 1 또는 2이며 p가 0인 일반식(Ⅰ)의 화합물을 포함하는 약제학적 조성물.
  4. 제2항에 있어서, X가 산소이고, Y가 염소이며, m이 0이고, n이 0이며, o가 1이고, r이 2이며 p가 0인 일반식(Ⅰ)의 화합물을 포함하는 약제학적 조성물.
  5. 제1항 내지 제4항 중의 어느 한 항에 있어서, 총혼합물을 기준하여, 0.01 내지 15중량%, 바람직하게는 0.1 내지 4중량%의 양으로 일반식(Ⅰ)의 화합물을 포함하는 약제학적 조성물.
  6. 제1항 내지 제5항 중의 어느 한 항에 있어서, 침투 촉진제를 부가적으로 포함하는 약제학적 조성물.
  7. 제6항에 있어서, 침투 촉진제로서 우레아, 프로필렌 글리콜 또는 올레산을 포함하는 약제학적 조성물.
  8. 제1항 내지 제4항 중의 어느 한 항에 있어서, 소염성, 항건선성, 세포증식-조절성, 항알레르기성, 진경성 위보호성, 또는 항천식성 활성성분중의 하나 이상을 부가적으로 포함하는 약제학적 조성물.
  9. 염증성, 알레르기성 및 진경성 질환, 및 건선, 기관지천식 및 세포증식 장해를 일으키는 질병을 국부적 및/또는 흡입성 치료하기 위한 제1항 내지 제8항중의 어느 한 항에 따르는 약제학적 조성물의 용도.
  10. 염증성, 알레르기성 및 진경성 질환, 및 건선, 기관지천식 및 세포증식 장해를 질병을 치료하기 위한 약제학적 제제를 제조하는데 있어서의 제1항 내지 제4항 중의 어느 한 항에 기술된 화합물의 용도.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019910015407A 1990-09-05 1991-09-04 아라키돈산 대사를 억제하는 디페닐 화합물을 포함하는 약제학적 조성물_ KR100201749B1 (ko)

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CH2875/90-3 1990-09-05
CH287590 1990-09-05

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KR920005988A true KR920005988A (ko) 1992-04-27
KR100201749B1 KR100201749B1 (ko) 1999-06-15

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US (1) US5185377A (ko)
EP (1) EP0474597B1 (ko)
JP (1) JP3264950B2 (ko)
KR (1) KR100201749B1 (ko)
AT (1) ATE156353T1 (ko)
AU (1) AU645599B2 (ko)
CA (1) CA2050569C (ko)
CZ (1) CZ279624B6 (ko)
DE (1) DE59108814D1 (ko)
DK (1) DK0474597T3 (ko)
ES (1) ES2106770T3 (ko)
FI (1) FI914185A (ko)
GR (1) GR3024440T3 (ko)
HU (2) HUT58998A (ko)
IE (1) IE913110A1 (ko)
IL (1) IL99376A (ko)
MX (1) MX9100917A (ko)
NO (1) NO913472L (ko)
PT (1) PT98874B (ko)
RU (1) RU2060731C1 (ko)
SK (1) SK279104B6 (ko)
ZA (1) ZA917005B (ko)

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GB9117140D0 (en) * 1991-08-08 1991-09-25 Unilever Plc Treatment of periodontitis
US6440395B1 (en) 1992-06-22 2002-08-27 Barry M. Libin Antiplaque mouth rinse
CH686285A5 (fr) * 1992-08-06 1996-02-29 Beiersdorf Ag Preparation cosmetique ou pharmaceutique servant a retarder le vieillissement de la peau humaine.
US5880146A (en) * 1995-06-07 1999-03-09 Fuji Immunopharmaceuticals Corporation Inhibition of IL-12-induced IFN-γ synthesis by specific bis-phenol compounds as a method of immune modulation
DE19680594D2 (de) * 1995-07-20 1997-09-18 Uwe Juergens Verwendung eines nicht-steroidalen Antiphlogistikums zur topischen und systemischen Behandlung der akutven und chronischen polypoiden Rhinosinusitis
AUPN814496A0 (en) * 1996-02-19 1996-03-14 Monash University Dermal penetration enhancer
US6108850A (en) * 1997-06-03 2000-08-29 Mclaughlin; Gerald Accelerated method and instrumentation for whitening teeth
DE19834355A1 (de) * 1998-07-30 2000-02-03 Henkel Kgaa Entzündungshemmende Zahnpflegemittel
US7566740B2 (en) * 1998-10-06 2009-07-28 Bml Pharmaceuticals, Inc. Method of treating mucositis
DE69931182T2 (de) * 1999-06-23 2007-03-01 Jawaharlal Nehru Centre For Advanced Scientific Research Verwendung von triclosan als antimalariamittel
WO2002050008A2 (en) * 2000-12-20 2002-06-27 Warner-Lambert Company Llc Non-halogenated phenoxy and/or benzyloxy phenols and antimicrobial compositions containing them
US20030229149A1 (en) * 2002-05-28 2003-12-11 Werner Baschong Anti-inflammatory agents
EP1366763A1 (en) * 2002-05-28 2003-12-03 Ciba SC Holding AG Hydroxy diphenyl ether compounds as anti-inflammatory agents
EP2600864B1 (en) * 2010-08-04 2019-01-09 University Of Virginia Patent Foundation Compositions and methods for treating inflammatory diseases

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US4512987A (en) * 1982-07-15 1985-04-23 Ciba-Geigy Corporation New pharmaceutical preparations
GB2148116B (en) * 1983-10-27 1986-07-30 Ciba Geigy Ag Topical steroid preparations
GB8526093D0 (en) * 1985-10-22 1985-11-27 Beecham Group Plc Composition
US4735802A (en) * 1986-05-05 1988-04-05 Le Bich N Topical dermatological composition and method of treatment
US4942029A (en) * 1986-09-19 1990-07-17 Smith & Nephew United, Inc. Medicated skin preparation
GB8629640D0 (en) * 1986-12-11 1987-01-21 Beecham Group Plc Composition & method
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AU610906B2 (en) * 1987-07-31 1991-05-30 Sumitomo Chemical Company, Limited Method for preventing harm from bloodsucking insects

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PT98874A (pt) 1992-07-31
GR3024440T3 (en) 1997-11-28
JP3264950B2 (ja) 2002-03-11
PT98874B (pt) 1999-02-26
MX9100917A (es) 1992-05-04
EP0474597A3 (en) 1992-07-01
RU2060731C1 (ru) 1996-05-27
FI914185A0 (fi) 1991-09-04
NO913472L (no) 1992-03-06
CA2050569C (en) 2004-01-27
NO913472D0 (no) 1991-09-04
HU211292A9 (en) 1995-11-28
DK0474597T3 (da) 1997-10-20
CA2050569A1 (en) 1992-03-06
ZA917005B (en) 1992-04-29
CZ279624B6 (cs) 1995-05-17
IL99376A (en) 1996-01-19
KR100201749B1 (ko) 1999-06-15
EP0474597A2 (de) 1992-03-11
EP0474597B1 (de) 1997-08-06
IL99376A0 (en) 1992-08-18
JPH04257517A (ja) 1992-09-11
ES2106770T3 (es) 1997-11-16
FI914185A (fi) 1992-03-06
AU8364091A (en) 1992-03-12
IE913110A1 (en) 1992-03-11
CS271891A3 (en) 1992-03-18
HUT58998A (en) 1992-04-28
ATE156353T1 (de) 1997-08-15
SK279104B6 (sk) 1998-06-03
AU645599B2 (en) 1994-01-20
DE59108814D1 (de) 1997-09-11
US5185377A (en) 1993-02-09

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