KR920002217A - 비응집성 코우팅층의 제조방법 - Google Patents

비응집성 코우팅층의 제조방법 Download PDF

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Publication number
KR920002217A
KR920002217A KR1019910011329A KR910011329A KR920002217A KR 920002217 A KR920002217 A KR 920002217A KR 1019910011329 A KR1019910011329 A KR 1019910011329A KR 910011329 A KR910011329 A KR 910011329A KR 920002217 A KR920002217 A KR 920002217A
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KR
South Korea
Prior art keywords
microcapsules
inorganic compound
coating layer
compound
slurry
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KR1019910011329A
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English (en)
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KR0168850B1 (ko
Inventor
히로아끼 지조모또
고이찌로 히라노
에리 가나오까
Original Assignee
요시또시 가즈오
시오노기세이야꾸 가부시끼가이샤
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Application filed by 요시또시 가즈오, 시오노기세이야꾸 가부시끼가이샤 filed Critical 요시또시 가즈오
Publication of KR920002217A publication Critical patent/KR920002217A/ko
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Publication of KR0168850B1 publication Critical patent/KR0168850B1/ko

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5073—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J13/00—Colloid chemistry, e.g. the production of colloidal materials or their solutions, not otherwise provided for; Making microcapsules or microballoons
    • B01J13/02—Making microcapsules or microballoons
    • B01J13/20—After-treatment of capsule walls, e.g. hardening
    • B01J13/22—Coating
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5089—Processes
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00—Stock material or miscellaneous articles
    • Y10T428/29—Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
    • Y10T428/2982—Particulate matter [e.g., sphere, flake, etc.]
    • Y10T428/2984—Microcapsule with fluid core [includes liposome]

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Organic Chemistry (AREA)
  • Dispersion Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Preparation (AREA)
  • Manufacturing Of Micro-Capsules (AREA)
  • Cosmetics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

내용 없음

Description

비응집성 코우팅층의 제조방법
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
제1도는 경과된 시간의 함수로서 단식시킨 쥐의 혈장내의 프로부콜의 농도변화를 나타낸다.
제2도는 경과된 시간의 함수로서 단식시키지 않는 쥐의 혈장내의 프로부콜의 농도 변화를 나타낸다.
제3도는 경과된 시간의 함수로서 단식시킨 비이글 개의 혈장내의 S-312-d의 농도변화를 나타낸다.

Claims (19)

  1. 물, 한가지 이상의 유기 용매 또는 이의 혼합물로 부터 선택한 매질에 불용성인 약제학적으로 허용가능한 무기 화합물의 분말을 상기 매질내의 접착성 코우팅층을 가진 마이크로 캡슐의 슬러리에 가하여 상기 무기화합물이 대체적으로 상기 접착성 코우팅 층의 전표면에 부착되도록함을 특징으로하는 마이크로캡슐상에 비응집성 코우팅 층을 제조하는 방법.
  2. 제1항에 있어서, 코우팅 층이 젤라틴을 함유함을 특징으로 하는 제조방법.
  3. 제1항에 있어서, 마이크로캡슐이 약제학적 활성 화합물을 캡슐화하는 제조방법.
  4. 제3항에 있어서, 약제학적 활성 화합물이 실온에서 액체인 제조방법.
  5. 제1항에 있어서, 무기 화합물이 규소함유 화합물인 제조방법.
  6. 제5항에 있어서, 무기 화합물이 이산화규소인 제조방법.
  7. 제1항에 있어서, 무기 화합물을 첨가하기 전에 마이크로캡슐의 슬러리를 산으로 처리하는 제조방법.
  8. 제7항에 있어서 산이 아세트산인 제조방법.
  9. 제1항에 있어서, 무기 화합물을 첨가하기 전에 마이크로캡슐이 부분적으로 경화되는 제조방법
  10. 물, 한가지 이상의 유기 용매 또는 이의 혼합물로 부터 선택된 매질에 코아세르베이션법에 의해 마이크로캡슐의 슬러리를 형성시키고, 상기 매질에 불용성인 약제학적으로 허용가능한 무기 화합물의 분말을 슬러리에 첨가하여, 상기 무기 화합물이 대체적으로 접착성 코우팅층의 전표면에 부착되어 상기 매질로 부터 마이크로캡슐을 분리함을 특징으로 하는 접착성 코우팅층을 가진 마이크로캡슐의 제조방법.
  11. 제10항에 있어서, 코우팅층이 젤라틴을 함유함을 특징으로 하는 제조방법.
  12. 제10항에 있어서, 마이크로캡슐이 약제학적 활성 화합물을 캡슐화하는 제조방법.
  13. 제12항에 있어서, 약제학적 활성 화합물이 실온에서 액체인 제조방법.
  14. 제10항에 있어서, 무기 화합물이 규소 함유 화합물인 제조방법.
  15. 제14항에 있어서, 무기 화합물이 이산화규소의 제조방법.
  16. 제10항에 있어서, 무기화합물을 첨가하기 전에 마이크로캡슐의 슬러리를 산으로 처리하는 제조방법.
  17. 제16항에 있어서, 산이 아세트산인 제조방법.
  18. 제10항에 있어서, 무기화합물을 첨가하기 전에 마이크로캡슐이 부분적으로 경화되는 제조방법.
  19. 제10항에 따른 제조방법에 의해 제조된 마이크로캡슐.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019910011329A 1990-07-04 1991-07-04 비응집성 코우팅층의 제조방법 KR0168850B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP178097/1990 1990-07-04
JP17809790 1990-07-04
JP90-178097 1990-07-04

Publications (2)

Publication Number Publication Date
KR920002217A true KR920002217A (ko) 1992-02-28
KR0168850B1 KR0168850B1 (ko) 1999-01-15

Family

ID=16042590

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019910011329A KR0168850B1 (ko) 1990-07-04 1991-07-04 비응집성 코우팅층의 제조방법

Country Status (8)

Country Link
US (1) US5480655A (ko)
EP (1) EP0465238B1 (ko)
JP (1) JP3179132B2 (ko)
KR (1) KR0168850B1 (ko)
AT (1) ATE103806T1 (ko)
DE (1) DE69101594T2 (ko)
DK (1) DK0465238T3 (ko)
ES (1) ES2055541T3 (ko)

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DE4310076A1 (de) * 1993-03-27 1994-09-29 Boehringer Ingelheim Kg Neue Suspensionsformulierungen
JP3625940B2 (ja) * 1996-01-29 2005-03-02 信越化学工業株式会社 水系液のカプセルおよびその製造方法
EP1393706A1 (en) * 2002-08-14 2004-03-03 Quest International B.V. Fragranced compositions comprising encapsulated material
EP1534216B1 (en) * 2002-08-14 2017-01-04 Givaudan S.A. Compositions comprising encapsulated material
ES2665464T3 (es) * 2003-03-28 2018-04-25 Sigmoid Pharma Limited Forma de dosificación oral sólida que contiene microcápsulas sin costuras
JP2005036001A (ja) * 2003-07-03 2005-02-10 Shiseido Co Ltd 油性粒子を含有する外用組成物
WO2006003733A1 (ja) * 2004-07-02 2006-01-12 Shiseido Company, Ltd. 油性粒子を含有する外用組成物
CA2581775A1 (en) * 2004-09-27 2006-04-06 Sigmoid Biotechnologies Limited Dihydropyrimidine microcapsule - formulations
JP2010523554A (ja) * 2007-04-04 2010-07-15 シグモイド・ファーマ・リミテッド タクロリムスの医薬組成物
ES2963291T3 (es) * 2007-04-26 2024-03-26 Sublimity Therapeutics Ltd Fabricación de múltiples minicápsulas
CA2685591A1 (en) * 2007-05-01 2008-11-06 Sigmoid Pharma Limited Pharmaceutical nimodipine compositions
CA2762179A1 (en) 2009-05-18 2010-11-25 Sigmoid Pharma Limited Composition comprising oil drops
IN2012DN00781A (ko) 2009-08-12 2015-06-26 Sigmoid Pharma Ltd
KR100978583B1 (ko) * 2009-09-02 2010-08-27 (주)바이오제닉스 화장품용 색조캡슐 조성물, 이의 제조방법 및 이를 이용한 화장품 제제
BR112013006381B1 (pt) 2010-09-20 2024-02-15 Spi Pharma Inc Composição que compreende um material de núcleo tendo um valor de sabor e um revestimento polimérico e formulação farmacêutica
GB201020032D0 (en) 2010-11-25 2011-01-12 Sigmoid Pharma Ltd Composition
BR112013029422B1 (pt) * 2011-06-07 2021-12-28 Firmenich Sa Cápsulas núcleo-revestimento
GB201212010D0 (en) 2012-07-05 2012-08-22 Sigmoid Pharma Ltd Formulations
GB201319791D0 (en) 2013-11-08 2013-12-25 Sigmoid Pharma Ltd Formulations
ES2858517T3 (es) 2014-11-07 2021-09-30 Sublimity Therapeutics Ltd Composiciones que comprenden ciclosporina
JP6768551B2 (ja) * 2017-02-17 2020-10-14 テクノロジック スリー エス．アール．エル．Ｔｅｃｎｏｌｏｇｉｃ ３ Ｓ．ｒ．ｌ． ボルトおよびナットを封止し、遮断するための嫌気性硬化性配合物

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Also Published As

Publication number Publication date
ATE103806T1 (de) 1994-04-15
JP3179132B2 (ja) 2001-06-25
EP0465238A1 (en) 1992-01-08
ES2055541T3 (es) 1994-08-16
DE69101594T2 (de) 1994-07-21
DE69101594D1 (de) 1994-05-11
JPH04358533A (ja) 1992-12-11
US5480655A (en) 1996-01-02
KR0168850B1 (ko) 1999-01-15
DK0465238T3 (da) 1994-05-02
EP0465238B1 (en) 1994-04-06

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