KR910021240A - 나프록센의 나트륨염을 함유하는 주사가능한 포뮬레이션 - Google Patents

나프록센의 나트륨염을 함유하는 주사가능한 포뮬레이션 Download PDF

Info

Publication number
KR910021240A
KR910021240A KR1019900021881A KR900021881A KR910021240A KR 910021240 A KR910021240 A KR 910021240A KR 1019900021881 A KR1019900021881 A KR 1019900021881A KR 900021881 A KR900021881 A KR 900021881A KR 910021240 A KR910021240 A KR 910021240A
Authority
KR
South Korea
Prior art keywords
naproxen
vial
sodium salt
pharmaceutical formulation
container
Prior art date
Application number
KR1019900021881A
Other languages
English (en)
Other versions
KR0180230B1 (ko
Inventor
피오리니 로베르타
마르치 에지디오
Original Assignee
귀도 궤라
알파 와셔만 에스.피.에이.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 귀도 궤라, 알파 와셔만 에스.피.에이. filed Critical 귀도 궤라
Publication of KR910021240A publication Critical patent/KR910021240A/ko
Application granted granted Critical
Publication of KR0180230B1 publication Critical patent/KR0180230B1/ko

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/20—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing sulfur, e.g. dimethyl sulfoxide [DMSO], docusate, sodium lauryl sulfate or aminosulfonic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D65/00—Wrappers or flexible covers; Packaging materials of special type or form
    • B65D65/02—Wrappers or flexible covers
    • B65D65/16—Wrappers or flexible covers with provision for excluding or admitting light
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D75/00—Packages comprising articles or materials partially or wholly enclosed in strips, sheets, blanks, tubes, or webs of flexible sheet material, e.g. in folded wrappers
    • B65D75/28—Articles or materials wholly enclosed in composite wrappers, i.e. wrappers formed by associating or interconnecting two or more sheets or blanks
    • B65D75/30—Articles or materials enclosed between two opposed sheets or blanks having their margins united, e.g. by pressure-sensitive adhesive, crimping, heat-sealing, or welding
    • B65D75/32—Articles or materials enclosed between two opposed sheets or blanks having their margins united, e.g. by pressure-sensitive adhesive, crimping, heat-sealing, or welding one or both sheets or blanks being recessed to accommodate contents
    • B65D75/325—Articles or materials enclosed between two opposed sheets or blanks having their margins united, e.g. by pressure-sensitive adhesive, crimping, heat-sealing, or welding one or both sheets or blanks being recessed to accommodate contents one sheet being recessed, and the other being a flat not- rigid sheet, e.g. puncturable or peelable foil
    • B65D75/327—Articles or materials enclosed between two opposed sheets or blanks having their margins united, e.g. by pressure-sensitive adhesive, crimping, heat-sealing, or welding one or both sheets or blanks being recessed to accommodate contents one sheet being recessed, and the other being a flat not- rigid sheet, e.g. puncturable or peelable foil and forming several compartments

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Mechanical Engineering (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Organic Chemistry (AREA)
  • Composite Materials (AREA)
  • Pain & Pain Management (AREA)
  • Dermatology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Rheumatology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Medicinal Preparation (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

내용 없음

Description

나프록센의 나트륨염을 함유하는 주사가능한 포뮬레이션
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
제1도는 유리병 또는 약병 용기의 평면도, 제2도는 제1도의 측면도, 제3도는 제1도의 정면도.

Claims (10)

  1. 치료하기에 효과적인 분량의 나프록센의 나트륨임. 안정화제, 폴리히드록실릭 알콜올 및 경우에 따라서는 부형약(excipent; 賦形藥)을 함유하는 수성의 주사가능한 의약 포뮬레이션.
  2. 청구범위 1항에 있어서, 나프록센의 나트륨염량은 용액의 3-15중량%이며, 안정화제의 량은 0.25-5중량%이고 폴리히드록실릭 알코올의 량은 5-50중량%인 의약 포뮬레에션.
  3. 청구범위 제2항에 있어서, 1회용 투여량은 나프록센의 나트륨염이 200-1000㎎, 안정화제가 10-300㎎ 및 폴리히드록실릭 알코올이 200-2000㎎인 의약 포뮬레이션.
  4. 청구범위 제1, 2 및 제3항중 어느 한항에 있어서, 안정화제는 Ｎ-아세틸-Ｌ-시스테인, 시스테인, 시스테아민, 시스타민, 글루타치온, 이미다졸 및 이들의 혼합물로 부터 선택되는 의약 포뮬레이션.
  5. 청구범위 제1, 2항 및 3항중 어느 한항에 있어서, 폴리히드록실릭 알코올은 프로필렌글리골, 솔리톨, 만니톨, 크실리톨, 글리세톨, 이노시톨 및 이들의 혼합물로 부터 선택되는 의약포뮬레이션.
  6. 제1, 2및 3도에 도시된 바와같이 복사 광을 흡수하는 필름(4)으로 씌어진 1회용 유리병 또는 약병을 위한 러징(lodgin; 3)의 구역을 나타내는 일연의 간막이 벽(2)이 그 내부에 포함되어 있는 평행육면체(1) 모양을 갖는 폴리스티렌 상자로 만들어진 것을 특징으로하는 유리병 또는 약병의 용기.
  7. 청구범위의 제6항에 있어서, 필름(4)을 형성하는 물질은 다양한 색깔의 투명하거나불투명한 열 용접(thermowelable) 알루미늄 및 플래스틱물질로 부터 선택되며 폴리텐, 셀로판, 폴리비닐클로라이드 및 폴리스티렌으로 부터 선택되는 용기.
  8. 청구범위 제1-5항에 따른 의약 포뮬레이션의 청구범위 제6항, 7항에 따른 용기내에 들어 있는 유리병 또는 약병에 나눠담는 포장.
  9. 청구범위 제8항에 있어서, 암록색 폴리스티렌 필름으로 씌어진 4㎖용적의 유리병 6개를 한 용기에 담는 포장으로서, 상기 각 유리병에는 다음의 조성물, 즉 나프록센 나트륨염 275㎖, Ｎ-아세틸-Ｌ-시스테인 50㎖, 프로필렌 글리콜 400㎖, 리도카인에 해당하는 당량의 리도카인 및 리도카인 드로 클로라이드 혼합물 20㎖, 주사가능한 조제용 물 미량-4㎖이 들어 있는 포장.
  10. 질소 분위기하에서, 예측된 량의 주사가능한 조제용 물중 약 2/3분량에 안정화제를 용해시키는 공정과, 수산나트륨 또는 1Ｎ염산의 10%(ｗ/ｖ)수용액을 사용하여 상기 용액의 pH를 7.5-9.5사이로 조절하는 공정과, 질소 분위기 하에서 폴리히드록실릭 알코올, 나프록센의 나트륨염 및 경우에 따라서는 약간의 부형약을 첨가하여 용해시키는 공정과, 질소 분위기하에서 주사가능한 조제용 물을 첨가하여 원하는 최종 부피로 만들면서 동시에 수산화나트륨 또는 1Ｎ염산의 10%(ｗ/ｖ)수용액을 첨가하여 pH값을 조절하는 공정과, 무균상태로 여과하는 공정과, 질소 분위기하의 무균상태에서 유리병 또는 약병에 상기 용액을 담는 공정 및 청구범위 제6, 7에 따른 용기안에 상기 유리병 또는 약병을 포장하는 공정을 포함하는 청구범위 8항에 따른 포장의 제조공정.
    ※ 참고사항 : 최초출원 내용에 의하여 공개되는 것임.
KR1019900021881A 1990-04-17 1990-12-27 수성 주사 약제 포물레이션과 그 제조방법 KR0180230B1 (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT00345290A IT1242642B (it) 1990-04-17 1990-04-17 Formulazioni iniettabili contenenti naproxen sale sodico.
IT3452A/90 1990-04-17

Publications (2)

Publication Number Publication Date
KR910021240A true KR910021240A (ko) 1991-12-20
KR0180230B1 KR0180230B1 (ko) 1999-03-20

Family

ID=11107641

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019900021881A KR0180230B1 (ko) 1990-04-17 1990-12-27 수성 주사 약제 포물레이션과 그 제조방법

Country Status (11)

Country Link
US (2) US5096926A (ko)
EP (1) EP0463228A3 (ko)
JP (1) JPH045230A (ko)
KR (1) KR0180230B1 (ko)
AU (1) AU627639B2 (ko)
CA (1) CA2031994A1 (ko)
IE (1) IE904291A1 (ko)
IT (1) IT1242642B (ko)
NZ (1) NZ236356A (ko)
PT (1) PT96263A (ko)
ZA (1) ZA909949B (ko)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4135277C2 (de) * 1991-10-25 1994-12-22 Rexroth Mannesmann Gmbh Regeleinrichtung für eine verstellbare Hydraulikpumpe
SE9202128D0 (sv) * 1992-07-09 1992-07-09 Astra Ab Precipitation of one or more active compounds in situ
US5834479A (en) * 1993-03-05 1998-11-10 Mayer; David J. Method and composition for alleviating pain
ATE221919T1 (de) * 1994-05-06 2002-08-15 Beckman Coulter Inc In flüssiger form stabiler thiolaktivator
US5904935A (en) * 1995-06-07 1999-05-18 Alza Corporation Peptide/protein suspending formulations
US6197787B1 (en) 1997-03-03 2001-03-06 Sanofi-Synthelabo Pharmaceutical formulations containing poorly soluble drug substances
DE19715594A1 (de) * 1997-04-15 1998-10-22 Bayer Ag Analgetika-Kombination
US6153225A (en) * 1998-08-13 2000-11-28 Elan Pharma International Limited Injectable formulations of nanoparticulate naproxen
US6552082B2 (en) * 2000-06-29 2003-04-22 Ono Pharmaceutical Co., Ltd. Solution of N-[o-(p-pivaloyloxybenzenesulfonylamino)benzoyl] glycine monosodium salt tetra-hydrate and drug product thereof
MXPA05000232A (es) 2002-06-21 2005-06-17 Transform Pharmaceuticals Inc Composiciones farmaceuticas con disolucion mejorada.
US7166641B2 (en) * 2002-10-02 2007-01-23 Yung Shin Pharmaceutical Industrial Co., Ltd. Pharmaceutically acceptable salts containing local anesthetic and anti-inflammatory activities and methods for preparing the same
US8183290B2 (en) 2002-12-30 2012-05-22 Mcneil-Ppc, Inc. Pharmaceutically acceptable propylene glycol solvate of naproxen
US20060020035A1 (en) * 2004-03-11 2006-01-26 Oregon Health & Science University Bone marrow protection with N-acetyl-L-cysteine
CN105314212B (zh) * 2014-07-07 2018-03-02 河南科技大学第一附属医院 一种药品切割存放盒
WO2023043207A1 (ko) * 2021-09-15 2023-03-23 구주제약주식회사 안정성이 향상된 프로피오닉산 계열 약물 및 안정화제를 포함하는 약학 조성물

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3207302A (en) * 1962-07-10 1965-09-21 American Home Prod Tamper-proof container for hypodermic syringes
US3707227A (en) * 1970-07-06 1972-12-26 Owens Illinois Inc Tray package for tubes
US3873718A (en) * 1973-03-29 1975-03-25 Syntex Corp Method for delaying the onset of, or postponing, parturition
US4150744A (en) * 1976-02-27 1979-04-24 Smith & Nephew Pharmaceuticals Ltd. Packaging
DE2914788A1 (de) * 1979-04-11 1980-10-16 Nattermann A & Cie Parenteral applizierbare, stabile arzneimittelloesungen mit entzuendungshemmender wirkung
FR2525108B1 (fr) * 1982-04-19 1989-05-12 Elan Corp Ltd Medicaments a haut degre de solubilite et procede pour leur obtention
EP0106290B1 (en) * 1982-10-08 1988-04-06 TERUMO KABUSHIKI KAISHA trading as TERUMO CORPORATION Evacuated blood collecting device
FR2545066B1 (fr) * 1983-04-27 1986-01-24 Levy Claude Emballage, notamment pour le transport et l'expedition de produits, biologiques, par exemple
DE3328401A1 (de) * 1983-08-05 1985-02-21 Merckle GmbH, 7902 Blaubeuren Injizierbare loesung zur behandlung von entzuendungen
DE3446873A1 (de) * 1984-12-21 1986-07-10 Merckle Gmbh Fluessige diclofenac-zubereitungen
DE3522550A1 (de) * 1985-06-24 1987-01-02 Klinge Co Chem Pharm Fab Aufspruehbare pharmazeutische zubereitung fuer die topische anwendung
US4799590A (en) * 1987-02-02 1989-01-24 Furman Theodore J Package and method of packaging

Also Published As

Publication number Publication date
IT9003452A0 (it) 1990-04-17
ZA909949B (en) 1991-10-30
JPH045230A (ja) 1992-01-09
EP0463228A3 (en) 1992-03-25
AU627639B2 (en) 1992-08-27
US5096926A (en) 1992-03-17
KR0180230B1 (ko) 1999-03-20
CA2031994A1 (en) 1991-10-18
NZ236356A (en) 1993-01-27
IE904291A1 (en) 1991-10-23
IT9003452A1 (it) 1991-10-18
PT96263A (pt) 1991-10-31
IT1242642B (it) 1994-05-16
EP0463228A2 (en) 1992-01-02
AU6769190A (en) 1991-10-24
US5128373A (en) 1992-07-07

Similar Documents

Publication Publication Date Title
KR910021240A (ko) 나프록센의 나트륨염을 함유하는 주사가능한 포뮬레이션
ES2198127T3 (es) Composiciones farmaceuticas autoclaveables que contienen un agente quelante.
ES2808050T3 (es) Método y composición para tratar la hipertensión ocular y el glaucoma
ES2247711T3 (es) Composiciones oftalmicas que contienen terpenoides para lentes de contacto.
UA73584C2 (en) High concentrated stable solutions of meloxicam
ES2220716T3 (es) Composicion farmaceutica que comprende pemetrexed con monotioglicerol, l-cisteina y acido tioglicolico.
US4164569A (en) Stabilized soft gelatin capsule composition of 1 α-hydroxy-vitamin D
JPS5016594B1 (ko)
KR20200099547A (ko) 2-아미노-3-(4-브로모벤조일)페닐아세트산 또는 그의 염을 함유하는 점안제
US5362758A (en) Ophthalmic piroxicam solution
BRPI0418005B1 (pt) composição farmacêutica de vinflunina, utilização de uma composição, e, processo de preparação de uma composição
GB2021946A (en) Pharmaceutical Formulations Containing Cis-platinum (II) Diamminedichloride
RU2662067C2 (ru) Прозрачный водный раствор
PE20211892A1 (es) Composicion liquida de clotrimazol envasada de dosis unica
BR0313064A (pt) Forma de dosagem farmacêutica compreendendo um composto de sulfito
JP7541984B2 (ja) エピネフリンの安定な水性注射溶液
CA2496796A1 (en) Medicinal product packaging
WO2008147169A2 (es) Microemolsion conteniendo pirfenidona
US3526698A (en) Stabilization of levo-3-(3,4-dihydroxyphenyl)-2-methylalanine with sodium bisulfite and sorbitol
ITTO20030053U1 (it) Unita' per il dosaggio giornaliero di melatonina.
ES2277657T3 (es) Uso de un recipiente hecho de un material plastico que contiene un aditivo inorganico.
PT1562585E (pt) Unidades de dosagem diária de melatonina
KR20210001695U (ko) 동물성 연질캡슐 손 소독제
KR20010072412A (ko) 경피 투여용 아스피린
KR20220000033U (ko) 이중 씰링 구조의 공기 노출 차단용 화장품 용기

Legal Events

Date Code Title Description
A201 Request for examination
E902 Notification of reason for refusal
E701 Decision to grant or registration of patent right
GRNT Written decision to grant
FPAY Annual fee payment

Payment date: 20011126

Year of fee payment: 4

LAPS Lapse due to unpaid annual fee