KR910021240A - 나프록센의 나트륨염을 함유하는 주사가능한 포뮬레이션 - Google Patents
나프록센의 나트륨염을 함유하는 주사가능한 포뮬레이션 Download PDFInfo
- Publication number
- KR910021240A KR910021240A KR1019900021881A KR900021881A KR910021240A KR 910021240 A KR910021240 A KR 910021240A KR 1019900021881 A KR1019900021881 A KR 1019900021881A KR 900021881 A KR900021881 A KR 900021881A KR 910021240 A KR910021240 A KR 910021240A
- Authority
- KR
- South Korea
- Prior art keywords
- naproxen
- vial
- sodium salt
- pharmaceutical formulation
- container
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/20—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing sulfur, e.g. dimethyl sulfoxide [DMSO], docusate, sodium lauryl sulfate or aminosulfonic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
- B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
- B65D65/00—Wrappers or flexible covers; Packaging materials of special type or form
- B65D65/02—Wrappers or flexible covers
- B65D65/16—Wrappers or flexible covers with provision for excluding or admitting light
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
- B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
- B65D75/00—Packages comprising articles or materials partially or wholly enclosed in strips, sheets, blanks, tubes, or webs of flexible sheet material, e.g. in folded wrappers
- B65D75/28—Articles or materials wholly enclosed in composite wrappers, i.e. wrappers formed by associating or interconnecting two or more sheets or blanks
- B65D75/30—Articles or materials enclosed between two opposed sheets or blanks having their margins united, e.g. by pressure-sensitive adhesive, crimping, heat-sealing, or welding
- B65D75/32—Articles or materials enclosed between two opposed sheets or blanks having their margins united, e.g. by pressure-sensitive adhesive, crimping, heat-sealing, or welding one or both sheets or blanks being recessed to accommodate contents
- B65D75/325—Articles or materials enclosed between two opposed sheets or blanks having their margins united, e.g. by pressure-sensitive adhesive, crimping, heat-sealing, or welding one or both sheets or blanks being recessed to accommodate contents one sheet being recessed, and the other being a flat not- rigid sheet, e.g. puncturable or peelable foil
- B65D75/327—Articles or materials enclosed between two opposed sheets or blanks having their margins united, e.g. by pressure-sensitive adhesive, crimping, heat-sealing, or welding one or both sheets or blanks being recessed to accommodate contents one sheet being recessed, and the other being a flat not- rigid sheet, e.g. puncturable or peelable foil and forming several compartments
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Mechanical Engineering (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Organic Chemistry (AREA)
- Composite Materials (AREA)
- Pain & Pain Management (AREA)
- Dermatology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biomedical Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Rheumatology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Medicinal Preparation (AREA)
- Medical Preparation Storing Or Oral Administration Devices (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
내용 없음
Description
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
제1도는 유리병 또는 약병 용기의 평면도, 제2도는 제1도의 측면도, 제3도는 제1도의 정면도.
Claims (10)
- 치료하기에 효과적인 분량의 나프록센의 나트륨임. 안정화제, 폴리히드록실릭 알콜올 및 경우에 따라서는 부형약(excipent; 賦形藥)을 함유하는 수성의 주사가능한 의약 포뮬레이션.
- 청구범위 1항에 있어서, 나프록센의 나트륨염량은 용액의 3-15중량%이며, 안정화제의 량은 0.25-5중량%이고 폴리히드록실릭 알코올의 량은 5-50중량%인 의약 포뮬레에션.
- 청구범위 제2항에 있어서, 1회용 투여량은 나프록센의 나트륨염이 200-1000㎎, 안정화제가 10-300㎎ 및 폴리히드록실릭 알코올이 200-2000㎎인 의약 포뮬레이션.
- 청구범위 제1, 2 및 제3항중 어느 한항에 있어서, 안정화제는 N-아세틸-L-시스테인, 시스테인, 시스테아민, 시스타민, 글루타치온, 이미다졸 및 이들의 혼합물로 부터 선택되는 의약 포뮬레이션.
- 청구범위 제1, 2항 및 3항중 어느 한항에 있어서, 폴리히드록실릭 알코올은 프로필렌글리골, 솔리톨, 만니톨, 크실리톨, 글리세톨, 이노시톨 및 이들의 혼합물로 부터 선택되는 의약포뮬레이션.
- 제1, 2및 3도에 도시된 바와같이 복사 광을 흡수하는 필름(4)으로 씌어진 1회용 유리병 또는 약병을 위한 러징(lodgin; 3)의 구역을 나타내는 일연의 간막이 벽(2)이 그 내부에 포함되어 있는 평행육면체(1) 모양을 갖는 폴리스티렌 상자로 만들어진 것을 특징으로하는 유리병 또는 약병의 용기.
- 청구범위의 제6항에 있어서, 필름(4)을 형성하는 물질은 다양한 색깔의 투명하거나불투명한 열 용접(thermowelable) 알루미늄 및 플래스틱물질로 부터 선택되며 폴리텐, 셀로판, 폴리비닐클로라이드 및 폴리스티렌으로 부터 선택되는 용기.
- 청구범위 제1-5항에 따른 의약 포뮬레이션의 청구범위 제6항, 7항에 따른 용기내에 들어 있는 유리병 또는 약병에 나눠담는 포장.
- 청구범위 제8항에 있어서, 암록색 폴리스티렌 필름으로 씌어진 4㎖용적의 유리병 6개를 한 용기에 담는 포장으로서, 상기 각 유리병에는 다음의 조성물, 즉 나프록센 나트륨염 275㎖, N-아세틸-L-시스테인 50㎖, 프로필렌 글리콜 400㎖, 리도카인에 해당하는 당량의 리도카인 및 리도카인 드로 클로라이드 혼합물 20㎖, 주사가능한 조제용 물 미량-4㎖이 들어 있는 포장.
- 질소 분위기하에서, 예측된 량의 주사가능한 조제용 물중 약 2/3분량에 안정화제를 용해시키는 공정과, 수산나트륨 또는 1N염산의 10%(w/v)수용액을 사용하여 상기 용액의 pH를 7.5-9.5사이로 조절하는 공정과, 질소 분위기 하에서 폴리히드록실릭 알코올, 나프록센의 나트륨염 및 경우에 따라서는 약간의 부형약을 첨가하여 용해시키는 공정과, 질소 분위기하에서 주사가능한 조제용 물을 첨가하여 원하는 최종 부피로 만들면서 동시에 수산화나트륨 또는 1N염산의 10%(w/v)수용액을 첨가하여 pH값을 조절하는 공정과, 무균상태로 여과하는 공정과, 질소 분위기하의 무균상태에서 유리병 또는 약병에 상기 용액을 담는 공정 및 청구범위 제6, 7에 따른 용기안에 상기 유리병 또는 약병을 포장하는 공정을 포함하는 청구범위 8항에 따른 포장의 제조공정.※ 참고사항 : 최초출원 내용에 의하여 공개되는 것임.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IT00345290A IT1242642B (it) | 1990-04-17 | 1990-04-17 | Formulazioni iniettabili contenenti naproxen sale sodico. |
IT3452A/90 | 1990-04-17 |
Publications (2)
Publication Number | Publication Date |
---|---|
KR910021240A true KR910021240A (ko) | 1991-12-20 |
KR0180230B1 KR0180230B1 (ko) | 1999-03-20 |
Family
ID=11107641
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
KR1019900021881A KR0180230B1 (ko) | 1990-04-17 | 1990-12-27 | 수성 주사 약제 포물레이션과 그 제조방법 |
Country Status (11)
Country | Link |
---|---|
US (2) | US5096926A (ko) |
EP (1) | EP0463228A3 (ko) |
JP (1) | JPH045230A (ko) |
KR (1) | KR0180230B1 (ko) |
AU (1) | AU627639B2 (ko) |
CA (1) | CA2031994A1 (ko) |
IE (1) | IE904291A1 (ko) |
IT (1) | IT1242642B (ko) |
NZ (1) | NZ236356A (ko) |
PT (1) | PT96263A (ko) |
ZA (1) | ZA909949B (ko) |
Families Citing this family (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE4135277C2 (de) * | 1991-10-25 | 1994-12-22 | Rexroth Mannesmann Gmbh | Regeleinrichtung für eine verstellbare Hydraulikpumpe |
SE9202128D0 (sv) * | 1992-07-09 | 1992-07-09 | Astra Ab | Precipitation of one or more active compounds in situ |
US5834479A (en) * | 1993-03-05 | 1998-11-10 | Mayer; David J. | Method and composition for alleviating pain |
ATE221919T1 (de) * | 1994-05-06 | 2002-08-15 | Beckman Coulter Inc | In flüssiger form stabiler thiolaktivator |
US5904935A (en) * | 1995-06-07 | 1999-05-18 | Alza Corporation | Peptide/protein suspending formulations |
US6197787B1 (en) | 1997-03-03 | 2001-03-06 | Sanofi-Synthelabo | Pharmaceutical formulations containing poorly soluble drug substances |
DE19715594A1 (de) * | 1997-04-15 | 1998-10-22 | Bayer Ag | Analgetika-Kombination |
US6153225A (en) * | 1998-08-13 | 2000-11-28 | Elan Pharma International Limited | Injectable formulations of nanoparticulate naproxen |
US6552082B2 (en) * | 2000-06-29 | 2003-04-22 | Ono Pharmaceutical Co., Ltd. | Solution of N-[o-(p-pivaloyloxybenzenesulfonylamino)benzoyl] glycine monosodium salt tetra-hydrate and drug product thereof |
MXPA05000232A (es) | 2002-06-21 | 2005-06-17 | Transform Pharmaceuticals Inc | Composiciones farmaceuticas con disolucion mejorada. |
US7166641B2 (en) * | 2002-10-02 | 2007-01-23 | Yung Shin Pharmaceutical Industrial Co., Ltd. | Pharmaceutically acceptable salts containing local anesthetic and anti-inflammatory activities and methods for preparing the same |
US8183290B2 (en) | 2002-12-30 | 2012-05-22 | Mcneil-Ppc, Inc. | Pharmaceutically acceptable propylene glycol solvate of naproxen |
US20060020035A1 (en) * | 2004-03-11 | 2006-01-26 | Oregon Health & Science University | Bone marrow protection with N-acetyl-L-cysteine |
CN105314212B (zh) * | 2014-07-07 | 2018-03-02 | 河南科技大学第一附属医院 | 一种药品切割存放盒 |
WO2023043207A1 (ko) * | 2021-09-15 | 2023-03-23 | 구주제약주식회사 | 안정성이 향상된 프로피오닉산 계열 약물 및 안정화제를 포함하는 약학 조성물 |
Family Cites Families (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3207302A (en) * | 1962-07-10 | 1965-09-21 | American Home Prod | Tamper-proof container for hypodermic syringes |
US3707227A (en) * | 1970-07-06 | 1972-12-26 | Owens Illinois Inc | Tray package for tubes |
US3873718A (en) * | 1973-03-29 | 1975-03-25 | Syntex Corp | Method for delaying the onset of, or postponing, parturition |
US4150744A (en) * | 1976-02-27 | 1979-04-24 | Smith & Nephew Pharmaceuticals Ltd. | Packaging |
DE2914788A1 (de) * | 1979-04-11 | 1980-10-16 | Nattermann A & Cie | Parenteral applizierbare, stabile arzneimittelloesungen mit entzuendungshemmender wirkung |
FR2525108B1 (fr) * | 1982-04-19 | 1989-05-12 | Elan Corp Ltd | Medicaments a haut degre de solubilite et procede pour leur obtention |
EP0106290B1 (en) * | 1982-10-08 | 1988-04-06 | TERUMO KABUSHIKI KAISHA trading as TERUMO CORPORATION | Evacuated blood collecting device |
FR2545066B1 (fr) * | 1983-04-27 | 1986-01-24 | Levy Claude | Emballage, notamment pour le transport et l'expedition de produits, biologiques, par exemple |
DE3328401A1 (de) * | 1983-08-05 | 1985-02-21 | Merckle GmbH, 7902 Blaubeuren | Injizierbare loesung zur behandlung von entzuendungen |
DE3446873A1 (de) * | 1984-12-21 | 1986-07-10 | Merckle Gmbh | Fluessige diclofenac-zubereitungen |
DE3522550A1 (de) * | 1985-06-24 | 1987-01-02 | Klinge Co Chem Pharm Fab | Aufspruehbare pharmazeutische zubereitung fuer die topische anwendung |
US4799590A (en) * | 1987-02-02 | 1989-01-24 | Furman Theodore J | Package and method of packaging |
-
1990
- 1990-04-17 IT IT00345290A patent/IT1242642B/it active IP Right Grant
- 1990-11-28 IE IE429190A patent/IE904291A1/en unknown
- 1990-11-28 EP EP19900122739 patent/EP0463228A3/en not_active Withdrawn
- 1990-12-03 AU AU67691/90A patent/AU627639B2/en not_active Ceased
- 1990-12-05 NZ NZ236356A patent/NZ236356A/xx unknown
- 1990-12-06 US US07/622,925 patent/US5096926A/en not_active Expired - Fee Related
- 1990-12-11 ZA ZA909949A patent/ZA909949B/xx unknown
- 1990-12-11 CA CA002031994A patent/CA2031994A1/en not_active Abandoned
- 1990-12-19 PT PT96263A patent/PT96263A/pt unknown
- 1990-12-26 JP JP2406772A patent/JPH045230A/ja active Pending
- 1990-12-27 KR KR1019900021881A patent/KR0180230B1/ko not_active IP Right Cessation
-
1991
- 1991-04-02 US US07/679,113 patent/US5128373A/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
IT9003452A0 (it) | 1990-04-17 |
ZA909949B (en) | 1991-10-30 |
JPH045230A (ja) | 1992-01-09 |
EP0463228A3 (en) | 1992-03-25 |
AU627639B2 (en) | 1992-08-27 |
US5096926A (en) | 1992-03-17 |
KR0180230B1 (ko) | 1999-03-20 |
CA2031994A1 (en) | 1991-10-18 |
NZ236356A (en) | 1993-01-27 |
IE904291A1 (en) | 1991-10-23 |
IT9003452A1 (it) | 1991-10-18 |
PT96263A (pt) | 1991-10-31 |
IT1242642B (it) | 1994-05-16 |
EP0463228A2 (en) | 1992-01-02 |
AU6769190A (en) | 1991-10-24 |
US5128373A (en) | 1992-07-07 |
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