KR910007871A - 아로일-우레아 - Google Patents
아로일-우레아 Download PDFInfo
- Publication number
- KR910007871A KR910007871A KR1019900015959A KR900015959A KR910007871A KR 910007871 A KR910007871 A KR 910007871A KR 1019900015959 A KR1019900015959 A KR 1019900015959A KR 900015959 A KR900015959 A KR 900015959A KR 910007871 A KR910007871 A KR 910007871A
- Authority
- KR
- South Korea
- Prior art keywords
- azabicyclo
- endo
- methyl
- octan
- compound
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
- C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
- C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Psychiatry (AREA)
- Anesthesiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Glass Compositions (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Removal Of Specific Substances (AREA)
- Saccharide Compounds (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
내용 없음
Description
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
Claims (7)
- (엔도)-N-〔〔(8-메틸-8-아자비사이클로〔3.2.1〕옥탄-3-일〕아미노〕카보닐〕-2-(사이클로프로필메톡시)벤젠 아미드 또는 이의 약제학적으로 허용되는 산부가염.
- (a) 2-사이클로프로필메톡시벤조일이소시아네이트를 (엔도)-8-메틸-8-아자비사이클로〔3.2.1〕옥탄-3-아민과 반응시키거나. (b) 2-사이클로프로필메톡시벤조일우레아를(엔도)-8-메틸-8-아자비사이클로〔3.2.1〕옥탄-3-아민과 반응시키거나, (c) 2-(사이클로프로필메톡시)벤즈아미드를(엔도)-8-메틸-8-아자비사이클로〔3.2.1〕옥탄-3-이소시아네이트와 반응시키거나. (d) 1-〔(엔도)-8-메틸-8-아자비사이클로〔3.2.1〕옥탄-3-일〕우레아를 2-(사이클로프로필메톡시)벤조산 또는 이의 아실화 유도체로 아실화시키거나, (e) (엔도)-N-〔〔(8-메틸-8-아자비사이클로〔3.2.1〕옥탄-3-일〕아미노〕카보닐〕-2-하이드록시벤즈아미드를 사이클로프로필메틸화 시키거나, (f) 사이클로프로필메탄올을 일반식(Ⅷ)의 화합물과 반응시키거나, (g) 구조식(Ⅸ)의 화합2물을 메틸화시키거나, (h) 유리염기, (엔도)-N-〔〔(8-메틸-8-아자비사이클로〔3.2.1〕옥탄-3-일〕아미노〕카보닐〕-2-(사이클로프로필메톡시)벤즈 아미드를 이의 약제학적으로 허용되는 산부가염으로 전환시키거나 산부가염을 유리 염기로 전환시킴을 특징으로 하여, 제1항에 따른 화합물을제조하는 방법.상기식에서 X는 이탈그룹이다.
- 제1항에서 청구한 화합물을 약제학적으로 허용되는 담체와 결합된 형태로 포함하는 약제학적 조성물.
- 제3항에 있어서 사이클로-옥시게나제 억제제를 추가로 함유하는 약제학적 조성물.
- 제1항에 따른 화합물 및 암 치료에 있어서 동시, 별도 또는 연속 투여용 배합제제로서 암화학 요법제를 함유하는 약제.
- 약제로서의 용도를 위한 제1항에 청구된 화합물.
- 불안 해소제로서의 용도를 위한 제1항에 청구된 화합물.※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB89226229 | 1989-10-07 | ||
GB898922622A GB8922622D0 (en) | 1989-10-07 | 1989-10-07 | Aroylureas |
Publications (2)
Publication Number | Publication Date |
---|---|
KR910007871A true KR910007871A (ko) | 1991-05-30 |
KR100196263B1 KR100196263B1 (ko) | 1999-06-15 |
Family
ID=10664224
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
KR1019900015959A KR100196263B1 (ko) | 1989-10-07 | 1990-10-06 | 아로일 우레아 유도체 |
Country Status (22)
Country | Link |
---|---|
EP (1) | EP0422846B1 (ko) |
JP (1) | JP2960141B2 (ko) |
KR (1) | KR100196263B1 (ko) |
CN (1) | CN1042534C (ko) |
AT (1) | ATE101607T1 (ko) |
AU (1) | AU634584B2 (ko) |
CA (1) | CA2027041C (ko) |
CZ (1) | CZ280228B6 (ko) |
DE (1) | DE69006675T2 (ko) |
DK (1) | DK0422846T3 (ko) |
ES (1) | ES2062398T3 (ko) |
FI (1) | FI96419C (ko) |
GB (2) | GB8922622D0 (ko) |
HU (1) | HU204821B (ko) |
IE (1) | IE64043B1 (ko) |
IL (1) | IL95892A (ko) |
MX (1) | MX22719A (ko) |
NZ (1) | NZ235583A (ko) |
PT (1) | PT95490B (ko) |
RU (2) | RU1817778C (ko) |
SK (1) | SK480890A3 (ko) |
ZA (1) | ZA907993B (ko) |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB8922622D0 (en) * | 1989-10-07 | 1989-11-22 | Wyeth John & Brother Ltd | Aroylureas |
GB9106571D0 (en) * | 1991-03-27 | 1991-05-15 | Erba Carlo Spa | Derivatives of substituted imidazol-2-one and process for their preparation |
GB2269747B (en) * | 1992-08-19 | 1996-06-05 | Wyeth John & Brother Ltd | Aroyl-ureas as pharmaceuticals, particularly 5-ht3 antagonists |
GB9217629D0 (en) * | 1992-08-19 | 1992-09-30 | Wyeth John & Brother Ltd | Aroylureas |
GB9314174D0 (en) * | 1993-07-08 | 1993-08-18 | American Home Prod | 5-ht3-antagonists |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IE62231B1 (en) * | 1987-12-24 | 1995-01-11 | Wyeth John & Brother Ltd | Heterocyclic compounds |
DK443489D0 (da) * | 1989-09-08 | 1989-09-08 | Ferrosan As | Substituerede urinstofforbindelser, deres fremstilling og anvendelse |
GB8922622D0 (en) * | 1989-10-07 | 1989-11-22 | Wyeth John & Brother Ltd | Aroylureas |
-
1989
- 1989-10-07 GB GB898922622A patent/GB8922622D0/en active Pending
-
1990
- 1990-10-02 PT PT95490A patent/PT95490B/pt not_active IP Right Cessation
- 1990-10-03 CZ CS904808A patent/CZ280228B6/cs not_active IP Right Cessation
- 1990-10-03 SK SK4808-90A patent/SK480890A3/sk unknown
- 1990-10-03 IL IL9589290A patent/IL95892A/en not_active IP Right Cessation
- 1990-10-04 AU AU63749/90A patent/AU634584B2/en not_active Ceased
- 1990-10-05 DE DE69006675T patent/DE69006675T2/de not_active Expired - Fee Related
- 1990-10-05 ES ES90310933T patent/ES2062398T3/es not_active Expired - Lifetime
- 1990-10-05 CA CA002027041A patent/CA2027041C/en not_active Expired - Fee Related
- 1990-10-05 NZ NZ235583A patent/NZ235583A/en unknown
- 1990-10-05 GB GB9021695A patent/GB2236528B/en not_active Expired - Fee Related
- 1990-10-05 AT AT90310933T patent/ATE101607T1/de not_active IP Right Cessation
- 1990-10-05 MX MX2271990A patent/MX22719A/es unknown
- 1990-10-05 DK DK90310933.8T patent/DK0422846T3/da active
- 1990-10-05 RU SU904831445A patent/RU1817778C/ru active
- 1990-10-05 EP EP90310933A patent/EP0422846B1/en not_active Expired - Lifetime
- 1990-10-05 HU HU906355A patent/HU204821B/hu not_active IP Right Cessation
- 1990-10-05 ZA ZA907993A patent/ZA907993B/xx unknown
- 1990-10-05 FI FI904912A patent/FI96419C/fi not_active IP Right Cessation
- 1990-10-05 JP JP2269294A patent/JP2960141B2/ja not_active Expired - Lifetime
- 1990-10-05 IE IE358390A patent/IE64043B1/en not_active IP Right Cessation
- 1990-10-06 KR KR1019900015959A patent/KR100196263B1/ko not_active IP Right Cessation
- 1990-10-06 CN CN90108269A patent/CN1042534C/zh not_active Expired - Fee Related
-
1992
- 1992-02-28 RU SU925010951A patent/RU2036923C1/ru active
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Legal Events
Date | Code | Title | Description |
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A201 | Request for examination | ||
E902 | Notification of reason for refusal | ||
E701 | Decision to grant or registration of patent right | ||
GRNT | Written decision to grant | ||
LAPS | Lapse due to unpaid annual fee |