ES2035824T3 - Procedimiento para preparar compuestos profarmacos y preparaciones que los contienen. - Google Patents

Procedimiento para preparar compuestos profarmacos y preparaciones que los contienen.

Info

Publication number
ES2035824T3
ES2035824T3 ES198787103518T ES87103518T ES2035824T3 ES 2035824 T3 ES2035824 T3 ES 2035824T3 ES 198787103518 T ES198787103518 T ES 198787103518T ES 87103518 T ES87103518 T ES 87103518T ES 2035824 T3 ES2035824 T3 ES 2035824T3
Authority
ES
Spain
Prior art keywords
profarmac
preparing
compounds
procedure
preparations containing
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES198787103518T
Other languages
English (en)
Inventor
Masashi Hashimoto
Hidekazu Takeno
Hiroshi Kayakiri
Akira Kagayama
Yuji Tokunaga
Tomoaki Iwasa
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Fujisawa Pharmaceutical Co Ltd
Original Assignee
Fujisawa Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Fujisawa Pharmaceutical Co Ltd filed Critical Fujisawa Pharmaceutical Co Ltd
Application granted granted Critical
Publication of ES2035824T3 publication Critical patent/ES2035824T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J43/00—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C07J43/003—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton not condensed

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Steroid Compounds (AREA)

Abstract

LA INVENCION SE REFIERE A COMPUESTOS PRO-FARMACOS DE FORMULA A-CO(CH2)M(NHCO)N-R, EN LA QUE A ES UN GRUPO DE UN COMPUESTO FARMACEUTICO QUE TIENE EL GRUPO =NH O -NH2 EN LA MOLECULA, R ES UNA PORCION DE UN COMPUESTO ESTEROIDICO, M ES UN NUMERO ENTERO ENTRE 1 Y 5 Y N ES CERO O 1. TAMBIEN SE REFIERE A LAS SALES DE LOS CITADOS COMPUESTOS, A UN PROCEDIMIENTO PARA SU PREPARACION Y A UNA PREPARACION DE LIBERACION SOSTENIDA QUE LOS CONTIENE.
ES198787103518T 1986-03-14 1987-03-11 Procedimiento para preparar compuestos profarmacos y preparaciones que los contienen. Expired - Lifetime ES2035824T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP5792386 1986-03-14

Publications (1)

Publication Number Publication Date
ES2035824T3 true ES2035824T3 (es) 1993-05-01

Family

ID=13069519

Family Applications (1)

Application Number Title Priority Date Filing Date
ES198787103518T Expired - Lifetime ES2035824T3 (es) 1986-03-14 1987-03-11 Procedimiento para preparar compuestos profarmacos y preparaciones que los contienen.

Country Status (6)

Country Link
US (1) US4772594A (es)
EP (1) EP0237051B1 (es)
AT (1) ATE63124T1 (es)
DE (1) DE3769676D1 (es)
ES (1) ES2035824T3 (es)
GR (1) GR3001889T3 (es)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK406686D0 (da) * 1986-08-26 1986-08-26 Hans Bundgaard Carboxylsyrederivater
US5071598A (en) * 1987-12-03 1991-12-10 California Institute Of Technology Cryoprotective reagent
TW211015B (es) * 1990-01-11 1993-08-11 Nippon Shinyaku Co Ltd
DE69215722T3 (de) * 1991-03-22 2001-03-08 Katsuro Tachibana Verstärker zur Ultraschalltherapie von Erkrankungen sowie diesen enthaltende flüssige Arzneimittelzusammensetzungen
US5641758A (en) * 1993-11-10 1997-06-24 Kluge; Michael Cytarabine derivatives, the preparation and use thereof
FR2714382B1 (fr) * 1993-12-27 1996-02-02 Roussel Uclaf Phospholipides vecteur de molécule active, leur préparation et leur utilisation dans des compositions cosmétiques ou dermatologiques.
US5972379A (en) * 1995-02-14 1999-10-26 Sequus Pharmaceuticals, Inc. Liposome composition and method for administering a quinolone
SE9600229D0 (sv) * 1996-01-23 1996-01-23 Pharmacia Ab Novel potentiating agents
US6676626B1 (en) 1998-05-01 2004-01-13 Ekos Corporation Ultrasound assembly with increased efficacy
US6582392B1 (en) 1998-05-01 2003-06-24 Ekos Corporation Ultrasound assembly for use with a catheter
IL131887A0 (en) * 1999-09-14 2001-03-19 Dpharm Ltd Phospholipid prodrugs of anti-proliferative drugs
ATE319378T1 (de) 2001-12-03 2006-03-15 Ekos Corp Katheter mit mehreren ultraschall-abstrahlenden teilen
US8226629B1 (en) 2002-04-01 2012-07-24 Ekos Corporation Ultrasonic catheter power control
US6921371B2 (en) 2002-10-14 2005-07-26 Ekos Corporation Ultrasound radiating members for catheter
US7341569B2 (en) * 2004-01-30 2008-03-11 Ekos Corporation Treatment of vascular occlusions using ultrasonic energy and microbubbles
CA2604380A1 (en) * 2005-04-12 2006-10-19 Ekos Corporation Ultrasound catheter with cavitation promoting surface
EP2015846A2 (en) 2006-04-24 2009-01-21 Ekos Corporation Ultrasound therapy system
US10182833B2 (en) 2007-01-08 2019-01-22 Ekos Corporation Power parameters for ultrasonic catheter
DE102007029471A1 (de) * 2007-06-20 2008-12-24 Novosom Ag Neue fakultativ kationische Sterole
EP2170181B1 (en) 2007-06-22 2014-04-16 Ekos Corporation Method and apparatus for treatment of intracranial hemorrhages
EP2344447B1 (en) 2008-10-08 2016-06-08 Xgene Pharmaceutical Inc Gaba conjugates and methods of use thereof
US20100120727A1 (en) * 2008-11-12 2010-05-13 Kyphia Pharmaceuticals, Inc. Eflornithine Prodrugs, Conjugates and Salts, and Methods of Use Thereof
US8740835B2 (en) 2010-02-17 2014-06-03 Ekos Corporation Treatment of vascular occlusions using ultrasonic energy and microbubbles
CN104582732A (zh) 2012-06-15 2015-04-29 布里格姆及妇女医院股份有限公司 治疗癌症的组合物及其制造方法
WO2016201136A1 (en) 2015-06-10 2016-12-15 Ekos Corporation Ultrasound catheter
US20200164078A1 (en) * 2017-07-17 2020-05-28 Technische Universiteit Eindhoven Applicable chemical composition comprising an agent conjugated to a hydrophobic moiety and a carrier
CN114249791A (zh) * 2021-12-27 2022-03-29 北京工商大学 一种甾醇衍生的酰胺基寡肽型表面活性剂及其制备方法

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4260736A (en) * 1978-08-14 1981-04-07 Kureha Kagaku Kogyo Kabushiki Kaisha Steroid hormone-antitumor derivatives
JPS56147800A (en) * 1980-04-18 1981-11-16 Ajinomoto Co Inc N1-cholesteryloxycarbonyl-5-fluorouracil

Also Published As

Publication number Publication date
GR3001889T3 (en) 1992-11-23
EP0237051A3 (en) 1987-12-02
DE3769676D1 (de) 1991-06-06
EP0237051A2 (en) 1987-09-16
EP0237051B1 (en) 1991-05-02
US4772594A (en) 1988-09-20
ATE63124T1 (de) 1991-05-15

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