ES2035824T3 - PROCEDURE FOR PREPARING PROFARMAC COMPOUNDS AND PREPARATIONS CONTAINING THEM. - Google Patents

PROCEDURE FOR PREPARING PROFARMAC COMPOUNDS AND PREPARATIONS CONTAINING THEM.

Info

Publication number
ES2035824T3
ES2035824T3 ES198787103518T ES87103518T ES2035824T3 ES 2035824 T3 ES2035824 T3 ES 2035824T3 ES 198787103518 T ES198787103518 T ES 198787103518T ES 87103518 T ES87103518 T ES 87103518T ES 2035824 T3 ES2035824 T3 ES 2035824T3
Authority
ES
Spain
Prior art keywords
profarmac
preparing
compounds
procedure
preparations containing
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES198787103518T
Other languages
Spanish (es)
Inventor
Masashi Hashimoto
Hidekazu Takeno
Hiroshi Kayakiri
Akira Kagayama
Yuji Tokunaga
Tomoaki Iwasa
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Fujisawa Pharmaceutical Co Ltd
Original Assignee
Fujisawa Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Fujisawa Pharmaceutical Co Ltd filed Critical Fujisawa Pharmaceutical Co Ltd
Application granted granted Critical
Publication of ES2035824T3 publication Critical patent/ES2035824T3/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J43/00—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C07J43/003—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton not condensed

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Steroid Compounds (AREA)

Abstract

A Prodrug compound of the formula :     A-CO(CH2)m(NHCO)n-R wherein A is a residue of pharmaceutical compound having @@NH or -NH2 group in the molecule, R is a residue of steroid compound, m is an integer of l to 5 and n is 0 or l, and its salts, process for its preparation and a sustained release preparation comprising it.
ES198787103518T 1986-03-14 1987-03-11 PROCEDURE FOR PREPARING PROFARMAC COMPOUNDS AND PREPARATIONS CONTAINING THEM. Expired - Lifetime ES2035824T3 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP5792386 1986-03-14

Publications (1)

Publication Number Publication Date
ES2035824T3 true ES2035824T3 (en) 1993-05-01

Family

ID=13069519

Family Applications (1)

Application Number Title Priority Date Filing Date
ES198787103518T Expired - Lifetime ES2035824T3 (en) 1986-03-14 1987-03-11 PROCEDURE FOR PREPARING PROFARMAC COMPOUNDS AND PREPARATIONS CONTAINING THEM.

Country Status (6)

Country Link
US (1) US4772594A (en)
EP (1) EP0237051B1 (en)
AT (1) ATE63124T1 (en)
DE (1) DE3769676D1 (en)
ES (1) ES2035824T3 (en)
GR (1) GR3001889T3 (en)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK406686D0 (en) * 1986-08-26 1986-08-26 Hans Bundgaard carboxylic acid derivatives
US5071598A (en) * 1987-12-03 1991-12-10 California Institute Of Technology Cryoprotective reagent
TW211015B (en) * 1990-01-11 1993-08-11 Nippon Shinyaku Co Ltd
DE69215722T3 (en) * 1991-03-22 2001-03-08 Katsuro Tachibana Amplifiers for ultrasound therapy of diseases and liquid pharmaceutical compositions containing them
US5641758A (en) * 1993-11-10 1997-06-24 Kluge; Michael Cytarabine derivatives, the preparation and use thereof
FR2714382B1 (en) * 1993-12-27 1996-02-02 Roussel Uclaf Phospholipids vector of active molecule, their preparation and their use in cosmetic or dermatological compositions.
US5972379A (en) * 1995-02-14 1999-10-26 Sequus Pharmaceuticals, Inc. Liposome composition and method for administering a quinolone
SE9600229D0 (en) * 1996-01-23 1996-01-23 Pharmacia Ab Novel potentiating agents
US6582392B1 (en) * 1998-05-01 2003-06-24 Ekos Corporation Ultrasound assembly for use with a catheter
US6676626B1 (en) 1998-05-01 2004-01-13 Ekos Corporation Ultrasound assembly with increased efficacy
IL131887A0 (en) 1999-09-14 2001-03-19 Dpharm Ltd Phospholipid prodrugs of anti-proliferative drugs
ATE319378T1 (en) 2001-12-03 2006-03-15 Ekos Corp CATHETER WITH MULTIPLE ULTRASONIC EMITTING PARTS
US8226629B1 (en) 2002-04-01 2012-07-24 Ekos Corporation Ultrasonic catheter power control
US6921371B2 (en) 2002-10-14 2005-07-26 Ekos Corporation Ultrasound radiating members for catheter
US7341569B2 (en) 2004-01-30 2008-03-11 Ekos Corporation Treatment of vascular occlusions using ultrasonic energy and microbubbles
US20060264809A1 (en) * 2005-04-12 2006-11-23 Hansmann Douglas R Ultrasound catheter with cavitation promoting surface
US20070265560A1 (en) 2006-04-24 2007-11-15 Ekos Corporation Ultrasound Therapy System
US10182833B2 (en) 2007-01-08 2019-01-22 Ekos Corporation Power parameters for ultrasonic catheter
DE102007029471A1 (en) * 2007-06-20 2008-12-24 Novosom Ag New optional cationic sterols
PL2170181T3 (en) 2007-06-22 2014-08-29 Ekos Corp Method and apparatus for treatment of intracranial hemorrhages
WO2010042759A2 (en) * 2008-10-08 2010-04-15 Kyphia Pharmaceuticals Inc Gaba conjugates and methods of use thereof
US20100120727A1 (en) * 2008-11-12 2010-05-13 Kyphia Pharmaceuticals, Inc. Eflornithine Prodrugs, Conjugates and Salts, and Methods of Use Thereof
US8740835B2 (en) 2010-02-17 2014-06-03 Ekos Corporation Treatment of vascular occlusions using ultrasonic energy and microbubbles
JP6427097B2 (en) 2012-06-15 2018-11-21 ザ ブリガム アンド ウィメンズ ホスピタル インコーポレイテッドＴｈｅ Ｂｒｉｇｈａｍ ａｎｄ Ｗｏｍｅｎ’ｓ Ｈｏｓｐｉｔａｌ， Ｉｎｃ． Compositions for treating cancer and methods for producing said compositions
EP3307388B1 (en) 2015-06-10 2022-06-22 Ekos Corporation Ultrasound catheter
WO2019016208A1 (en) * 2017-07-17 2019-01-24 Technische Universiteit Eindhoven Applicable chemical composition comprising an agent conjugated to a hydrophobic moiety and a carrier
CN114249791A (en) * 2021-12-27 2022-03-29 北京工商大学 Sterol-derived amido oligopeptide surfactant and preparation method thereof

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4260736A (en) * 1978-08-14 1981-04-07 Kureha Kagaku Kogyo Kabushiki Kaisha Steroid hormone-antitumor derivatives
JPS56147800A (en) * 1980-04-18 1981-11-16 Ajinomoto Co Inc N1-cholesteryloxycarbonyl-5-fluorouracil

Also Published As

Publication number Publication date
ATE63124T1 (en) 1991-05-15
US4772594A (en) 1988-09-20
EP0237051A2 (en) 1987-09-16
GR3001889T3 (en) 1992-11-23
DE3769676D1 (en) 1991-06-06
EP0237051A3 (en) 1987-12-02
EP0237051B1 (en) 1991-05-02

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