KR910000700A - 레티노이드와 유사한 작용을 갖는 페놀과 테레프탈레이트의 티오크로만 에스텔류 - Google Patents

레티노이드와 유사한 작용을 갖는 페놀과 테레프탈레이트의 티오크로만 에스텔류 Download PDF

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KR910000700A
KR910000700A KR1019890009019A KR890009019A KR910000700A KR 910000700 A KR910000700 A KR 910000700A KR 1019890009019 A KR1019890009019 A KR 1019890009019A KR 890009019 A KR890009019 A KR 890009019A KR 910000700 A KR910000700 A KR 910000700A
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compound
pharmaceutically acceptable
oxy
acceptable salt
dimethyl
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KR1019890009019A
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에이. 에스. 챤드라라트나 로쉬안타
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제임스 엠. 캐내지
알러간, 인코포레이티드
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D335/00—Heterocyclic compounds containing six-membered rings having one sulfur atom as the only ring hetero atom
    • C07D335/04—Heterocyclic compounds containing six-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D335/06—Benzothiopyrans; Hydrogenated benzothiopyrans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

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  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
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  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Laminated Bodies (AREA)
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  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)

Abstract

내용 없음

Description

레티노이드와 유사한 작용을 갖는 페놀과 테레프탈레이트의 티오크로만 에스텔류
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (15)

  1. 다음 일반식의 화합물.
    상기식에서, R그룹은 독립적으로 수소이거나 저급알킬이며; A와 B중의 하나는 O이거나 S이고 다른 하나는 -C(O)이며, A는 6이나 7위치에 있는 티오크로만 고리에 부착되어 있으며; n은 0-5이고, E는 H이나, 또는 Z는 D가 -OH이거나 제약적 허용염이거나, D가 -OR1(여기서 R1은 에스텔 형성그룹임)이거나, D가 -N(R4)2(여기서 R4는 수소이거나, 지방족이거나 치환된 지방족임)인 -COD이거나, 또는 Z는 -COD이고, 또는 Z는 E가 수소이거나 에텔-형성그룹이나 아실에 에스텔 형성그룹이며, 또는 Z는 -CHO이거나 그것의 아세탈 유도체이며, 또는 Z는 R3가 -(CH2)mCH3초과하지 않음)이거나 그것의 게탈 유도체이다.
  2. 제1항에 있어서, A가 0이고, 6-위치에서 티오크로만 고리에 부착된 화합물.
  3. 제2항에 있어서, Z가 COOH이거나 에스텔 또는 그것의 아미드 또는 그것의 제약상 허용가능한 염인 화합물.
  4. 제3항에 있어서, 에틸 4,4-디메틸-6-티오크로마닐 테레프탈레이트; 또는 4,4-디메틸-6-티오크로마닐하이드로진 테레프탈이트이거나 그것의 제약적 허용염인 화합물.
  5. 제1항에 있어서, A가 0이고, 7-위치에서 티오크로만 고리에 부착된 화합물.
  6. 제2항에 있어서, Z가 COOH이거나 에스텔 또는 그것의 아미드 또는 그것의 제약상 허용가능한 염인 화합물.
  7. 제1항에 있어서, A가 C=0이고, 6위치에 있는 티오크로만 고리에 부착된 화합물.
  8. 제7항에 있어서, Z가 COOH이거나 에스텔 또는 그것의 아미드이거나 이것의 제약적 허용염인 화합물.
  9. 제8항에 있어서, 에틸 4-(4,4-디메틸-6-티오크로마노일 옥시)벤조에이트, 에틸 4-(4,4-트리메틸-6-티오크로마노일 옥시)벤조에이트, 4-(4,4,-디메틸-6-티오크로마노일 옥시)벤조산, 4-(4,4,7-트리메틸-6-티오크로마노일 옥시)벤조산이거나 그 산의 제약적 허용염인 화합물.
  10. 제8항에 있어서, 에틸 4-(2,2,4,4-테트라메틸-6-티오크로마노일 옥시)벤조에이트, 에틸 4-(2,2,4,4-펜타메틸-6-티오크로마닐 옥시)벤조에이트, 4-(2,2,4,4-디메틸-6-티오크로마노일 옥시)벤조산, 4-(2,2,4,4,7-테트라메틸-6-티오크로마노일 옥시)벤조산이거나 그 산의 제약적 허용염인 화합물.
  11. 제1항에 있어서, A가 C=0이고, 7-위치에서 티오크로만 고리에 부착된 화합물.
  12. 제11항에 있어서, Z가 COOH이거나 에스텔 또는 그것의 아미드 또는 그것의 제약적 허용가능염인 화합물.
  13. 제12항에 있어서, 4-(4,4-디메틸-7-티오크로마노일 옥시)벤조에이트이거나 그것의 제약적 허용염; 또는 에틸 4-(4,4-디메틸-7-티오크로마노일 옥시)벤조에이트인 화합물.
  14. 제약적으로 허용가능 부형제와 제1항의 화합물로 구성되는 제약조성물.
  15. 제1항의 화합물의 치료학적으로 유효한 양을 단독으로나, 제약학적으로 허용가능 부형제와 함께 투여하는 것으로 구성되는 포유동물에서 건선을 치료하는 방법.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019890009019A 1988-06-29 1989-06-29 레티노이드와 유사한 작용을 갖는 페놀과 테레프탈레이트의 티오크로만 에스텔류 KR0129091B1 (ko)

Applications Claiming Priority (2)

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US07/212,855 US4895868A (en) 1988-06-29 1988-06-29 Thiochroman esters of phenols and terephthallates having retinoid-like activity
US212855 1988-06-29

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US (1) US4895868A (ko)
EP (1) EP0405028B1 (ko)
JP (1) JPH0276874A (ko)
KR (1) KR0129091B1 (ko)
CN (1) CN1025332C (ko)
AT (1) ATE128976T1 (ko)
AU (1) AU619865B2 (ko)
CA (1) CA1334424C (ko)
DE (1) DE68924529T2 (ko)
DK (1) DK325389A (ko)
ES (1) ES2078238T3 (ko)
FI (1) FI893187A (ko)
HU (1) HU205925B (ko)
IL (1) IL90758A (ko)
MY (1) MY106972A (ko)
NO (1) NO172578C (ko)
NZ (1) NZ229721A (ko)
PT (1) PT90996B (ko)
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CN1025332C (zh) 1994-07-06
KR0129091B1 (ko) 1998-04-09
EP0405028A1 (en) 1991-01-02
ATE128976T1 (de) 1995-10-15
AU3715189A (en) 1990-01-04
US4895868A (en) 1990-01-23
NO892696L (no) 1990-01-02
HU205925B (en) 1992-07-28
FI893187A0 (fi) 1989-06-29
NO172578B (no) 1993-05-03
MY106972A (en) 1995-08-30
AU619865B2 (en) 1992-02-06
DK325389A (da) 1989-12-30
HUT51267A (en) 1990-04-28
DE68924529D1 (de) 1995-11-16
JPH0276874A (ja) 1990-03-16
CA1334424C (en) 1995-02-14
EP0405028B1 (en) 1995-10-11
NZ229721A (en) 1990-12-21
DE68924529T2 (de) 1996-05-15
FI893187A (fi) 1989-12-30
IL90758A0 (en) 1990-01-18
NO892696D0 (no) 1989-06-28
ES2078238T3 (es) 1995-12-16
NO172578C (no) 1993-08-11
PT90996B (pt) 1995-01-31
DK325389D0 (da) 1989-06-29
IL90758A (en) 1994-06-24
PT90996A (pt) 1989-12-29
ZA894899B (en) 1990-03-28
CN1042147A (zh) 1990-05-16

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