KR900012918A - 칼슘 길항제 - Google Patents

칼슘 길항제 Download PDF

Info

Publication number
KR900012918A
KR900012918A KR1019900001501A KR900001501A KR900012918A KR 900012918 A KR900012918 A KR 900012918A KR 1019900001501 A KR1019900001501 A KR 1019900001501A KR 900001501 A KR900001501 A KR 900001501A KR 900012918 A KR900012918 A KR 900012918A
Authority
KR
South Korea
Prior art keywords
compound
compound according
treating
alkyl
substituent
Prior art date
Application number
KR1019900001501A
Other languages
English (en)
Other versions
KR0149165B1 (ko
Inventor
안토니 카르 알버트
마이클 캐인 존
창 쳉 쉬엔
Original Assignee
개리 디.스트리트
메렐 다우 파마슈티칼즈 인코포레이티드
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US07/457,997 external-priority patent/US5106845A/en
Application filed by 개리 디.스트리트, 메렐 다우 파마슈티칼즈 인코포레이티드 filed Critical 개리 디.스트리트
Publication of KR900012918A publication Critical patent/KR900012918A/ko
Application granted granted Critical
Publication of KR0149165B1 publication Critical patent/KR0149165B1/ko

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/06—Antigout agents, e.g. antihyperuricemic or uricosuric agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
    • A61P3/14—Drugs for disorders of the metabolism for electrolyte homeostasis for calcium homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/04—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D233/28—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/44—Nitrogen atoms not forming part of a nitro radical
    • C07D233/48—Nitrogen atoms not forming part of a nitro radical with acyclic hydrocarbon or substituted acyclic hydrocarbon radicals, attached to said nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • C07D235/30—Nitrogen atoms not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/06—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D239/08—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms directly attached in position 2
    • C07D239/12—Nitrogen atoms not forming part of a nitro radical
    • C07D239/14—Nitrogen atoms not forming part of a nitro radical with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached to said nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
    • C07D243/04—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D245/00—Heterocyclic compounds containing rings of more than seven members having two nitrogen atoms as the only ring hetero atoms
    • C07D245/02—Heterocyclic compounds containing rings of more than seven members having two nitrogen atoms as the only ring hetero atoms not condensed with other rings

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Pain & Pain Management (AREA)
  • Neurosurgery (AREA)
  • Obesity (AREA)
  • Diabetes (AREA)
  • Psychiatry (AREA)
  • Hematology (AREA)
  • Rheumatology (AREA)
  • Epidemiology (AREA)
  • Endocrinology (AREA)
  • Vascular Medicine (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)
  • Compounds Of Alkaline-Earth Elements, Aluminum Or Rare-Earth Metals (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Amplifiers (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

내용 없음

Description

칼슘 길항제
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (27)

  1. 하기 일반식(Ⅰ)의 화합물, 이의 토우토머 또는 광학 이성체, 또는 이의 약제학적으로 허용되는 산 부가염.
    Q는 (CH2)n (여기에서, n은 2 내지 10의 정수이다),및로 이루어진 그룹중에서 선택되는 치환체이고 ; A는 -NH-(CH2)m (여기에서, 0 내지 5의 정수이다), 피페리디노 치환체 및 피페라지노 치환체로 이루어진 그룹중에서 선택되는 치환체이고 : Ar 및 Ar1은 각각 독립적으로 페닐환이고, 각각은 할로겐, C1-4알킬, C1-4알콕시, 하이드록시 및 트리플루오로메틸로 이루어진 그룹중에서 선택되는 3개 이하의 치환체로 임의로 치환될 수 있으며 ; R은 수소 또는 C1-4알킬이고 ; R1은 수소 또는 C1-4알킬이며 ; 단, 1) Q가 (CH2)2,3또는 4인 경우, A는 N-(CH2)0가 아니고 ; 2) Q가 (CH2)2이고 R이 C1-4알킬인 경우, A는 N-(CH2)가 아니다.
  2. 제1항에 있어서, Q가 (CH2)n인 화합물.
  3. 제1항에 있어서, Q가인 화합물.
  4. 제1항에 있어서, Q가인 화합물.
  5. 제1항에 있어서, A가 NH(CH2)m인 화합물.
  6. 제1항에 있어서, A가 피페리디노 치환체인 화합물.
  7. 제1항에 있어서, A가 피페라지노 치환체인 화합물.
  8. 제1항에 있어서, Q가 (CH2)2-5인 화합물.
  9. 제8항에 있어서, A가 NH-CH2, NH-(CH2)2또는 NH-(CH2)3인 화합물.
  10. 제9항에 있어서, R 및 R1가 수소인 화합물.
  11. 제9항에 있어서, Ar 및 Ar1이 C6H5또는 C5H4F인 화합물.
  12. 하기 일반식(Ⅰ)의 화합물, 이의 광학 이성체 또는 토우토머, 또는 이의 약제학적으로 허용되는 산 부가염을 칼슘 길항적 양으로 이를 필요로 하는 환자에게 투여함을 특징으로 하여, 칼슘 길항작용을 수행하는 방법.
    상기식에서, Q는 (CH2)n (여기에서, n은 2 내지 10의 정수이다),및로 이루어진 그룹중에서 선택되는 치환체이고 ; A는 -NH-(CH2)m (여기에서, m은 0 내지 5의 정수이다), 피페리디노 치환체 및 피페라지노 치환체로 이루어진 그룹중에서 선택되는 치환체이고 ; Ar 및 Ar1는 각각 독립적으로 페닐환이고, 각각은 할로겐, C1-4알킬, C1-4알콕시 및 트리플루오로메틸로 이루어진 그룹중에서 선택되는 3개 이하의 치환체로 임의로 치환될 수 있으며 ; R은 수소 또는 C1-4알킬이고 ; R1은 수소 또는 C1-4알킬이다.
  13. 제12항에 따른 화합물의 앙기나 치료량을 이를 필요로하는 환자에게 투여함을 특징으로 하는 앙기나 치료방법.
  14. 제12항에 따른 화합물의 부정맥 치료량을 이를 필요로하는 환자에게 투여함을 특징으로 하는 부정맥 치료방법.
  15. 제12항에 따른 화합물의 고혈압 치료량을 이를 필요로하는 환자에게 투여함을 특징으로 하는 고열압 치료방법.
  16. 제12항에 따른 화합물의 조병 치료량을 이를 필요로하는 환자에게 투여함을 특징으로 하는 조병 치료방법.
  17. 제12항에 따른 화합물의 우울증 치료량을 이를 필요로하는 환자에게 투여함을 특징으로 하는 우울증 치료방법.
  18. 제12항에 따른 화합물의 혈관확장양을 투여함을 특징으로 하여 을혈성 심장질환을 치료하는 방법.
  19. 제12항에 따른 화합물의 간질 치료량을 투여함을 특징으로 하여 간질을 치료하는 방법.
  20. 제12항에 따른 화합물의 유효량을 투여함을 특징으로 하여 칼슘과적을 치료하는 방법.
  21. 제12항에 따른 화합물의 유효량을 투여함을 특징으로 하여 원발성 폐고혈압을 치료하는 방법.
  22. 제12항에 따른 화합물의 유효량을 투여함을 특징으로 하여 과뇨산증을 치료하는 방법.
  23. 제12항에 따른 화합물의 유효량을 투여함을 특징으로 하는 경련을 치료하는 방법.
  24. 제12항에 따른 화합물의 유효량을 투여함을 특징으로 하는 천식을 치료하는 방법.
  25. 제12항에 따른 화합물의 유효량을 투여함을 특징으로 하여 레이나우드 현상을 치료하는 방법.
  26. 유효량의 제1항에 따른 화합물을 약제학적으로 허용되는 담체와 배합하여 함유함을 특징으로 하는 약제학적 조성물.
  27. 유효량의 제1항에 따른 화합물을 불활성 담체와 배합하여 함유함을 특징으로 하는 조성물.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019900001501A 1989-02-10 1990-02-08 사이클릭 구아니딘 유도체 및 이를 함유하는 칼슘 길항제 KR0149165B1 (ko)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US30975089A 1989-02-10 1989-02-10
US309,750 1989-02-10
US309.750 1989-02-10
US457,997 1990-01-10
US07/457,997 US5106845A (en) 1990-01-10 1990-01-10 Calcium antagonists
US457.997 1990-01-10

Publications (2)

Publication Number Publication Date
KR900012918A true KR900012918A (ko) 1990-09-03
KR0149165B1 KR0149165B1 (ko) 1998-10-15

Family

ID=26976983

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019900001501A KR0149165B1 (ko) 1989-02-10 1990-02-08 사이클릭 구아니딘 유도체 및 이를 함유하는 칼슘 길항제

Country Status (14)

Country Link
EP (1) EP0389765B1 (ko)
JP (1) JP2879918B2 (ko)
KR (1) KR0149165B1 (ko)
CN (1) CN1044813A (ko)
AT (1) ATE110367T1 (ko)
AU (1) AU621193B2 (ko)
CA (1) CA2009542C (ko)
DE (1) DE69011714T2 (ko)
ES (1) ES2063177T3 (ko)
FI (1) FI900650A0 (ko)
HU (1) HU204795B (ko)
NO (1) NO900646L (ko)
NZ (1) NZ232396A (ko)
PT (1) PT93106A (ko)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5380721A (en) * 1990-09-10 1995-01-10 Sterling Winthrop Inc. Aryl-fused and hetaryl-fused-2,4-diazepine and 2,4-diazocine antiarrhythmic agents
TW245719B (ko) * 1990-09-10 1995-04-21 Sterling Winthrop Inc
US5314903A (en) * 1991-12-03 1994-05-24 Neurosearch A/S Benzimidazole compounds useful as calcium channel blockers
CA2104060A1 (en) * 1992-11-10 1994-05-11 Robert Ed Johnson Aryl-fused and hetaryl-fused-2,4-diazepine and 2,4-diazocine antiarrhythmic agents

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4136188A (en) * 1976-06-25 1979-01-23 Daiichi Seiyaku Co., Ltd. Treatment of diabetes with 2-substituted-1,3-diazacyclic compounds
US4093726A (en) * 1976-12-02 1978-06-06 Abbott Laboratories N-(2-benzimidazolyl)-piperazines
US4174401A (en) * 1977-07-13 1979-11-13 Mcneil Laboratories, Incorporated 2-Benzhydrylimino-imidazolidines
US4235894A (en) * 1979-01-30 1980-11-25 Mcneilab, Inc. 2-Benzhydrylimino-1,3-diazacarbocyclic compounds, compositions and methods of use
US4243667A (en) * 1979-01-30 1981-01-06 Mcneil Laboratories, Incorporated 2-Benzhydrylimino-1,3-diazacarbocyclic compounds as inhibitors of gastric secretion
US4868181A (en) * 1986-08-04 1989-09-19 E. I. Du Pont De Nemours And Company 1,4-dihydropyridine derivatives with calcium agonist and alpha1 -antagonist activity
US5374637A (en) * 1989-03-22 1994-12-20 Janssen Pharmaceutica N.V. N-(3-hydroxy-4-piperidinyl)(dihydrobenzofuran, dihydro-2H-benzopyran or dihydrobenzodioxin)carboxamide derivatives
FR2658823B1 (fr) * 1990-02-27 1992-04-30 Adir Nouveaux derives d'aminomethylpiperidine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent .

Also Published As

Publication number Publication date
NZ232396A (en) 1991-07-26
HU204795B (en) 1992-02-28
ES2063177T3 (es) 1995-01-01
CA2009542C (en) 2000-03-14
EP0389765A1 (en) 1990-10-03
CA2009542A1 (en) 1990-08-10
HUT53089A (en) 1990-09-28
DE69011714T2 (de) 1994-12-15
JP2879918B2 (ja) 1999-04-05
PT93106A (pt) 1990-08-31
KR0149165B1 (ko) 1998-10-15
HU900728D0 (en) 1990-04-28
NO900646L (no) 1990-08-13
ATE110367T1 (de) 1994-09-15
CN1044813A (zh) 1990-08-22
JPH02282368A (ja) 1990-11-19
AU4932590A (en) 1990-08-16
AU621193B2 (en) 1992-03-05
EP0389765B1 (en) 1994-08-24
FI900650A0 (fi) 1990-02-09
DE69011714D1 (de) 1994-09-29
NO900646D0 (no) 1990-02-09

Similar Documents

Publication Publication Date Title
SE0104334D0 (sv) Therapeutic agents
RU96115142A (ru) Производные 5-(2-имидазолиниламино)бензимидазола, их получение и применение в качестве агонистов альфа-2-адреноцепторов
NO20004485D0 (no) Sykloalkenderivater, deres fremstilling og anvendelse
FR2800735B1 (fr) Nouvelles aralkyle-1,2-diamines possedant une activite calcimimetique et leur mode de preparation
KR890011596A (ko) 불면증 치료용 의약품의 제조에 있어서 1,4-이치환-피페리디닐 화합물의 용도
ES2051834T3 (es) El uso de tetrahidrobenzeno(c,d)indol-6 carboxamidas para la preparacion de un medicamento para el tratamiento de la ansiedad.
KR900012918A (ko) 칼슘 길항제
KR920016456A (ko) 5-(치환 아미노) -1,2,4-트리아졸로 [1,5-a]피리미딘 유도체
KR950702544A (ko) 비페닐메탄 유도체 및 이를 함유하는 약제
KR960029319A (ko) 4-아미노벤조일구아니딘 유도체
DE69518706T2 (de) Verwendung von Diphenylethanderivaten zur Herstellung eines Arzneimittels zur Behandlung von Glaukom
KR900014339A (ko) 헤테로시클릭 화합물, 그의 제조방법, 이를 함유하는 제약 조성물 및 의약으로서의 용도
ES2082273T3 (es) Nuevos derivados del benzopirano y procesos para su preparacion.
KR960029331A (ko) 3-알콕시카르보닐-티아디아지논 유도체
DE69219219T2 (de) Verwendung von 3-Pyridazinone zur Verringerung der Blutplätchenzahl
ES2141134T3 (es) Derivados de carbamoil pirrolidona para el tratamiento de la depresion y de los trastornos cerebrovasculares.
ATE96144T1 (de) 2-aminoacetamid derivate.
RU2009130726A (ru) Терапия
DE3782229T2 (de) Verwendung von 2-oxo-imidazolidin-derivaten zur behandlung von nierenkrankheiten.
DE69407227D1 (de) Die Verwendung von 2-Phenylmethylene-1-3'-(amino)-2-(hydroxy)-propoxy-imino-cyclohexane-Derivaten
DE69010606D1 (de) 3-Isoxazolonderivate, ihre Herstellung und ihre Anwendung in der Therapeutik.
SE8500963D0 (sv) Nitraminodiaryl sulfoxide derivatives, process for their preparation and pharmaceutical and pesticidal compositions containing them

Legal Events

Date Code Title Description
A201 Request for examination
E902 Notification of reason for refusal
E701 Decision to grant or registration of patent right
GRNT Written decision to grant
FPAY Annual fee payment

Payment date: 20030528

Year of fee payment: 6

LAPS Lapse due to unpaid annual fee