ES2082273T3 - Nuevos derivados del benzopirano y procesos para su preparacion. - Google Patents

Nuevos derivados del benzopirano y procesos para su preparacion.

Info

Publication number
ES2082273T3
ES2082273T3 ES92108703T ES92108703T ES2082273T3 ES 2082273 T3 ES2082273 T3 ES 2082273T3 ES 92108703 T ES92108703 T ES 92108703T ES 92108703 T ES92108703 T ES 92108703T ES 2082273 T3 ES2082273 T3 ES 2082273T3
Authority
ES
Spain
Prior art keywords
alkyl group
chem
independently
straight
optionally substituted
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES92108703T
Other languages
English (en)
Inventor
Sung-Eun Yoo
Kyiu Yang Yi
Nak Cheol Jeong
Jee Hee Suh
Seon-Ju Kim
Hwa-Sup Shin
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Korea Research Institute of Chemical Technology KRICT
Original Assignee
Korea Research Institute of Chemical Technology KRICT
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Korea Research Institute of Chemical Technology KRICT filed Critical Korea Research Institute of Chemical Technology KRICT
Application granted granted Critical
Publication of ES2082273T3 publication Critical patent/ES2082273T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pyrane Compounds (AREA)

Abstract

LA PRESENTE INVENCION SE REFIERE A NUEVOS DERIVADOS DE BENZOPIRANO DE FORMULA (I) QUE TIENEN SELECTIVIDAD SUPERIOR EN EL TRATAMIENTO DE LA HIPERTENSION REDUCIENDO LA PRESION SANGUINEA CON UNA ACTIVIDAD DE RELAJACION EN EL MUSCULO SUAVE VASCULAR. LA PRESENTE INVENCION TAMBIEN SE REFIERE A LOS PROCESOS PARA LA PREPARACION DE DICHOS COMPUESTOS; Y A UNA COMPOSICION FARMACEUTICA QUE CONTIENE TALES COMPUESTOS COMO INGREDIENTE ACTIVO. EN DONDE: R1 ES -CN, -NO2, -OCX1X2X3, -NH2, -NHSO2RA, -SO2RC O -SO2NRCRD EN DONDE X1, X2 Y X3 SON, INDEPENDIENTEMENTE, UN ATOMO DE FLUOR, CLORO O DE HIDROGENO; RA Y RB SON, INDEPENDIENTEMENTE, UN AMINO, ALCOXI C1-6, UN GRUPO ALKILO C1-6 O UN GRUPO FENILO OPCIONALMENTE SUBSTITUIDO; Y RC Y RD SON UN ATOMO DE HIDROGENO, O UN GRUPO ALKILO C1-6 O UN GRUPO FENILO OPCIONALMENTE SUBSTITUIDO CON UN ATOMO DE HALOGENO, O UN GRUPO ALKILO C1-3 UNIFORME O RAMIFICADO; R2 ES DONDE RE ES UN ATOMO DE HIDROGENO, O UN GRUPO ALKILO C1-6, CICLOPROPILO, CICLOPROPILMETILO; RF ES -CORA O -CSRA; X ES O, S O NRC, Y N ES UN ENTERO DEL 0 AL 3, DONDE RA Y RC TIENEN LOS MISMOS SIGNIFICADOS DEFINIDOS ANTERIORMENTE; R3 ES UN GRUPO ALKILO C1-4 UNIFORME O RAMIFICADO; Y R4 ES DONDE RG Y RH SON, INDEPENDIENTEMENTE, UN GRUPO ALKILO C1-16 O UN GRUPO FENILO OPCIONALMENTE SUSTITUIDO; A Y B SON, INDEPENDIENTEMENTE, S U O; Y Z ES UN GRUPO ALKILO C1-3 UNIFORME O RAMIFICADO.
ES92108703T 1991-05-22 1992-05-22 Nuevos derivados del benzopirano y procesos para su preparacion. Expired - Lifetime ES2082273T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR910008244 1991-05-22
KR1019910024352A KR950009862B1 (ko) 1991-05-22 1991-12-26 벤조피란 유도체와 그의 제조방법(1)

Publications (1)

Publication Number Publication Date
ES2082273T3 true ES2082273T3 (es) 1996-03-16

Family

ID=26628610

Family Applications (1)

Application Number Title Priority Date Filing Date
ES92108703T Expired - Lifetime ES2082273T3 (es) 1991-05-22 1992-05-22 Nuevos derivados del benzopirano y procesos para su preparacion.

Country Status (8)

Country Link
EP (1) EP0514935B1 (es)
JP (1) JP2989712B2 (es)
KR (1) KR950009862B1 (es)
AT (1) ATE130003T1 (es)
DE (1) DE69205886T2 (es)
DK (1) DK0514935T3 (es)
ES (1) ES2082273T3 (es)
GR (1) GR3018329T3 (es)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995013272A1 (fr) 1993-11-10 1995-05-18 Japan Tobacco Inc. Derive de chromanne et utilisation therapeutique de ce dernier
US6455554B1 (en) 1999-06-07 2002-09-24 Targacept, Inc. Oxopyridinyl pharmaceutical compositions and methods for use
KR100389127B1 (ko) * 2000-10-09 2003-06-25 동부한농화학 주식회사 벤조피라닐 헤테로고리 유도체, 그의 제조방법 및 그를포함하는 약학적 조성물
KR100907475B1 (ko) * 2007-08-29 2009-07-13 한국화학연구원 2-메틸-2'-하이드록시메틸-6-아미도 벤조피란 유도체 또는 약제학적으로 허용 가능한 그의 염 및 그를 유효성분으로 함유하는 치매 및 뇌졸중 치료를 위한 약학적 조성물

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3926001A1 (de) * 1989-08-05 1991-02-07 Merck Patent Gmbh Chromanderivate

Also Published As

Publication number Publication date
EP0514935B1 (en) 1995-11-08
DE69205886D1 (de) 1995-12-14
DK0514935T3 (da) 1996-01-22
KR950009862B1 (ko) 1995-08-29
JPH05178850A (ja) 1993-07-20
ATE130003T1 (de) 1995-11-15
DE69205886T2 (de) 1996-06-13
GR3018329T3 (en) 1996-03-31
EP0514935A1 (en) 1992-11-25
JP2989712B2 (ja) 1999-12-13

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