KR900009624A - 황-함유 헤테로 고리 화합물 - Google Patents

황-함유 헤테로 고리 화합물 Download PDF

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KR900009624A
KR900009624A KR1019890019906A KR890019906A KR900009624A KR 900009624 A KR900009624 A KR 900009624A KR 1019890019906 A KR1019890019906 A KR 1019890019906A KR 890019906 A KR890019906 A KR 890019906A KR 900009624 A KR900009624 A KR 900009624A
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다까시 소오다
쓰다마사오
이와요 야마자끼
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우메모또 요시마사
다께다야꾸힝 고오교 가부시끼가이샤
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Abstract

내용 없음

Description

황-함유 헤테로 고리 화합물
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (15)

  1. 식(Ⅰ)의 황-함유 헤테로 고리 화합물 또는 약학적으로 허용 가능한 그의 염36-1
    [상기식에서, 고리 A는 치환 가능한 벤젠고리이며, R은 수소 원자 또는 치환 가능한 탄화수소기이고, B는 에스테르화 또는 아미드화 가능한 카르복실기이며, X는 -CH(OH)- 또는 -CO-이고, k는 0 또는 1이며, k'은 0. 1 또는 2이다]
  2. 제1항에 있어서, 고리 A가 할로겐, C1~10 알킬 및 C1~6알콕시로 구성된 군으로 부터 선택된, 동일하거나 상이한. 1 또는 2개의 치환체에 의해 치환 가능한 벤젠고리인 화합물.
  3. 제1항에 있어서, 고리 A가 동일하거나 상이한, 1 또는 2개의 C1~10알킬기에 의해 치환가능한 벤젠 고리인 화합물.
  4. 제1항에 있어서, 고리 A가 C3~7시클로알킬기에 의해 치환가능한 벤젠고리인 화합물.
  5. 제1항에 있어서, R이 수소원자, C1~10알킬 또는 페닐기인 화합물.
  6. 제1항에 있어서, R이 수소원자 또는 메틸기인 화합물.
  7. 제1항에 있어서, B가 C1~10알콕시카르보닐기 또는 식 -CONR1R2의 기(식중, R1및 R2각각은 수소원자,치환가능한 탄화수소기 또는 치환가능한 5- 내지 7-원소로 된 헤테로고리기이다.)인 화합물.
  8. 제1항에 있어서, B가 식 -CONR1R2의 기(식중, R1및 R2각각은 수소원자, 치환가능한 탄화수소기 또는 치환가능한 5- 내지 7-원소로된 헤테로고리기 이다.)인 화합물.
  9. 제8항에 있어서, R1이 수소원자이며 R2가 식 -C6H5(CH2)nP(0)(OR')2의 기(식중, n은 0 또는 1이며 R'은 C1~6알킬기 이다.)인 화합물.
  10. 제1항에 있어서, 고리 A가 할로겐, C1~10알킬 및 C1~6알콕시로 구성된 군으로 부터 선택된, 동일하거나 상이한, 1 또는 2개의 치환체에 의해 치환 가능한 벤젠고리이며, R은 수소원자, C1~10알킬 또는 페닐기이며, B는 C1~10 알콕시카르보닐기 또는 식 -CONR1R2의 기(식중, R1및 R2각각은 수소원자, 치환가능한 탄화수소기 또는 치환가능한 5- 내지 7-원소로된 헤테로 고리기 이다.)이고, k 및 k'은 각각 0인 화합물.
  11. 제1항에 있어서, 6-시클로헥실-N-(4-디에톡시포스포릴메틸페닐)-3,4-디히드로-1H-2-벤조티오피란-4-온-1-카르복사미드라고 명명되는 화합물.
  12. 제1항에 있어서, 6,7-디멜틸-N-(4-디에톡시포스포릴페닐)-3,4-디히도로-1H-2-벤조티오피란-4-온-1-키르복사미드라고 명명되는 화합물.
  13. 제1항에 있어서, 6,7-디메틸-N-(4-디에톡시포스포릴메틸페닐)-3,4-디히드로- 1H-2-벤조티오피란-4-온-1-카르복사미드라고 명명되는 화합물.
  14. (1)하기 일반식(Ⅱ)의 화합물 또는 그의 염을 고리화 반응시키고, 필요한 경우, 산화 또는/및 가수분해, 가수분해후 아미드화, 또는 가수분해후 아미드화 및 산화반응을 더 수행하여 하기 일반식(Ⅰa)의 황-함유 헤테로고리 화합물 또는 그의 염을 제조하거나, 또는 (2)하기 일반식(Ⅰa)의 화합물 또는 그의 염을 환원시켜 하기 일반식(Ⅰb)의 황-함유 헤테로고리 화합물 또는 그의 염을 제조함을 특징으로 하는 하기 일반식(Ⅰ)의 황-함유 헤테로고리 화합물 또는 그의 염의 제조방법
    [상기식에서, B'은 에스테르화 카르복실기이며, B는 에스테르화 또는 아미드화 가능한 카르복실기이고, Y는 히도록시기 또는 할로겐 원자이며, X는 -CH(OH)- 또는 -CO-이고, 고리 A는 치환 가능한 벤젠고리이며, R은 수소원자 또는 치환가능한 탄화수소기이고, k는 0 또는 1이며, k'은 0.1 또는 2이다.]
  15. 유효량의 하기 일반식(Ⅰ)의 항-골다공성 화합물 또는 약학적으로 허용 가능한 염 및 약학적으로 허용가능한 담체 또는 희석제를 함유하는, 골다공증 치료에 사용하는 약학제제.
    [상기식에서, 고리 A는 치환 가능한 벤젠 고리이며, R은 수소원자 또는 치환 가능한 탄화수소기이고, B는 에스테르화 또는 아미드화 가능한 카르복실기이며, X는 -CH(OH)- 또는 -CO-이고, k는 0 또는 1이며, k'은 0.1 또는 2이다.]
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019890019906A 1988-12-28 1989-12-28 황-함유 헤테로고리화합물 KR0142429B1 (ko)

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US5158943A (en) * 1988-11-21 1992-10-27 Takeda Chemical Industries, Ltd. Sulfur-containing heterocyclic compounds
EP0460488B1 (en) * 1990-05-30 2001-07-11 Takeda Chemical Industries, Ltd. Sulfur-containing heterocyclic compounds
EP0769015B1 (en) * 1994-07-04 2001-03-14 Takeda Chemical Industries, Ltd. Phosphonic acid compounds, their production and use
TW403757B (en) 1994-12-28 2000-09-01 Takeda Chemical Industries Ltd Optically active benzothiepin derivative, its preparation and use
US5910492A (en) * 1995-06-05 1999-06-08 Takeda Chemical Industries, Ltd. Osteogenic promoting pharmaceutical composition
CA2226317A1 (en) * 1995-07-24 1997-02-06 Takeda Chemical Industries, Ltd. Production of optically active benzothiepin salts
ID18079A (id) 1996-08-26 1998-02-26 Takeda Chemical Industries Ltd Komposisi farmasi yang mengandung bahan pemercepat osteogenesis
CA2267930A1 (en) * 1996-10-09 1998-04-16 Nobuyuki Takechi A method for producing a microparticle
CA2287228A1 (en) 1997-04-24 1998-10-29 Tetsuo Hoshino Apatite-coated solid composition
CA2334815A1 (en) * 1998-06-15 1999-12-23 Haruhiko Makino Composition for treating cartilage disease
US6355672B1 (en) 1998-08-07 2002-03-12 Takeda Chemical Industries, Ltd. Benzothiepin derivatives, process for the preparation of the same and uses thereof
TW557298B (en) * 2000-08-14 2003-10-11 Ciba Sc Holding Ag A compound, a photopolymerizible composition, a process for producing coatings and a method for causing a photoinitiator to accumulate at the surface of coatings
EP1324994A4 (en) * 2000-10-10 2004-06-16 Calyx Therapeutics Inc TRICYCLIC COMPOUNDS AND USES THEREOF
CA2637194A1 (en) 2006-01-18 2007-07-26 National University Corporation Tokyo Medical And Dental University Biomaterial for osteogenesis containing osteogenesis promoter and nanogel
KR101613745B1 (ko) 2008-02-29 2016-04-19 닛산 가가쿠 고교 가부시키 가이샤 티오펜 화합물 및 그 중간체의 제조 방법
TWI594975B (zh) 2013-04-24 2017-08-11 第一三共股份有限公司 二羧酸化合物
ES2864277T3 (es) 2014-09-26 2021-10-13 Daiichi Sankyo Co Ltd Sal de compuestos de ácido dicarboxílico

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1935685A1 (de) * 1969-07-10 1971-01-14 Schering Ag Neue antimikrobiell wirksame Verbindungen
US3636049A (en) * 1969-11-26 1972-01-18 Pfizer Isothiochroman carboxamides
FR2621038B1 (fr) * 1987-09-28 1989-12-29 Rhone Poulenc Sante Derives d'alcadienes, leurs preparations, les medicaments les contenant et produits intermediaires

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FI102896B (fi) 1999-03-15
DE68918827D1 (de) 1994-11-17
ES2060735T3 (es) 1994-12-01
EP0376197B1 (en) 1994-10-12
CN1045106A (zh) 1990-09-05
ATE112770T1 (de) 1994-10-15
FI102896B1 (fi) 1999-03-15
CN1032470C (zh) 1996-08-07
HU896790D0 (en) 1990-03-28
FI896289A0 (fi) 1989-12-27
AU623722B2 (en) 1992-05-21
DK656789A (da) 1990-06-29
CA2006723A1 (en) 1990-06-28
DK656789D0 (da) 1989-12-21
HK17396A (en) 1996-02-09
AU4732089A (en) 1990-07-19
NZ231939A (en) 1991-07-26
DE68918827T2 (de) 1995-02-16
NO895267D0 (no) 1989-12-27
NO895267L (no) 1990-06-29
JP2924033B2 (ja) 1999-07-26
CA2006723C (en) 1998-08-25
NO179977C (no) 1997-01-22
KR0142429B1 (ko) 1998-06-01
US5071841A (en) 1991-12-10
EP0376197A1 (en) 1990-07-04
NO179977B (no) 1996-10-14
JPH03232880A (ja) 1991-10-16
HU209453B (en) 1994-06-28

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