KR900009043A - 헥사 히드로-5 피리미딘 아민 화합물과 티몰을 함유한 방부성 조성물 및 그 제조 방법 - Google Patents
헥사 히드로-5 피리미딘 아민 화합물과 티몰을 함유한 방부성 조성물 및 그 제조 방법 Download PDFInfo
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- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/494—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with more than one nitrogen as the only hetero atom
- A61K8/4953—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with more than one nitrogen as the only hetero atom containing pyrimidine ring derivatives, e.g. minoxidil
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- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
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- A23G3/00—Sweetmeats; Confectionery; Marzipan; Coated or filled products
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- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
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- A23G2200/00—COCOA; COCOA PRODUCTS, e.g. CHOCOLATE; SUBSTITUTES FOR COCOA OR COCOA PRODUCTS; CONFECTIONERY; CHEWING GUM; ICE-CREAM; PREPARATION THEREOF containing organic compounds, e.g. synthetic flavouring agents
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- A23G—COCOA; COCOA PRODUCTS, e.g. CHOCOLATE; SUBSTITUTES FOR COCOA OR COCOA PRODUCTS; CONFECTIONERY; CHEWING GUM; ICE-CREAM; PREPARATION THEREOF
- A23G2200/00—COCOA; COCOA PRODUCTS, e.g. CHOCOLATE; SUBSTITUTES FOR COCOA OR COCOA PRODUCTS; CONFECTIONERY; CHEWING GUM; ICE-CREAM; PREPARATION THEREOF containing organic compounds, e.g. synthetic flavouring agents
- A23G2200/04—COCOA; COCOA PRODUCTS, e.g. CHOCOLATE; SUBSTITUTES FOR COCOA OR COCOA PRODUCTS; CONFECTIONERY; CHEWING GUM; ICE-CREAM; PREPARATION THEREOF containing organic compounds, e.g. synthetic flavouring agents containing vitamins, antibiotics, other medicaments
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/52—Stabilizers
- A61K2800/524—Preservatives
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
- A61K2800/92—Oral administration
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Abstract
내용 없음.
Description
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
제1도는 헥세티딘, 티몰 및 헥세티딘과 티몰의 혼합물이 연쇄상구균속(Streptococcus mutans, A.T.C.C. 수납 번호 25175)에 미치는 항미생물 활성을 예시한 균사멸 그라프,
제2도는 헥세티딘 및 헥세티딘과 각각의 정유(精油)와의 혼합물이 연쇄상구균속(Streptococcus mutans, A.T.C.C. 수납번호 25175)에 미치는 항미생물 활성을 예시한 균사멸 그라프.
Claims (35)
- 방부제인 헥사히드로-5-피리미딘아민 화합물과 티몰을 구강용 담체중에 함유시켜서 된 상승작용이 있는 방부성 조성물 치료유효량을 함유하는 구강용 방부성 조성물.
- 제1항에 있어서, 헥세티딘, 약제학적으로 허용되는 헥세티딘의 염 및 이들의 혼합물중에서 방부제인 헥사히드로-5-피리미딘아민 화합물을 선택하여서되는 구강용 방부성 조성물.
- 제1항에 있어서, 헥사히드로-5-피리미딘아민 화합물의 함량 범위가 구강용 방부성 조성물에 대하여 약 0.01wt.%-약 0.3wt.%인 구강용 방부성 조성물.
- 제3항에 있어서, 헥사히드로-5-피리미딘아민 화합물의 함량 범위가 구강용 방부성 조성물에 대하여 약 0.05wt.%-약 0.2wt.%인 구강용 방부성 조성물.
- 제4항에 있어서, 헥사히드로-5-피리미딘아민 화합물의 함량 범위가 구강용 방부성 조성물에 대하여 약 0.1wt.%-약 0.15wt.%인 구강용 방부성 조성물.
- 제1항에 있어서, 티몰의 함량 범위가 구강용 방부성 조성물에 대하여 약 0.01wt.%-약 0.4wt.%인 구강용 방부성 조성물.
- 제6항에 있어서, 티몰의 함량 범위가 구강용 방부성 조성물에 대하여 약 0.05wt.5-약 0.1wt.%인 구강용 방부성 조성물.
- 제7항에 있어서, 티몰의 함량 범위가 구강용 방부성 조성물에 대하여 약 0.06wt.%-약 0.08wt.%인 구강용 방부성 조성물.
- 제1항에 있어서, 구강용 담체가 물인 구강용 방부성 조성물.
- 제1항에 있어서, 구강용 담체가 알코올-물의 혼합물인 구강용 방부성 조성물.
- 제1항에 있어서, 구강 세척제, 구강 분무제 또는 치과용 겔 형태의 구강용 방부성 조성물.
- 제1항에 있어서, 소르비톨, 계면활성제, 플루오르 생성화합물, 감미제, 향미제, 착색제, 보습제, 완충제, 겔화제, 광택제, 탈감각제 및 보존제중에서 선택되는 첨가제를 함유하는 구강용 방부성 조성물.
- 구강용 담체중에 방부제인 헥사히드로-5-피리미딘아민 화합물과 티몰을 함유시켜서된 상승작용이 있는 방부성 조성물 치료유효량을 함유하는 구강용의 방부성 조성물 유효량을 구강에다 가해서 되는 구강 위생 개선방법.
- 방부제인 헥사히드로-5-피리디민아민 화합물과 티몰을 구강용 담체중에 함유시켜서 된 상승 작용이 있는 방부성 조성물 치료 유효량을 혼합하여서 되는 구강용의 방부성 조성물 제조방법.
- 약제학적으로 허용되는 담체중에 방부제인 헥사히드로-5-피리미딘아민 화합물과 티몰을 함유시켜서된 상승작용이 있는 방부성 조성물 치료유효량을 함유하는 구강용 방부성 조성물.
- 제15항에 있어서, 헥세티딘, 약제학적으로 허용되는 헥세티딘의 염 및 이들의 혼합물중에서 방부제인 헥사히드로-5-피리디민아민 화합물을 선택하여서 되는 구강용 방부성 조성물.
- 제15항에 있어서, 헥사히드로-5-피리미딘아민 화합물의 함량 범위가 구강용 방부성 조성물에 대하여 약 0.01wt.%-약 0.3wt.%인 구강용 방부성 조성물.
- 제17항에 있어서, 헥사히드로-5-피리미딘아민 화합물의 함량 범위가 구강용 방부성 조성물에 대하여 약 0.05wt.%-약 0.2wt.%인 구강용 방부성 조성물.
- 제18항에 있어서, 헥사히드로-5-피리미딘아민 화합물의 함량 범위가 구강용 방부성 조성물에 대하여 약 0.1wt.%-약 0.15wt.%인 구강용 방부성 조성물.
- 제15항에 있어서, 티몰의 함량 범위가 구강용 방부성 조성물에 대하여 약 0.01wt.%-약 0.4wt.%인 구강용 방부성 조성물.
- 제20항에 있어서, 티몰의 함량 범위가 구강용 방부성 조성물에 대하여 약 0.05wt.%-약 0.1wt.%인 구강용 방부성 조성물.
- 제21항에 있어서, 티몰의 함량 범위가 구강용 방부성 조성물에 대하여 약 0.06wt.%-약 0.08wt.%인 구강용 방부성 조성물.
- 제15항에 있어서, 약제학적으로 허용되는 담체를 로젠지, 정제, 토피, 누가, 현탁액, 씹는 캔디 및 츄잉검중에서 선택하여서 되는 구강용 방부성 조성물.
- 구강용 당과제 제품에 대하여 방부제인 헥사히드로-5-피리미딘아민 화합물과 티몰을 함유하는 상승작용이 있는 방부성 조성물 치료유효량과 당과제 중량제 99.98wt.%을 함유하고, 상승작용이 있는 방부성 조성물을 당과제중에서 혼합하여서 되는 구강용 방부성 당과제 제품.
- 당과제 중량제를 약 120℃-약 170℃의 온도까지 가열하고나서 약 100℃-약 120℃의 온도까지 냉각한 다음 상승작용이 있는 방부성 조성물과 위의 중량제를 혼합하여 당과제 중량제와 상승작용이 있는 방부성 조성물의 균일한 혼합물을 얻어 이것을 적당한 당과제 형상으로 성형하여서 되는 제24항에 의한 구강용 방부성 당과제 제품 제조방법.
- 방부제인 헥사히드로-5-피리미딘아민 화합물과 티몰을 함유하는 상승작용이 있는 방부성 조성물 치료유효량과 츄잉검 베이스로 된 츄잉검 조성물.
- 제26항에 있어서, 방부제인 헥사히드로-5-피리미딘아민 화합물을 헥세티딘, 약제학적으로 허용되는 헥세티딘의 염 및 이들의 혼합물중에서 선택하여서 되는 츄잉검 조성물.
- 제26항에 있어서, 헥사히드로-5-피리미딘아민 화합물의 함량 범위가 츄잉검 조성물에 대하여 약 0.01wt.%-약 0.3wt.%인 츄잉검 조성물.
- 제28항에 있어서, 헥사히드로-5-피리미딘아민 화합물의 함량 범위가 츄잉검 조성물에 대하여 약 0.05wt.%-약 0.2wt.%인 츄잉검 조성물.
- 제29항에 있어서, 헥사히드로-5-피리미딘아민 화합물의 함량 범위가 츄잉검 조성물에 대하여 약 0.1wt.%-약 0.15wt.%인 츄잉검 조성물.
- 제26항에 있어서, 티몰의 함량범위가 츄잉검 조성물에 대하여 약 0.01wt.%-약 0.4wt.%인 츄잉검 조성물.
- 제30항에 있어서, 티몰의 함량범위가 츄잉검 조성물에 대하여 약 0.05wt.%-약 0.1wt.%인 츄잉검 조성물.
- 제32항에 있어서, 티몰의 함량범위가 츄잉검 조성물에 대하여 약 0.06wt.%-약 0.08wt.%인 츄잉검 구강용 조성물.
- 방부성 츄잉검 제품에 대하여 방부제인 헥사히드로-5-피리미딘아민 화합물과 티몰을 함유한 상승작용이 있는 방부성 조성물 치료유효량과 검 베이스로 된 츄잉검 조성물 약 99wt.%를 함유하고, 상승작용이 있는 방부성 조성물을 츄잉검 조성물중에서 혼합해서 되는 방부성 츄잉검 제품.
- 검 베이스를 상승작용이 있는 방부성 조성물과 약 60℃-약 120℃의 온도에서 혼합하여 검 베이스와 상승작용이 있는 방부성 조성물의 균일한 혼합물을 얻은 다음 이 혼합물을 적당한 츄잉검 형상으로 성형하여서 되는 제34항에 의한 방부성 츄잉검 제품 제조방법.※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US07/284,213 US4992276A (en) | 1988-12-14 | 1988-12-14 | Antiseptic compositions containing hexahydro-5-pyrimidinamine compounds and thymol and methods for preparing same |
US284213 | 1988-12-14 |
Publications (1)
Publication Number | Publication Date |
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KR900009043A true KR900009043A (ko) | 1990-07-02 |
Family
ID=23089325
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
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KR1019890018389A KR900009043A (ko) | 1988-12-14 | 1989-12-12 | 헥사 히드로-5 피리미딘 아민 화합물과 티몰을 함유한 방부성 조성물 및 그 제조 방법 |
Country Status (14)
Country | Link |
---|---|
US (1) | US4992276A (ko) |
EP (1) | EP0373758A3 (ko) |
JP (1) | JPH0678219B2 (ko) |
KR (1) | KR900009043A (ko) |
AR (1) | AR246431A1 (ko) |
AU (1) | AU618154B2 (ko) |
CA (1) | CA2001824A1 (ko) |
DK (1) | DK629989A (ko) |
FI (1) | FI895910A0 (ko) |
MX (1) | MX166594B (ko) |
NO (1) | NO894999L (ko) |
PH (1) | PH26683A (ko) |
PT (1) | PT92570A (ko) |
ZA (1) | ZA899530B (ko) |
Families Citing this family (24)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU8879591A (en) * | 1990-11-09 | 1992-06-11 | Warner-Lambert Company | Improved anti-plaque compositions comprising a combination of morpholinoamino alcohol and anti-microbial agent |
WO1992009283A1 (en) * | 1990-11-26 | 1992-06-11 | Warner-Lambert Company | Stabilized hexahydro-5-pyrimidinamine compounds in aqueous solution and methods for preparing same |
NZ240818A (en) * | 1990-12-14 | 1993-08-26 | Mcneil Ppc Inc | Liquid sucralose concentrate compositions containing preservative, buffer and liquid |
US5292527A (en) * | 1992-07-02 | 1994-03-08 | Bausch & Lomb Incorporated | Non-alcoholic aqueous mouthwash |
AU682489B2 (en) * | 1993-01-27 | 1997-10-09 | Warner-Lambert Company | Reduced alcohol mouthwash antiseptic and antiseptic preparations |
EP0735856A1 (en) * | 1993-12-22 | 1996-10-09 | The Procter & Gamble Company | Concentrated mouthrinse for efficient delivery of antimicrobials |
ATE191844T1 (de) * | 1994-06-10 | 2000-05-15 | Procter & Gamble | Mundspülungsmittel |
US5534243A (en) * | 1994-09-26 | 1996-07-09 | The Procter & Gamble Company | Aqueous oral compositions |
ES2236752T3 (es) * | 1995-10-11 | 2005-07-16 | Warner-Lambert Company Llc | Composiciones antimicrobianas que contienen un alcohol c3-c6. |
EP0901366B1 (en) * | 1996-02-08 | 2002-04-17 | Warner-Lambert Company | Anticalculus dentifrice containing highly soluble pyrophosphate |
AU5355296A (en) * | 1996-02-23 | 1997-09-10 | Warner-Lambert Company | Reduced alcohol mouthwash |
US5961958A (en) * | 1996-07-16 | 1999-10-05 | Four Star Partners | Methods, compositions, and dental delivery systems for the protection of the surfaces of teeth |
US5780015A (en) * | 1997-05-14 | 1998-07-14 | Colgate Palmolive Company | Dentifrice for the treatment of dentinal hypersensitivity having limited astringency |
US6607716B1 (en) | 1998-09-29 | 2003-08-19 | Tech Labs, Inc. | Pediculicidal compositions, a kit, and methods of use |
US6414036B1 (en) | 1999-09-01 | 2002-07-02 | Van Beek Global/Ninkov Llc | Composition for treatment of infections of humans and animals |
US6582682B2 (en) * | 2000-10-30 | 2003-06-24 | Noville, Inc. | Oral care compositions comprising stabilized chlorine dioxide |
ES2201932B2 (es) * | 2001-11-23 | 2005-03-16 | Glaxo Group Limited | Composicion farmaceutica. |
US7411005B2 (en) * | 2002-02-13 | 2008-08-12 | Van Beek Natural Science, Llc | Compositions and methods for increasing milk production in animals |
ITMI20020421A1 (it) * | 2002-03-01 | 2003-09-01 | Restituita Castellaccio | Colluttorio per l'igiene orale a base di clorexidina |
US8517728B2 (en) | 2007-01-24 | 2013-08-27 | Colgate-Palmolive Company | Oral care implement having fluid delivery system |
JP2011256125A (ja) * | 2010-06-08 | 2011-12-22 | Lion Corp | 歯磨剤組成物 |
CN103025266B (zh) * | 2010-07-30 | 2015-08-19 | 高露洁-棕榄公司 | 与牙刷递送装置一起使用的漱口水制剂 |
KR20130128009A (ko) | 2011-03-09 | 2013-11-25 | 콜게이트-파아므올리브캄파니 | 치간 세척기구 |
EP2911554B1 (en) | 2012-10-26 | 2017-04-26 | Colgate-Palmolive Company | Oral care implement |
Family Cites Families (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2263753B1 (ko) * | 1974-03-12 | 1978-07-21 | Roeck Yannick De | |
DE2626935A1 (de) * | 1976-06-16 | 1977-12-29 | Dolorgiet Arzneimittelfabrik | Desinfizierende mittel |
GB2084870B (en) * | 1980-10-10 | 1985-05-09 | Muhlemann R Hans | Oral compositions containing pyrimidine amine compounds and zinc salts |
JPS59101417A (ja) * | 1982-12-02 | 1984-06-12 | Lion Corp | 口腔用組成物 |
US4476107A (en) * | 1983-06-13 | 1984-10-09 | Basf Wyandotte Corporation | Mouthwash composition |
DE3578313D1 (de) * | 1984-02-20 | 1990-07-26 | Blendax Werke Schneider Co | Mittel zur oralen hygiene. |
DE3600165A1 (de) * | 1986-01-07 | 1987-07-09 | Blendax Werke Schneider Co | Mittel zur oralen hygiene |
US4666517A (en) * | 1986-06-04 | 1987-05-19 | Colgate-Palmolive Co. | Antiplaque oral composition |
DE3702983A1 (de) * | 1986-06-09 | 1987-12-10 | Henkel Kgaa | Desinfektionsmittel und ihre verwendung zur haut- und schleimhautdesinfektion |
US4713243A (en) * | 1986-06-16 | 1987-12-15 | Johnson & Johnson Products, Inc. | Bioadhesive extruded film for intra-oral drug delivery and process |
US4774078A (en) * | 1986-10-06 | 1988-09-27 | Colgate-Palmolive Company | Stable antiplaque dentifrice based on hexetidine, zinc ion and fluoride |
DE3634697A1 (de) * | 1986-10-11 | 1988-04-21 | Dentaire Ivoclar Ets | Dentalwerkstoff zur bekaempfung von karies und parodontose |
US5100650A (en) * | 1987-06-30 | 1992-03-31 | Warner-Lambert Company | Anti-bacterial oral composition containing bis-biguanido hexanes |
CA1273576A (en) * | 1987-09-16 | 1990-09-04 | Patrick A. Beauchamp | Topical treatment for diseased skin disorders |
-
1988
- 1988-12-14 US US07/284,213 patent/US4992276A/en not_active Expired - Fee Related
-
1989
- 1989-10-31 CA CA002001824A patent/CA2001824A1/en not_active Abandoned
- 1989-11-01 EP EP89311282A patent/EP0373758A3/en not_active Withdrawn
- 1989-11-21 MX MX018431A patent/MX166594B/es unknown
- 1989-12-11 AR AR89315641A patent/AR246431A1/es active
- 1989-12-11 FI FI895910A patent/FI895910A0/fi not_active Application Discontinuation
- 1989-12-12 AU AU46127/89A patent/AU618154B2/en not_active Ceased
- 1989-12-12 PH PH39678A patent/PH26683A/en unknown
- 1989-12-12 KR KR1019890018389A patent/KR900009043A/ko not_active Application Discontinuation
- 1989-12-13 DK DK629989A patent/DK629989A/da not_active Application Discontinuation
- 1989-12-13 ZA ZA899530A patent/ZA899530B/xx unknown
- 1989-12-13 JP JP1321605A patent/JPH0678219B2/ja not_active Expired - Lifetime
- 1989-12-13 NO NO89894999A patent/NO894999L/no unknown
- 1989-12-14 PT PT92570A patent/PT92570A/pt not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
MX166594B (es) | 1993-01-20 |
JPH02288825A (ja) | 1990-11-28 |
PT92570A (pt) | 1990-06-29 |
PH26683A (en) | 1992-09-15 |
EP0373758A2 (en) | 1990-06-20 |
AU4612789A (en) | 1990-06-21 |
DK629989A (da) | 1990-06-15 |
AR246431A1 (es) | 1994-08-31 |
US4992276A (en) | 1991-02-12 |
EP0373758A3 (en) | 1990-07-25 |
FI895910A0 (fi) | 1989-12-11 |
ZA899530B (en) | 1990-09-26 |
AU618154B2 (en) | 1991-12-12 |
NO894999D0 (no) | 1989-12-13 |
JPH0678219B2 (ja) | 1994-10-05 |
NO894999L (no) | 1990-06-15 |
DK629989D0 (da) | 1989-12-13 |
CA2001824A1 (en) | 1990-06-14 |
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Legal Events
Date | Code | Title | Description |
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WITN | Application deemed withdrawn, e.g. because no request for examination was filed or no examination fee was paid |