KR900005607B1 - 호모노지리마이신 글리코사이드의 제조방법 - Google Patents

호모노지리마이신 글리코사이드의 제조방법 Download PDF

Info

Publication number
KR900005607B1
KR900005607B1 KR1019850009529A KR850009529A KR900005607B1 KR 900005607 B1 KR900005607 B1 KR 900005607B1 KR 1019850009529 A KR1019850009529 A KR 1019850009529A KR 850009529 A KR850009529 A KR 850009529A KR 900005607 B1 KR900005607 B1 KR 900005607B1
Authority
KR
South Korea
Prior art keywords
heptitol
gulo
glycero
dideoxy
imino
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
KR1019850009529A
Other languages
English (en)
Korean (ko)
Other versions
KR860004921A (ko
Inventor
에스.리우 파울
Original Assignee
메렐 다우 파마슈티칼스 인코포레이티드
가리 디.스트리트
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 메렐 다우 파마슈티칼스 인코포레이티드, 가리 디.스트리트 filed Critical 메렐 다우 파마슈티칼스 인코포레이티드
Publication of KR860004921A publication Critical patent/KR860004921A/ko
Application granted granted Critical
Publication of KR900005607B1 publication Critical patent/KR900005607B1/ko
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/02—Heterocyclic radicals containing only nitrogen as ring hetero atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/26—Acyclic or carbocyclic radicals, substituted by hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Diabetes (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Emergency Medicine (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Endocrinology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Luminescent Compositions (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
KR1019850009529A 1984-12-18 1985-12-18 호모노지리마이신 글리코사이드의 제조방법 Expired KR900005607B1 (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US683127 1984-12-18
US06/683,127 US4634765A (en) 1984-12-18 1984-12-18 Homodisaccharide hypoglycemic agents

Publications (2)

Publication Number Publication Date
KR860004921A KR860004921A (ko) 1986-07-16
KR900005607B1 true KR900005607B1 (ko) 1990-07-31

Family

ID=24742682

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019850009529A Expired KR900005607B1 (ko) 1984-12-18 1985-12-18 호모노지리마이신 글리코사이드의 제조방법

Country Status (20)

Country Link
US (1) US4634765A (https=)
EP (1) EP0186103B1 (https=)
JP (1) JPS61158994A (https=)
KR (1) KR900005607B1 (https=)
CN (1) CN1016784B (https=)
AT (1) ATE62249T1 (https=)
AU (1) AU574246B2 (https=)
CA (1) CA1240989A (https=)
DE (1) DE3582420D1 (https=)
DK (1) DK587085A (https=)
ES (1) ES8706164A1 (https=)
FI (1) FI80707C (https=)
GR (1) GR853032B (https=)
HU (1) HU194263B (https=)
IE (1) IE58186B1 (https=)
NO (1) NO162387B (https=)
NZ (1) NZ214570A (https=)
PH (1) PH23660A (https=)
PT (1) PT81689B (https=)
ZA (1) ZA859573B (https=)

Families Citing this family (45)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2181729B (en) * 1985-10-12 1990-04-04 Nippon Shinyaku Co Ltd Glucosylmoranoline derivatives and production thereof
JPS62242692A (ja) * 1986-04-15 1987-10-23 Nippon Shinyaku Co Ltd モラノリン誘導体の製造法
EP0345104B1 (en) * 1988-06-02 1995-11-02 Merrell Dow Pharmaceuticals Inc. Novel Alpha-glucosidase inhibitors
EP0344383A1 (en) * 1988-06-02 1989-12-06 Merrell Dow Pharmaceuticals Inc. Novel alpha-Glucosidase inhibitors
US4880917A (en) * 1988-07-01 1989-11-14 Merrell Dow Pharmaceuticals Inc. Process for hydrolyzing 2,6-dideoxy-2,6-iminoheptononitrile derivatives using trifluoroacetic acid and dinitrogen tetroxide
US4908439A (en) * 1988-09-16 1990-03-13 Merrell Dow Pharmaceuticals Inc. Synthesis of intermediate useful in the preparation of nojirimycin and related compounds
US5227479A (en) * 1989-12-20 1993-07-13 Merrell Dow Pharmaceuticals Inc. Process for the preparation of nojirimycin and related compounds
US5504078A (en) * 1990-06-08 1996-04-02 Merrell Dow Pharmaceuticals Inc. α-glucosidase inhibitors
GB2338235B (en) * 1997-04-15 2001-11-14 Csir Appetite suppressing plant extracts
GB2396815B (en) * 1999-10-27 2004-09-08 Phytopharm Plc A composition comprising a pregnenone derivative and an NSAID
JP4060079B2 (ja) 2000-03-31 2008-03-12 ミシガン ステイト ユニバーシティー オキシム又はイミンからの１，５―ジデオキシ―１，５−イミノヘキシトールの製法
GB2363985B (en) 2000-06-30 2004-09-29 Phytopharm Plc Extracts,compounds & pharmaceutical compositions having anti-diabetic activity and their use
US7262318B2 (en) * 2004-03-10 2007-08-28 Pfizer, Inc. Substituted heteroaryl- and phenylsulfamoyl compounds
US20050288340A1 (en) * 2004-06-29 2005-12-29 Pfizer Inc Substituted heteroaryl- and phenylsulfamoyl compounds
WO2006056845A1 (en) * 2004-11-23 2006-06-01 Warner-Lambert Company Llc 7-(2h-pyrazol-3-yl)-3, 5-dihyroxy-heptanoic acid derivatives as hmg co-a reductase inhibitors for the treatment of lipidemia
PL2027137T3 (pl) * 2005-06-08 2015-08-31 Amicus Therapeutics Inc Oczyszczanie imino- i aminocukrów
BRPI0613224A2 (pt) * 2005-06-08 2010-12-28 Amicus Therapeutics Inc método para estabilizar um açúcar triflatado, método para aumentar o rendimento da reação de um produto de açúcar e composição de açúcar triflatado estabilizada
EP1888612A1 (en) * 2005-06-08 2008-02-20 Amicus Therapeutics, Inc. Crystalline sugar compositions and method of making
US7741317B2 (en) 2005-10-21 2010-06-22 Bristol-Myers Squibb Company LXR modulators
US7888376B2 (en) 2005-11-23 2011-02-15 Bristol-Myers Squibb Company Heterocyclic CETP inhibitors
CN101663262B (zh) 2006-12-01 2014-03-26 百时美施贵宝公司 用于治疗动脉粥样硬化和心血管疾病的作为cetp抑制剂的n-(3-苄基)-2,2-(二苯基)-丙-1胺衍生物
US8877717B2 (en) 2007-03-12 2014-11-04 Zadec Aps Anti-diabetic extract of rooibos
EP2527360B1 (en) 2007-06-04 2015-10-28 Synergy Pharmaceuticals Inc. Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders
US8969514B2 (en) 2007-06-04 2015-03-03 Synergy Pharmaceuticals, Inc. Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases
EP2810951B1 (en) 2008-06-04 2017-03-15 Synergy Pharmaceuticals Inc. Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders
EP3241839B1 (en) 2008-07-16 2019-09-04 Bausch Health Ireland Limited Agonists of guanylate cyclase useful for the treatment of gastrointestinal, inflammation, cancer and other disorders
WO2011145022A1 (en) 2010-05-21 2011-11-24 Pfizer Inc. 2-phenyl benzoylamides
US20130156720A1 (en) 2010-08-27 2013-06-20 Ironwood Pharmaceuticals, Inc. Compositions and methods for treating or preventing metabolic syndrome and related diseases and disorders
US9616097B2 (en) 2010-09-15 2017-04-11 Synergy Pharmaceuticals, Inc. Formulations of guanylate cyclase C agonists and methods of use
CN102462726B (zh) * 2010-11-04 2016-03-09 中国医学科学院药物研究所 白树总生物碱及多羟基生物碱化合物的提取、分离及用途
JP2014513923A (ja) 2011-03-04 2014-06-19 ファイザー・インク Ｅｄｎ３様ペプチドおよびその使用
EP2712362A4 (en) * 2011-05-13 2014-12-24 Glycom As MANUFACTURE OF LACTO-N-TETRAOSE
US20150050371A1 (en) 2012-03-09 2015-02-19 Biotropics Malaysia Berhad Extract Formulations of Rhodamnia Cinerea And Uses Thereof
CA2905438A1 (en) 2013-03-15 2014-09-25 Synergy Pharmaceuticals Inc. Agonists of guanylate cyclase and their uses
CA2905435A1 (en) 2013-03-15 2014-09-25 Synergy Pharmaceuticals Inc. Compositions useful for the treatment of gastrointestinal disorders
MX2015014666A (es) 2013-04-17 2016-03-01 Pfizer Derivados de n-piperidin-3-ilbenzamida para tratar enfermedades cardiovasculares.
SI3004138T1 (sl) 2013-06-05 2024-07-31 Bausch Health Ireland Limited Ultra čisti agonisti gvanilat ciklaze C, postopek za njihovo pripravo in uporabo
KR102431436B1 (ko) 2014-08-29 2022-08-10 테스 파마 에스.알.엘. α-아미노-β-카복시뮤콘산 세미알데히드 데카복실라제의 억제제
WO2016055901A1 (en) 2014-10-08 2016-04-14 Pfizer Inc. Substituted amide compounds
CN104530150A (zh) * 2015-01-14 2015-04-22 佛山市赛维斯医药科技有限公司 含胺基苯和双葡萄糖苷结构化合物、其制备方法和用途
AR109950A1 (es) 2016-10-14 2019-02-06 Tes Pharma S R L INHIBIDORES DE LA ÁCIDO a-AMINO-b-CARBOXIMUCÓNICO SEMIALDEHÍDO DESCARBOXILASA
IT201700078102A1 (it) 2017-07-11 2019-01-11 Dipharma Francis Srl Sintesi di un azazucchero e suoi intermedi
CN108828121B (zh) * 2018-06-14 2020-06-05 华润三九医药股份有限公司 一种白树药材中α-高野尻霉素的含量检测方法
AR117122A1 (es) 2018-11-20 2021-07-14 Tes Pharma S R L INHIBIDORES DE LA ÁCIDO a-AMINO-b-CARBOXIMUCÓNICO SEMIALDEHÍDO DESCARBOXILASA
SG11202107614PA (en) 2019-01-18 2021-08-30 Astrazeneca Ab Pcsk9 inhibitors and methods of use thereof

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4065562A (en) * 1975-12-29 1977-12-27 Nippon Shinyaku Co., Ltd. Method and composition for reducing blood glucose levels
NO154918C (no) * 1977-08-27 1987-01-14 Bayer Ag Analogifremgangsmaate til fremstilling av terapeutisk aktive derivater av 3,4,5-trihydroksypiperidin.
DE2848117A1 (de) * 1978-11-06 1980-05-14 Bayer Ag Derivate des 2-hydroxymethyl-3,4,5- trihydroxy-piperidins, ihre herstellung und verwendung zur beeinflussung des kohlenhydrat- und fettstoffwechsels
DE2942365A1 (de) * 1979-10-19 1981-05-14 Bayer Ag, 5090 Leverkusen 2-hydroxyalkyl-3,4,5-trihydroxy-(pi)-peridine, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
GB2064527B (en) * 1979-12-08 1984-05-02 Nippon Shinyaku Co Ltd Moranoline derivatives and process for preparation thereof
IT1210476B (it) * 1981-05-28 1989-09-14 Erba Farmitalia Antracicline.

Also Published As

Publication number Publication date
IE58186B1 (en) 1993-07-28
FI854944L (fi) 1986-06-19
DK587085D0 (da) 1985-12-17
EP0186103B1 (en) 1991-04-03
PT81689B (pt) 1987-11-30
ZA859573B (en) 1986-08-27
PH23660A (en) 1989-09-27
EP0186103A3 (en) 1988-02-03
AU574246B2 (en) 1988-06-30
HUT40137A (en) 1986-11-28
DE3582420D1 (de) 1991-05-08
ES8706164A1 (es) 1987-06-01
KR860004921A (ko) 1986-07-16
CN1016784B (zh) 1992-05-27
ATE62249T1 (de) 1991-04-15
PT81689A (en) 1986-01-01
FI80707B (fi) 1990-03-30
GR853032B (https=) 1986-04-18
IE853179L (en) 1986-06-18
US4634765A (en) 1987-01-06
JPH0565519B2 (https=) 1993-09-17
DK587085A (da) 1986-06-19
HU194263B (en) 1988-01-28
ES550060A0 (es) 1987-06-01
FI854944A0 (fi) 1985-12-13
JPS61158994A (ja) 1986-07-18
EP0186103A2 (en) 1986-07-02
NO855087L (no) 1986-06-19
AU5081085A (en) 1986-06-26
NZ214570A (en) 1988-03-30
CA1240989A (en) 1988-08-23
NO162387B (no) 1989-09-11
CN85109548A (zh) 1986-07-09
FI80707C (fi) 1990-07-10

Similar Documents

Publication Publication Date Title
KR900005607B1 (ko) 호모노지리마이신 글리코사이드의 제조방법
CS270585B2 (en) Method of 4-demethoxy-4-aminoanthracycline derivatives production
Fuchs et al. Synthesis and antitumor activity of sugar-ring hydroxyl analogs of daunorubicin
Takahashi et al. Design and synthesis of a heparanase inhibitor with pseudodisaccharide structure
US5066645A (en) Epipodophyllotoxin altroside derivatives
KR950004897B1 (ko) 안트라사이클린 글리코사이드 유도체의 제조방법
EP0199920B1 (en) New antitumor anthracyclines
NO170687B (no) Analogifremgangsmaate til fremstilling av fluorsubstituerte 4'-demetylepipodofyllotoksin-glukosider
US4839346A (en) Antitumor anthracycline glycosides, intermediates thereof, and composition and use thereof
Koto et al. Pentoside synthesis by dehydrative glycosylation. Synthesis of O-. ALPHA.-L-arabinofuranosyl-(1. RAR. 3)-O-. BETA.-D-xylopyranosyl-(1. RAR. 4)-D-xylopyranose.
EP1829884B1 (en) Sugar donor
IE43088B1 (en) Cardenolide glycosides and methods of making the same
Monneret et al. Synthesis and antitumour activity of a new series of nitrosoureido sugars
Popsavin et al. Conversion of D-xylose to protected D-lyxose derivatives and to D-lyxose, via the corresponding 1, 2-anhydride
Attolino et al. An efficient and highly regioselective synthesis of 4-deoxy-and 2-acetamido-2, 4-dideoxy-β-d-threo-hex-3-enopyranosides
Hayashida et al. Displacement of “pseudoanomeric” hydroxyl groups by using the diethyl azodicarboxylate-triphenylphosphine system
Sakakibara et al. Preparation and structural determination of methyl 4, 6-O-benzylidene-2, 3-dideoxy-β-d-erythro-hexopyranosid [2, 3-d] triazole and of its adducts with 3-nitrohex-2-enopyranosides
Reist et al. Neighboring group participation in carbohydrates. Synthesis of 2, 3-diamino-2, 3-dideoxy-L-ribose
FR2883561A1 (fr) Nouveaux composes derives du 5-thioxylose et leur utilisation therapeutique
GB2034707A (en) Anthracycline glycosides
GB2159518A (en) New anthracyclines and process for manufacture
Tezuka Synthetic studies of azasugars
JPH0770167A (ja) グリコシド及びこれを含有する抗肝炎剤

Legal Events

Date Code Title Description
PA0109 Patent application

St.27 status event code: A-0-1-A10-A12-nap-PA0109

R17-X000 Change to representative recorded

St.27 status event code: A-3-3-R10-R17-oth-X000

P11-X000 Amendment of application requested

St.27 status event code: A-2-2-P10-P11-nap-X000

P13-X000 Application amended

St.27 status event code: A-2-2-P10-P13-nap-X000

PG1501 Laying open of application

St.27 status event code: A-1-1-Q10-Q12-nap-PG1501

A201 Request for examination
P11-X000 Amendment of application requested

St.27 status event code: A-2-2-P10-P11-nap-X000

P13-X000 Application amended

St.27 status event code: A-2-2-P10-P13-nap-X000

PA0201 Request for examination

St.27 status event code: A-1-2-D10-D11-exm-PA0201

G160 Decision to publish patent application
PG1605 Publication of application before grant of patent

St.27 status event code: A-2-2-Q10-Q13-nap-PG1605

E701 Decision to grant or registration of patent right
PE0701 Decision of registration

St.27 status event code: A-1-2-D10-D22-exm-PE0701

GRNT Written decision to grant
PR0701 Registration of establishment

St.27 status event code: A-2-4-F10-F11-exm-PR0701

PR1002 Payment of registration fee

St.27 status event code: A-2-2-U10-U11-oth-PR1002

Fee payment year number: 1

FPAY Annual fee payment

Payment date: 19930615

Year of fee payment: 4

PR1001 Payment of annual fee

St.27 status event code: A-4-4-U10-U11-oth-PR1001

Fee payment year number: 4

LAPS Lapse due to unpaid annual fee
PC1903 Unpaid annual fee

St.27 status event code: A-4-4-U10-U13-oth-PC1903

Not in force date: 19940801

Payment event data comment text: Termination Category : DEFAULT_OF_REGISTRATION_FEE

PC1903 Unpaid annual fee

St.27 status event code: N-4-6-H10-H13-oth-PC1903

Ip right cessation event data comment text: Termination Category : DEFAULT_OF_REGISTRATION_FEE

Not in force date: 19940801

PN2301 Change of applicant

St.27 status event code: A-5-5-R10-R13-asn-PN2301

St.27 status event code: A-5-5-R10-R11-asn-PN2301