KR900003371A - 재조합 천연 킬러 세포 활성화제 - Google Patents

재조합 천연 킬러 세포 활성화제 Download PDF

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KR900003371A
KR900003371A KR1019890012546A KR890012546A KR900003371A KR 900003371 A KR900003371 A KR 900003371A KR 1019890012546 A KR1019890012546 A KR 1019890012546A KR 890012546 A KR890012546 A KR 890012546A KR 900003371 A KR900003371 A KR 900003371A
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natural killer
killer cell
recombinant natural
activating factor
cell activating
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KR1019890012546A
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겐따로오 요시마쓰
유끼오 오오야
야스시 시가따
이사오 다나까
요시가쯔 하세가와
도시오 세또
도시아끼 오사와
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나이또오 하루오
에자이 가부시끼가이샤
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Publication of KR900003371A publication Critical patent/KR900003371A/ko

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/82—Proteins from microorganisms
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S930/00—Peptide or protein sequence
    • Y10S930/01—Peptide or protein sequence
    • Y10S930/12—Growth hormone, growth factor other than t-cell or b-cell growth factor, and growth hormone releasing factor; related peptides

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
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  • Proteomics, Peptides & Aminoacids (AREA)
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  • Physics & Mathematics (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
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Abstract

내용 없음

Description

재조합 천연 킬러 세포 활성화제
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
제1도는 단일클론성 항체 컬럼에의한 천연 NKAF의 정제 결과를 나타내느 크로마토그램.
제2도는 2개의 단일클론성 항체에 대한 EIA를 나타내고,
제3도는 역상(逆相) HPLC에 의한 NKAF의 정제 결과를 나타내는 크로마토그램.

Claims (12)

  1. 재조합 천연 킬러세포 활성화 인자.
  2. 제1항에 있어서, 그 분자내에 다음의 아미노산 서열의 펩티드가 있는 것을 특징으로 하는 재조합 천연 킬러 세포 활성화 인자 :
  3. 재조합 천연 킬러 세포 활성화 인자를 코딩하는 cDNA.
  4. 그 분자내에 제2항에서 정의한 것과 같은 아미노산 서열의 펩티드가 있는 재조합 천연 킬러 세포 활성화 인자를 코딩하는 cDNA.
  5. 제4항에 있어서, 다음의 염기 서열을 가지는 것을 특징으로 하는 cDNA :
  6. 제3항에서 설명한 cDNA를 외래 유전자로서 함유하고, 선택된 숙주내에서 조절과 발현을 가능케 하는 방법으로 링킹하여 얻어지는 것을 특징으로 하는 발현 플라스미드.
  7. 제4항에서 설명한 cDNA를 외래 유전자로서 함유하고, 선택된 숙주내에서 조절과 발현을 가능케 하는 방법으로 링킹하여 얻어지는 것을 특징으로 하는 발현 플라스미드.
  8. 제6항에서 설명한 플라스미드로 형질전환된 숙주.
  9. 제7항에서 설명한 플라스미드로 형질전환된 숙주.
  10. 재조합 천연 킬러 세포 활성화 인자로 이루어지는 항종양제제.
  11. 제10항에 있어서, 그 분자내에 제2항에서 정의한 것과 같은 아미노산 서열의 펩티드가 있는 것을 특징으로 하는 재조합 천연 킬러 세포 활성화 인자.
  12. 약리학적으로 효과적인 양의 제10항 또는 제11항에서 정의한 항종양 제제와 약리학적으로허용되는 담체로 이루어지는 제약적 조성물.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019890012546A 1988-08-31 1989-08-31 재조합 천연 킬러 세포 활성화제 KR900003371A (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP21759988 1988-08-31
JP88-217599 1988-08-31

Publications (1)

Publication Number Publication Date
KR900003371A true KR900003371A (ko) 1990-03-26

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ID=16706821

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Application Number Title Priority Date Filing Date
KR1019890012546A KR900003371A (ko) 1988-08-31 1989-08-31 재조합 천연 킬러 세포 활성화제

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Country Link
US (2) US5185431A (ko)
EP (1) EP0357067B1 (ko)
KR (1) KR900003371A (ko)
AT (1) ATE118037T1 (ko)
AU (1) AU4009789A (ko)
CA (1) CA1335360C (ko)
DE (1) DE68920931T2 (ko)
DK (1) DK424989A (ko)
FI (1) FI893833A (ko)
NO (1) NO893452L (ko)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5457038A (en) * 1988-11-10 1995-10-10 Genetics Institute, Inc. Natural killer stimulatory factor
ATE140483T1 (de) * 1988-11-10 1996-08-15 Genetics Inst Natürlicher killerzellen-stimulationsfaktor
US5811523A (en) 1988-11-10 1998-09-22 Trinchieri; Giorgio Antibodies to natural killer stimulatory factor
US6683046B1 (en) 1989-12-22 2004-01-27 Hoffmann-La Roche Inc. Purification and characterization of cytotoxic lymphocyte maturation factor and monoclonal antibodies thereto
JP3479539B2 (ja) 1992-04-10 2003-12-15 エーザイ株式会社 ヒトアンチトロンビンｉｉｉ変異体
US6255079B1 (en) 1995-06-06 2001-07-03 Human Genome Sciences, Inc. Polynucleotides encoding natural killer cell enhancing factor C
AU2818695A (en) * 1995-06-06 1996-12-24 Human Genome Sciences, Inc. Natural killer cell enhancing factor c
EP0832255B1 (en) * 1995-06-07 2005-12-14 Washington University Recombinant bacterial system with environmentally limited viability
US6448044B2 (en) 1996-04-03 2002-09-10 Human Genome Sciences, Inc. DNA encoding human natural killer cell activating factor II
CA2250269A1 (en) * 1996-04-03 1997-10-09 Human Genome Sciences, Inc. Human natural killer cell activating factor ii
US7026456B1 (en) 1998-01-23 2006-04-11 Hoffman-La Roche, Inc. Antibodies against human IL-12
EP1930438A1 (en) * 2006-12-07 2008-06-11 Academisch Medisch Centrum bij de Universiteit van Amsterdam Transcription factor for killer cell activation, differentiation and uses thereof
US9616114B1 (en) 2014-09-18 2017-04-11 David Gordon Bermudes Modified bacteria having improved pharmacokinetics and tumor colonization enhancing antitumor activity
US11180535B1 (en) 2016-12-07 2021-11-23 David Gordon Bermudes Saccharide binding, tumor penetration, and cytotoxic antitumor chimeric peptides from therapeutic bacteria
US11129906B1 (en) 2016-12-07 2021-09-28 David Gordon Bermudes Chimeric protein toxins for expression by therapeutic bacteria
CN114736268A (zh) * 2022-03-01 2022-07-12 吉林农业大学 一种提高活性肽ace抑制率的修饰方法、ace抑制肽及其应用

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS58110548A (ja) * 1981-12-24 1983-07-01 Asahi Chem Ind Co Ltd 新規な生理活性ペプチド
JPS6197224A (ja) * 1984-10-19 1986-05-15 Eisai Co Ltd 新規なリンホカイン

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Publication number Publication date
AU4009789A (en) 1990-03-08
FI893833A0 (fi) 1989-08-15
EP0357067A3 (en) 1991-08-21
DK424989A (da) 1990-03-01
NO893452L (no) 1990-03-01
EP0357067A2 (en) 1990-03-07
NO893452D0 (no) 1989-08-29
CA1335360C (en) 1995-04-25
ATE118037T1 (de) 1995-02-15
EP0357067B1 (en) 1995-02-01
DE68920931D1 (de) 1995-03-16
DE68920931T2 (de) 1995-07-06
US5316933A (en) 1994-05-31
US5185431A (en) 1993-02-09
FI893833A (fi) 1990-03-01
DK424989D0 (da) 1989-08-29

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