KR900701826A - 프로버어신 - Google Patents
프로버어신Info
- Publication number
- KR900701826A KR900701826A KR1019900700053A KR900700053A KR900701826A KR 900701826 A KR900701826 A KR 900701826A KR 1019900700053 A KR1019900700053 A KR 1019900700053A KR 900700053 A KR900700053 A KR 900700053A KR 900701826 A KR900701826 A KR 900701826A
- Authority
- KR
- South Korea
- Prior art keywords
- peptide
- arg
- lys
- gly
- phe
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K17/00—Carrier-bound or immobilised peptides; Preparation thereof
- C07K17/02—Peptides being immobilised on, or in, an organic carrier
- C07K17/08—Peptides being immobilised on, or in, an organic carrier the carrier being a synthetic polymer
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Gastroenterology & Hepatology (AREA)
- Immunology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
Abstract
내용 없음
Description
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
제1도는 소간으로 부터의 프로버어신의 정제된 분획의 광학말도를 나타내는 그래프도이다; 제2도는 프로버어신의 박층 크로마토그래피겔의 예시도이다: 제3도는 항-버어신항제(점)와 토끼혈청(사각형)의 다양한 역가의 광학밀도를 나타내는 그래프도이다.
Claims (12)
- 식 Phe-Phe-Trp-Lys-Tys-Lys-Pro-Arg-Lys-His-Gly-Gly-Arg-Arg 그의 유사체의 서열과 동일한 또는 실질적으로 동일한 아미노산 서열로 이루어지는 펩티드, 및 그의 약학적으로 허용가능한 산-부가염.
- 제1항에 있어서, 고상 또는 액상 화학합성법에 의하여 제조되는 것을 특징으로 하는 펩티드.
- 제1항에 있어서, 사람 간세포 또는 사람 골수세포로부터 선택된 포유동물 세포로부터 정제되는 것을 특징으로 하는 펩티드.
- 제1항에 있어서, 제조합 기법에 의해 제조되는 것을 특징으로 하는 펩티드.
- 제1항에 있이서, 약 1㎍/㎖농도에서 다우디 또는 MOPC-315 세포의 세포내 cGMP 상승을 유도하는 역치 환성을 특징으로 하는 펩티드.
- 서열 Phe-Phe-Trp-Lys-Tys-Lys-Pro-Arg-Lys-His-Gly-Gly-Arg-Arg 를 가지는 펩티드, 및 그의 약학적으로 허용가능한 산-부가염.
- 적당한 제어서열과 효력있게 결합된 식 Phe-Phe-Trp-Lys-Tys-Lys-Pro-Arg-Lys-His-Gly-Gly-Arg-Arg 과 동일한 또는 실질적으로 동일한 아미노산 서열로 이루어지는 펩티드를 코드화 하는 서열로 이루어지는 DNA 분자.
- 약학적으로 허용 가능한 체형중의 치료적으로 유효한 양의 제1항의 펩티드로 이루어지는 약학 조성물.
- 환자의 면역시스템 조절에 적당한 약학 조성들의 제조에 대한 제1항의 펩티드 또는 그의 염의 이용.
- 종양성장을 저해하기에 층분한 양의 성장호르몬의 방출을 저해하기에 적당한 약학조성물의 제조에 대한 제1항의 펩티드 또는 그의 염의 이용.
- 식. R1-Phe-Phe-(R2)Trp-(R3)Lys-(R4)Thr-(R5)Lys-Pro-(R|6)Arg-(R7)Lay-(R8)His-Gly-Gly-(R9)Arg-(R10)Arg 수지의 펩티드-수지 중간체로서 상기 식중 R1에서 R10은 각각 독립적으로 적절한 보호기로 부터 선택되고, 수지는 적절한 고체상 중합체인 것을 특징으로 하는 펩티드-수지 중간제.
- 제1항의 펩티드 또는 상기 펩티드에 대한 항체를 포함하는 진단시약.※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US19248288A | 1988-05-11 | 1988-05-11 | |
US192,482 | 1988-05-11 | ||
US287,462 | 1988-12-20 | ||
US07/287,462 US4994554A (en) | 1988-05-11 | 1988-12-20 | Probursin |
PCT/US1989/001962 WO1989010735A1 (en) | 1988-05-11 | 1989-05-08 | Probursin |
Publications (1)
Publication Number | Publication Date |
---|---|
KR900701826A true KR900701826A (ko) | 1990-12-04 |
Family
ID=26888111
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
KR1019900700053A KR900701826A (ko) | 1988-05-11 | 1989-05-08 | 프로버어신 |
Country Status (13)
Country | Link |
---|---|
US (1) | US4994554A (ko) |
EP (1) | EP0342015A3 (ko) |
JP (1) | JPH02504155A (ko) |
KR (1) | KR900701826A (ko) |
CN (1) | CN1037712A (ko) |
AU (1) | AU623148B2 (ko) |
BR (1) | BR8906960A (ko) |
DK (1) | DK6590A (ko) |
HU (1) | HU202885B (ko) |
IL (1) | IL90228A0 (ko) |
NZ (1) | NZ229003A (ko) |
PT (1) | PT90525A (ko) |
WO (1) | WO1989010735A1 (ko) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6177405B1 (en) * | 1992-07-22 | 2001-01-23 | Kenji Nishioka | Cyclic analogs of tuftsin |
FR2801848B1 (fr) * | 1999-12-01 | 2003-11-28 | Pga Electronic | Systeme de gestion des mouvements d'un ou de plusieurs sieges de vehicule |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4291022A (en) * | 1975-03-11 | 1981-09-22 | Sandoz Ltd. | Organic compounds |
US4190648A (en) * | 1979-03-13 | 1980-02-26 | Merck & Co., Inc. | Peptides having somatostatin activity |
US4584284A (en) * | 1985-01-31 | 1986-04-22 | Ortho Pharmaceutical Corporation | Bursopoietin |
-
1988
- 1988-12-20 US US07/287,462 patent/US4994554A/en not_active Expired - Fee Related
-
1989
- 1989-05-04 NZ NZ229003A patent/NZ229003A/en unknown
- 1989-05-08 AU AU36889/89A patent/AU623148B2/en not_active Ceased
- 1989-05-08 KR KR1019900700053A patent/KR900701826A/ko not_active Application Discontinuation
- 1989-05-08 HU HU893527A patent/HU202885B/hu not_active IP Right Cessation
- 1989-05-08 BR BR898906960A patent/BR8906960A/pt unknown
- 1989-05-08 WO PCT/US1989/001962 patent/WO1989010735A1/en active Application Filing
- 1989-05-08 JP JP1505997A patent/JPH02504155A/ja active Pending
- 1989-05-08 IL IL90228A patent/IL90228A0/xx unknown
- 1989-05-10 PT PT90525A patent/PT90525A/pt not_active Application Discontinuation
- 1989-05-10 EP EP19890304750 patent/EP0342015A3/en not_active Withdrawn
- 1989-05-11 CN CN89103304A patent/CN1037712A/zh active Pending
-
1990
- 1990-01-10 DK DK006590A patent/DK6590A/da not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
CN1037712A (zh) | 1989-12-06 |
AU3688989A (en) | 1989-11-29 |
DK6590D0 (da) | 1990-01-10 |
IL90228A0 (en) | 1989-12-15 |
BR8906960A (pt) | 1990-11-20 |
EP0342015A2 (en) | 1989-11-15 |
JPH02504155A (ja) | 1990-11-29 |
WO1989010735A1 (en) | 1989-11-16 |
HU202885B (en) | 1991-04-29 |
US4994554A (en) | 1991-02-19 |
EP0342015A3 (en) | 1990-10-10 |
AU623148B2 (en) | 1992-05-07 |
NZ229003A (en) | 1992-01-29 |
HU893527D0 (en) | 1990-11-28 |
HUT53913A (en) | 1990-12-28 |
PT90525A (pt) | 1989-11-30 |
DK6590A (da) | 1990-01-10 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
WITN | Application deemed withdrawn, e.g. because no request for examination was filed or no examination fee was paid |