KR860000072A - 임균 예방 백신의 제조방법 - Google Patents

임균 예방 백신의 제조방법 Download PDF

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KR860000072A
KR860000072A KR1019850004400A KR850004400A KR860000072A KR 860000072 A KR860000072 A KR 860000072A KR 1019850004400 A KR1019850004400 A KR 1019850004400A KR 850004400 A KR850004400 A KR 850004400A KR 860000072 A KR860000072 A KR 860000072A
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glu
ala
asp
ser
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KR1019850004400A
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슐니크(외 1) 게리케이.
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캐더린쿠
더보드오브 트루스티스오브더리랜드 스탠포드 주니어유니버시티
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Publication of KR860000072A publication Critical patent/KR860000072A/ko

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/22—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Neisseriaceae (F)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/385—Haptens or antigens, bound to carriers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
    • A61K2039/6031—Proteins
    • A61K2039/6081—Albumin; Keyhole limpet haemocyanin [KLH]
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/806—Antigenic peptides or proteins

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
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  • Animal Behavior & Ethology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
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  • Pharmacology & Pharmacy (AREA)
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  • Gastroenterology & Hepatology (AREA)
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  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

내용 없음

Description

임균 예방 백신의 제조방법
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
제1도는 N-메틸(페닐알라)MSll 필린의 아미노산 서열 및 본 발명의 프로테인 부분을 나타낸다.

Claims (8)

  1. 엔. 고노리아에(N.gnorrhoeae) MSII(Tr) 필린의 잔기 21-35, 41-50, 48-60, 69-84, 107-121, 135-151 또는 151-159에 상응하는 펩타이드와 거의 동일한 아미노산 서열을 갖는 펩타이드를 거의 항원적으로 중성인 담체에 결합시킴을 특징으로 하여, 상기 펩타이드 유효량을 함유하는 인체임균 예방백신을 제조하는 방법.
  2. 제1항에 있어서, 잔기 21-35, 41-50, 48-60 또는 69-84에, 또는 N-말단 Cys가 삭제된 잔기 151-159에 상응하는 펩타이드가 그의 C말단에서 Cys 잔기를 추가로 함유하는 백신을 제조하는 방법.
  3. 제1항에 있어서, 잔기 21-35, 41-50, 48-60, 또는 69-84에, 또는 N-말단 Cys를 갖는 잔기 151-159에 상응하는 펩타이드가 그의 C말단에서 Gly-Cys 디펩타이드를 추가로 함유하는 백신을 제조하는 방법.
  4. 제1항에 있어서, (a) Glu-Gly-Gln-Lys-Ser-Ala-Val-Thr-Glu-Tyr; (b) Pro-Pro-Ser-Asp-Ile-Lys-Gly-Lys-Tyr-Val-Lys-Glu-Val-Glu-Val-Lys; (c) Leu-Pro-Ala-Tyr-Gln-Asp-Tyr-Ala-Arg-Ala-Gln-Val-Ser-Glu; (d) Thr- Glu-Tyr-Tyr-Leu-Asn-His-Gly-Lys-Trp-Pro-Glu-Asn; (e) Ser-Leu-Trp-Ala-Arg-Glu-Asn-Gly-Ser-Val-Lys-Trp-Phe-Cys; (f) Asp-Ala-Lys-Asp-Gly-Lys-Glu-Ile-Asp-Thr-Lys-His-Leu-Pro-Ser-Thr-Cys;-and, (g) Cys-Arg-Arg-Asp-Lys-Ala-Ser-Asp-Ala-Lys로 구성된 그룹중에서 선택된 펩타이드 유효량을 함유하는, 인체임균예방 백신을 제조하는 방법.
  5. 제4항에 있어서, a 내지 d 또는 N-말단 Cys가 삭제된 g의 각 서열이 c-말단 Cys 잔기 또는 C-말단 Gly-Cys 잔기를 추가로 함유하는 백신을 제조하는 방법.
  6. 엔. 고노리아에 MSII(Tr) 필린의 잔기 21-35, 41-50, 48-60, 69-84, 107-121, 135-151 또는 151-159에 상응하는 팹타이드와 거의 동일한 아미노산 서열을 갖는 펩타이드를 만들수 있는 재조합체 미생물을 배양시키거나 상기 펩타이드의 아미노산을 순서대로 연결시킴을 특징으로 하여, 상기 펩타이드 유효량을 함유하는, 인체임균 예방백신을 제조하는 방법.
  7. 제6항에 있어서, (a) Glu-Gly-Gln-Lys-Ser-Ala-Val-Thr-Glu-Tyr; (b) Pro-Pro-Ser-Asp-Ile-Lys-Gly-Lys-Tyr-Val-Lys-Glu-Val-Lys; (c) Leu-Pro-Ala-Tyr-Gln-Asp-Tyr-Thr-Ala-Arg-Ala-Gln-Val-Ser-Glu; (d) Thr-Glu-Tyr-Tyr-Leu-Asn-His-Gly-Lys-Trp-Pro-Glu-Asn; (e) Ser-Leu-Trp-Ala-Arg-Arg-Glu-Asn-Gly-Ser-Val-Lys-Trp-Phe-Cys; (f) Asp-Ala-Lys-Asp-Gly-Lys-Glu-Ile-Asp-Thr-Lys-His-Leu-Pro-Ser-Thr-Cys;and, (g) Cys-Arg-Asp-Lys-Ala-Ser-Asp-Ala-Lys로 구성된 그룹중에서 선택된 거의 순수한 형태의 펩타이드를 제조하는 방법.
  8. 제6항에 있어서, a 내지 d, 또는 N-말단 Cys가 삭제된 g의 각서열이 C-말단 Cys 잔기 또는 C-말단 Gly-Cys 잔기를 추가로 함유하는 펩타이드를 제조하는 방법.
    ※ 참고사항 : 최초출원내용에 의하여 공개하는 것임.
KR1019850004400A 1984-06-21 1985-06-21 임균 예방 백신의 제조방법 KR860000072A (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US06/623,178 US4584195A (en) 1984-06-21 1984-06-21 Broad spectrum vaccine against gonorrhea
US623178 1984-06-21

Publications (1)

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KR860000072A true KR860000072A (ko) 1986-01-25

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Country Status (7)

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US (1) US4584195A (ko)
EP (1) EP0166548A3 (ko)
JP (1) JPS6117523A (ko)
KR (1) KR860000072A (ko)
CA (1) CA1262799A (ko)
PH (1) PH22983A (ko)
ZA (1) ZA854375B (ko)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4786592A (en) * 1986-06-18 1988-11-22 Scripps Clinic And Research Foundation Neisseria gonorrhoeae lectin useful as a vaccine and diagnostic marker and means for producing this lectin
EP0273116A3 (en) * 1986-10-09 1990-05-02 Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. Gonococcal and meningococcal polypeptides, vaccines and diagnostics
EP0270295A3 (en) * 1986-12-03 1989-08-02 Connaught Laboratories Limited Conjugate vaccine
US4882145A (en) * 1986-12-09 1989-11-21 Scripps Clinic And Research Foundation T cell epitopes of the hepatitis B virus nucleocapsid protein
US4818527A (en) * 1986-12-09 1989-04-04 Scripps Clinic And Research Foundation T cell epitopes of the hepatitis B virus nucleocapsid protein
WO1989007449A1 (en) * 1988-02-16 1989-08-24 Immunetech Pharmaceuticals Methods for treating immunoinflammatory and other disease conditions
EP0351604B1 (en) 1988-06-29 1994-09-14 The Rockefeller University Neisserial vaccines
AU1411492A (en) * 1991-01-31 1992-09-07 Washington University Polypeptides and polynucleotides useful for the diagnosis and treatment of pathogenic neisseria
US5834591A (en) * 1991-01-31 1998-11-10 Washington University Polypeptides and antibodies useful for the diagnosis and treatment of pathogenic neisseria and other microorganisms having type 4 pilin
US5622649A (en) * 1991-06-27 1997-04-22 Emory University Multiple emulsions and methods of preparation

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4443431A (en) * 1981-05-27 1984-04-17 The United States Of America As Represented By The Department Of Health And Human Services Neisseria gonorrhoeae vaccine
DK219084D0 (da) * 1984-05-02 1984-05-02 Frederik Carl Peter Lindberg Antigen
EP0177583A4 (en) * 1984-04-06 1988-06-08 Scripps Clinic Res PEPTIDE VACCINE OR DIAGNOSTIC, AND POLYPEPTIDE FOR USE THEREOF.

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Publication number Publication date
EP0166548A3 (en) 1988-01-07
US4584195A (en) 1986-04-22
JPS6117523A (ja) 1986-01-25
EP0166548A2 (en) 1986-01-02
ZA854375B (en) 1986-01-29
CA1262799A (en) 1989-11-07
PH22983A (en) 1989-02-24

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