KR890701142A - 니코틴 조절 공급기재(Apparatus for the controlled delivery), 그 제조방법 및 그 용도 - Google Patents

니코틴 조절 공급기재(Apparatus for the controlled delivery), 그 제조방법 및 그 용도

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Publication number
KR890701142A
KR890701142A KR1019890700765A KR890700765A KR890701142A KR 890701142 A KR890701142 A KR 890701142A KR 1019890700765 A KR1019890700765 A KR 1019890700765A KR 890700765 A KR890700765 A KR 890700765A KR 890701142 A KR890701142 A KR 890701142A
Authority
KR
South Korea
Prior art keywords
weight
melt adhesive
substrate
hot melt
nicotine
Prior art date
Application number
KR1019890700765A
Other languages
English (en)
Other versions
KR970006447B1 (ko
Inventor
할포 자에거
한스-라이너 호프만
라인홀트 메코니
로베르트-페터 클레인
Original Assignee
호프만, 마쓰
엘테에스 로오만 데라피-지스데메 게엠베하 운트 컴퍼니 카게
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Publication date
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=25859262&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=KR890701142(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by 호프만, 마쓰, 엘테에스 로오만 데라피-지스데메 게엠베하 운트 컴퍼니 카게 filed Critical 호프만, 마쓰
Publication of KR890701142A publication Critical patent/KR890701142A/ko
Application granted granted Critical
Publication of KR970006447B1 publication Critical patent/KR970006447B1/ko

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
    • A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
    • A61L15/42—Use of materials characterised by their function or physical properties
    • A61L15/58—Adhesives
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/52—Use of compounds or compositions for colorimetric, spectrophotometric or fluorometric investigation, e.g. use of reagent paper and including single- and multilayer analytical elements
    • G01N33/521—Single-layer analytical elements
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/465—Nicotine; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence

Abstract

내용 없음

Description

니코틴 조절 공급기재(Apparatus for the controlled delivery), 그 제조방법 및 그 용도
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
제 1 도에서 14는 니코틴 저장소이고, 12는 열용융 접착성 접촉물층이고, 10은 니코틴 불투과성 배면층인데, 여기에 니코틴 저장소 14가 자리하고, 피부 18표면에 부착하도록 한다. 니코틴은 예정된 속도로 열용융 접착성 접촉물층을 통해 피부 18내로 침투하고, 열용융 접착성 접촉물 층의 니코틴 성분은 감소한다. 감소된 니코틴 성분은 니코틴 저장소 14로부터 유입 보충되고, 열용융 접착성 접촉물 12의 니코틴 함량은 평형농도로 유지되어 일정량의 니코틴을 피부 18로 계속 공급할 수 있도록 한다. 니코틴 저장 14에는 고농도의 니코틴이 저장되며, 불활성 담체나 지지물질(예 : 섬유물질)에 흡착시킬 수 있다. 제 2 도는 본 발명의 다른 기재의 단면도 인데, 니코틴 저장소14가 전방향 열용융 접착성 접촉물 12에 의해 둘러 쌓여 있다. 제 3 도는 본 발명의 또 다른 기재의 단면도로서, 니코틴을 함유하는 열용융 접착성 접촉물중 12가 불투과성 배면층 10에 의하여 3방향으로 둘러 쌓여 있다. 열용융 접착성 접촉물 표면에 의하여 경고제는 피부 18위에 부착하고, 접촉면을 통해 일정량의 니코틴이 일정속도로 공급된다.

Claims (9)

  1. 40°내지 80℃, 바람직하기로는 40℃ 내지 60℃, 특히 바람직하기로는 40°내지 55℃의 처리온도를 가진 열용융 접착성 접촉물을 사용하여 제조한 저장소를 특징으로 하는, 균일 또는 불균일적으로 니코틴이 분포된 저장소가 비치된 니코틴의 조절 공급 기재.
  2. 제 1 항에 있어서, 열용융 접착성 접촉물이 하나 이상의 층으로 형성된 니코틴층임을 특징으로 하는 기재.
  3. 제 1 항에 있어서, 열용융 접착성 접촉물이 스티렌 - 이소프렌 - 스테렌블럭중합체, 폴리카프로락톤, 에틸렌 - 비닐아세테이트 코폴리머, 폴리우레탄, 폴리에폭시드, 폴리이소부텐, 폴리비닐에테르, 그리고 임의로 점착제(tackifier), 가소제, 충전제(filler), 항에이저(antiager) 및/또는 틱소트로피제(thixotropic agent)로 제조됨을 특징으로 하는 기재.
  4. 제 1 항 또는 제 2 항에 있어서, 열용융 접착성 접촉물이 중합체 10 내지 100중량%, 바람직하기로는 20 내지 80중량%, 특히 바람직하기로는 20 내지 50중량% : 가속제 10 내지 80중량%, 바람직하기로는 15 내지 60중량% : 점착제 10 내지 80중량%, 바람직하기로는 15 내지 60중량% : 그리고 임의로 항에이져 0.1 내지 5중량%와 임의로 충전제 0내지 70중량%로 이루어지고 총량이 100중량%되게 함을 특징으로 하는 기재.
  5. 제 1 항 또는 제 3 항의 어느 한항에 있어서, 제거용 보호층을 가짐을 특징으로 하는 기재.
  6. 40°내지 80℃, 바람직하기로는 40℃ 내지 60℃, 특히 바람직하기로는 45°내지 55℃의 온도에서, 니코틴을 함유하는 열용융 접착성 접촉물의 용융물을 담체에 연속 또는 불연속을 도입하고, 임의로 보호층 물질을 적용함을 특징으로 하는 제 1 항 내지 제 5 항의 기재를 제조하는 방법.
  7. 40°내지 80℃, 바람직하기로는 40℃ 내지 60℃, 특히 바람직하기로는 45°내지 55℃의 온도에서, 니코틴을 함유하는 열용융 접착성 접촉물의 용융물을 보호층 물질 연속 또는 불연속으로 도입하고 임의로 담체를 적용함을 특징으로 하는 제 1 항 내지 제 5 항의 기재를 제조하는 방법.
  8. 제 6 항 또는 제 7 항에 있어서, 열용융 접착성 접촉물로 된 기재의 조성성분을 40°내지 80℃의 처리온도에서 압출(extrusion), 주입(pouring), 롤러처리, 마이프코팅, 분무 또는 압착(press) 공정에 의하여 형성시킴을 특징으로 하는 제조방법.
  9. 제 1 항 또는 제 5 항의 기재를 사람 또는 동물에, 특히 사람의 금연요법이나, 해충구제에서 호흡기장애, 접촉, 또는 위장 해독(害毒)에 이용하는 방법.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019890700765A 1987-09-01 1988-08-03 니코틴 조절 공급기재(Apparatus for the controlled delivery), 그 제조방법 및 그 용도 KR970006447B1 (ko)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
DEP3729165.3 1987-09-01
DE3729165 1987-09-01
DE19873743947 DE3743947A1 (de) 1987-09-01 1987-12-23 Vorrichtung zur gesteuerten abgabe von nicotin, verfahren zu ihrer herstellung sowie ihre verwendung
DEP3743947.2 1987-12-23
PCT/DE1988/000479 WO1989001789A1 (en) 1987-09-01 1988-08-03 Device for controlled release of nicotine, process for manufacturing it, and use thereof

Publications (2)

Publication Number Publication Date
KR890701142A true KR890701142A (ko) 1989-12-19
KR970006447B1 KR970006447B1 (ko) 1997-04-28

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ID=25859262

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KR1019890700765A KR970006447B1 (ko) 1987-09-01 1988-08-03 니코틴 조절 공급기재(Apparatus for the controlled delivery), 그 제조방법 및 그 용도

Country Status (24)

Country Link
US (1) US5411739A (ko)
EP (1) EP0305757B1 (ko)
JP (1) JP2718531B2 (ko)
KR (1) KR970006447B1 (ko)
AT (1) ATE98877T1 (ko)
AU (1) AU613945B2 (ko)
CA (1) CA1333052C (ko)
CZ (1) CZ278699B6 (ko)
DE (2) DE3743947A1 (ko)
DK (1) DK210389D0 (ko)
ES (1) ES2047511T3 (ko)
FI (1) FI96482C (ko)
HU (1) HU205255B (ko)
IE (1) IE66100B1 (ko)
IL (1) IL87540A (ko)
MY (1) MY104817A (ko)
NO (1) NO180106B (ko)
NZ (1) NZ225917A (ko)
PH (1) PH25355A (ko)
PL (1) PL274487A1 (ko)
PT (1) PT88380B (ko)
SK (1) SK587488A3 (ko)
WO (1) WO1989001789A1 (ko)
YU (1) YU47291B (ko)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4781924A (en) 1987-11-09 1988-11-01 Alza Corporation Transdermal drug delivery device
US5004610A (en) * 1988-06-14 1991-04-02 Alza Corporation Subsaturated nicotine transdermal therapeutic system
PT90820B (pt) * 1988-06-14 1995-05-31 Alza Corp Dispositivo de libertacao transdermica sub-saturado
DE4031881C2 (de) * 1990-10-08 1994-02-24 Sanol Arznei Schwarz Gmbh Lösungsmittelfreie, oral zu verabreichende pharmazeutische Zubereitung mit verzögerter Wirkstoffreisetzung und Verfahren zu deren Herstellung
DE4224325C1 (de) * 1992-07-23 1994-02-10 Sanol Arznei Schwarz Gmbh Wirkstoffpflaster für niedrigschmelzende und/oder flüchtige Wirkstoffe und Verfahren zu seiner Herstellung
FR2739031B1 (fr) * 1995-09-27 1997-11-21 Lhd Lab Hygiene Dietetique Systeme matriciel transdermique d'administration d'un oestrogene et/ou d'un progestatif a base de copolymere styrene-isoprene-styrene, procede de preparation et utilisation en therapeutique
US5730721A (en) 1996-01-25 1998-03-24 Vesture Corporation Medical applicator and method
DE19825499C2 (de) 1998-06-08 2003-07-17 Beiersdorf Ag Wirkstoffhaltige Pflaster
DE19834496B4 (de) 1998-07-31 2004-02-26 Beiersdorf Ag Verbesserte Freisetzung von Ibuprofen aus Heißschmelzklebemassen in wirkstoffhaltigen Pflastern durch Zusatz von pharmazeutischen Hilfsstoffen und Verwendung von Hilfsstoffen zur Verbesserung der Freisetzung von Ibuprofen
EP1140039B1 (en) 1998-12-18 2009-11-04 Alza Corporation Transparent transdermal nicotine delivery devices
US6974588B1 (en) 1999-12-07 2005-12-13 Elan Pharma International Limited Transdermal patch for delivering volatile liquid drugs
FR2810237B1 (fr) 2000-06-15 2002-07-26 Oreal Composition cosmetique filmogene
FR2810238B1 (fr) 2000-06-15 2002-07-19 Oreal Composition cosmetique filmogene
FR2810239B1 (fr) 2000-06-15 2002-12-20 Oreal Composition cosmetique filmogene
DE10118282A1 (de) * 2001-04-12 2002-12-05 Lohmann Therapie Syst Lts Haftkleber auf Basis von Ethylen-Vinylacetat-Copolymeren und Klebharzen, für medizinische Verwendungszwecke
WO2003061613A1 (fr) * 2002-01-24 2003-07-31 L'oreal Composition contenant un polymere semi-cristallin et un ester
DE10212864B4 (de) 2002-03-22 2005-12-22 Beiersdorf Ag Polymermatrizes umfassend ein Mischsystem zur Löslichkeitsvermittlung von pharmazeutischen Wirkstoffen, Verfahren zu deren Herstellung und deren Verwendung
JP2004277345A (ja) * 2003-03-17 2004-10-07 Daikyo Yakuhin Kogyo Kk 硬膏剤及びその製造法
DE10360592A1 (de) * 2003-12-19 2005-07-28 Beiersdorf Ag Pflastersystem zur Verabreichung von Antihistaminika
DE102004039728A1 (de) * 2004-08-16 2006-02-23 Beiersdorf Ag Wirkstoffhaltiges Tape zur Behandlung von Gelenkerkrankungen
DE102004040840A1 (de) * 2004-08-23 2006-03-02 Henkel Kgaa Wärmeleitfähige Haftklebstoffe
DE102005053909A1 (de) 2005-05-13 2006-11-16 Beiersdorf Ag Selbstklebende Hautauflage und Kombinationsset zur kosmetischen Hautpflege
US20060264455A1 (en) * 2005-05-23 2006-11-23 Schachter Steven C Use of huperzine for disorders
EP1795556B1 (en) 2005-12-07 2017-02-15 The Procter and Gamble Company Polymeric compositions for sustained release of volatile materials
US8399007B2 (en) * 2006-12-05 2013-03-19 Landec Corporation Method for formulating a controlled-release pharmaceutical formulation
EP2324837A1 (en) 2006-12-21 2011-05-25 Trustees Of Tufts College Synthetic lipophilic inositol glycans for treatment of glucose-metabolism disorders
US20110224245A1 (en) * 2008-09-04 2011-09-15 President And Fellows Of Harvard College Treatment Of Neurological Disorders Using Huperzine

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE606885C (de) * 1933-09-14 1934-12-12 American Ball Mill Company Auswechselbare Ausfuetterung, z. B. fuer Rohrmuehlen
JPS54138124A (en) * 1978-04-19 1979-10-26 Hisamitsu Pharmaceut Co Inc Novel plaster and its preparation
JPS6034922B2 (ja) * 1978-09-01 1985-08-12 久光製薬株式会社 新規貼付薬
JPS55141408A (en) * 1979-04-19 1980-11-05 Hisamitsu Pharmaceut Co Inc Novel plaster containing steroid and its production
GB2045618B (en) * 1979-04-03 1983-05-11 Hisamitsu Pharmaceutical Co Adhesive plaster
JPS6059207B2 (ja) * 1981-03-13 1985-12-24 日東電工株式会社 複合製剤の製法
GB2118040A (en) * 1982-02-15 1983-10-26 Hoechst Uk Ltd Oral anti-diabetic preparation
JPS58141225A (ja) * 1982-02-16 1983-08-22 Takasago Corp 芳香材用樹脂組成物
JPS58189112A (ja) * 1982-04-30 1983-11-04 Nitto Electric Ind Co Ltd 生理活性物質含有物の製法
DE3315272C2 (de) * 1983-04-27 1986-03-27 Lohmann Gmbh & Co Kg, 5450 Neuwied Pharmazeutisches Produkt und Verfahren zu seiner Herstellung
GR79183B (ko) * 1983-04-27 1984-10-02 Lohmann Gmbh & Co Kg
US4564364A (en) * 1983-05-26 1986-01-14 Alza Corporation Active agent dispenser
DE3586707T2 (de) * 1984-10-05 1993-02-11 Hercon Lab System zur transdermalen applikation eines arzneimittels.
DE3438284A1 (de) * 1984-10-16 1985-03-07 Hans-Harald von 2400 Lübeck Tilly Nikotinhaltiges depotpflaster
EP0186019B1 (de) * 1984-12-22 1993-10-06 Schwarz Pharma Ag Wirkstoffpflaster
US4597961A (en) * 1985-01-23 1986-07-01 Etscorn Frank T Transcutaneous application of nicotine
JPS61251619A (ja) * 1985-04-30 1986-11-08 Nitto Electric Ind Co Ltd ニコチン含有テ−プ製剤
US4714655A (en) * 1985-10-04 1987-12-22 Avery International Corporation Pressure-sensitive adhesive containing heat-sensitive materials, and method of making the same
DE3629304A1 (de) * 1986-08-28 1988-03-24 Lohmann Gmbh & Co Kg Transdermales therapeutisches system, seine verwendung und verfahren zu seiner herstellung
US4840796A (en) * 1988-04-22 1989-06-20 Dow Corning Corporation Block copolymer matrix for transdermal drug release

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CZ278699B6 (en) 1994-05-18
EP0305757A1 (de) 1989-03-08
DE3743947C2 (ko) 1991-06-20
AU613945B2 (en) 1991-08-15
HUT53520A (en) 1990-11-28
IE882556L (en) 1989-03-01
IL87540A (en) 1994-02-27
PH25355A (en) 1991-05-13
FI96482B (fi) 1996-03-29
ATE98877T1 (de) 1994-01-15
DE3886477D1 (de) 1994-02-03
CZ587488A3 (en) 1994-01-19
PT88380B (pt) 1995-03-31
FI892055A0 (fi) 1989-04-28
FI96482C (fi) 1996-07-10
HU205255B (en) 1992-04-28
NZ225917A (en) 1990-04-26
NO891509D0 (no) 1989-04-12
SK277941B6 (en) 1995-08-09
EP0305757B1 (de) 1993-12-22
NO891509L (no) 1989-04-12
KR970006447B1 (ko) 1997-04-28
DK210389A (da) 1989-04-28
IL87540A0 (en) 1989-01-31
PL274487A1 (en) 1989-05-30
CA1333052C (en) 1994-11-15
DE3743947A1 (de) 1989-03-09
NO180106B (no) 1996-11-11
YU166488A (sh) 1992-09-07
IE66100B1 (en) 1995-12-13
US5411739A (en) 1995-05-02
YU47291B (sh) 1995-01-31
PT88380A (pt) 1989-07-31
JP2718531B2 (ja) 1998-02-25
DK210389D0 (da) 1989-04-28
AU2139688A (en) 1989-03-31
ES2047511T3 (es) 1994-03-01
SK587488A3 (en) 1995-08-09
MY104817A (en) 1994-06-30
FI892055A (fi) 1989-04-28
HU884780D0 (en) 1990-02-28
JPH02500569A (ja) 1990-03-01
WO1989001789A1 (en) 1989-03-09

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